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DK0678097T3 - Hidtil ukendte colon- eller ileumspecifikke steroidderivater - Google Patents

Hidtil ukendte colon- eller ileumspecifikke steroidderivater

Info

Publication number
DK0678097T3
DK0678097T3 DK94904364T DK94904364T DK0678097T3 DK 0678097 T3 DK0678097 T3 DK 0678097T3 DK 94904364 T DK94904364 T DK 94904364T DK 94904364 T DK94904364 T DK 94904364T DK 0678097 T3 DK0678097 T3 DK 0678097T3
Authority
DK
Denmark
Prior art keywords
ileum
steroid derivatives
specific steroid
compounds
newly known
Prior art date
Application number
DK94904364T
Other languages
Danish (da)
English (en)
Inventor
Ralph Lennart Brattsand
Peter Edman
Stinabritt Nilsson
Bror Arne Thalen
Jan Erik Ulmius
Thomas Higberg
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9300030A external-priority patent/SE9300030D0/xx
Priority claimed from SE9300082A external-priority patent/SE9300082D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Application granted granted Critical
Publication of DK0678097T3 publication Critical patent/DK0678097T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK94904364T 1993-01-08 1993-12-17 Hidtil ukendte colon- eller ileumspecifikke steroidderivater DK0678097T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9300030A SE9300030D0 (sv) 1993-01-08 1993-01-08 Novel colon- or ileum-specific steroid derivatives
SE9300082A SE9300082D0 (sv) 1993-01-14 1993-01-14 Novel colon- or ileum-specific steroid derivatives
PCT/SE1993/001081 WO1994015947A1 (en) 1993-01-08 1993-12-17 Novel colon- or ileum-specific steroid derivatives

Publications (1)

Publication Number Publication Date
DK0678097T3 true DK0678097T3 (da) 2000-02-07

Family

ID=26661623

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94904364T DK0678097T3 (da) 1993-01-08 1993-12-17 Hidtil ukendte colon- eller ileumspecifikke steroidderivater

Country Status (22)

Country Link
US (2) US5908833A (el)
EP (1) EP0678097B1 (el)
JP (1) JP3366640B2 (el)
KR (1) KR960700266A (el)
AT (1) ATE183192T1 (el)
BR (1) BR9307746A (el)
CA (1) CA2152374A1 (el)
CZ (1) CZ171095A3 (el)
DK (1) DK0678097T3 (el)
ES (1) ES2137353T3 (el)
FI (1) FI953358A7 (el)
GR (1) GR3031789T3 (el)
HU (1) HU221584B (el)
IS (1) IS4111A (el)
LV (1) LV10961B (el)
NO (1) NO305367B1 (el)
NZ (1) NZ259596A (el)
PL (1) PL178307B1 (el)
RU (1) RU95115547A (el)
SK (1) SK87295A3 (el)
TW (1) TW261615B (el)
WO (1) WO1994015947A1 (el)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU95115547A (ru) * 1993-01-08 1997-06-10 Астра Актиеболаг (SE) Стероидные соединения, способы их получения и фармацевтический препарат
EP0721956B1 (en) * 1993-09-29 2000-08-02 Nissin Shokuhin Kabushiki Kaisha 21-substituted steroid compound
US6028190A (en) 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
US6166024A (en) 1995-03-30 2000-12-26 Mayo Foundation For Medical Education And Research Use of topical azathioprine and thioguanine to treat colorectal adenomas
JP4610734B2 (ja) * 1998-03-19 2011-01-12 三笠製薬株式会社 ２１−置換グリコシルステロイド化合物
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
US6630453B1 (en) 1999-05-04 2003-10-07 Strakan Limited Androgen derivatives and uses thereof
US8895064B2 (en) 1999-06-14 2014-11-25 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
HK1046244B (zh) 1999-06-14 2005-06-03 科斯默技术有限公司 控制釋放與掩蔽味道的口服藥物組合物
AU2001225363A1 (en) * 2000-01-14 2001-07-24 Strakan Limited Glycosides and orthoester glycosides of glucocorticoids and uses thereof
SE0101220D0 (sv) * 2001-04-04 2001-04-04 Astrazeneca Ab New use
ES2315600T3 (es) * 2004-08-09 2009-04-01 Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts Conjugados de albumina que contienen un ligador glucuronico.
WO2008100560A2 (en) * 2007-02-14 2008-08-21 University Of Southern California Estrogen receptor modulators, associated pharmaceutical compositions and methods of use
US10154964B2 (en) 2011-09-07 2018-12-18 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
BR112019009019A2 (pt) 2016-11-08 2019-07-09 Regeneron Pharma esteroides e conjugados de proteínas dos mesmos
WO2018177381A1 (zh) * 2017-03-30 2018-10-04 合肥合源药业有限公司 乳果糖糖苷化合物、其制备方法及其用途
KR20200007905A (ko) 2017-05-18 2020-01-22 리제너론 파마슈티칼스 인코포레이티드 사이클로덱스트린 단백질 약물 접합체
AU2019205542A1 (en) * 2018-01-08 2020-07-16 Regeneron Pharmaceuticals, Inc. Steroids and antibody-conjugates thereof
EA202091135A1 (ru) 2018-05-09 2020-10-14 Регенерон Фармасьютикалз, Инк. Гидрофильные линкеры для конъюгатов антитело-лекарственное средство
EP3790899A1 (en) 2018-05-09 2021-03-17 Regeneron Pharmaceuticals, Inc. Anti-msr1 antibodies and methods of use thereof

