DK0589924T3 - Fluoralkoxybenzylaminoderivater af nitrogenholdige heterocyclusser - Google Patents

Fluoralkoxybenzylaminoderivater af nitrogenholdige heterocyclusser

Info

Publication number: DK0589924T3
Authority: DK; Denmark
Prior art keywords: pct; compounds; sec; fluoroalkoxybenzylamino; derivatives
Prior art date: 1991-06-20

Application number

DK92911210.0T

Other languages

English (en)

Inventor

John Adams Lowe Iii

Terry Jay Rosen

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-20

Filing date

1992-05-05

Publication date

1996-09-30

1992-05-05 Application filed by Pfizer filed Critical Pfizer

1996-09-30 Application granted granted Critical

1996-09-30 Publication of DK0589924T3 publication Critical patent/DK0589924T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/44—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reduction and hydrolysis of nitriles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
- C07C45/513—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an etherified hydroxyl group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Anesthesiology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Indole Compounds (AREA)

DK92911210.0T 1991-06-20 1992-05-05 Fluoralkoxybenzylaminoderivater af nitrogenholdige heterocyclusser DK0589924T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US71794391A	1991-06-20	1991-06-20

Publications (1)

Publication Number	Publication Date
DK0589924T3 true DK0589924T3 (da)	1996-09-30

Family

ID=24884155

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92911210.0T DK0589924T3 (da)	1991-06-20	1992-05-05	Fluoralkoxybenzylaminoderivater af nitrogenholdige heterocyclusser

Country Status (32)

