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DK1062190T3 - Process for producing [15O] butanol and device for carrying out the process - Google Patents

Process for producing [15O] butanol and device for carrying out the process

Info

Publication number
DK1062190T3
DK1062190T3 DK99913104T DK99913104T DK1062190T3 DK 1062190 T3 DK1062190 T3 DK 1062190T3 DK 99913104 T DK99913104 T DK 99913104T DK 99913104 T DK99913104 T DK 99913104T DK 1062190 T3 DK1062190 T3 DK 1062190T3
Authority
DK
Denmark
Prior art keywords
butanol
adsorbent
columns
container
butylborane
Prior art date
Application number
DK99913104T
Other languages
Danish (da)
Inventor
Werner Roden
Wilhelm Hamkens
Original Assignee
Forschungszentrum Juelich Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forschungszentrum Juelich Gmbh filed Critical Forschungszentrum Juelich Gmbh
Application granted granted Critical
Publication of DK1062190T3 publication Critical patent/DK1062190T3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to a method for producing [<15>O] butanol. The invention also relates to a device for implementing said method. According to the inventive method for producing [<15>O] butanol, a column containing an adsorbent is exposed to tri-n-butylborane, a gas containing [<15>O]O2 produced in a cyclotron is guided through the column, the reaction product is then hydrolyzed, the [<15>O]O2 obtained is purified and the solution containing the purified [<15>O]O2 is fed to a container. A plurality of columns containing the adsorbent is fixed on an exchangeable element and the exposure to tri-n-butylborane is carried out on the columns fixed on the element. The steps for conducting the inventive method can be carried out in a particularly quick and safe manner. The inventive device is particularly suitable for implementing said method. The device comprises a protective gas inlet, a container with water, an element for receiving a plurality of columns containing an adsorbent, a system for purifying the [<15>O]butanol obtained and a container for receiving the purified [<15>O]butanol. The device also includes a container with tri-n-butylborane. The element for receiving the columns containing an adsorbent can be exchanged and is arranged in such a way that it can be displaced. The method can be conducted with particularly good results when columns with adsorbent Sep-Pak Alumina N Plus cartridges are used, when purification of the [<15>O]butanol obtained is conducted using Sep-Pak C-18 Plus cartridges and when said cartridges are fixed on a disc-shaped element consisting of a top and a bottom part.
DK99913104T 1998-03-07 1999-03-03 Process for producing [15O] butanol and device for carrying out the process DK1062190T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19809960A DE19809960C2 (en) 1998-03-07 1998-03-07 Process for the preparation of [· 1 ·· 5 · O] butanol and device for carrying out the process
PCT/DE1999/000565 WO1999044970A1 (en) 1998-03-07 1999-03-03 Method for producing [15o] butanol and device for implementing said method

Publications (1)

Publication Number Publication Date
DK1062190T3 true DK1062190T3 (en) 2003-03-24

Family

ID=7860159

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99913104T DK1062190T3 (en) 1998-03-07 1999-03-03 Process for producing [15O] butanol and device for carrying out the process

Country Status (6)

Country Link
EP (1) EP1062190B1 (en)
AT (1) ATE228985T1 (en)
DE (2) DE19809960C2 (en)
DK (1) DK1062190T3 (en)
ES (1) ES2183531T3 (en)
WO (1) WO1999044970A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10108440A1 (en) * 2001-02-22 2002-10-10 Forschungszentrum Juelich Gmbh Precision automatic syringe for e.g. fluid injection to cyclotron target, includes piston with longitudinal bore
AT503011B1 (en) * 2006-02-14 2007-07-15 Univ Wien Med SYNTHESIS CONTAINER, SYNTHESIS DEVICE AND SYNTHESIS PROCESS FOR THE PREPARATION OF A PHARMACEUTICALLY ACTIVE SUBSTANCE FROM A SUITABLE PRECURSORING SUBSTANCE
JP2012532164A (en) * 2009-07-10 2012-12-13 バイエル ファーマ アクチエンゲゼルシャフト Use of low-medium pressure liquid chromatography for the purification of radioactive tracers.
AU2015258247B2 (en) * 2009-10-08 2016-12-15 Ge Healthcare Limited Purification method
PT2509637T (en) * 2009-10-08 2016-10-05 Ge Healthcare Ltd Purification method
WO2011044422A2 (en) * 2009-10-08 2011-04-14 Ge Healthcare Limited Solid phase extraction purification method

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5082980A (en) * 1990-06-13 1992-01-21 Case Western Reserve University Process and apparatus for synthesizing oxygen-15 labelled butanol for positron emission tomography

Also Published As

Publication number Publication date
WO1999044970A1 (en) 1999-09-10
DE59903651D1 (en) 2003-01-16
EP1062190B1 (en) 2002-12-04
DE19809960A1 (en) 1999-09-09
EP1062190A1 (en) 2000-12-27
ATE228985T1 (en) 2002-12-15
DE19809960C2 (en) 2002-09-19
ES2183531T3 (en) 2003-03-16

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