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DK0619837T3 - Fremgangsmåde til opnåelse af glycosyltransferaser - Google Patents

Fremgangsmåde til opnåelse af glycosyltransferaser

Info

Publication number
DK0619837T3
DK0619837T3 DK93901223T DK93901223T DK0619837T3 DK 0619837 T3 DK0619837 T3 DK 0619837T3 DK 93901223 T DK93901223 T DK 93901223T DK 93901223 T DK93901223 T DK 93901223T DK 0619837 T3 DK0619837 T3 DK 0619837T3
Authority
DK
Denmark
Prior art keywords
immobilized
glycosyltransferase
acceptor moiety
complex
obtaining
Prior art date
Application number
DK93901223T
Other languages
English (en)
Inventor
Stephen Roth
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Application granted granted Critical
Publication of DK0619837T3 publication Critical patent/DK0619837T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1051Hexosyltransferases (2.4.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/18Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/814Enzyme separation or purification
    • Y10S435/815Enzyme separation or purification by sorption

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
DK93901223T 1991-12-20 1992-12-21 Fremgangsmåde til opnåelse af glycosyltransferaser DK0619837T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/810,858 US5874261A (en) 1988-09-02 1991-12-20 Method for the purification of glycosyltransferases
PCT/US1992/010891 WO1993013198A1 (en) 1991-12-20 1992-12-21 A method for obtaining glycosyltransferases

Publications (1)

Publication Number Publication Date
DK0619837T3 true DK0619837T3 (da) 2001-12-03

Family

ID=25204895

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93901223T DK0619837T3 (da) 1991-12-20 1992-12-21 Fremgangsmåde til opnåelse af glycosyltransferaser

Country Status (14)

Country Link
US (1) US5874261A (da)
EP (1) EP0619837B1 (da)
JP (1) JPH07502412A (da)
AT (1) ATE207117T1 (da)
AU (1) AU685387B2 (da)
CA (1) CA2126213A1 (da)
DE (1) DE69232138T2 (da)
DK (1) DK0619837T3 (da)
ES (1) ES2162619T3 (da)
FI (1) FI942916A (da)
NO (1) NO942317D0 (da)
PT (1) PT619837E (da)
RU (1) RU94034735A (da)
WO (1) WO1993013198A1 (da)

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EP0481038B1 (en) 1990-04-16 2002-10-02 The Trustees Of The University Of Pennsylvania Saccharide compositions, methods and apparatus for their synthesis
KR920702721A (ko) * 1990-04-16 1992-10-06 원본미기재 사카라이드 조성물, 그의 합성 방법 및 장치
US6518051B1 (en) 1991-04-11 2003-02-11 The Trustees Of The University Of Pennsylvania Saccharide compositions, methods and apparatus for their synthesis
US5665561A (en) * 1994-06-06 1997-09-09 The Rockefeller University Modulators of pneumococcal adherence to pulmonary and vascular cells and diagnostic and therapeutic applications
US5545553A (en) * 1994-09-26 1996-08-13 The Rockefeller University Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them
US6096725A (en) * 1997-07-02 2000-08-01 Neose Technologies, Inc. Methods of using αGal oligosaccharides as immune system targeting agents
AU1585999A (en) 1997-11-12 1999-05-31 Neurotherapeutics Methods for the detection and treatment of disease using a glycosyltransferase
US20040204381A1 (en) * 1997-11-12 2004-10-14 Moskal Joseph R Detection and treatment of glyco-enzyme-related disease
US20030143662A1 (en) * 1998-06-16 2003-07-31 Cummings Richard D. Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof
US7223845B2 (en) 1998-06-16 2007-05-29 The Board Of Regents Of The University Of Oklahoma Synthetic glycosulfopeptides and methods of synthesis thereof
WO1999065712A2 (en) 1998-06-16 1999-12-23 The Board Of Regents Of The University Of Oklahoma Glycosulfopeptides and methods of synthesis and use thereof
US20030235884A1 (en) * 1999-06-15 2003-12-25 Cummings Richard D. Polynucleotides encoding core 1 beta3-galactosyl transferase and methods of use thereof
US6492152B1 (en) 1999-06-15 2002-12-10 The Board Of Regents Of The University Of Oklahoma Core 1 β3-galactosyl transferases and methods of use thereof
US20030059915A1 (en) * 1999-06-15 2003-03-27 Canfield William M. Core 1 beta3-galactosyl transferases and methods of use thereof
AU1431101A (en) 1999-10-04 2001-05-10 University Of Maryland Biotechnology Institute Novel adjuvant comprising a lipopolysaccharide antagonist
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
WO2004099231A2 (en) 2003-04-09 2004-11-18 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
AU2003201619A1 (en) * 2002-01-18 2003-07-30 Biotie Therapies Corporation Novel binding epitopes for helicobacter pylori and use thereof
US7309600B2 (en) 2003-02-12 2007-12-18 University Of Iowa Research Foundation Haemophilus influenzae sialyltransferase and methods of use thereof
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US7893041B2 (en) 2003-12-05 2011-02-22 Children's Hospital Medical Center Oligosaccharide compositions and use thereof in the treatment of infection
HUE026826T2 (en) 2004-10-29 2016-07-28 Ratiopharm Gmbh Modeling and glycopegylation of fibroblast growth factor (FGF)
EP1858543B1 (en) 2005-01-10 2013-11-27 BioGeneriX AG Glycopegylated granulocyte colony stimulating factor
TWI264608B (en) * 2005-04-08 2006-10-21 Delta Electronics Inc Light tunnel module
WO2006121569A2 (en) 2005-04-08 2006-11-16 Neose Technologies, Inc. Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
US20080280818A1 (en) 2006-07-21 2008-11-13 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
JP2010505874A (ja) 2006-10-03 2010-02-25 ノヴォ ノルディスク アー/エス ポリペプチドコンジュゲートの精製方法
ES2406267T3 (es) 2007-04-03 2013-06-06 Biogenerix Ag Métodos de tratamiento usando G-CSF glicopegilado
MX2009013259A (es) 2007-06-12 2010-01-25 Novo Nordisk As Proceso mejorado para la produccion de azucares de nucleotidos.
CN103497246B (zh) 2008-02-27 2016-08-10 诺沃—诺迪斯克有限公司 缀合的因子viii分子
WO2010120682A1 (en) 2009-04-13 2010-10-21 Morrow Ardythe L Milk oligosaccharide compositions and use thereof in treating infection in animals
UA110325C2 (en) 2009-07-03 2015-12-25 Australian Biomedical Company Pty Ltd Medicinal carbohydrates for treating respiratory conditions
ES2651067T3 (es) 2009-07-06 2018-01-24 Children's Hospital Medical Center Inhibición de la inflamación con oligosacáridos de la leche
ES2671555T3 (es) 2011-06-07 2018-06-07 Hero Ag Obtención de oligosacáridos mediante un proceso biotecnológico
RU2624241C1 (ru) * 2016-03-25 2017-07-03 Акционерное Общество "ГенТерра" Твердофазный носитель для иммобилизации и/или хранения биологических образцов, содержащих нуклеиновые кислоты

