DK0669936T3 - Mercaptoacetylamidsubstitueret bicyklisk lactam til anvendelse som enkephalinase- og ACE-inhibitorer - Google Patents

Mercaptoacetylamidsubstitueret bicyklisk lactam til anvendelse som enkephalinase- og ACE-inhibitorer

Info

Publication number: DK0669936T3
Authority: DK; Denmark
Prior art keywords: mercaptoacetylamide; pct; enkephalinase; bicyclic lactam; hydrogen
Prior art date: 1992-10-30

Application number

DK94914243T

Other languages

English (en)

Inventor

Gary A Flynn

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-30

Filing date

1993-09-23

Publication date

2001-02-05

1993-09-23 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

2001-02-05 Application granted granted Critical

2001-02-05 Publication of DK0669936T3 publication Critical patent/DK0669936T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Ophthalmology & Optometry (AREA)
Diabetes (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Transplantation (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK94914243T 1992-10-30 1993-09-23 Mercaptoacetylamidsubstitueret bicyklisk lactam til anvendelse som enkephalinase- og ACE-inhibitorer DK0669936T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US96877092A	1992-10-30	1992-10-30
PCT/US1993/009001 WO1994010193A1 (en)	1992-10-30	1993-09-23	Novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ace

Publications (1)

Publication Number	Publication Date
DK0669936T3 true DK0669936T3 (da)	2001-02-05

Family

ID=25514751

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94914243T DK0669936T3 (da)	1992-10-30	1993-09-23	Mercaptoacetylamidsubstitueret bicyklisk lactam til anvendelse som enkephalinase- og ACE-inhibitorer

Country Status (21)

Country	Link
US (1)	US5635502A (da)
EP (1)	EP0669936B1 (da)
JP (1)	JP3420766B2 (da)
KR (1)	KR100311166B1 (da)
AT (1)	ATE197714T1 (da)
AU (1)	AU673857B2 (da)
CA (1)	CA2146238C (da)
DE (1)	DE69329701T2 (da)
DK (1)	DK0669936T3 (da)
ES (1)	ES2155852T3 (da)
FI (1)	FI110263B (da)
GR (1)	GR3035416T3 (da)
HU (1)	HUT71243A (da)
IL (1)	IL107413A (da)
MX (1)	MX9306758A (da)
NO (1)	NO951646L (da)
NZ (1)	NZ256589A (da)
PT (1)	PT669936E (da)
TW (1)	TW327172B (da)
WO (1)	WO1994010193A1 (da)
ZA (1)	ZA937912B (da)

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US5646276A (en) *	1992-05-13	1997-07-08	Bristol-Myers Squibb Co.	Diazepine containing dual action inhibitors
US5552397A (en) *	1992-05-18	1996-09-03	E. R. Squibb & Sons, Inc.	Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
US5504080A (en) *	1992-10-28	1996-04-02	Bristol-Myers Squibb Co.	Benzo-fused lactams
CA2140553A1 (en) *	1993-06-11	1994-12-22	Hitoshi Oinuma	Amino acid derivative
US5508272A (en) *	1993-06-15	1996-04-16	Bristol-Myers Squibb Company	Compounds containing a fused bicycle ring and processes therefor
US5525723A (en) *	1993-11-18	1996-06-11	Bristol-Myers Squibb Co.	Compounds containing a fused multiple ring lactam
AU689192B2 (en) *	1994-02-14	1998-03-26	Merrell Pharmaceuticals Inc.	Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
DE69524064T2 (de) *	1994-02-14	2002-07-11	Merrell Pharmaceuticals Inc., Cincinnati	Indan-2-mercaptoacetylamid disulfidderivate als enkephalinase inhibitoren
CA2183315C (en) *	1994-02-14	1999-08-31	Gary A. Flynn	Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo[c]azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace
DK0719779T3 (da) *	1994-07-18	2004-03-22	Eisai Co Ltd	Substituerede thiazolo[3,2-alpha]azepinderivater
US5587375A (en) *	1995-02-17	1996-12-24	Bristol-Myers Squibb Company	Azepinone compounds useful in the inhibition of ACE and NEP
US6245764B1 (en)	1995-03-24	2001-06-12	Molecumetics Ltd.	β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US6020331A (en) *	1995-03-24	2000-02-01	Molecumetics, Ltd.	β-sheet mimetics and use thereof as protease inhibitors
US6699869B1 (en)	1995-03-24	2004-03-02	Myriad Genetics Inc.	β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US5877313A (en)	1995-05-17	1999-03-02	Bristol-Myers Squibb	Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5650408A (en) *	1995-06-07	1997-07-22	Karanewsky; Donald S.	Thiazolo benzazepine containing dual action inhibitors
US5635504A (en) *	1995-06-07	1997-06-03	Bristol-Myers Squibb Co.	Diazepine containing dual action inhibitors
AU750122C (en)	1998-06-17	2003-02-27	Bristol-Myers Squibb Company	Preventing cerebral infarction through administration of ADP-receptor antiplatelet and antihypertensive drugs in combination
EP1169311A4 (en) *	1999-03-22	2004-09-15	Rhode Island Education	COMBINATORIAL OXAZOLE AND THIAZOLE BANKS
US7015212B1 (en)	1999-05-12	2006-03-21	The United States Of America As Represented By The Department Of Health And Human Services	Thiazepine inhibitors of HIV-1 integrase
WO2003068237A1 (en)	2002-02-14	2003-08-21	Myriad Genetics, Inc.	Beta-sheet mimetics and composition and methods relating thereto
FR2984716B1 (fr)	2011-12-22	2013-12-27	Essilor Int	Dispositif et procede de determination d'au moins un parametre de refraction oculaire objective d'un sujet en fonction d'une pluralite de directions de regard
CA2896577C (en)	2012-11-30	2024-01-23	Sanford-Burnham Medical Research Institute	Inhibitor of apoptosis protein (iap) antagonists
EP3151920A4 (en)	2014-06-04	2017-12-27	Sanford-Burnham Medical Research Institute	Use of inhibitor of apoptosis protein (iap) antagonists in hiv therapy
US10513515B2 (en)	2017-08-25	2019-12-24	Biotheryx, Inc.	Ether compounds and uses thereof
EP3830093A1 (en)	2018-07-27	2021-06-09	Biotheryx, Inc.	Bifunctional compounds as cdk modulators
EP4143329A4 (en)	2020-04-28	2024-10-16	Anwita Biosciences Inc	INTERLEUKIN-2 POLYPEPTIDES AND FUSION PROTEINS THEREOF, AS WELL AS THEIR PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC APPLICATIONS

