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DK1071710T3 - Genomic sequence of the 5-lipoxygenase activation protein (FLAP), polymorphic markers therein, and methods for detecting asthma - Google Patents

Genomic sequence of the 5-lipoxygenase activation protein (FLAP), polymorphic markers therein, and methods for detecting asthma

Info

Publication number
DK1071710T3
DK1071710T3 DK99913538T DK99913538T DK1071710T3 DK 1071710 T3 DK1071710 T3 DK 1071710T3 DK 99913538 T DK99913538 T DK 99913538T DK 99913538 T DK99913538 T DK 99913538T DK 1071710 T3 DK1071710 T3 DK 1071710T3
Authority
DK
Denmark
Prior art keywords
flap
genomic sequence
methods
activation protein
polymorphic markers
Prior art date
Application number
DK99913538T
Other languages
Danish (da)
Other versions
DK1071710T4 (en
Inventor
Marta Blumenfeld
Ilya Chumakov
Lydie Bougueleret
Original Assignee
Serono Genetics Inst Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27374096&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1071710(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Serono Genetics Inst Sa filed Critical Serono Genetics Inst Sa
Application granted granted Critical
Publication of DK1071710T3 publication Critical patent/DK1071710T3/en
Publication of DK1071710T4 publication Critical patent/DK1071710T4/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention concerns the genomic sequence of the FLAP gene. The invention also concerns biallelic markers of a FLAP gene and the association established between these markers and diseases involving the leukotriene pathway such as asthma. The invention provides means to determine the predisposition of individuals to diseases involving the leukotriene pathway as well as means for the diagnosis of such diseases and for the prognosis/detection of an eventual treatment response to agents acting on the leukotriene pathway.
DK99913538.7T 1998-04-15 1999-04-15 Genomic sequence of the 5-lipoxygenase activation protein (FLAP), polymorphic markers therein and methods for detecting asthma DK1071710T4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8189398P 1998-04-15 1998-04-15
US9131498P 1998-06-30 1998-06-30
US12340699P 1999-03-08 1999-03-08
PCT/IB1999/000744 WO1999052942A2 (en) 1998-04-15 1999-04-15 Genomic sequence of the 5-lipoxygenase-activating protein (flap), polymorphic markers thereof and methods for detection of asthma

Publications (2)

Publication Number Publication Date
DK1071710T3 true DK1071710T3 (en) 2007-02-19
DK1071710T4 DK1071710T4 (en) 2011-12-12

Family

ID=27374096

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99913538.7T DK1071710T4 (en) 1998-04-15 1999-04-15 Genomic sequence of the 5-lipoxygenase activation protein (FLAP), polymorphic markers therein and methods for detecting asthma

Country Status (11)

