DK0751992T3 - Karendotelvækstfaktor 2 - Google Patents
Karendotelvækstfaktor 2Info
- Publication number
- DK0751992T3 DK0751992T3 DK94923874T DK94923874T DK0751992T3 DK 0751992 T3 DK0751992 T3 DK 0751992T3 DK 94923874 T DK94923874 T DK 94923874T DK 94923874 T DK94923874 T DK 94923874T DK 0751992 T3 DK0751992 T3 DK 0751992T3
- Authority
- DK
- Denmark
- Prior art keywords
- polypeptide
- vegf2
- karendothelial
- growth factor
- antibodies
- Prior art date
Links
- 239000003102 growth factor Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- 239000005557 antagonist Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000008024 pharmaceutical diluent Substances 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 238000010188 recombinant method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20755094A | 1994-03-08 | 1994-03-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0751992T3 true DK0751992T3 (da) | 2006-03-06 |
Family
ID=22771051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94923874T DK0751992T3 (da) | 1994-03-08 | 1994-05-12 | Karendotelvækstfaktor 2 |
Country Status (12)
Country | Link |
---|---|
US (4) | US5935820A (da) |
EP (1) | EP0751992B1 (da) |
JP (4) | JPH09510093A (da) |
CN (1) | CN1267550C (da) |
AT (1) | ATE309360T1 (da) |
AU (1) | AU696764B2 (da) |
CA (2) | CA2184584C (da) |
DE (1) | DE69434538T2 (da) |
DK (1) | DK0751992T3 (da) |
ES (1) | ES2249762T3 (da) |
WO (1) | WO1995024473A1 (da) |
ZA (1) | ZA943464B (da) |
Families Citing this family (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6824777B1 (en) | 1992-10-09 | 2004-11-30 | Licentia Ltd. | Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy |
US7109308B1 (en) | 1994-03-08 | 2006-09-19 | Human Genome Sciences, Inc. | Antibodies to human vascular endothelial growth factor 2 |
US5932540A (en) | 1994-03-08 | 1999-08-03 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US6734285B2 (en) | 1994-03-08 | 2004-05-11 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 proteins and compositions |
AU696764B2 (en) | 1994-03-08 | 1998-09-17 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US7186688B1 (en) | 1994-03-08 | 2007-03-06 | Human Genome Sciences, Inc. | Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2 |
US6608182B1 (en) | 1994-03-08 | 2003-08-19 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 2 |
US6040157A (en) | 1994-03-08 | 2000-03-21 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US7153827B1 (en) | 1994-03-08 | 2006-12-26 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 and methods of use |
US6645933B1 (en) * | 1995-08-01 | 2003-11-11 | Helsinki University Licensing Ltd. Oy | Receptor ligand VEGF-C |
US6403088B1 (en) | 1995-08-01 | 2002-06-11 | Helsinki University Licensing, Ltd. | Antibodies reactive with VEGF-C, a ligand for the Flt4 receptor tyrosine kinase (VEGFR-3) |
US6221839B1 (en) * | 1994-11-14 | 2001-04-24 | Helsinki University Licensing Ltd. Oy | FIt4 ligand and methods of use |
US6818220B1 (en) | 1994-11-14 | 2004-11-16 | Licentia Ltd. | Vascular endothelial growth factor C (VEGF-C) protein and gene mutants thereof, and uses thereof |
US6245530B1 (en) | 1995-08-01 | 2001-06-12 | Ludwig Institute For Cancer Research | Receptor ligand |
US6130071A (en) * | 1997-02-05 | 2000-10-10 | Helsinki University Licensing, Ltd. | Vascular endothelial growth factor C (VEGF-C) ΔCys156 protein and gene, and uses thereof |
US5607918A (en) * | 1995-03-01 | 1997-03-04 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-B and DNA coding therefor |