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US4219571A (en) * 1978-06-15 1980-08-26 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Process for producing a sweetener
US4261976A (en) * 1978-10-03 1981-04-14 The Massachusetts General Hospital Method and glycoprotein composition for inhibition of growth of transformed cells and tumors
JPS5836959B2 (ja) * 1980-08-21 1983-08-12 三井製糖株式会社 固定化α−グルコシルトランスフエラ−ゼによるパラチノ−スの製造法
JPS58870A (ja) * 1981-06-20 1983-01-06 Hayashibara Biochem Lab Inc 飲食物及びその製造方法
FR2509313A1 (fr) * 1981-07-08 1983-01-14 Choay Sa Derives de 3-fucosyl-n-acetyl lactosamine, leur preparation et leurs applications biologiques
JPS58149697A (ja) * 1982-02-27 1983-09-06 Dainippon Ink & Chem Inc β−1,3グリコシルステビオシドの製造方法
US4569909A (en) * 1982-06-03 1986-02-11 Seitetsu Kagaku Co., Ltd. Process for preparing uridine diphosphate-N-acetylgalactosamine
US4770994A (en) * 1982-07-30 1988-09-13 Abbott Laboratories Determination of carbohydrate acceptors
US4557927A (en) * 1983-03-10 1985-12-10 Kabushiki Kaisha Hoyashibara Food products and process for producing same
GB8316790D0 (en) * 1983-06-21 1983-07-27 Tate & Lyle Plc Chemical process
DE3446380C1 (de) * 1984-12-19 1986-05-22 Pfeifer & Langen, 5000 Köln Suessungsmittel,Verfahren zur Herstellung und Verwendung desselben
SE451849B (sv) * 1985-12-11 1987-11-02 Svenska Sockerfabriks Ab Sett att syntetisera glykosidiska bindningar samt anvendning av pa detta sett erhallna produkter
NL8701616A (nl) * 1987-07-09 1989-02-01 Stamicarbon Fructosyltransferase en bereiding van fructose-oligomeren daarmee.
SE466403B (sv) * 1988-03-24 1992-02-10 Kurt G I Nilsson Saett att syntetisera oligosackarider
EP0356048A3 (en) * 1988-08-05 1990-11-14 Uop Novel cylodextrin glycosyltransferases
DK626488D0 (da) * 1988-11-10 1988-11-10 Torben Falck Oerntoft Fremgangsmaade til udtagning af en sekretproeve via en legemsaabning og til praeparation af proeven med henblik paa kvantitativ bestemmelse af molekylaere strukturer og enzymaktivitet i proeven samt proeveudtagningsindretning til brug derved
EP0481038B1 (en) * 1990-04-16 2002-10-02 The Trustees Of The University Of Pennsylvania Saccharide compositions, methods and apparatus for their synthesis

Also Published As

Publication number Publication date
AU3323693A (en) 1993-07-28
CA2126213A1 (en) 1993-06-24
PT619837E (pt) 2002-03-28
FI942916A0 (fi) 1994-06-17
ES2162619T3 (es) 2002-01-01
ATE207117T1 (de) 2001-11-15
EP0619837A1 (en) 1994-10-19
EP0619837A4 (en) 1995-11-15
RU94034735A (ru) 1996-07-20
US5874261A (en) 1999-02-23
NO942317L (da) 1994-08-09
DE69232138D1 (de) 2001-11-22
NO942317D0 (no) 1994-06-17
AU685387B2 (en) 1998-01-22
JPH07502412A (ja) 1995-03-16
EP0619837B1 (en) 2001-10-17
DE69232138T2 (de) 2002-06-06
FI942916A (fi) 1994-06-17
WO1993013198A1 (en) 1993-07-08

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