DK0864583T3 - Alkalimetal-8,9-dihydroöstronfulfatestere - Google Patents

Alkalimetal-8,9-dihydroöstronfulfatestere

Info

Publication number: DK0864583T3
Authority: DK; Denmark
Prior art keywords: dihydroöstronfulfatestere; alkali metal; alkali; metal
Prior art date: 1992-02-26

Application number

DK98201290T

Other languages

Danish (da)

English (en)

Inventor

John Anthony Wichtowski

Panolil Chirukan Raveendranath

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-26

Filing date

1993-02-19

Publication date

2006-12-04

1993-02-19 Application filed by Wyeth Corp filed Critical Wyeth Corp

2006-12-04 Application granted granted Critical

2006-12-04 Publication of DK0864583T3 publication Critical patent/DK0864583T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Endocrinology (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Reproductive Health (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Catalysts (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK98201290T 1992-02-26 1993-02-19 Alkalimetal-8,9-dihydroöstronfulfatestere DK0864583T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/841,694 US5210081A (en)	1992-02-26	1992-02-26	Alkali metal 8,9-dehydroestrone sulfate esters
EP93906093A EP0628052B1 (en)	1992-02-26	1993-02-19	Alkali metal 8,9-dehydroestrone sulfate esters

Publications (1)

Publication Number	Publication Date
DK0864583T3 true DK0864583T3 (da)	2006-12-04

Family

ID=25285489

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK98201290T DK0864583T3 (da)	1992-02-26	1993-02-19	Alkalimetal-8,9-dihydroöstronfulfatestere
DK93906093T DK0628052T3 (da)	1992-02-26	1993-02-19	Alkalimetal-8,9-dehydroestron-sulfatestere

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK93906093T DK0628052T3 (da)	1992-02-26	1993-02-19	Alkalimetal-8,9-dehydroestron-sulfatestere

Country Status (22)

