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DK1004592T3 - Nye erythromycinderivater, deres fremstilling og deres anvendelse som medikamenter - Google Patents

Nye erythromycinderivater, deres fremstilling og deres anvendelse som medikamenter

Info

Publication number
DK1004592T3
DK1004592T3 DK99402907T DK99402907T DK1004592T3 DK 1004592 T3 DK1004592 T3 DK 1004592T3 DK 99402907 T DK99402907 T DK 99402907T DK 99402907 T DK99402907 T DK 99402907T DK 1004592 T3 DK1004592 T3 DK 1004592T3
Authority
DK
Denmark
Prior art keywords
drugs
preparation
erythromycin derivatives
new erythromycin
new
Prior art date
Application number
DK99402907T
Other languages
English (en)
Inventor
Alexis Denis
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of DK1004592T3 publication Critical patent/DK1004592T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DK99402907T 1998-11-24 1999-11-23 Nye erythromycinderivater, deres fremstilling og deres anvendelse som medikamenter DK1004592T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9814782A FR2786188B1 (fr) 1998-11-24 1998-11-24 Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments

Publications (1)

Publication Number Publication Date
DK1004592T3 true DK1004592T3 (da) 2003-10-27

Family

ID=9533122

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99402907T DK1004592T3 (da) 1998-11-24 1999-11-23 Nye erythromycinderivater, deres fremstilling og deres anvendelse som medikamenter

Country Status (24)

Country Link
US (2) US6440941B1 (da)
EP (1) EP1004592B1 (da)
JP (1) JP2000159790A (da)
KR (1) KR100587445B1 (da)
CN (1) CN1165546C (da)
AR (1) AR021388A1 (da)
AT (1) ATE245160T1 (da)
AU (1) AU772171B2 (da)
BR (1) BR9905735A (da)
CA (1) CA2290136C (da)
DE (1) DE69909577T2 (da)
DK (1) DK1004592T3 (da)
ES (1) ES2198867T3 (da)
FR (1) FR2786188B1 (da)
HU (1) HUP9904392A3 (da)
IL (1) IL133101A (da)
MX (1) MXPA99010813A (da)
NO (1) NO314729B1 (da)
PL (1) PL336736A1 (da)
PT (1) PT1004592E (da)
RU (1) RU2237672C2 (da)
TR (1) TR199902888A3 (da)
TW (1) TWI247747B (da)
ZA (1) ZA997176B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
ES2212655T3 (es) 1999-01-27 2004-07-16 Pfizer Products Inc. Antibioticos de cetolidos.
OA11945A (en) 1999-05-24 2006-04-13 Pfizer Prod Inc 13-Methyl erythromycin derivatives.
DE60104240T2 (de) 2000-06-30 2005-08-04 Pfizer Products Inc., Groton Makrolid-Antibiotika
US7601695B2 (en) 2003-03-10 2009-10-13 Optimer Pharmaceuticals, Inc. Antibacterial agents
FR2862647B1 (fr) 2003-11-25 2008-07-04 Aventis Pharma Sa Derives de pyrazolyle, procede de preparation et intermediaires de ce procede a titre de medicaments et de compositions pharmaceutiques les renfermant
US20080287376A1 (en) * 2004-07-28 2008-11-20 Mohammad Salman Ketolide Derivatives as Antibacterial Agents
WO2009055557A1 (en) 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
WO2009137787A1 (en) * 2008-05-09 2009-11-12 Enanta Pharmaceuticals, Inc. Processes for the preparation of 2-fluoro 6-11 bicyclic erythromycin derivatives
EP3031460A1 (en) 2008-10-24 2016-06-15 Cempra Pharmaceuticals Inc. Biodefenses using triazole-containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
EP2475253B1 (en) 2009-09-10 2016-10-26 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
DK2550286T3 (da) 2010-03-22 2016-02-29 Cempra Pharmaceuticals Inc Krystallinske former af et macrolid og anvendelser deraf
US9051346B2 (en) 2010-05-20 2015-06-09 Cempra Pharmaceuticals, Inc. Process for preparing triazole-containing ketolide antibiotics
KR20180110181A (ko) * 2010-09-10 2018-10-08 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
BR112013009823A2 (pt) 2010-10-22 2016-07-05 Bayer Ip Gmbh novos compostos heterocíclicos como pesticidas
MX2014011537A (es) 2012-03-27 2015-02-10 Cempra Pharmaceuticals Inc Formulaciones parenterales para la administracion de antibioticos macrolidos.
RU2015138796A (ru) 2013-03-14 2017-04-19 Семпра Фармасьютикалс, Инк. Способы и составы для лечения респираторных заболеваний
EP2968384A4 (en) 2013-03-15 2017-02-15 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
CN106432383A (zh) * 2016-09-14 2017-02-22 重庆两江药物研发中心有限公司 索利霉素及其中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1098527A (en) * 1976-12-20 1981-03-31 Denis M. Bailey 1-amino-lower-alkyl-3,4-diphenyl-1h-pyrazoles
US4182895A (en) * 1976-12-20 1980-01-08 Sterling Drug Inc. 1-Amino-lower-alkyl-3,4-diphenyl-1H-pyrazoles
JPH04234891A (ja) * 1990-03-05 1992-08-24 Fujisawa Pharmaceut Co Ltd 新規セフェム化合物およびその塩
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2727969B1 (fr) * 1994-12-09 1997-01-17 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
IL132767A0 (en) * 1997-06-11 2001-03-19 Pfizer Prod Inc 9-Oxime erythromycin derivatives
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments

Also Published As

Publication number Publication date
CN1165546C (zh) 2004-09-08
HU9904392D0 (en) 2000-01-28
HUP9904392A2 (hu) 2000-05-28
US20030050254A1 (en) 2003-03-13
NO995745L (no) 2000-05-25
DE69909577D1 (de) 2003-08-21
BR9905735A (pt) 2000-08-08
NO995745D0 (no) 1999-11-23
IL133101A0 (en) 2001-03-19
KR100587445B1 (ko) 2006-06-08
CN1263101A (zh) 2000-08-16
IL133101A (en) 2007-02-11
ATE245160T1 (de) 2003-08-15
TR199902888A2 (xx) 2000-06-21
EP1004592B1 (fr) 2003-07-16
CA2290136C (fr) 2010-07-20
RU2237672C2 (ru) 2004-10-10
TWI247747B (en) 2006-01-21
TR199902888A3 (tr) 2000-06-21
FR2786188A1 (fr) 2000-05-26
FR2786188B1 (fr) 2002-10-31
ZA997176B (en) 2000-11-20
MXPA99010813A (es) 2005-09-08
EP1004592A1 (fr) 2000-05-31
CA2290136A1 (fr) 2000-05-24
ES2198867T3 (es) 2004-02-01
DE69909577T2 (de) 2004-06-03
HUP9904392A3 (en) 2001-08-28
JP2000159790A (ja) 2000-06-13
AU5952299A (en) 2000-05-25
US6664398B2 (en) 2003-12-16
AU772171B2 (en) 2004-04-08
KR20000057017A (ko) 2000-09-15
AR021388A1 (es) 2002-07-17
PT1004592E (pt) 2003-12-31
US6440941B1 (en) 2002-08-27
PL336736A1 (en) 2000-06-05
NO314729B1 (no) 2003-05-12

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