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DK0998477T3 - Alkyl-4-silylheterocykliske phenoler og thiophenoler som antioxidantmidler - Google Patents

Alkyl-4-silylheterocykliske phenoler og thiophenoler som antioxidantmidler

Info

Publication number
DK0998477T3
DK0998477T3 DK98923681T DK98923681T DK0998477T3 DK 0998477 T3 DK0998477 T3 DK 0998477T3 DK 98923681 T DK98923681 T DK 98923681T DK 98923681 T DK98923681 T DK 98923681T DK 0998477 T3 DK0998477 T3 DK 0998477T3
Authority
DK
Denmark
Prior art keywords
thiophenols
alkyl
antioxidant agents
heterocyclic phenols
silyl
Prior art date
Application number
DK98923681T
Other languages
English (en)
Inventor
Roger A Parker
Paul S Wright
Mark J Vaal
Kim S Chen
Michael L Edwards
Steven J Busch
James E Matt Jr
Mark T Yates
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of DK0998477T3 publication Critical patent/DK0998477T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • C07F7/081Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK98923681T 1997-06-24 1998-05-21 Alkyl-4-silylheterocykliske phenoler og thiophenoler som antioxidantmidler DK0998477T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88162797A 1997-06-24 1997-06-24
PCT/US1998/010510 WO1998058938A1 (en) 1997-06-24 1998-05-21 Alkyl-4-silylheterocyclic phenols and thiophenols as antioxidant agents

Publications (1)

Publication Number Publication Date
DK0998477T3 true DK0998477T3 (da) 2003-07-21

Family

ID=25378856

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98923681T DK0998477T3 (da) 1997-06-24 1998-05-21 Alkyl-4-silylheterocykliske phenoler og thiophenoler som antioxidantmidler

Country Status (22)

Country Link
EP (1) EP0998477B1 (da)
JP (1) JP2002514226A (da)
KR (1) KR20010014118A (da)
CN (1) CN1147495C (da)
AR (1) AR013114A1 (da)
AT (1) ATE235498T1 (da)
AU (1) AU731278B2 (da)
BR (1) BR9810311A (da)
CA (1) CA2293461C (da)
DE (1) DE69812635T2 (da)
DK (1) DK0998477T3 (da)
ES (1) ES2190592T3 (da)
HK (1) HK1027815A1 (da)
HU (1) HUP0002775A3 (da)
IL (1) IL133598A (da)
NO (1) NO996395L (da)
NZ (1) NZ501342A (da)
PT (1) PT998477E (da)
SI (1) SI0998477T1 (da)
TW (1) TW517054B (da)
WO (1) WO1998058938A1 (da)
ZA (1) ZA985318B (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1677804A1 (en) * 2003-10-17 2006-07-12 Amylin Pharmaceuticals, Inc. Silyl phenols for promoting vascular health

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5155250A (en) * 1990-07-05 1992-10-13 Merrell Dow Pharmaceuticals Inc. 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents
HU220761B1 (hu) * 1993-12-10 2002-05-28 Merrell Pharmaceuticals Inc. 2,6-Dialkil-4-szilil-helyettesített fenolok alkalmazása szérum koleszterinszint csökkentésére használható gyógyszerkészítmények előállítására

Also Published As

Publication number Publication date
ZA985318B (en) 1999-01-11
HUP0002775A2 (hu) 2001-05-28
DE69812635T2 (de) 2003-10-23
NO996395L (no) 2000-02-23
CA2293461A1 (en) 1998-12-30
EP0998477A1 (en) 2000-05-10
TW517054B (en) 2003-01-11
SI0998477T1 (en) 2003-08-31
HK1027815A1 (en) 2001-01-23
ES2190592T3 (es) 2003-08-01
CN1261367A (zh) 2000-07-26
NO996395D0 (no) 1999-12-22
DE69812635D1 (de) 2003-04-30
HUP0002775A3 (en) 2001-08-28
JP2002514226A (ja) 2002-05-14
BR9810311A (pt) 2000-09-19
CA2293461C (en) 2004-02-24
NZ501342A (en) 2001-10-26
AU7591598A (en) 1999-01-04
AU731278B2 (en) 2001-03-29
AR013114A1 (es) 2000-12-13
PT998477E (pt) 2003-07-31
IL133598A0 (en) 2001-04-30
ATE235498T1 (de) 2003-04-15
KR20010014118A (ko) 2001-02-26
EP0998477B1 (en) 2003-03-26
IL133598A (en) 2004-08-31
WO1998058938A1 (en) 1998-12-30
CN1147495C (zh) 2004-04-28

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