US5928939A (en) * | 1995-03-01 | 1999-07-27 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-b and dna coding therefor |
NZ337634A (en) * | 1995-03-02 | 2001-06-29 | Amrad Operations Pty | method of inducing astroglial proliferation or promoting neuronal survival and/or proliferation by administering vascular endothelial growth factor (VEGF) |
US7160991B1 (en) | 1995-03-02 | 2007-01-09 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor polypeptides |
AU2005244575B2 (en) * | 1995-06-06 | 2008-06-05 | Human Genome Sciences, Inc. | Human Vascular Endothelial Growth Factor 2 |
AU2003201371B2 (en) * | 1995-08-01 | 2007-03-01 | Helsinki University Licensing Ltd. Oy | Receptor Ligand VEGF-C |
US7727761B2 (en) | 1995-08-01 | 2010-06-01 | Vegenics Limited | Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof |
US6361946B1 (en) | 1997-02-05 | 2002-03-26 | Licentia Ltd | Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof |
PT848755E (pt) * | 1995-09-08 | 2003-12-31 | Genentech Inc | Proteina relacionada com o vegf |
ES2239338T5 (es) | 1995-09-29 | 2013-05-31 | Vegenics Pty Ltd | Genes regulados y sus usos |
WO1997017442A1 (en) * | 1995-11-08 | 1997-05-15 | Immunex Corporation | Flk-1 binding protein |
US6994989B1 (en) | 1995-11-08 | 2006-02-07 | Immunex Corp. | FLK-1 binding proteins |
DE69733204T3 (de) | 1996-07-15 | 2012-03-08 | Chugai Seiyaku K.K. | Neuartige vegf-ähnliche faktoren |
ES2251740T3 (es) | 1996-08-23 | 2006-05-01 | Ludwig Institute For Cancer Research | Factor de crecimiento de celulas de endotelio vascular d recombinante (vegf-d). |
US20060171907A1 (en) * | 1996-11-21 | 2006-08-03 | The Procter & Gamble Company | Oral care compositions providing enhanced whitening and stain prevention |
HUP0001964A3 (en) | 1997-01-29 | 2002-01-28 | Cornell Res Foundation Inc Ith | Multiple site delivery of adenoviral vector for the induction of angiogenesis |
US7125714B2 (en) | 1997-02-05 | 2006-10-24 | Licentia Ltd. | Progenitor cell materials and methods |
AU6691098A (en) * | 1997-03-07 | 1998-09-22 | Wistar Institute Of Anatomy & Biology, The | Method and compositions for healing tissue defects and inducing hypervascularityin mammalian tissue |
PT2301580E (pt) * | 1997-04-07 | 2012-05-02 | Genentech Inc | Recipiente contendo anticorpos anti-vegf |
WO1999033485A1 (en) | 1997-12-24 | 1999-07-08 | Ludwig Institute For Cancer Research | Expression vectors and cell lines expressing vascular endothelial growth factor d, and method of treating melanomas |
US7722671B1 (en) | 1998-01-27 | 2010-05-25 | St. Jude Medical, Inc. | Medical devices with associated growth factors |
EP1062319A4 (en) * | 1998-03-13 | 2003-04-23 | Human Genome Sciences Inc | VASCULAR ENDOTHELIAL GROWTH FACTOR 2 |
NZ511408A (en) | 1998-10-09 | 2004-04-30 | Licentia Ltd | Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy |
US6958147B1 (en) | 1998-10-26 | 2005-10-25 | Licentia Ltd | Use of VEGF-C to prevent restenosis |
DE69941791D1 (de) | 1998-11-10 | 2010-01-21 | Ludwig Inst Cancer Res | Von blutplättchen abstammender wachstumsfaktor d, dafür kodierende dns und deren verwendungen |
US6375680B1 (en) | 1998-12-01 | 2002-04-23 | St. Jude Medical, Inc. | Substrates for forming synthetic tissues |
EP1137773B1 (en) | 1998-12-07 | 2008-08-13 | ZymoGenetics, Inc. | Growth factor homolog zvegf3 |
US6783953B1 (en) | 1998-12-22 | 2004-08-31 | Janssen Pharmaceutica N.V. | Vascular endothelial growth factor-X |