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GB1525845A (en) *	1976-07-30	1978-09-20	Ucb Sa	1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones
IE50839B1 (en) *	1980-02-26	1986-07-23	Wyeth John & Brother Ltd	Novel processes for preparing proline derivatives and analogous compounds
EP0042100A1 (de) *	1980-06-13	1981-12-23	F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft	Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
US4320057A (en) *	1980-06-23	1982-03-16	American Home Products Corporation	Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones
US4415496A (en) *	1981-03-23	1983-11-15	Merck & Co., Inc.	Bicyclic lactams
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AU2650692A (en) *	1991-09-16	1993-04-27	Schering Corporation	Pharmaceutical compositions comprising natriuretic peptides or neutral endopeptidase inhibitors for treating or preventing myointimal proliferation
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US5362727A (en) *	1993-07-26	1994-11-08	Bristol-Myers Squibb	Substituted azepino[2,1-a]isoquinoline compounds

1993
- 1993-09-23 EP EP94914243A patent/EP0669936B1/en not_active Expired - Lifetime
- 1993-09-23 WO PCT/US1993/009001 patent/WO1994010193A1/en active IP Right Grant
- 1993-09-23 AU AU51362/93A patent/AU673857B2/en not_active Expired
- 1993-09-23 DK DK94914243T patent/DK0669936T3/da active
- 1993-09-23 AT AT94914243T patent/ATE197714T1/de active
- 1993-09-23 PT PT94914243T patent/PT669936E/pt unknown
- 1993-09-23 US US08/406,979 patent/US5635502A/en not_active Expired - Lifetime
- 1993-09-23 KR KR1019950701668A patent/KR100311166B1/ko not_active IP Right Cessation
- 1993-09-23 JP JP51105294A patent/JP3420766B2/ja not_active Expired - Fee Related
- 1993-09-23 ES ES94914243T patent/ES2155852T3/es not_active Expired - Lifetime
- 1993-09-23 DE DE69329701T patent/DE69329701T2/de not_active Expired - Lifetime
- 1993-09-23 CA CA002146238A patent/CA2146238C/en not_active Expired - Lifetime
- 1993-09-23 NZ NZ256589A patent/NZ256589A/en not_active IP Right Cessation
- 1993-09-23 HU HU9501239A patent/HUT71243A/hu unknown
- 1993-10-25 ZA ZA937912A patent/ZA937912B/xx unknown
- 1993-10-26 TW TW082108885A patent/TW327172B/zh not_active IP Right Cessation
- 1993-10-27 IL IL10741393A patent/IL107413A/en not_active IP Right Cessation
- 1993-10-29 MX MX9306758A patent/MX9306758A/es unknown
1995
- 1995-04-27 FI FI952014A patent/FI110263B/fi not_active IP Right Cessation
- 1995-04-28 NO NO951646A patent/NO951646L/no not_active Application Discontinuation
2001
- 2001-02-14 GR GR20010400246T patent/GR3035416T3/el unknown