Country	Link
US (3)	US5773450A (da)
EP (1)	EP0589924B1 (da)
JP (1)	JPH07110850B2 (da)
KR (1)	KR0154882B1 (da)
CN (1)	CN1056373C (da)
AT (1)	ATE142199T1 (da)
AU (1)	AU657967B2 (da)
BR (2)	BR9206161A (da)
CA (1)	CA2109613C (da)
CZ (1)	CZ290475B6 (da)
DE (2)	DE9290083U1 (da)
DK (1)	DK0589924T3 (da)
EG (1)	EG20280A (da)
ES (1)	ES2092113T3 (da)
FI (3)	FI108794B (da)
GR (1)	GR3021411T3 (da)
HK (1)	HK1000247A1 (da)
HU (2)	HU221634B1 (da)
IE (1)	IE921986A1 (da)
IL (1)	IL102188A (da)
MX (1)	MX9203018A (da)
NO (1)	NO180715C (da)
NZ (1)	NZ243230A (da)
PL (2)	PL172054B1 (da)
PT (1)	PT100606B (da)
RU (1)	RU2114848C1 (da)
SK (1)	SK282203B6 (da)
TW (1)	TW201301B (da)
UA (1)	UA39168C2 (da)
WO (1)	WO1993000331A1 (da)
YU (1)	YU48997B (da)
ZA (1)	ZA924528B (da)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5364943A (en) *	1991-11-27	1994-11-15	Pfizer Inc.	Preparation of substituted piperidines
ES2092113T3 (es) *	1991-06-20	1996-11-16	Pfizer	Derivados fluoroalcoxibencilamino de heterociclos que contienen nitrogeno.
EP0533280B2 (en)	1991-09-20	2004-12-01	Glaxo Group Limited	Novel medical use for tachykinin antagonists
WO1993023380A1 (en) *	1992-05-18	1993-11-25	Pfizer Inc.	Bridged aza-bicyclic derivatives as substance p antagonists
WO1994003445A1 (en) *	1992-08-04	1994-02-17	Pfizer Inc.	3-benzylamino-2-phenyl-piperidine derivatives as substance p receptor antagonists
EP0655996B1 (en) *	1992-08-19	2001-11-07	Pfizer Inc.	Substituted benzylamino nitrogen containing non-aromatic heterocycles
FR2700472B1 (fr)	1993-01-19	1995-02-17	Rhone Poulenc Rorer Sa	Association synergisante ayant un effet antagoniste des récepteurs NK1 et NK2.
GB9305718D0 (en)	1993-03-19	1993-05-05	Glaxo Group Ltd	Medicaments
JP2822274B2 (ja) *	1993-05-19	1998-11-11	ファイザー製薬株式会社	Ｐ物質拮抗剤としてのヘテロ原子置換アルキルベンジルアミノキヌクリジン類
IL109646A0 (en) *	1993-05-19	1994-08-26	Pfizer	Heteroatom substituted alkyl benzylamino-quinuclidines
CA2162400A1 (en) *	1993-05-28	1994-12-08	William M. Snyder	Process for preparing and resolving 2-phenyl-3-aminopiperidine
US5393762A (en) *	1993-06-04	1995-02-28	Pfizer Inc.	Pharmaceutical agents for treatment of emesis
US5703065A (en) *	1993-09-17	1997-12-30	Pfizer Inc.	Heteroarylamino and heteroarylsulfonamido substituted 3-benyzlaminomethyl piperidines and related compounds
US6083943A (en) *	1993-09-17	2000-07-04	Pfizer Inc	Substituted azaheterocyclecarboxylic acid
CA2171637C (en) *	1993-09-17	2000-05-23	Masaya Ikunaka	Substituted azaheterocyclecarboxylic acids
IL111002A (en) *	1993-09-22	1998-09-24	Glaxo Group Ltd	History of piperidine, their preparation and the pharmaceutical preparations containing them
EP0653208A3 (en) *	1993-11-17	1995-10-11	Pfizer	Substance P antagonists for the treatment or prevention of sunburn.
EP0659409A3 (en) *	1993-11-23	1995-08-09	Pfizer	Substance P antagonists for the inhibition of angiogenesis.
EP0655246A1 (en) *	1993-11-30	1995-05-31	Pfizer Inc.	Substance P antagonists for the treatment of disorders caused by helicobacter pylori or other spiral urease-positive gram-negative bacteria
FR2728169A1 (fr)	1994-12-19	1996-06-21	Oreal	Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2728166A1 (fr)	1994-12-19	1996-06-21	Oreal	Composition topique contenant un antagoniste de substance p
FR2728165A1 (fr)	1994-12-19	1996-06-21	Oreal	Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
JP3925662B2 (ja) *	1995-01-12	2007-06-06	グラクソ，グループ，リミテッド	タキキニンアンタゴニスト活性を有するピペリジン誘導体
GB9505692D0 (en) *	1995-03-21	1995-05-10	Glaxo Group Ltd	Chemical compounds
TW340842B (en)	1995-08-24	1998-09-21	Pfizer	Substituted benzylaminopiperidine compounds