Country Link
US (4) US6531279B1 (en)
EP (1) EP1071710B2 (en)
JP (1) JP4472173B2 (en)
AT (1) ATE342918T1 (en)
AU (1) AU768721B2 (en)
CA (1) CA2321226C (en)
DE (1) DE69933661T3 (en)
DK (1) DK1071710T4 (en)
ES (1) ES2272061T5 (en)
PT (1) PT1071710E (en)
WO (1) WO1999052942A2 (en)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU768721B2 (en) * 1998-04-15 2004-01-08 Genset S.A. Genomic sequence of the 5-lipoxygenase-activating protein (FLAP), polymorphic markers thereof and methods for detection of asthma
US6537751B1 (en) * 1998-04-21 2003-03-25 Genset S.A. Biallelic markers for use in constructing a high density disequilibrium map of the human genome
US6986987B1 (en) * 1998-07-24 2006-01-17 The Uab Research Foundation Genetic polymorphism in the receptor for IgA
CA2362586A1 (en) * 1999-02-12 2000-08-17 Genset S.A. Biallelic markers derived from genomic regions carrying genes involved in arachidonic acid metabolism
EP1236803A4 (en) * 1999-11-30 2003-05-02 Asahi Breweries Ltd Method of judging flocculating properties of bottom brewer's yeast
US20020077775A1 (en) * 2000-05-25 2002-06-20 Schork Nicholas J. Methods of DNA marker-based genetic analysis using estimated haplotype frequencies and uses thereof
US7205146B1 (en) * 2000-06-14 2007-04-17 Oscient Pharmaceuticals Corporation Nucleotide and amino acid sequences relating to respiratory diseases and obesity
CN1329012A (en) * 2000-06-21 2002-01-02 上海博德基因开发有限公司 A novel polypeptide-nicotinamide adenine deoxydinucleotide dependent leukotriene B412-hydroxydehydrogenase 36 and polynucleotide for coding this polypeptide
JP2004522418A (en) * 2000-09-08 2004-07-29 アイオワ ステート ユニバーシティ リサーチ ファウンデーション，インコーポレーティッド Novel PRKAG3 allele and its use as a genetic marker for reproductive and flesh traits
US7537888B2 (en) * 2000-10-31 2009-05-26 Michel Alphonse Julien Georges Marker assisted selection of bovine for improved milk production using diacylglycerol acyltransferase gene DGAT1
ATE469966T1 (en) * 2000-12-12 2010-06-15 Inst Nagoya Ind Science Res METHOD FOR ESTIMATING THE RISK OF EXPRESSION OF AN ADVERSE DRUG EFFECT CAUSED BY THE ADMINISTRATION OF A COMPOUND EITHER PER SE METABOLIZED BY UGT1A1 OR WHICH INTERMEDIATE COMPOUND IS METABOLIZED BY THE ENZYME
FI114483B (en) * 2001-02-20 2004-10-29 Jurilab Ltd Oy Procedure for detecting a risk of elevated blood pressure and its uses
US7271240B2 (en) 2001-03-14 2007-09-18 Agensys, Inc. 125P5C8: a tissue specific protein highly expressed in various cancers
AU785425B2 (en) 2001-03-30 2007-05-17 Genetic Technologies Limited Methods of genomic analysis
US7115726B2 (en) * 2001-03-30 2006-10-03 Perlegen Sciences, Inc. Haplotype structures of chromosome 21
EP1386973B1 (en) * 2001-04-19 2006-08-09 Hubit Genomix, Inc. Method of inferring diplotype configuration from the genotype of individual
ATE441727T1 (en) * 2001-10-01 2009-09-15 Sinai School Medicine NOONANIC SYNDROME GENE
TWI329105B (en) * 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
WO2003076573A2 (en) * 2002-03-04 2003-09-18 The Texas A & M University System Quantitative trait loci and somatostatin
US7579147B2 (en) * 2002-05-07 2009-08-25 Wake Forest University Health Sciences Mutations in the macrophage scavenger receptor 1 gene alter risk of prostate cancer, asthma, and cardiovascular disease
WO2004016733A2 (en) * 2002-08-16 2004-02-26 Agensys, Inc. Nucleic acid and corresponding protein entitled 251p5g2 useful in treatment and detection of cancer
AU2003253440A1 (en) * 2002-08-30 2004-04-30 Japan As Represented By The President Of The University Of Tokyo Method of diagnosing ovarian endometriosis
US20080293750A1 (en) * 2002-10-17 2008-11-27 Anna Helgadottir Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment
US7851486B2 (en) * 2002-10-17 2010-12-14 Decode Genetics Ehf. Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment
US20060019269A1 (en) * 2002-10-17 2006-01-26 Decode Genetics, Inc. Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment
EP1562973A4 (en) * 2002-10-17 2007-01-03 Decode Genetics Ehf Susceptibility gene for myocardial infarction
US7507531B2 (en) * 2002-10-17 2009-03-24 Decode Genetics Chf. Use of 5-lipoxygenase activating protein (FLAP) gene to assess susceptibility for myocardial infarction
WO2004035741A2 (en) * 2002-10-17 2004-04-29 Decode Genetics Ehf. Susceptibility gene for myocardial infarction; methods of treatment
US20040146870A1 (en) * 2003-01-27 2004-07-29 Guochun Liao Systems and methods for predicting specific genetic loci that affect phenotypic traits
US7803538B2 (en) * 2003-06-20 2010-09-28 Aventis Pharma Sa Method for detecting Alzheimer's disease
CN102358738A (en) * 2003-07-30 2012-02-22 里格尔药品股份有限公司 2,4-pyrimidinediamine compounds and uses of treating or preventing autoimmune diseases thereof
WO2005027719A2 (en) 2003-09-12 2005-03-31 Perlegen Sciences, Inc. Methods and systems for identifying predisposition to the placebo effect
CA2539276A1 (en) * 2003-09-17 2005-03-31 Decode Genetics Ehf. Methods of preventing or treating recurrence of myocardial infarction
US8158362B2 (en) * 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
US20100216863A1 (en) * 2004-01-30 2010-08-26 Decode Genetics Ehf. Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment
JP2007315752A (en) * 2004-08-16 2007-12-06 Ajinomoto Co Inc Judging method of hepatic fibrillation stage
WO2007053844A2 (en) * 2005-10-31 2007-05-10 Rigel Pharmaceuticals, Inc. Compositions and methods for treating inflammatory disorders