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
SE378110B (el) * 1972-05-19 1975-08-18 Bofors Ab
SE378109B (el) * 1972-05-19 1975-08-18 Bofors Ab
US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
US3938233A (en) * 1974-08-12 1976-02-17 Cannon Robert B Heat transfer apparatus
DE2803660A1 (de) * 1978-01-25 1979-07-26 Schering Ag Neue in 17-position substituierte steroide der pregnanreihe, ihre herstellung und verwendung
BG33736A3 (bg) * 1978-01-25 1983-04-15 Schering Aktiengesellschaft Метод за получаване на заместени в 17-а позиция стероиди от прегнановия ред
US4221787A (en) * 1978-03-28 1980-09-09 Interx Research Corporation Esteramide prodrugs of anti-inflammatory corticosteroids
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
US4456602A (en) * 1982-08-23 1984-06-26 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4443440A (en) * 1982-08-30 1984-04-17 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4472392A (en) * 1983-01-21 1984-09-18 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
US4469689A (en) * 1983-03-30 1984-09-04 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
WO1984004041A1 (en) * 1983-04-14 1984-10-25 Univ California Colon-specific drug delivery system
US4548922A (en) * 1983-06-06 1985-10-22 Beth Israel Hospital Drug administration
US4959358A (en) * 1983-06-06 1990-09-25 Beth Israel Hospital Assn. Drug administration
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
US4588718A (en) * 1984-03-28 1986-05-13 The Upjohn Company Carboxy containing ester prodrugs of corticosteroids
SE8403905D0 (sv) * 1984-07-30 1984-07-30 Draco Ab Liposomes and steroid esters
US5215979A (en) * 1985-12-19 1993-06-01 Aktiebolaget Draco 16,17-acetalsubstituted pregnane 21-oic acid derivatives
GB8600489D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside steroids
GB8600491D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside norcholanic acid derivatives
GB8600490D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside norcholanic acid lactams
HU198216B (en) * 1986-05-12 1989-08-28 Kanto Ishi Pharma Co Ltd Process for producing sialosyl-cholesterin and pharmaceutical compositions containing them as active components
CA1299653C (en) * 1988-07-07 1992-04-28 Markwell Medical Institute, Inc. Biological fluid measuring device
SE8903914D0 (sv) * 1989-11-22 1989-11-22 Draco Ab Oral composition for the treatment of inflammatory bowel diseases
US5643602A (en) * 1989-11-22 1997-07-01 Astra Aktiebolag Oral composition for the treatment of inflammatory bowel disease
US5888995A (en) * 1991-02-04 1999-03-30 Astra Aktiebolag Steroid esters
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
SE9100342D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
WO1993022334A1 (en) * 1992-05-04 1993-11-11 Sri International Pharmaceutical compositions and methods for colonic delivery of corticosteroids
RU95115547A (ru) * 1993-01-08 1997-06-10 Астра Актиеболаг (SE) Стероидные соединения, способы их получения и фармацевтический препарат

Also Published As

Publication number Publication date
KR960700266A (ko) 1996-01-19
US6140308A (en) 2000-10-31
NO952683L (no) 1995-07-06
CA2152374A1 (en) 1994-07-21
IS4111A (is) 1994-07-09
HUT73227A (en) 1996-07-29
FI953358L (fi) 1995-07-07
LV10961A (lv) 1995-12-20
NO305367B1 (no) 1999-05-18
JP3366640B2 (ja) 2003-01-14
NO952683D0 (no) 1995-07-06
FI953358A0 (fi) 1995-07-07
CZ171095A3 (en) 1996-01-17
PL178307B1 (pl) 2000-04-28
TW261615B (el) 1995-11-01
WO1994015947A1 (en) 1994-07-21
GR3031789T3 (en) 2000-02-29
NZ259596A (en) 1997-04-24
FI953358A7 (fi) 1995-07-07
AU678803B2 (en) 1997-06-12
SK87295A3 (en) 1996-04-03
EP0678097B1 (en) 1999-08-11
RU95115547A (ru) 1997-06-10
BR9307746A (pt) 1995-11-14
HU9502087D0 (en) 1995-09-28
AU5844794A (en) 1994-08-15
ES2137353T3 (es) 1999-12-16
ATE183192T1 (de) 1999-08-15
EP0678097A1 (en) 1995-10-25
JPH08505616A (ja) 1996-06-18
PL309777A1 (en) 1995-11-13
US5908833A (en) 1999-06-01
LV10961B (en) 1996-08-20
HU221584B (hu) 2002-11-28

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