ES2134639T3 (es)	1995-10-10	1999-10-01	Pfizer	Antagonistas del receptor de nk-1 para la prevencion de la inflamacion neurologica en terapia de genes.
TW458774B (en)	1995-10-20	2001-10-11	Pfizer	Antiemetic pharmaceutical compositions
FR2741262B1 (fr)	1995-11-20	1999-03-05	Oreal	Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
PT780375E (pt)	1995-12-21	2002-12-31	Pfizer	3-¬(benzilo substituido em 5)amino\|-2-phenilpiperidinas como antagonistas da substancia p
US6329396B1 (en)	1996-06-10	2001-12-11	Pfizer Inc.	Substituted benzylaminopiperidine compounds
MX9706196A (es) *	1996-08-14	1998-02-28	Pfizer	Compuestos triciclicos de piperidinilamino como antagonistas de la sustancia p.
US5750549A (en) *	1996-10-15	1998-05-12	Merck & Co., Inc.	Cycloalkyl tachykinin receptor antagonists
NZ329807A (en) *	1997-04-23	2000-07-28	Pfizer	NK-1 receptor antagonists and P receptor antagonists 2-Diarylmethyl-3-amino-1-azabicyclo[2.2.2]octane derivatives and amino substituted N-containing rings as agents for treating irritable bowel syndrome
KR19990030614A (ko) *	1997-10-02	1999-05-06	성재갑	스쿠알렌 합성 효소 억제활성을 갖는 신규 화합물, 그의 제조방법 및 그를 포함하는 조성물
RS49964B (sr)	1999-05-17	2008-09-29	Pfizer Products Inc.,	Postupak za dobijanje 2-fenil-3-aminopiridina,njegovih supstituisanih fenil derivata, i njegovih soli
JP2001172178A (ja) *	1999-10-25	2001-06-26	Pfizer Prod Inc	偏頭痛治療用のｎｋ−１レセプターアンタゴニスト及びエレトリプタン
JP4907818B2 (ja)	1999-11-03	2012-04-04	エーエムアールテクノロジーインコーポレイテッド	アリールおよびヘテロアリール置換テトラヒドロイソキノリン、ならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを阻止するためのそれらの使用
US7163949B1 (en)	1999-11-03	2007-01-16	Amr Technology, Inc.	4-phenyl substituted tetrahydroisoquinolines and use thereof
WO2002004455A2 (en)	2000-07-11	2002-01-17	Albany Molecular Research, Inc	4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
US20020049211A1 (en) *	2000-09-06	2002-04-25	Sobolov-Jaynes Susan Beth	Combination treatment for depression and anxiety
EP1192952A3 (en) *	2000-09-28	2003-03-26	Pfizer Products Inc.	Combination, for treating depression and anxiety, containing an NK-3 receptor antagonist and a CNS penetrant NK-1 receptor antagonist
JP2005504029A (ja) *	2001-07-20	2005-02-10	ファイザー・プロダクツ・インク	犬の好ましくない行動を改善するためのｎｋ−１受容体アンタゴニストの使用
US6686507B2 (en)	2002-03-06	2004-02-03	Pfizer Inc	Purification of 2-methoxy-5-trifluoromethoxybenzaldehyde
US6911544B2 (en)	2002-10-23	2005-06-28	Pfizer Inc.	Process for the preparation of (S,S)-cis-2-phenyl-3-aminopiperidine
US20040204455A1 (en) *	2003-04-10	2004-10-14	Cody Wayne Livingston	Piperidine derivative rennin inhibitors
DK1689721T3 (da) *	2003-11-26	2010-09-20	Pfizer Prod Inc	Aminopyrazolderivater som GSK-3-ihibitorer
ZA200701232B (en)	2004-07-15	2008-08-27	Amr Technology Inc	Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
ATE550019T1 (de)	2005-05-17	2012-04-15	Merck Sharp & Dohme	Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
EA019115B1 (ru)	2005-07-15	2014-01-30	Олбани Молекьюлар Рисерч, Инк.	Арил- и гетероарилзамещенные тетрагидробензазепины и их применение для блокировки обратного захвата норэпинефрина, допамина и серотонина
CA2624030A1 (en)	2005-09-29	2007-04-12	Tianying Jian	Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
GB0603041D0 (en)	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
CA2770486C (en)	2006-09-22	2014-07-15	Merck Sharp & Dohme Corp.	Use of platencin and platensimycin as fatty acid synthesis inhibitors to treat obesity, diabetes and cancer
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
EP2336120B1 (en)	2007-01-10	2014-07-16	MSD Italia S.r.l.	Combinations containing amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
