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DK1049689T3 - 4-(2-keto-1-benzimidazolinyl)piperidinderivater som ORL1-receptoragonister - Google Patents

4-(2-keto-1-benzimidazolinyl)piperidinderivater som ORL1-receptoragonister

Info

Publication number
DK1049689T3
DK1049689T3 DK99900012T DK99900012T DK1049689T3 DK 1049689 T3 DK1049689 T3 DK 1049689T3 DK 99900012 T DK99900012 T DK 99900012T DK 99900012 T DK99900012 T DK 99900012T DK 1049689 T3 DK1049689 T3 DK 1049689T3
Authority
DK
Denmark
Prior art keywords
benzimidazolinyl
keto
receptor agonists
piperidine derivatives
orl1 receptor
Prior art date
Application number
DK99900012T
Other languages
English (en)
Inventor
Fumitaka Ito
Hiroshi Kondo
Hirohide Noguchi
Yoriko Ohashi
Tatsuya Yamagishi
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DK1049689T3 publication Critical patent/DK1049689T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12Antidiuretics, e.g. drugs for diabetes insipidus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DK99900012T 1998-01-19 1999-01-08 4-(2-keto-1-benzimidazolinyl)piperidinderivater som ORL1-receptoragonister DK1049689T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB9800069 1998-01-19
PCT/IB1999/000012 WO1999036421A1 (en) 1998-01-19 1999-01-08 4-(2-keto-1-benzimidazolinyl)piperidine compounds as orl1-receptor agonists

Publications (1)

Publication Number Publication Date
DK1049689T3 true DK1049689T3 (da) 2002-07-22

Family

ID=11004651

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99900012T DK1049689T3 (da) 1998-01-19 1999-01-08 4-(2-keto-1-benzimidazolinyl)piperidinderivater som ORL1-receptoragonister

Country Status (30)

Country Link
US (1) US6423725B1 (da)
EP (1) EP1049689B1 (da)
JP (1) JP3342478B2 (da)
CN (1) CN1288464A (da)
AP (1) AP9901442A0 (da)
AR (1) AR014421A1 (da)
AT (1) ATE219772T1 (da)
AU (1) AU1679099A (da)
BG (1) BG104670A (da)
BR (1) BR9907104A (da)
CA (1) CA2317462C (da)
CO (1) CO4990962A1 (da)
DE (1) DE69901934T2 (da)
DK (1) DK1049689T3 (da)
EA (1) EA200000683A1 (da)
ES (1) ES2175925T3 (da)
GT (1) GT199900008A (da)
IL (1) IL137149A0 (da)
IS (1) IS5539A (da)
MA (1) MA26598A1 (da)
NO (1) NO20003671L (da)
OA (1) OA11445A (da)
PA (1) PA8467101A1 (da)
PE (1) PE20000166A1 (da)
PL (1) PL342046A1 (da)
PT (1) PT1049689E (da)
TN (1) TNSN99006A1 (da)
TR (1) TR200002090T2 (da)
WO (1) WO1999036421A1 (da)
ZA (1) ZA99314B (da)