Country	Link
US (3)	US5210081A (es)
EP (2)	EP0864583B1 (es)
JP (1)	JP3715645B2 (es)
KR (1)	KR100256861B1 (es)
AR (2)	AR042262A2 (es)
AT (2)	ATE174342T1 (es)
AU (2)	AU677181B2 (es)
CA (1)	CA2089707A1 (es)
DE (2)	DE69322497T2 (es)
DK (2)	DK0864583T3 (es)
ES (2)	ES2274555T3 (es)
FI (1)	FI115915B (es)
GR (1)	GR3029620T3 (es)
HK (2)	HK1011369A1 (es)
HU (2)	HUT67553A (es)
LV (1)	LV12240B (es)
MX (1)	MX9300969A (es)
PT (1)	PT864583E (es)
SG (1)	SG49715A1 (es)
TW (1)	TW257677B (es)
WO (1)	WO1993017036A1 (es)
ZA (1)	ZA93746B (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5210081A (en) *	1992-02-26	1993-05-11	American Home Products Corporation	Alkali metal 8,9-dehydroestrone sulfate esters
US6407082B1 (en) *	1996-09-13	2002-06-18	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a vitamin D compound
DE4334823C2 (de) *	1993-10-09	1998-09-17	Schering Ag	Verfahren zur Herstellung von Schwefelsäurehalbestern von Estrogenen
US5395831A (en) *	1994-04-08	1995-03-07	American Home Products Corporation	Treating cardiac disorders with Δ9(11)-dehydro-8-isoestrone
US5861431A (en) *	1995-06-07	1999-01-19	Iotek, Inc.	Incontinence treatment
US5998639A (en) *	1995-11-06	1999-12-07	Akzo Nobel, N.V.	Sulfatation of estrogen mixtures
AU703814B2 (en) *	1995-12-04	1999-04-01	Wyeth	Antioxidant
DE19631542C1 (de) *	1996-07-25	1997-08-28	Schering Ag	Verfahren zur Herstellung von 3-Sulfatoxy-estra-1,3,5(10)-trien-Derivaten II
DE19631543C1 (de) *	1996-07-25	1997-11-20	Schering Ag	Verfahren zur Herstellung von 3-Sulfatoxy-estra-1,3,5(10)-trien-Derivaten I
US6511970B1 (en)	1996-09-13	2003-01-28	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6028064A (en)	1996-09-13	2000-02-22	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of progestin products
US6765002B2 (en)	2000-03-21	2004-07-20	Gustavo Rodriguez	Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6034074A (en)	1996-09-13	2000-03-07	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a Vitamin D compound
ID18256A (id) *	1996-09-16	1998-03-19	American Home Prod	Penggunaan dari 8,9-dehidro estron sebagai estrogen dengan hasil netral pada tingkat prolaktin
AR014096A1 (es) *	1996-10-11	2001-02-07	Wyeth Corp	17 alfa,8,9-deshidroestradiol y 17 beta delta 8,9 deshidroestradiol, el uso de los mismos para la manufactura de un medicamento, una composicionfarmaceutica que los comprende y un procedimiento para su preparacion.
ZA979204B (en) *	1996-10-16	1999-04-14	American Home Prod	Use of 8,9-dehydroestrone in treating vasomotor symptoms
IL124213A (en) *	1997-05-02	2004-12-15	Akzo Nobel Nv	Sulfation of estrogen mixtures
US6432643B1 (en)	1999-10-22	2002-08-13	Duke University	Method of determining Alzheimer's disease risk using apolipoprotein E4 genotype analysis in combination with decreased estrogen levels
US6660726B2 (en)	2000-03-10	2003-12-09	Endeavor Pharmaceuticals	Estrogenic compounds, pharmaceutical compositions thereof, and methods of using same
US7989436B2 (en)	2003-07-23	2011-08-02	Duramed Pharmaceuticals, Inc.	Estrogenic compounds and pharmaceutical formulations comprising the same
US7459445B2 (en) *	2000-03-10	2008-12-02	Duramed Pharmaceuticals, Inc.	Estrogenic compounds and topical pharmaceutical formulations of the same
US6855703B1 (en) *	2000-03-10	2005-02-15	Endeavor Pharmaceuticals	Pharmaceutical compositions of conjugated estrogens and methods of analyzing mixtures containing estrogenic compounds
US20010044431A1 (en) *	2000-03-21	2001-11-22	Rodriguez Gustavo C.	Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
US20030158432A1 (en) *	2002-01-08	2003-08-21	Leonard Thomas W.	Synthesis of a mixture of sulfated estrogens using a sulfur trioxide complex
US8349819B2 (en) *	2002-10-09	2013-01-08	Dr. Reddy's Laboratories New York, Inc.	Steroid extraction process from urine sources
US6992075B2 (en) *	2003-04-04	2006-01-31	Barr Laboratories, Inc.	C(14) estrogenic compounds
CA2521471A1 (en) *	2003-04-11	2004-10-28	Barr Laboratories, Inc.	Methods of administering estrogens and progestins
BRPI0511663A (pt) *	2004-06-07	2008-01-02	Wyeth Corp	composição compreendendo água e um componente de sólidos, processo, e, tablete revestido
US20060040904A1 (en) *	2004-08-17	2006-02-23	Ahmed Salah U	Vaginal cream compositions, kits thereof and methods of using thereof
EP1853272A1 (en) *	2005-02-03	2007-11-14	Duramed Pharmaceuticals, Inc.	Compositions of unconjugated estrogens and methods for their use
CA2613102A1 (en) *	2005-06-29	2007-01-04	Wyeth	Formulations of conjugated estrogens and bazedoxifene
US8217024B2 (en) *	2005-12-27	2012-07-10	Teva Women's Health, Inc.	Conjugated estrogen compositions, applicators, kits, and methods of making and use thereof
KR20090076963A (ko) *	2006-11-07	2009-07-13	와이어쓰	당 코팅 및 이의 방법
EP2117518A2 (en) *	2007-01-12	2009-11-18	Wyeth a Corporation of the State of Delaware	Tablet-in-tablet compositions
WO2008100769A2 (en) *	2007-02-09	2008-08-21	Wyeth	Process for selective sulfation of aromatic hydroxyl groups
US7902147B2 (en)	2007-11-05	2011-03-08	Duke University	Chronic lymphocytic leukemia prognosis and treatment
EP2493477B1 (en)	2009-10-27	2013-10-16	Wyeth LLC	Bazedoxifene formulations with antioxidants