WO2008090117A1 (en)	2007-01-24	2008-07-31	Glaxo Group Limited	Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1
US8106086B2 (en)	2007-04-02	2012-01-31	Msd K.K.	Indoledione derivative
WO2009002495A1 (en)	2007-06-27	2008-12-31	Merck & Co., Inc.	4-carboxybenzylamino derivatives as histone deacetylase inhibitors
TWI410650B (zh) *	2007-11-09	2013-10-01	Hon Hai Prec Ind Co Ltd	轉接板
JP2011515343A (ja)	2008-03-03	2011-05-19	タイガーファーマテック	チロシンキナーゼ阻害薬
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
UA105182C2 (ru)	2008-07-03	2014-04-25	Ньюрексон, Інк.	Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
US8691825B2 (en)	2009-04-01	2014-04-08	Merck Sharp & Dohme Corp.	Inhibitors of AKT activity
AU2010247735B2 (en)	2009-05-12	2015-07-16	Albany Molecular Research, Inc.	Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydroisoquinoline and use thereof
MX2011011901A (es)	2009-05-12	2012-01-20	Albany Molecular Res Inc	Tetrahidroisoquinolinas aril, heteroaril, y heterociclo sustituidas y uso de las mismas.
AU2010247763B2 (en)	2009-05-12	2015-12-24	Albany Molecular Research, Inc.	7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof
AU2010307198C9 (en)	2009-10-14	2014-02-13	Merck Sharp & Dohme Corp.	Substituted piperidines that increase p53 activity and the uses thereof
EP2584903B1 (en)	2010-06-24	2018-10-24	Merck Sharp & Dohme Corp.	Novel heterocyclic compounds as erk inhibitors
WO2012018754A2 (en)	2010-08-02	2012-02-09	Merck Sharp & Dohme Corp.	RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
DK2606134T3 (da)	2010-08-17	2019-07-22	Sirna Therapeutics Inc	RNA-Interferens-formidlet inhibering af hepatitis-B-virus (HBV)-genekspression ved hjælp af kort interfererende nukleinsyre (siNA)
US8883801B2 (en)	2010-08-23	2014-11-11	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
EP2613782B1 (en)	2010-09-01	2016-11-02	Merck Sharp & Dohme Corp.	Indazole derivatives useful as erk inhibitors
WO2012036997A1 (en)	2010-09-16	2012-03-22	Schering Corporation	Fused pyrazole derivatives as novel erk inhibitors
US9260471B2 (en)	2010-10-29	2016-02-16	Sirna Therapeutics, Inc.	RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
WO2012087772A1 (en)	2010-12-21	2012-06-28	Schering Corporation	Indazole derivatives useful as erk inhibitors
CA2833009A1 (en)	2011-04-21	2012-10-26	Merck Sharp & Dohme Corp.	Insulin-like growth factor-1 receptor inhibitors
WO2013063214A1 (en)	2011-10-27	2013-05-02	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
EP3453762B1 (en)	2012-05-02	2021-04-21	Sirna Therapeutics, Inc.	Short interfering nucleic acid (sina) compositions
MX2015004041A (es)	2012-09-28	2015-07-06	Merck Sharp & Dohme	Compuestos novedosos que son inhibidores de erk.
JP6440625B2 (ja)	2012-11-14	2018-12-19	ザ・ジョンズ・ホプキンス・ユニバーシティー	精神分裂病を処置するための方法および組成物
DK2925888T3 (da)	2012-11-28	2017-12-18	Merck Sharp & Dohme	Sammensætninger og fremgangsmåder til behandling af cancer
BR112015013611A2 (pt)	2012-12-20	2017-11-14	Merck Sharp & Dohme	composto, e, composição farmacêutica
WO2014120748A1 (en)	2013-01-30	2014-08-07	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as hdm2 inhibitors
WO2015034925A1 (en)	2013-09-03	2015-03-12	Moderna Therapeutics, Inc.	Circular polynucleotides
US10975084B2 (en)	2016-10-12	2021-04-13	Merck Sharp & Dohme Corp.	KDM5 inhibitors
US10947234B2 (en)	2017-11-08	2021-03-16	Merck Sharp & Dohme Corp.	PRMT5 inhibitors
US11098059B2 (en)	2017-11-08	2021-08-24	Merck Sharp & Dohme Corp.	PRMT5 inhibitors
EP3833667B1 (en)	2018-08-07	2024-03-13	Merck Sharp & Dohme LLC	Prmt5 inhibitors
US11993602B2 (en)	2018-08-07	2024-05-28	Merck Sharp & Dohme Llc	PRMT5 inhibitors