Also Published As

Publication number	Publication date
NO951646D0 (no)	1995-04-28
IL107413A (en)	1999-08-17
KR100311166B1 (ko)	2002-02-28
EP0669936B1 (en)	2000-11-22
DE69329701D1 (de)	2000-12-28
AU673857B2 (en)	1996-11-28
MX9306758A (es)	1994-07-29
DE69329701T2 (de)	2001-05-10
ZA937912B (en)	1994-06-01
FI952014A0 (fi)	1995-04-27
US5635502A (en)	1997-06-03
FI110263B (fi)	2002-12-31
JP3420766B2 (ja)	2003-06-30
KR950704349A (ko)	1995-11-20
JPH08502746A (ja)	1996-03-26
HU9501239D0 (en)	1995-06-28
CA2146238C (en)	2001-03-13
CA2146238A1 (en)	1994-05-11
HUT71243A (en)	1995-11-28
TW327172B (en)	1998-02-21
AU5136293A (en)	1994-05-24
NZ256589A (en)	1996-05-28
ES2155852T3 (es)	2001-06-01
EP0669936A1 (en)	1995-09-06
ATE197714T1 (de)	2000-12-15
FI952014A (fi)	1995-04-27
WO1994010193A1 (en)	1994-05-11
IL107413A0 (en)	1994-01-25
PT669936E (pt)	2001-04-30
GR3035416T3 (en)	2001-05-31
NO951646L (no)	1995-06-23

Publication	Publication Date	Title
DK0669936T3 (da)	2001-02-05	Mercaptoacetylamidsubstitueret bicyklisk lactam til anvendelse som enkephalinase- og ACE-inhibitorer
ES2000842A6 (es)	1988-03-16	Un procedimiento para la preparacion de analogos semisinteticos de compactina y mevinolina
TW430664B (en)	2001-04-21	Substituted carboxamidothiazoles, their preparation and pharmaceutical compositions containing them
DE69309670D1 (de)	1997-05-15	Heterocyclische carbonsäure-derivate, die an rar rezeptoren binden können
EP0845985A4 (en)	1998-11-04	NON-STEROIDIAN SULFATASE INHIBITOR COMPOUNDS AND METHODS OF USE
GR3029355T3 (en)	1999-05-28	New azolidinediones as antihyperglycemic agents
EP0322738A3 (en)	1991-05-08	Benzylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells
UA41291C2 (uk)	2001-09-17	ФТОРОВАНІ ПОХІДНІ 17<font face="Symbol">b</font>-ЗАМІЩЕНОГО-4-AЗA-5<font face="Symbol">a-</font>АНДРОСТАН-3-ОНУ І ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ НА ЇХ ОСНОВІ
NO944926L (no)	1995-06-22	Fremgangsmåter for å inhibere myeloperoksidaseaktivitet
FI943931A (fi)	1994-08-26	Indolijohdannaisia steroidi-5alfa-reduktaasin inhibiittoreina
UA43338C2 (uk)	2001-12-17	Похідні бензолу
MY131544A (en)	2007-08-30	Fluorinated 4-aminoandrostadienone derivatives and process for their preparation
DK0652879T3 (da)	1999-10-25	1-Azaadamantanderivater som 5-HT4-agonister eller -antagonister og/eller 5-HT3-antagonister
TW340844B (en)	1998-09-21	Amide derivatives
DE69405760D1 (de)	1997-10-23	4-aza-pregnan-5-alpha-reductase isozym 1 inhibitoren
ES2128572T3 (es)	1999-05-16	Utilizacion de los derivados de cefem como agentes antimetastaticos.
ATE188695T1 (de)	2000-01-15	Indolderivate als 5-alpha-reductase-1 inhibitoren
YU200791A (sh)	1994-01-20	Trifluorometil 1-karba (1-detia) cefemi
KR970701188A (ko)	1997-03-17	엔케팔리나제 및 안지오텐신 전환 효소(ACE)의 억제제로서 유용한 신규의 머캅토아세틸아미드 디설파이드 유도체(Novel mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE)
ES8301199A1 (es)	1982-12-01	Procedimiento para la preparacion de un derivado fluorado de diaminobutano que es enlubidor de transaminasa de acido gamma- aminobutirico.
DK0850217T3 (da)	2000-09-11	Fremgangsmåde til fremstilling af arylalkynyl-N-hydroxy-carbamid-derivater med lipoxygenaseinhibitor-aktivitet