US7223724B1 (en) * | 1999-02-08 | 2007-05-29 | Human Genome Sciences, Inc. | Use of vascular endothelial growth factor to treat photoreceptor cells |
ATE400289T1 (de) * | 1999-02-08 | 2008-07-15 | Human Genome Sciences Inc | Verwendung vom vaskulären endothelialen wachstumsfaktor 2 (vegf-2) |
IL128852A0 (en) * | 1999-03-05 | 2000-01-31 | Compugen Ltd | Novel nucleic acid and amino acid sequences |
WO2000058511A1 (en) * | 1999-03-26 | 2000-10-05 | Ludwig Institute For Cancer Research | Screening and therapy for lymphatic disorders involving the flt4 receptor tyrosine kinase (vegfr-3) |
US6764820B2 (en) * | 1999-03-26 | 2004-07-20 | Ludwig Institute For Cancer Research | Screening for lymphatic disorders involving the FLT4 receptor tyrosine kinase (VEGFR-3) |
US7125856B1 (en) | 1999-04-15 | 2006-10-24 | St. Elizabeth's Medical Center Of Boston, Inc. | Angiogenic growth factors for treatment of peripheral neuropathy |
CA2370246C (en) * | 1999-04-16 | 2017-03-21 | Genentech, Inc. | Vascular endothelial cell growth factor variants and uses thereof |
US6475796B1 (en) * | 1999-05-20 | 2002-11-05 | Scios, Inc. | Vascular endothelial growth factor variants |
JP2003500053A (ja) * | 1999-05-20 | 2003-01-07 | サイオス,インコーポレーテッド | 血管内皮増殖因子ダイマー |
CN100399030C (zh) * | 1999-11-16 | 2008-07-02 | 杰南技术公司 | 用于vegf的elisa |
US6726718B1 (en) | 1999-12-13 | 2004-04-27 | St. Jude Medical, Inc. | Medical articles prepared for cell adhesion |
WO2001052875A1 (en) | 2000-01-18 | 2001-07-26 | Ludwig Institute For Cancer Research | Vegf-d/vegf-c/vegf peptidomimetic inhibitor |
DE60131146T2 (de) * | 2000-02-25 | 2008-03-06 | Ludwig Institute For Cancer Research | Material und verfahren die hybridvaskularendothelwachstumfaktoren dns und proteine enthalten und screeningverfahren für modulatoren |
DK1272208T3 (da) | 2000-04-12 | 2011-10-31 | Vib Vzw | Anvendelse af VEGF 165 og homologer til at behandle neuron-sygdomme |
US6939540B1 (en) | 2000-07-31 | 2005-09-06 | Cornell Research Foundation, Inc. | Method of enhancing bone density |
KR20020059609A (ko) | 2000-08-04 | 2002-07-13 | 벤슨 로버트 에이치. | 혈관 내피 성장 인자 2 |
WO2002046412A2 (en) | 2000-12-07 | 2002-06-13 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
US7067317B2 (en) | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
US7611711B2 (en) * | 2001-01-17 | 2009-11-03 | Vegenics Limited | VEGFR-3 inhibitor materials and methods |
JP4669984B2 (ja) | 2001-01-19 | 2011-04-13 | ベジェニクス リミテッド | 腫瘍画像化のターゲットとしてのF1t4(VEGFR−3)および抗腫瘍療法 |
EP2228389B1 (en) | 2001-04-13 | 2015-07-08 | Human Genome Sciences, Inc. | Antibodies against vascular endothelial growth factor 2 |
AU2002256172A1 (en) * | 2001-04-13 | 2002-10-28 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US7402312B2 (en) | 2001-04-13 | 2008-07-22 | Human Genome Sciences, Inc. | Antibodies to vascular endothelial growth factor 2 (VEGF-2) |
CA2444624A1 (en) * | 2001-04-13 | 2002-10-24 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US20050232921A1 (en) * | 2001-04-13 | 2005-10-20 | Rosen Craig A | Vascular endothelial growth factor 2 |
CN1555488A (zh) * | 2001-07-12 | 2004-12-15 | 路德维格癌症研究院 | 淋巴管内皮细胞物质及方法 |
WO2003018752A2 (en) | 2001-08-23 | 2003-03-06 | The Wistar Institute Of Anatomy And Biology | An organotypic intestinal culture and methods of use thereof |
US20040214766A1 (en) * | 2001-10-01 | 2004-10-28 | Kari Alitalo | VEGF-C or VEGF-D materials and methods for treatment of neuropathologies |
US20030113324A1 (en) * | 2001-10-01 | 2003-06-19 | Kari Alitalo | Neuropilin/VEGF-C/VEGFR-3 materials and methods |