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3452026A (en) *	1966-03-15	1969-06-24	Bristol Myers Co	Substituted 1,2,3,4-tetrahydroquinolines
US3560510A (en) *	1969-03-05	1971-02-02	Aldrich Chem Co Inc	2-benzhydrylquinuclidines
MX18467A (es) *	1988-11-23	1993-07-01	Pfizer	Agentes terapeuticos de quinuclidinas
WO1991009844A1 (en) *	1990-01-04	1991-07-11	Pfizer Inc.	Substance p antagonists
US5232929A (en) *	1990-11-28	1993-08-03	Pfizer Inc.	3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use
WO1991018899A1 (en) *	1990-06-01	1991-12-12	Pfizer Inc.	3-amino-2-aryl quinuclidines, process for their preparation and pharmaceutical compositions containing them
US5422354A (en) *	1990-07-23	1995-06-06	Pfizer Inc	Quinuclidine derivatives
BR9106905A (pt) *	1990-09-28	1993-08-17	Pfizer	Analogos de anel condensado de heterociclos nao aromaticos contendo nitrogenio
KR930702298A (ko) *	1990-10-03	1993-09-08	알프레드 퍼넷	에폭시 수지의 주성분인 디아미노비스이미드 화합물
US5138060A (en) *	1991-01-03	1992-08-11	Pfizer Inc.	Process and intermediates for preparing azabicyclo(2.2.2)octan-3-imines
CA2106200C (en) *	1991-03-26	1996-11-19	Terry J. Rosen	Stereoselective preparation of substituted piperidines
ES2168260T3 (es) *	1991-05-22	2002-06-16	Pfizer	3-aminoquinuclidinas sustituidas.
US5807867A (en) *	1991-05-31	1998-09-15	Pfizer Inc.	Quinuclidine derivatives
ES2092113T3 (es) *	1991-06-20	1996-11-16	Pfizer	Derivados fluoroalcoxibencilamino de heterociclos que contienen nitrogeno.
WO1994003445A1 (en) *	1992-08-04	1994-02-17	Pfizer Inc.	3-benzylamino-2-phenyl-piperidine derivatives as substance p receptor antagonists
US5393762A (en) *	1993-06-04	1995-02-28	Pfizer Inc.	Pharmaceutical agents for treatment of emesis
US5576317A (en) *	1994-12-09	1996-11-19	Pfizer Inc.	NK-1 receptor antagonists and 5HT3 receptor antagonists for the treatment of emesis

