DK0790987T3 - Aminotetrazol-derivater, der er anvendelige som nitrogenoxidsynthaseinhibitorer - Google Patents
Aminotetrazol-derivater, der er anvendelige som nitrogenoxidsynthaseinhibitorerInfo
- Publication number
- DK0790987T3 DK0790987T3 DK95937674T DK95937674T DK0790987T3 DK 0790987 T3 DK0790987 T3 DK 0790987T3 DK 95937674 T DK95937674 T DK 95937674T DK 95937674 T DK95937674 T DK 95937674T DK 0790987 T3 DK0790987 T3 DK 0790987T3
- Authority
- DK
- Denmark
- Prior art keywords
- nitric oxide
- oxide synthase
- synthase inhibitors
- derivatives useful
- aminotetrazole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/18—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/336,596 US5684008A (en) | 1994-11-09 | 1994-11-09 | Aminotetrazole derivatives useful as nitric oxide synthase inhibitors |
PCT/US1995/014001 WO1996015120A1 (en) | 1994-11-09 | 1995-11-08 | Aminotetrazole derivatives useful as nitric oxide synthase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0790987T3 true DK0790987T3 (da) | 2001-11-12 |
Family
ID=23316811
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95937674T DK0790987T3 (da) | 1994-11-09 | 1995-11-08 | Aminotetrazol-derivater, der er anvendelige som nitrogenoxidsynthaseinhibitorer |
DK01104598T DK1113011T3 (da) | 1994-11-09 | 1995-11-08 | Aminotetrazol-derivater, der er anvendelige som nitrogenoxidsynthaseinhibitorer |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01104598T DK1113011T3 (da) | 1994-11-09 | 1995-11-08 | Aminotetrazol-derivater, der er anvendelige som nitrogenoxidsynthaseinhibitorer |
Country Status (17)
Country | Link |
---|---|
US (5) | US5684008A (da) |
EP (2) | EP1113011B1 (da) |
JP (1) | JP3278165B2 (da) |
KR (1) | KR970707107A (da) |
CN (1) | CN1065531C (da) |
AT (2) | ATE334974T1 (da) |
AU (1) | AU696527B2 (da) |
BR (1) | BR9509629A (da) |
CA (1) | CA2203237C (da) |
DE (2) | DE69522703T2 (da) |
DK (2) | DK0790987T3 (da) |
ES (2) | ES2164164T3 (da) |
HK (1) | HK1036802A1 (da) |
NZ (1) | NZ296019A (da) |
PT (2) | PT1113011E (da) |
RU (1) | RU2152927C1 (da) |
WO (1) | WO1996015120A1 (da) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5684008A (en) * | 1994-11-09 | 1997-11-04 | G. D. Searle & Co. | Aminotetrazole derivatives useful as nitric oxide synthase inhibitors |
US5919940A (en) * | 1995-01-20 | 1999-07-06 | British Biotech Pharmaceuticals Limited | Metalloproteinase inhibitors |
US5981511A (en) * | 1996-03-06 | 1999-11-09 | G.D. Searle & Co. | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors |
US5945408A (en) * | 1996-03-06 | 1999-08-31 | G.D. Searle & Co. | Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors |
US6552052B2 (en) | 1998-06-10 | 2003-04-22 | Monsanto/G.D. Searle | Pyrrolo[2,1-c][1,2,4] thiadiazoles and Pyrollo[2,1-c][1,12,4]oxadiazoles useful as nitric oxide synthase inhibitors |
BR9913526A (pt) | 1998-09-08 | 2001-06-05 | Monsanto Co | Métodos de tratamento da osteoartrite com inibidores de sintase de óxido nìtrico induzìvel |
AU1308400A (en) * | 1998-10-30 | 2000-05-22 | G.D. Searle & Co. | Novel amino acid heterocyclic amide derivatives useful as nitric oxide synthase inhibitors |
AU2847200A (en) * | 1999-01-27 | 2000-08-18 | G.D. Searle & Co. | Novel hydroxyamidino carboxylate derivatives useful as nitric oxide synthase inhibitors |
AU4329000A (en) * | 1999-04-19 | 2000-11-02 | G.D. Searle & Co. | Novel heterocyclic amino carbonyl derivatives useful as nitric oxide synthase inhibitors |
WO2001005748A1 (en) * | 1999-07-15 | 2001-01-25 | Monsanto Company | Oligomeric amino acid derivatives useful as nitric oxide synthase inhibitors |
CA2402436C (en) | 2000-03-24 | 2010-02-16 | Pharmacia Corporation | Amidino compound and salts thereof useful as nitric oxide synthase inhibitors |
AR032318A1 (es) * | 2000-04-13 | 2003-11-05 | Pharmacia Corp | Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa |
US6787668B2 (en) | 2000-04-13 | 2004-09-07 | Pharmacia Corporation | 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors |
AR030416A1 (es) | 2000-04-13 | 2003-08-20 | Pharmacia Corp | COMPUESTO DERIVADO HALOGENADO DEL ACIDO 2-AMINO-3,4 HEPTENOICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE Y SU USO EN LA FABRICACION DE UN MEDICAMENTO uTIL COMO INHIBIDOR DE LA OXIDO NITRICO SINTETASA |
US6956131B2 (en) | 2000-04-13 | 2005-10-18 | Pharmacia Corporation | 2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors |
AR034120A1 (es) | 2000-04-13 | 2004-02-04 | Pharmacia Corp | Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico |
US6545170B2 (en) | 2000-04-13 | 2003-04-08 | Pharmacia Corporation | 2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors |
MY131964A (en) | 2000-09-15 | 2007-09-28 | Pharmacia Corp | 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors |
US7012098B2 (en) * | 2001-03-23 | 2006-03-14 | Pharmacia Corporation | Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers |
US20030109522A1 (en) * | 2001-09-24 | 2003-06-12 | Manning Pamela T. | Ophthalmologic treatment methods using selective iNOS inhibitors |
MXPA05001255A (es) * | 2002-08-02 | 2005-06-08 | Pharmacia Corp | Metodos para el tratamiento y prevencion de condiciones gastrointestinales. |
ES2384969T3 (es) * | 2002-08-23 | 2012-07-16 | Pharmacia Corporation | Forma sólida cristalina del ácido (2S-5Z)-2-amino-7-(etanimidoilamino)-2-metilhept-5-enoico |
BR112017014996A2 (pt) * | 2015-01-14 | 2018-03-20 | Chiesi Farm Spa | formulações farmacêuticas e recipientes selados |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3505555A1 (de) * | 1985-02-18 | 1986-09-11 | Behringwerke Ag, 3550 Marburg | Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel |
US5196450A (en) * | 1985-12-19 | 1993-03-23 | Merrell Dow Pharmaceuticals Inc. | Method of inhibiting protozoal growth |
AU619613B2 (en) * | 1988-11-10 | 1992-01-30 | Merrell Dow Pharmaceuticals Inc. | Lactamimides in the treatment of drug-resistant protozoal infections |
US5059712A (en) * | 1989-09-13 | 1991-10-22 | Cornell Research Foundation, Inc. | Isolating aminoarginine and use to block nitric oxide formation in body |
US5028627A (en) * | 1989-09-13 | 1991-07-02 | Cornell Research Foundation, Inc. | Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor |
GB8929076D0 (en) * | 1989-12-22 | 1990-02-28 | Scras | Treatment of shock by blocking agents of edrf effect or formation |
CA2036770C (en) * | 1990-02-26 | 2003-09-09 | Jeffrey P. Whitten | Inhibitors of nitric oxide biosynthesis |
US5273875A (en) * | 1991-03-22 | 1993-12-28 | Cornell Research Foundation, Inc. | N6 -(hydrazinoiminomethyl)lysine and method of inhibiting nitric oxide formation in body |
US5132453A (en) * | 1991-03-22 | 1992-07-21 | Cornell Research Foundation, Inc. | N6 -(hydrazinoiminomethyl)lysine and method of inhibiting nitric oxide formation in body |
GB9127376D0 (en) * | 1991-12-24 | 1992-02-19 | Wellcome Found | Amidino derivatives |
US5296466A (en) * | 1992-02-19 | 1994-03-22 | Board Of Regents, The University Of Texas System | Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein |
US5281627A (en) * | 1992-05-28 | 1994-01-25 | Cornell Research Foundation, Inc. | Substituted arginines and substituted homoarginines and use thereof |
WO1994014780A1 (en) * | 1992-12-18 | 1994-07-07 | The Wellcome Foundation Limited | Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors |
GB9312761D0 (en) * | 1993-06-21 | 1993-08-04 | Wellcome Found | Amino acid derivatives |
US5424447A (en) * | 1993-07-07 | 1995-06-13 | The Medical College Of Wisconsin Research Foundation, Inc. | Heme binding compounds and use thereof |
ATE222100T1 (de) * | 1993-10-21 | 2002-08-15 | Searle & Co | Amidino-derivate nützlich als no synthase-hemmer |
US5364881A (en) * | 1993-11-15 | 1994-11-15 | The Medical College Of Wisconsin Research Foundation, Inc. | S-alkyl-isothioureido-amino acids and use thereof |