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US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
EP0997464B1 (en) * 1998-10-23 2005-02-16 Pfizer Inc. 1,3,8-Triazaspiro[4,5] decanone compounds as orl1-receptor agonists
AU1185300A (en) * 1998-11-20 2000-06-13 Banyu Pharmaceutical Co., Ltd. 2-oxoimidazole derivatives
SE9903544D0 (sv) 1999-10-01 1999-10-01 Astra Pharma Prod Novel compounds
DE60013464T2 (de) * 1999-10-13 2005-09-15 Banyu Pharmaceutical Co., Ltd. Substituierte imidazolin-derivate
JP3989247B2 (ja) 1999-12-06 2007-10-10 ユーロ−セルティーク エス.エイ. ノシセプチン受容体親和性を有するトリアゾスピロ化合物
WO2001039775A1 (en) * 1999-12-06 2001-06-07 Euro-Celtique, S.A. Benzimidazole compounds having nociceptin receptor affinity
EP1244437A4 (en) 1999-12-06 2005-02-09 Euro Celtique Sa TERTIARY AMINO COMPOUNDS HAVING AFFINITY FOR OPIOID RECEPTOR
GB2359078A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB2359081A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active thiazolopyrimidines
GB2359551A (en) 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en) 2000-03-10 2000-05-03 Astrazeneca Uk Ltd Chemical compounds
SE0003828D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Novel compounds
EP1342717A4 (en) * 2000-11-15 2005-02-16 Banyu Pharma Co Ltd benzimidazole derivatives
SE0101322D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab Novel compounds
ES2323876T3 (es) * 2001-04-18 2009-07-27 Euro-Celtique S.A. Derivados de 1-(4-piperidinil)-1,3-dihidro-2h-benzoxazol-2-ona y compuestos relacionados como analogos de la nociceptina y ligandos de orl1 para el tratamiento del dolor.
PL367263A1 (en) 2001-04-18 2005-02-21 Euro-Celtique, S.A. Spiropyrazole compounds
EP2033644A1 (en) 2001-04-18 2009-03-11 Euro-Celtique S.A. Spiroindene and spiroindane compounds
ATE456564T1 (de) * 2001-04-18 2010-02-15 Euro Celtique Sa Octahydrobenzimidazolon-verbindungen als analgetika
MXPA03009602A (es) 2001-04-18 2004-04-02 Euro Celtique Sa Analogos de nociceptina.
DE10123163A1 (de) 2001-05-09 2003-01-16 Gruenenthal Gmbh Substituierte Cyclohexan-1,4-diaminderivate
JP3896309B2 (ja) 2001-07-09 2007-03-22 ファイザー株式会社 プロテインキナーゼc阻害物質としてのピラゾロキノリノン誘導体
US7566728B2 (en) 2002-03-29 2009-07-28 Mitsubishi Tanabe Pharma Corporation Remedy for sleep disturbance
JP2005289816A (ja) * 2002-05-14 2005-10-20 Banyu Pharmaceut Co Ltd ベンズイミダゾール誘導体
GB0221828D0 (en) 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
WO2004043902A1 (de) * 2002-11-12 2004-05-27 Grünenthal GmbH 4-hydroxymethyl-1-aryl-cyclohexylamin-derivative
TW200519101A (en) * 2003-09-25 2005-06-16 Solvay Pharm Bv Benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors
AR045843A1 (es) * 2003-10-03 2005-11-16 Solvay Pharm Bv Derivados de bencimidazolonas y quinazolinonas sustituidas con hidronopol como agonistas en receptores orl 1 humanos
GB0328243D0 (en) 2003-12-05 2004-01-07 Astrazeneca Ab Methods
AR054816A1 (es) * 2005-07-13 2007-07-18 Banyu Pharma Co Ltd Derivados de n-dihidroxialquil 2-oxo- imidazol sustituidos
US7300947B2 (en) * 2005-07-13 2007-11-27 Banyu Pharmaceutical Co., Ltd. N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives
US20090111778A1 (en) * 2005-11-18 2009-04-30 Richard Apodaca 2-Keto-Oxazoles as Modulators of Fatty Acid Amide Hydrolase
EP1987009A1 (en) 2006-01-30 2008-11-05 Euro-Celtique S.A. Cyclourea compounds as calcium channel blockers
GB0605786D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
GB0605784D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
CA2666630C (en) 2006-10-16 2012-01-24 Mitsubishi Tanabe Pharma Corporation Agent for prophylaxis or treatment of alcohol dependence or drug dependence
ES2353448T3 (es) * 2007-01-16 2011-03-02 Purdue Pharma L.P. Piperidinas heterocíclico-sustituidas como ligandos de orl-1.
US8877779B2 (en) * 2007-03-01 2014-11-04 Mitsubishi Tanabe Pharma Corporation Benzimidazole compound and pharmaceutical use thereof
RU2488585C2 (ru) 2007-08-31 2013-07-27 Пэдью Фарма Л.П. Замещенные пиперидиновые соединения хиноксалинового типа и их применение
US8119661B2 (en) 2007-09-11 2012-02-21 Astrazeneca Ab Piperidine derivatives and their use as muscarinic receptor modulators
TW201016675A (en) * 2008-09-16 2010-05-01 Mitsubishi Tanabe Pharma Corp Crystalline benzoimidazole compound and salt thereof
CN102947275A (zh) * 2010-06-17 2013-02-27 诺瓦提斯公司 哌啶基取代的1,3-二氢-苯并咪唑-2-亚基胺衍生物
EP2976077A4 (en) 2013-03-22 2016-11-30 Scripps Research Inst BENZIMIDAZOLES SUBSTITUTED AS MODULATORS OF A NOCICEPTIN RECEPTOR
KR20190092464A (ko) * 2016-11-28 2019-08-07 미쓰비시 타나베 파마 코퍼레이션 코카인 의존증의 치료 또는 재발 예방약
US11739070B2 (en) 2018-01-19 2023-08-29 Idorsia Pharmaceuticals Ltd. C5A receptor modulators
CN116496270B (zh) * 2022-01-27 2024-09-24 四川大学华西医院 一类4-氨基哌啶衍生物及其制备方法和用途

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US3161645A (en) * 1962-12-18 1964-12-15 Res Lab Dr C Janssen N V 1-(1-aroylpropyl-4-piperidyl)-2-benzimidazolinones and related compounds
US3318900A (en) 1964-05-06 1967-05-09 Janssen Pharmaceutica Nv Derivatives of benzimidazolinyl piperidine
JPS58180481A (ja) 1982-04-15 1983-10-21 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体
AT388731B (de) * 1987-12-15 1989-08-25 Gerot Pharmazeutika Neue derivate von benzimidazol, ihre herstellung und verwendung
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Also Published As

Publication number Publication date
CA2317462C (en) 2005-09-13
CO4990962A1 (es) 2000-12-26
WO1999036421A1 (en) 1999-07-22
IS5539A (is) 2000-06-16
TR200002090T2 (tr) 2000-11-21
BR9907104A (pt) 2000-10-24
DE69901934D1 (de) 2002-08-01
ES2175925T3 (es) 2002-11-16
NO20003671D0 (no) 2000-07-18
EA200000683A1 (ru) 2000-12-25
US6423725B1 (en) 2002-07-23
AU1679099A (en) 1999-08-02
OA11445A (en) 2004-04-30
PE20000166A1 (es) 2000-03-07
TNSN99006A1 (fr) 2005-11-10
AR014421A1 (es) 2001-02-28
CN1288464A (zh) 2001-03-21
ATE219772T1 (de) 2002-07-15
JP3342478B2 (ja) 2002-11-11
PA8467101A1 (es) 2000-09-29
ZA99314B (en) 2000-07-18
PT1049689E (pt) 2002-09-30
AP9901442A0 (en) 1999-03-31
IL137149A0 (en) 2001-07-24
EP1049689B1 (en) 2002-06-26
PL342046A1 (en) 2001-05-21
GT199900008A (es) 2000-07-12
EP1049689A1 (en) 2000-11-08
JP2002509148A (ja) 2002-03-26
MA26598A1 (fr) 2004-12-20
DE69901934T2 (de) 2002-11-07
BG104670A (en) 2001-05-31
CA2317462A1 (en) 1999-07-22
NO20003671L (no) 2000-09-18

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