US7371258B2 (en) | 2001-10-26 | 2008-05-13 | St. Jude Medical, Inc. | Valved prosthesis with porous substrate |
US7985402B2 (en) * | 2002-03-01 | 2011-07-26 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
US20050250700A1 (en) * | 2002-03-01 | 2005-11-10 | Sato Aaron K | KDR and VEGF/KDR binding peptides |
AU2003278807A1 (en) | 2002-03-01 | 2004-08-13 | Bracco International B.V. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
US7666979B2 (en) * | 2002-03-01 | 2010-02-23 | Bracco International B.V. | Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
US7211240B2 (en) * | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
US7479270B2 (en) | 2002-07-23 | 2009-01-20 | Vegenics Limited | Methods and compositions for activating VEGF-D and VEGF-C |
US20040120950A1 (en) * | 2002-12-20 | 2004-06-24 | Kari Alitalo | Modulation of VEGF-C/VEGFR-3 interactions in the treatment of rheumatoid arthritis |
JP2006517586A (ja) * | 2003-02-04 | 2006-07-27 | ラドウィグ インスティテュート フォー キャンサー リサーチ | 幹細胞のvegf−b及びpdgf調節 |
DK2284180T3 (da) * | 2003-03-03 | 2015-12-21 | Dyax Corp | Anvendelser af peptider, som specifikt binder sig til HGF-receptor (cMET) |
EP1635860A2 (en) * | 2003-06-12 | 2006-03-22 | Ludwig Institute For Cancer Research | Use of vegf-c or vegf-d in reconstructive surgery |
WO2005016963A2 (en) * | 2003-06-12 | 2005-02-24 | Ludwig Institute For Cancer Research | Heparin binding veger-3 ligands |
AU2004313245B2 (en) | 2003-12-30 | 2011-04-14 | Durect Corporation | Polymeric implants, preferably containing a mixture of PEG and PLG, for controlled release of active agents, preferably a GNRH |
US7358085B2 (en) | 2005-02-28 | 2008-04-15 | Sangamo Biosciences, Inc. | Anti-angiogenic methods and compositions |
ATE497973T1 (de) | 2005-12-22 | 2011-02-15 | Genentech Inc | Rekombinante produktion heparinbindender proteine |
KR20100036389A (ko) * | 2006-01-27 | 2010-04-07 | (주)프로스테믹스 | 지방유래 줄기세포 배양액을 함유하는 화장료 조성물 |
WO2008008975A2 (en) | 2006-07-14 | 2008-01-17 | Genentech, Inc. | Refolding of recombinant proteins |
RS60026B1 (sr) | 2013-02-18 | 2020-04-30 | Vegenics Pty Ltd | Molekuli koji vezuju ligande i njihove upotrebe |
Family Cites Families (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0186084B1 (en) | 1984-12-24 | 1991-09-04 | Merck & Co. Inc. | Brain-derived growth factor |
US5073492A (en) * | 1987-01-09 | 1991-12-17 | The Johns Hopkins University | Synergistic composition for endothelial cell growth |
JPS6438100U (da) | 1987-08-26 | 1989-03-07 | ||
JPH02117698A (ja) | 1988-10-27 | 1990-05-02 | Toray Ind Inc | 血管内皮細胞成長因子 |
US5240848A (en) * | 1988-11-21 | 1993-08-31 | Monsanto Company | Dna sequences encoding human vascular permeability factor having 189 amino acids |
US5693622A (en) | 1989-03-21 | 1997-12-02 | Vical Incorporated | Expression of exogenous polynucleotide sequences cardiac muscle of a mammal |
EP0399816B1 (en) | 1989-05-24 | 1995-12-20 | Merck & Co. Inc. | Purification and characterization of a glioma-derived growth factor |
US5219739A (en) * | 1989-07-27 | 1993-06-15 | Scios Nova Inc. | DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121 |
US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
CA2051796A1 (en) * | 1990-09-21 | 1992-03-22 | Marvin L. Bayne | Vascular endothelial cell growth factor ii |
DK0536350T3 (da) | 1991-02-22 | 2002-09-02 | American Cyanamid Co | Identifikation af et nyt humant receptor-tyrosinkinase-gen |
DE69229454T2 (de) * | 1991-03-28 | 2000-01-05 | Merck & Co., Inc. | Untereinheit-C des vaskulären endothelialen Zellwachstumsfaktors |