US5362744A (en) * | 1993-11-22 | 1994-11-08 | Warner-Lambert Company | Tetrazole-substituted urea acat inhibitors |
PT751930E (pt) * | 1994-03-24 | 2000-04-28 | Searle & Co | Derivados amidino uteis como inibidores da sintetase de oxido nitrico |
US6124351A (en) * | 1994-08-18 | 2000-09-26 | Chugai Seiyaku Kabushiki Kaisha | Amino acid derivatives having a nitric oxide synthase inhibiting action |
US5684008A (en) * | 1994-11-09 | 1997-11-04 | G. D. Searle & Co. | Aminotetrazole derivatives useful as nitric oxide synthase inhibitors |
-
1994
- 1994-11-09 US US08/336,596 patent/US5684008A/en not_active Expired - Fee Related
-
1995
- 1995-11-08 DE DE69522703T patent/DE69522703T2/de not_active Expired - Fee Related
- 1995-11-08 US US08/817,971 patent/US5854251A/en not_active Expired - Fee Related
- 1995-11-08 ES ES95937674T patent/ES2164164T3/es not_active Expired - Lifetime
- 1995-11-08 WO PCT/US1995/014001 patent/WO1996015120A1/en not_active Application Discontinuation
- 1995-11-08 KR KR1019970703106A patent/KR970707107A/ko not_active Application Discontinuation
- 1995-11-08 NZ NZ296019A patent/NZ296019A/en not_active IP Right Cessation
- 1995-11-08 PT PT01104598T patent/PT1113011E/pt unknown
- 1995-11-08 EP EP01104598A patent/EP1113011B1/en not_active Expired - Lifetime
- 1995-11-08 ES ES01104598T patent/ES2269240T3/es not_active Expired - Lifetime
- 1995-11-08 DK DK95937674T patent/DK0790987T3/da active
- 1995-11-08 AT AT01104598T patent/ATE334974T1/de not_active IP Right Cessation
- 1995-11-08 CN CN95197112A patent/CN1065531C/zh not_active Expired - Fee Related
- 1995-11-08 AU AU39711/95A patent/AU696527B2/en not_active Ceased
- 1995-11-08 DK DK01104598T patent/DK1113011T3/da active
- 1995-11-08 JP JP51609696A patent/JP3278165B2/ja not_active Expired - Fee Related
- 1995-11-08 BR BR9509629A patent/BR9509629A/pt not_active IP Right Cessation
- 1995-11-08 EP EP95937674A patent/EP0790987B1/en not_active Expired - Lifetime
- 1995-11-08 RU RU97109847/04A patent/RU2152927C1/ru not_active IP Right Cessation
- 1995-11-08 AT AT95937674T patent/ATE205484T1/de not_active IP Right Cessation
- 1995-11-08 DE DE69535148T patent/DE69535148T2/de not_active Expired - Fee Related
- 1995-11-08 PT PT95937674T patent/PT790987E/pt unknown
- 1995-11-08 CA CA002203237A patent/CA2203237C/en not_active Expired - Fee Related
-
1998
- 1998-10-05 US US09/166,036 patent/US5919787A/en not_active Expired - Fee Related
-
1999
- 1999-03-12 US US09/267,266 patent/US6169089B1/en not_active Expired - Fee Related
-
2000
- 2000-10-13 US US09/687,350 patent/US6410542B1/en not_active Expired - Fee Related
-
2001
- 2001-11-06 HK HK01107758A patent/HK1036802A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2164164T3 (es) | 2002-02-16 |
WO1996015120A1 (en) | 1996-05-23 |
PT1113011E (pt) | 2006-11-30 |
ES2269240T3 (es) | 2007-04-01 |
DK1113011T3 (da) | 2006-11-27 |
KR970707107A (ko) | 1997-12-01 |
EP1113011B1 (en) | 2006-08-02 |
NZ296019A (en) | 1998-09-24 |
US5684008A (en) | 1997-11-04 |
EP0790987A1 (en) | 1997-08-27 |
AU3971195A (en) | 1996-06-06 |
EP0790987B1 (en) | 2001-09-12 |
AU696527B2 (en) | 1998-09-10 |
DE69522703T2 (de) | 2002-07-11 |
ATE205484T1 (de) | 2001-09-15 |
BR9509629A (pt) | 1998-01-06 |
US5854251A (en) | 1998-12-29 |
HK1036802A1 (en) | 2002-01-18 |
US6410542B1 (en) | 2002-06-25 |
DE69535148D1 (de) | 2006-09-14 |
CN1065531C (zh) | 2001-05-09 |
RU2152927C1 (ru) | 2000-07-20 |
US6169089B1 (en) | 2001-01-02 |
ATE334974T1 (de) | 2006-08-15 |
CA2203237A1 (en) | 1996-05-23 |
DE69535148T2 (de) | 2007-07-05 |
PT790987E (pt) | 2002-02-28 |
JP3278165B2 (ja) | 2002-04-30 |
JPH10508847A (ja) | 1998-09-02 |
US5919787A (en) | 1999-07-06 |
EP1113011A1 (en) | 2001-07-04 |
CN1171104A (zh) | 1998-01-21 |
CA2203237C (en) | 2008-06-03 |
DE69522703D1 (de) | 2001-10-18 |
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