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DK0894796T3 - Imidazoliner substitueret med en heterocyklisk ring som alfa-2-antagonister - Google Patents

Imidazoliner substitueret med en heterocyklisk ring som alfa-2-antagonister

Info

Publication number
DK0894796T3
DK0894796T3 DK98401919T DK98401919T DK0894796T3 DK 0894796 T3 DK0894796 T3 DK 0894796T3 DK 98401919 T DK98401919 T DK 98401919T DK 98401919 T DK98401919 T DK 98401919T DK 0894796 T3 DK0894796 T3 DK 0894796T3
Authority
DK
Denmark
Prior art keywords
optionally substituted
alkyl
substituted
cycloalkyl
alkoxy
Prior art date
Application number
DK98401919T
Other languages
Danish (da)
English (en)
Inventor
Gerald Guillaumet
Jean-Yves Merour
Frederique Touzeau
Bruno Pfeiffer
Pierre Renard
Elisabeth Scalbert
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Application granted granted Critical
Publication of DK0894796T3 publication Critical patent/DK0894796T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK98401919T 1997-07-30 1998-07-28 Imidazoliner substitueret med en heterocyklisk ring som alfa-2-antagonister DK0894796T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9709709A FR2766824B1 (fr) 1997-07-30 1997-07-30 Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
DK0894796T3 true DK0894796T3 (da) 2001-09-03

Family

ID=9509815

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98401919T DK0894796T3 (da) 1997-07-30 1998-07-28 Imidazoliner substitueret med en heterocyklisk ring som alfa-2-antagonister

Country Status (20)

Country Link
US (1) US6057317A (es)
EP (1) EP0894796B1 (es)
JP (1) JPH1192476A (es)
CN (1) CN1090631C (es)
AT (1) ATE201871T1 (es)
AU (1) AU736460B2 (es)
BR (1) BR9802803A (es)
CA (1) CA2244435A1 (es)
DE (1) DE69800883T2 (es)
DK (1) DK0894796T3 (es)
ES (1) ES2159921T3 (es)
FR (1) FR2766824B1 (es)
GR (1) GR3036474T3 (es)
HK (1) HK1017685A1 (es)
HU (1) HUP9801713A1 (es)
NO (1) NO311256B1 (es)
NZ (1) NZ331154A (es)
PL (1) PL327747A1 (es)
PT (1) PT894796E (es)
ZA (1) ZA986815B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2799757B1 (fr) * 1999-10-15 2001-12-14 Adir Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN1845911B (zh) * 2003-09-01 2012-07-04 小野药品工业株式会社 稠环化合物及其应用
EP2481732A1 (en) 2003-09-01 2012-08-01 Ono Pharmaceutical Co., Ltd. Condensed ring compound and use thereof
US20070197512A1 (en) * 2006-01-27 2007-08-23 Japan Tobacco Inc. Carboxylic Acid Compounds and Use Thereof
WO2007086504A1 (ja) * 2006-01-27 2007-08-02 Japan Tobacco Inc. カルボン酸化合物及びその用途
TWI469965B (zh) * 2008-12-22 2015-01-21 Ono Pharmaceutical Co 乙炔基吲哚化合物
MX2012014596A (es) 2010-06-21 2013-02-21 Ono Pharmaceutical Co Nuevas formas cristalinas de acido 4,4`-[4-fluoro-7-7{4-[4-(3-fluo ro-2-metilfenil)butoxi]fenil}etinil)-2-metil-1h-indol-1, 3-diil]dibutanoico, acido 4, 4´-[2-metil-7-({4-[4-(pentafluorofeni l)butoxi}fenil}etil)-1h-indol-1, 3-diil]-dibutanoico, y acido 4, 4´-[4-fluoro-2-metil-7-({4-[4-(2, 3, 4, 6-tetrafluorofenil)butoxi] fenil}etinil)-1h-indol-1, 3-diil]dibutanoico.
US9216998B2 (en) * 2012-02-15 2015-12-22 Janssen Pharmaceutica Nv Tricyclic indole derivatives useful endothelial lipase inhibitors
RU2687979C1 (ru) * 2018-03-19 2019-05-17 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Способ коррекции стрептозотоцин-индуцированного сахарного диабета у крыс с использованием лекарственного средства на основе амида гетероциклических кислот

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199469A (en) * 1981-01-30 1984-03-16 Reckitt & Colmann Prod Ltd Benzodioxanyl-2-imidazoline derivatives and pharmaceutical compositions
US4436914A (en) * 1981-08-03 1984-03-13 Kluge Arthur F Benzodioxane-imidazoline compounds as antihypertensives
NZ203680A (en) * 1982-04-17 1985-08-16 Reckitt & Colmann Prod Ltd Imidazolines and pharmaceutical compositions

Also Published As

Publication number Publication date
FR2766824B1 (fr) 1999-09-10
AU736460B2 (en) 2001-07-26
HU9801713D0 (en) 1998-09-28
EP0894796B1 (fr) 2001-06-06
BR9802803A (pt) 2000-03-21
DE69800883T2 (de) 2002-03-28
JPH1192476A (ja) 1999-04-06
NO983478D0 (no) 1998-07-28
CN1206712A (zh) 1999-02-03
ES2159921T3 (es) 2001-10-16
FR2766824A1 (fr) 1999-02-05
GR3036474T3 (en) 2001-11-30
US6057317A (en) 2000-05-02
CA2244435A1 (fr) 1999-01-30
ZA986815B (en) 1999-02-02
PL327747A1 (en) 1999-02-01
NO311256B1 (no) 2001-11-05
HUP9801713A1 (hu) 1999-12-28
DE69800883D1 (de) 2001-07-12
HK1017685A1 (en) 1999-11-26
PT894796E (pt) 2001-09-28
AU7860998A (en) 1999-02-11
ATE201871T1 (de) 2001-06-15
CN1090631C (zh) 2002-09-11
NZ331154A (en) 1999-05-28
EP0894796A1 (fr) 1999-02-03
NO983478L (no) 1999-02-01

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