US5185438A (en) * | 1991-04-02 | 1993-02-09 | The Trustees Of Princeton University | Nucleic acids encoding hencatoporetic stem cell receptor flk-2 |
US5234908A (en) * | 1991-04-12 | 1993-08-10 | Creative Biomolecules, Inc. | Method of treating gastrointestinal ulcers with platelet derived growth factor |
US5661133B1 (en) | 1991-11-12 | 1999-06-01 | Univ Michigan | Collateral blood vessel formation in cardiac muscle by injecting a dna sequence encoding an angiogenic protein |
US5861301A (en) * | 1992-02-20 | 1999-01-19 | American Cayanamid Company | Recombinant kinase insert domain containing receptor and gene encoding same |
US5326695A (en) * | 1992-05-15 | 1994-07-05 | Ludwig Institute For Cancer Research | Platelet derived growth factor agonists |
US5776755A (en) * | 1992-10-09 | 1998-07-07 | Helsinki University Licensing, Ltd. | FLT4, a receptor tyrosine kinase |
DE69333886T2 (de) | 1992-11-18 | 2006-07-27 | Arch Development Corp., Chicago | Adenovirus-gelenkter Gen-Transfer zum Herz-und glattem vaskulären Muskel |
US5922572A (en) | 1994-01-25 | 1999-07-13 | Human Genome Sciences, Inc. | Polynucleotides encoding haemopoietic maturation factor |
US7109308B1 (en) | 1994-03-08 | 2006-09-19 | Human Genome Sciences, Inc. | Antibodies to human vascular endothelial growth factor 2 |
US5932540A (en) * | 1994-03-08 | 1999-08-03 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
AU696764B2 (en) | 1994-03-08 | 1998-09-17 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US7153827B1 (en) | 1994-03-08 | 2006-12-26 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 and methods of use |
US7186688B1 (en) | 1994-03-08 | 2007-03-06 | Human Genome Sciences, Inc. | Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2 |
US6608182B1 (en) | 1994-03-08 | 2003-08-19 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 2 |
US6734285B2 (en) | 1994-03-08 | 2004-05-11 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 proteins and compositions |
US5817485A (en) | 1994-03-08 | 1998-10-06 | Human Genome Sciences, Inc. | Nucleic acids and cells for recombinant production of fibroblast growth factor-10 |
US6040157A (en) | 1994-03-08 | 2000-03-21 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US5633147A (en) * | 1994-03-08 | 1997-05-27 | Human Genome Sciences, Inc. | Transforming growth factor αH1 |
KR970705405A (ko) | 1994-08-23 | 1997-10-09 | 벤슨 로버트 에이취 | 사람 케모킨 폴리펩타이드(Human Chemokine Polypeptides) |
US5652225A (en) | 1994-10-04 | 1997-07-29 | St. Elizabeth's Medical Center Of Boston, Inc. | Methods and products for nucleic acid delivery |
US6245530B1 (en) | 1995-08-01 | 2001-06-12 | Ludwig Institute For Cancer Research | Receptor ligand |
US6403088B1 (en) | 1995-08-01 | 2002-06-11 | Helsinki University Licensing, Ltd. | Antibodies reactive with VEGF-C, a ligand for the Flt4 receptor tyrosine kinase (VEGFR-3) |
WO1998033917A1 (en) | 1994-11-14 | 1998-08-06 | The Ludwig Institute For Cancer Research | Vascular endothelial growth factor c (vegf-c) protein and gene, mutants thereof, and uses thereof |
US6221839B1 (en) | 1994-11-14 | 2001-04-24 | Helsinki University Licensing Ltd. Oy | FIt4 ligand and methods of use |
US6645933B1 (en) * | 1995-08-01 | 2003-11-11 | Helsinki University Licensing Ltd. Oy | Receptor ligand VEGF-C |
US6130071A (en) | 1997-02-05 | 2000-10-10 | Helsinki University Licensing, Ltd. | Vascular endothelial growth factor C (VEGF-C) ΔCys156 protein and gene, and uses thereof |