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2834712A (en) *	1953-05-27	1958-05-13	American Home Prod	Urinary estrogen compositions and methods for preparing them
US3079410A (en) *	1960-04-02	1963-02-26	Hoechst Ag	Process for stabilizing anionic and cationic ester salts of 21-hydroxy-20-ketosteroids in an aqueous solution
US3959322A (en) *	1960-09-22	1976-05-25	Herchel Smith	Synthesis of 13-alkyl-gon-4-ones
DE1200476B (de) *	1961-04-10	1965-09-09	Frosst & Co Charles E	Stabilisierung von trockenen Zubereitungen synthetischer Alkalisalze von OEstronsulfat
US3551459A (en) *	1962-10-04	1970-12-29	Herchel Smith	13-methyl-8-isogonanes
US3394153A (en) *	1965-08-18	1968-07-23	Merck & Co Inc	Process for the preparation of d, 1-8-dehydroestrone, and intermediates obtained therefrom
NL6805153A (es) *	1968-04-10	1969-10-14
US3644618A (en) *	1968-10-29	1972-02-22	Frosst & Co Charles E	Stable composition of synthetic sodium estrone sulfate
US3608077A (en) *	1969-11-13	1971-09-21	Syntex Corp	Stabilization of metal steroid alcohol sulfates
US3649621A (en) *	1969-12-19	1972-03-14	American Home Prod	Novel 3-cyclopentyl ethers of 13-alkylgon-poly-enes
GB1451109A (en) *	1973-08-17	1976-09-29	Rech Et Dapplications Scient S	Derivatives of oestrone and their use in therapy
GB1528321A (en) *	1975-07-07	1978-10-11	Leo Ab	Acylation process for the preparation of phenolic n,n-di-substituted carbamate esters
SE439586B (sv) *	1975-09-05	1985-06-24	Kanebo Ltd	Sett att framstella ett stabilt farmaceutiskt torrpreparat av ett alkalimetallsalt av dehydroepiandrosteronsulfat
US4154820A (en) *	1976-02-23	1979-05-15	Akzona Incorporated	Compositions containing alkali metal sulfate salts of conjugated estrogens and antioxidants as stabilizers
US5210081A (en) *	1992-02-26	1993-05-11	American Home Products Corporation	Alkali metal 8,9-dehydroestrone sulfate esters

1992
- 1992-02-26 US US07/841,694 patent/US5210081A/en not_active Expired - Lifetime
- 1992-12-03 US US07/984,741 patent/US5288717A/en not_active Expired - Lifetime
1993
- 1993-02-03 ZA ZA93746A patent/ZA93746B/xx unknown
- 1993-02-17 CA CA002089707A patent/CA2089707A1/en not_active Abandoned
- 1993-02-18 US US08/019,387 patent/US6169082B1/en not_active Expired - Fee Related
- 1993-02-19 DK DK98201290T patent/DK0864583T3/da active
- 1993-02-19 EP EP98201290A patent/EP0864583B1/en not_active Expired - Lifetime
- 1993-02-19 AU AU37260/93A patent/AU677181B2/en not_active Ceased
- 1993-02-19 AT AT93906093T patent/ATE174342T1/de not_active IP Right Cessation
- 1993-02-19 PT PT98201290T patent/PT864583E/pt unknown
- 1993-02-19 AT AT98201290T patent/ATE342272T1/de not_active IP Right Cessation
- 1993-02-19 SG SG1996004314A patent/SG49715A1/en unknown
- 1993-02-19 ES ES98201290T patent/ES2274555T3/es not_active Expired - Lifetime
- 1993-02-19 DE DE69322497T patent/DE69322497T2/de not_active Expired - Fee Related
- 1993-02-19 EP EP93906093A patent/EP0628052B1/en not_active Expired - Lifetime
- 1993-02-19 KR KR1019940702962A patent/KR100256861B1/ko not_active IP Right Cessation
- 1993-02-19 DE DE69334073T patent/DE69334073T2/de not_active Expired - Fee Related
- 1993-02-19 ES ES93906093T patent/ES2125975T3/es not_active Expired - Lifetime
- 1993-02-19 DK DK93906093T patent/DK0628052T3/da active
- 1993-02-19 JP JP51497793A patent/JP3715645B2/ja not_active Expired - Fee Related
- 1993-02-19 WO PCT/US1993/001500 patent/WO1993017036A1/en active IP Right Grant
- 1993-02-19 HU HU9402457A patent/HUT67553A/hu unknown
- 1993-02-22 TW TW082101242A patent/TW257677B/zh active
- 1993-02-23 MX MX9300969A patent/MX9300969A/es unknown
1994
- 1994-08-25 FI FI943903A patent/FI115915B/fi active IP Right Grant
1995
- 1995-06-28 HU HU95P/P00495P patent/HU211971A9/hu unknown
- 1995-10-24 AR ARP9501333967A patent/AR042262A2/es unknown
1997
- 1997-05-07 AU AU20076/97A patent/AU711571B2/en not_active Ceased
1998
- 1998-11-24 HK HK98112284A patent/HK1011369A1/xx not_active IP Right Cessation
- 1998-11-24 HK HK99105414A patent/HK1020282A1/xx not_active IP Right Cessation
1999
- 1999-01-13 LV LVP-99-05A patent/LV12240B/en unknown
- 1999-03-08 GR GR990400707T patent/GR3029620T3/el unknown
2003
- 2003-12-09 AR ARP030104530A patent/AR042345A2/es unknown