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
US20080109484A1 (en) * 2006-09-29 2008-05-08 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational systems for biomedical data
US7853626B2 (en) 2006-09-29 2010-12-14 The Invention Science Fund I, Llc Computational systems for biomedical data
US10068303B2 (en) 2006-09-29 2018-09-04 Gearbox Llc Computational systems for biomedical data
US20080082583A1 (en) * 2006-09-29 2008-04-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational systems for biomedical data
US10546652B2 (en) 2006-09-29 2020-01-28 Gearbox Llc Computational systems for biomedical data
US10503872B2 (en) * 2006-09-29 2019-12-10 Gearbox Llc Computational systems for biomedical data
US20080082306A1 (en) * 2006-09-29 2008-04-03 Searete Llc Computational systems for biomedical data
US20080082359A1 (en) * 2006-09-29 2008-04-03 Searete Llc, A Limited Liability Corporation Of State Of Delaware Computational systems for biomedical data
US20080091730A1 (en) * 2006-09-29 2008-04-17 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational systems for biomedical data
US20080082584A1 (en) * 2006-09-29 2008-04-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational systems for biomedical data
US10095836B2 (en) * 2006-09-29 2018-10-09 Gearbox Llc Computational systems for biomedical data
US20080082364A1 (en) * 2006-09-29 2008-04-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational systems for biomedical data
US8122073B2 (en) * 2006-09-29 2012-02-21 The Invention Science Fund I Computational systems for biomedical data
US20080082367A1 (en) * 2006-09-29 2008-04-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational systems for biomedical data
US20080082271A1 (en) * 2006-09-29 2008-04-03 Searete Llc Computational systems for biomedical data
JP2010511632A (en) 2006-11-30 2010-04-15 アミラ ファーマシューティカルス，インコーポレーテッド Compositions and methods of treatment comprising 5-lipoxygenase activated protein inhibitors and nitric oxide modulators
TW200920369A (en) * 2007-10-26 2009-05-16 Amira Pharmaceuticals Inc 5-lipoxygenase activating protein (flap) inhibitor
CN101918552B (en) * 2007-10-29 2012-11-21 独立行政法人理化学研究所 Method for determining inflammatory diseases by using single nucleotide polymorphism in BRCA 1-related protein (BRAP) gene
CA2724726C (en) 2008-05-23 2018-02-27 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein inhibitor
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US8568980B2 (en) 2009-01-27 2013-10-29 Mount Sinai School Of Medicine Nucleic acids, methods and kits for the diagnosis of DYT6 primary torsion dystonia
US20130261059A1 (en) * 2010-05-26 2013-10-03 The Children's Hospital Of Philadelphia Compositions and Methods for the Diagnosis and Treatment of Primary Insulin-Like Growth Factor Deficiency (PIGFD) and Idiopathic Short Stature (ISS)
WO2012047724A1 (en) 2010-09-29 2012-04-12 Agensys, Inc. Antibody drug conjugates (adc) that bind to 191p4d12 proteins
EP2865756A1 (en) 2013-10-22 2015-04-29 Sylentis, S.A.U. siRNA and their use in methods and compositions for inhibiting the expression of the FLAP gene.
ES2878405T3 (en) 2014-02-04 2021-11-18 Bioscience Pharma Partners Llc Use of flap inhibitors to reduce neuroinflammation-mediated injury in the central nervous system
EP4092416A1 (en) * 2015-12-11 2022-11-23 National University Corporation Kochi University Marker for pancreatic cancer and intraductal papillary mucinous neoplasms
KR102527520B1 (en) * 2020-09-16 2023-05-03 순천대학교 산학협력단 Composition for diagnosis of occupational asthma and method for diagnosis of occupational asthma using the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2032253C (en) 1989-12-15 2000-11-28 John W. Gillard 5-lipoxygenase activating protein
US5182367A (en) * 1990-11-30 1993-01-26 Merck & Co., Inc. 5-lipoxygenase activating protein
US5578443A (en) * 1991-03-06 1996-11-26 Regents Of The University Of Minnesota DNA sequence-based HLA typing method
CA2168096A1 (en) * 1993-07-26 1995-02-02 David E. Housman Inhibitors of alternative alleles of genes as a basis for cancer therapeutic agents
US5696076A (en) * 1994-06-22 1997-12-09 Human Genome Sciences, Inc. 5-lipoxygenase-activating protein II
CA2253823A1 (en) * 1996-05-06 1997-11-13 Brigham And Women's Hospital 5-lipoxygenase gene polymorphisms and their use in classifying patients
AU768721B2 (en) * 1998-04-15 2004-01-08 Genset S.A. Genomic sequence of the 5-lipoxygenase-activating protein (FLAP), polymorphic markers thereof and methods for detection of asthma

Also Published As

Publication number Publication date
DE69933661T2 (en) 2007-08-23
EP1071710B2 (en) 2011-11-02
DK1071710T4 (en) 2011-12-12
US20050196752A1 (en) 2005-09-08
US6531279B1 (en) 2003-03-11
ES2272061T5 (en) 2012-02-24
DE69933661D1 (en) 2006-11-30
AU3164499A (en) 1999-11-01
US7838241B2 (en) 2010-11-23
EP1071710B1 (en) 2006-10-18
CA2321226C (en) 2011-06-07
JP4472173B2 (en) 2010-06-02
US7494777B2 (en) 2009-02-24
JP2002511242A (en) 2002-04-16
CA2321226A1 (en) 1999-10-21
US20070003971A1 (en) 2007-01-04
US20090155806A1 (en) 2009-06-18
DE69933661T3 (en) 2012-01-26
EP1071710A2 (en) 2001-01-31
WO1999052942A3 (en) 2000-02-03
AU768721B2 (en) 2004-01-08
US7118869B2 (en) 2006-10-10
ATE342918T1 (en) 2006-11-15
WO1999052942A2 (en) 1999-10-21
PT1071710E (en) 2007-01-31
ES2272061T3 (en) 2007-04-16

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