US5792453A (en) | 1995-02-28 | 1998-08-11 | The Regents Of The University Of California | Gene transfer-mediated angiogenesis therapy |
US5607918A (en) * | 1995-03-01 | 1997-03-04 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-B and DNA coding therefor |
US5928939A (en) * | 1995-03-01 | 1999-07-27 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-b and dna coding therefor |
US5977322A (en) | 1995-06-14 | 1999-11-02 | The Regents Of The University Of California | High affinity human antibodies to tumor antigens |
US6361946B1 (en) | 1997-02-05 | 2002-03-26 | Licentia Ltd | Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof |
DK1143006T3 (da) | 1995-08-18 | 2008-07-14 | Morphosys Ip Gmbh | Vektorer/DNA-sekvenser fra humane kombinatoriske antistofbiblioteker |
PT848755E (pt) | 1995-09-08 | 2003-12-31 | Genentech Inc | Proteina relacionada com o vegf |
US6121246A (en) | 1995-10-20 | 2000-09-19 | St. Elizabeth's Medical Center Of Boston, Inc. | Method for treating ischemic tissue |
WO1997017442A1 (en) * | 1995-11-08 | 1997-05-15 | Immunex Corporation | Flk-1 binding protein |
US5641750A (en) | 1995-11-29 | 1997-06-24 | Amgen Inc. | Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product |
NZ333725A (en) | 1996-08-13 | 2000-10-27 | Human Genome Sciences Inc | Keratinocyte growth factor-2 (KGF-2) deletion mutants |
ES2251740T3 (es) | 1996-08-23 | 2006-05-01 | Ludwig Institute For Cancer Research | Factor de crecimiento de celulas de endotelio vascular d recombinante (vegf-d). |
WO1998024811A2 (en) | 1996-12-06 | 1998-06-11 | Zymogenetics, Inc. | Vascular endothelial growth factor |
AU6691098A (en) | 1997-03-07 | 1998-09-22 | Wistar Institute Of Anatomy & Biology, The | Method and compositions for healing tissue defects and inducing hypervascularityin mammalian tissue |
US6884879B1 (en) | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
CN1260835A (zh) | 1997-04-25 | 2000-07-19 | 科莱特诺医疗公司 | 截短的vegf相关蛋白质 |
JP2001513652A (ja) | 1997-06-06 | 2001-09-04 | アサト アクチエンゲゼルシャフト アプライド サイエンス アンド テクノロジー | 抗−gpiib/iiia組み換え抗体 |
EP0990042A1 (en) | 1997-06-10 | 2000-04-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Regulatory sequences involved in hypoxia regulated gene expression and uses thereof |
NZ501990A (en) | 1997-07-08 | 2002-09-27 | Viventia Biotech Inc | Compositions containing antigen-binding fragments that recognise the antigen recognised by a recombinant 4B5 antibody |
AU8905698A (en) | 1997-08-15 | 1999-03-08 | Helsinki University Licensing Ltd Oy | Stimulation, modulation and/or inhibition of endothelial proteolytic activity and/or angiogenic activity |
GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
WO1999021590A1 (en) | 1997-10-27 | 1999-05-06 | Merck & Co., Inc. | Gene therapy for stimulation of angiogenesis |
EP1062319A4 (en) | 1998-03-13 | 2003-04-23 | Human Genome Sciences Inc | VASCULAR ENDOTHELIAL GROWTH FACTOR 2 |
US7223724B1 (en) | 1999-02-08 | 2007-05-29 | Human Genome Sciences, Inc. | Use of vascular endothelial growth factor to treat photoreceptor cells |
ATE400289T1 (de) | 1999-02-08 | 2008-07-15 | Human Genome Sciences Inc | Verwendung vom vaskulären endothelialen wachstumsfaktor 2 (vegf-2) |
CA2375033A1 (en) | 1999-05-27 | 2000-12-07 | Max-Delbruck-Centrum Fur Molekulare Medizin | Vaccines against conformation-dependent antigens and against antigens that are not or are not only proteins or peptides |
JP2003509011A (ja) | 1999-06-03 | 2003-03-11 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 脈管形成タンパク質およびそれらの使用 |