Also Published As

Publication number	Publication date
US6169082B1 (en)	2001-01-02
KR100256861B1 (ko)	2000-08-01
DE69334073D1 (de)	2006-11-23
ES2125975T3 (es)	1999-03-16
HK1011369A1 (en)	1999-07-09
ATE342272T1 (de)	2006-11-15
PT864583E (pt)	2007-01-31
AU677181B2 (en)	1997-04-17
FI115915B (fi)	2005-08-15
TW257677B (es)	1995-09-21
EP0864583B1 (en)	2006-10-11
FI943903A0 (fi)	1994-08-25
HU9402457D0 (en)	1994-10-28
US5288717A (en)	1994-02-22
FI943903A (fi)	1994-08-25
GR3029620T3 (en)	1999-06-30
EP0864583A2 (en)	1998-09-16
AR042345A2 (es)	2005-06-15
AR042262A2 (es)	2005-06-15
ATE174342T1 (de)	1998-12-15
AU711571B2 (en)	1999-10-14
DE69322497T2 (de)	1999-05-06
SG49715A1 (en)	1998-06-15
HU211971A9 (en)	1996-01-29
AU2007697A (en)	1997-07-03
EP0864583A3 (en)	2004-07-21
ES2274555T3 (es)	2007-05-16
LV12240A (lv)	1999-03-20
US5210081A (en)	1993-05-11
AU3726093A (en)	1993-09-13
DE69322497D1 (de)	1999-01-21
JPH07504197A (ja)	1995-05-11
WO1993017036A1 (en)	1993-09-02
LV12240B (en)	1999-06-20
ZA93746B (en)	1994-08-03
DK0628052T3 (da)	1999-07-12
JP3715645B2 (ja)	2005-11-09
MX9300969A (es)	1993-09-01
DE69334073T2 (de)	2007-02-01
EP0628052B1 (en)	1998-12-09
HUT67553A (en)	1995-04-28
CA2089707A1 (en)	1993-08-27
KR950700318A (ko)	1995-01-16
HK1020282A1 (en)	2000-04-07
EP0628052A1 (en)	1994-12-14

Publication	Publication Date	Title
DK0864583T3 (da)	2006-12-04	Alkalimetal-8,9-dihydroöstronfulfatestere
FI953489A0 (fi)	1995-07-19	2,6-diaminopuriinijohdannaisia
FI920208A0 (fi)	1992-01-17	Vindkraftverk.
NO932842D0 (no)	1993-08-10	1,4-benzodioksanderivater
DE59308564D1 (de)	1998-06-25	2,4-Dialkyl-6-sec-alkylphenole
FI941909A (fi)	1994-10-28	2,6-disubstituoidut 4-kinolyylidihydropyridiinit
NO944024D0 (no)	1994-10-21	1,2-dihydro-2-okso-pyridin
NO943791D0 (no)	1994-10-07	1,2-dihydro-2-okso-3-metylsulfonylaminometylpyridin
NO942212D0 (no)	1994-06-13	13,14-dihydro-PGF2
ES1021196Y (es)	1994-01-01	Cubre-cajas pefeccionado.
ES1020681Y (es)	1993-03-01	Mueble-gimnasio.
FI921888A0 (fi)	1992-04-27	Kombinerad gas-vaete-behaollare foer en naturgasbil.
ES1022352Y (es)	1993-08-16	Munequera metacarpiana.
ES1022989Y (es)	1993-12-16	Carpeta-bolsa.
ES1022809Y (es)	1993-12-16	Mini-taquilla.
ES1021261Y (es)	1993-03-16	Envase-sonajero.
ES1021370Y (es)	1993-04-16	Muneco malabarista.
ES1020335Y (es)	1993-01-16	Estuche-escribania.
ES1021990Y (es)	1993-07-01	Estuche-expositor-sorpresa.
ES1020075Y (es)	1993-03-01	Columbario.
ES1019859Y (es)	1993-10-01	Interruptor-conmutador.
ES1022971Y (es)	1994-04-16	Perinola.
ES1023265Y (es)	1994-01-01	Cabina fotografica.
ES1023634Y (es)	1994-03-01	Poste-corta-trafico.
ES1028183Y (es)	1995-05-16	Venturi-caudalimetro.