EP1255844B1 (en) | 2000-02-03 | 2007-09-19 | Millennium Pharmaceuticals, Inc. | Humanized anti-ccr2 antibodies and methods of use therefor |
AR027404A1 (es) | 2000-02-10 | 2003-03-26 | Abbott Gmbh & Co Kg | Anticuerpos que ligan la interleucina-18 humana y metodos de preparacion y uso. |
KR20020059609A (ko) * | 2000-08-04 | 2002-07-13 | 벤슨 로버트 에이치. | 혈관 내피 성장 인자 2 |
EP2228389B1 (en) | 2001-04-13 | 2015-07-08 | Human Genome Sciences, Inc. | Antibodies against vascular endothelial growth factor 2 |
US20050232921A1 (en) | 2001-04-13 | 2005-10-20 | Rosen Craig A | Vascular endothelial growth factor 2 |
US7402312B2 (en) * | 2001-04-13 | 2008-07-22 | Human Genome Sciences, Inc. | Antibodies to vascular endothelial growth factor 2 (VEGF-2) |
CA2444624A1 (en) | 2001-04-13 | 2002-10-24 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
AU2002256172A1 (en) | 2001-04-13 | 2002-10-28 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
WO2003097660A1 (en) | 2002-04-12 | 2003-11-27 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
-
1994
- 1994-05-12 AU AU73941/94A patent/AU696764B2/en not_active Ceased
- 1994-05-12 AT AT94923874T patent/ATE309360T1/de not_active IP Right Cessation
- 1994-05-12 CA CA002184584A patent/CA2184584C/en not_active Expired - Fee Related
- 1994-05-12 DK DK94923874T patent/DK0751992T3/da active
- 1994-05-12 ES ES94923874T patent/ES2249762T3/es not_active Expired - Lifetime
- 1994-05-12 DE DE69434538T patent/DE69434538T2/de not_active Revoked
- 1994-05-12 WO PCT/US1994/005291 patent/WO1995024473A1/en active IP Right Grant
- 1994-05-12 CN CNB941950530A patent/CN1267550C/zh not_active Expired - Fee Related
- 1994-05-12 JP JP7523422A patent/JPH09510093A/ja not_active Withdrawn
- 1994-05-12 EP EP94923874A patent/EP0751992B1/en not_active Revoked
- 1994-05-12 CA CA002414016A patent/CA2414016A1/en not_active Abandoned
- 1994-05-19 ZA ZA943464A patent/ZA943464B/xx unknown
-
1997
- 1997-03-27 US US08/824,996 patent/US5935820A/en not_active Expired - Fee Related
-
2002
- 2002-02-01 US US10/060,523 patent/US20020182683A1/en not_active Abandoned
-
2003
- 2003-08-11 JP JP2003291861A patent/JP2004000267A/ja not_active Withdrawn
-
2004
- 2004-05-26 US US10/853,232 patent/US7498417B2/en not_active Expired - Fee Related
-
2006
- 2006-03-17 JP JP2006075735A patent/JP2006333865A/ja not_active Withdrawn
- 2006-05-15 JP JP2006135885A patent/JP4439490B2/ja not_active Expired - Fee Related
-
2009
- 2009-03-02 US US12/396,033 patent/US20090192088A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20090192088A1 (en) | 2009-07-30 |
JP4439490B2 (ja) | 2010-03-24 |
DE69434538D1 (de) | 2005-12-15 |
JP2006333865A (ja) | 2006-12-14 |
ATE309360T1 (de) | 2005-11-15 |
EP0751992A4 (en) | 1997-12-17 |
DE69434538T2 (de) | 2006-08-10 |
US20040214286A1 (en) | 2004-10-28 |
ES2249762T3 (es) | 2006-04-01 |
CA2184584A1 (en) | 1995-09-14 |
WO1995024473A1 (en) | 1995-09-14 |
CN1145636A (zh) | 1997-03-19 |
CA2184584C (en) | 2003-04-08 |
ZA943464B (en) | 1995-11-20 |
US20020182683A1 (en) | 2002-12-05 |
AU7394194A (en) | 1995-09-25 |
EP0751992A1 (en) | 1997-01-08 |
US7498417B2 (en) | 2009-03-03 |
JP2004000267A (ja) | 2004-01-08 |
AU696764C (en) | 1995-09-25 |
AU696764B2 (en) | 1998-09-17 |
JPH09510093A (ja) | 1997-10-14 |
CN1267550C (zh) | 2006-08-02 |
US5935820A (en) | 1999-08-10 |
EP0751992B1 (en) | 2005-11-09 |
JP2006238893A (ja) | 2006-09-14 |
CA2414016A1 (en) | 1995-09-14 |
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