1992
- 1992-05-05 ES ES92911210T patent/ES2092113T3/es not_active Expired - Lifetime
- 1992-05-05 BR BR9206161A patent/BR9206161A/pt not_active Application Discontinuation
- 1992-05-05 PL PL92301884A patent/PL172054B1/pl not_active IP Right Cessation
- 1992-05-05 JP JP4510950A patent/JPH07110850B2/ja not_active Expired - Fee Related
- 1992-05-05 DE DE9290083U patent/DE9290083U1/de not_active Expired - Lifetime
- 1992-05-05 SK SK3908-92A patent/SK282203B6/sk not_active IP Right Cessation
- 1992-05-05 PL PL92310851A patent/PL170516B1/pl not_active IP Right Cessation
- 1992-05-05 HU HU9303668A patent/HU221634B1/hu not_active IP Right Cessation
- 1992-05-05 CA CA002109613A patent/CA2109613C/en not_active Expired - Fee Related
- 1992-05-05 DK DK92911210.0T patent/DK0589924T3/da active
- 1992-05-05 HU HU9500836A patent/HU224443B1/hu not_active IP Right Cessation
- 1992-05-05 EP EP92911210A patent/EP0589924B1/en not_active Expired - Lifetime
- 1992-05-05 DE DE69213451T patent/DE69213451T2/de not_active Expired - Fee Related
- 1992-05-05 CZ CS19923908A patent/CZ290475B6/cs not_active IP Right Cessation
- 1992-05-05 RU RU93058531A patent/RU2114848C1/ru not_active IP Right Cessation
- 1992-05-05 US US08/167,881 patent/US5773450A/en not_active Expired - Fee Related
- 1992-05-05 KR KR1019930703935A patent/KR0154882B1/ko not_active IP Right Cessation
- 1992-05-05 UA UA93004396A patent/UA39168C2/uk unknown
- 1992-05-05 AU AU18893/92A patent/AU657967B2/en not_active Ceased
- 1992-05-05 AT AT92911210T patent/ATE142199T1/de not_active IP Right Cessation
- 1992-05-05 WO PCT/US1992/003571 patent/WO1993000331A1/en active IP Right Grant
- 1992-05-12 TW TW081103685A patent/TW201301B/zh active
- 1992-06-12 IL IL10218892A patent/IL102188A/en not_active IP Right Cessation
- 1992-06-17 EG EG31892A patent/EG20280A/xx active
- 1992-06-19 CN CN92104778A patent/CN1056373C/zh not_active Expired - Fee Related
- 1992-06-19 NZ NZ243230A patent/NZ243230A/en not_active IP Right Cessation
- 1992-06-19 YU YU64092A patent/YU48997B/sh unknown
- 1992-06-19 ZA ZA924528A patent/ZA924528B/xx unknown
- 1992-06-19 MX MX9203018A patent/MX9203018A/es not_active IP Right Cessation
- 1992-06-19 PT PT100606A patent/PT100606B/pt not_active IP Right Cessation
- 1992-07-01 IE IE198692A patent/IE921986A1/en not_active IP Right Cessation
1993
- 1993-12-17 FI FI935701A patent/FI108794B/fi active
- 1993-12-17 NO NO934691A patent/NO180715C/no unknown
1995
- 1995-05-22 US US08/443,418 patent/US5744480A/en not_active Expired - Fee Related
1996
- 1996-10-23 GR GR960402782T patent/GR3021411T3/el unknown
- 1996-11-18 BR BR1100086-4A patent/BR1100086A/pt active IP Right Grant
1997
- 1997-09-16 HK HK97101788A patent/HK1000247A1/xx not_active IP Right Cessation
1999
- 1999-02-26 FI FI990419A patent/FI990419A/fi unknown
- 1999-02-26 FI FI990418A patent/FI110686B/fi active
2003
- 2003-03-04 US US10/379,198 patent/US20030199540A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EG20280A (en)	1998-07-30
HK1000247A1 (en)	1998-02-13
UA39168C2 (uk)	2001-06-15
GR3021411T3 (en)	1997-01-31
FI990419A0 (fi)	1999-02-26
IL102188A0 (en)	1993-01-14
FI110686B (fi)	2003-03-14
SK282203B6 (sk)	2001-12-03
NO180715C (no)	1997-06-04
EP0589924A1 (en)	1994-04-06
ATE142199T1 (de)	1996-09-15
HU9500836D0 (en)	1995-05-29
CA2109613A1 (en)	1993-01-07
TW201301B (da)	1993-03-01
NO180715B (no)	1997-02-24
CZ290475B6 (cs)	2002-07-17
US5744480A (en)	1998-04-28
IL102188A (en)	2002-12-01
US5773450A (en)	1998-06-30
PL172054B1 (pl)	1997-07-31
DE9290083U1 (de)	1994-02-17
KR0154882B1 (ko)	1998-11-16
YU64092A (sh)	1995-03-27
AU1889392A (en)	1993-01-25
MX9203018A (es)	1993-07-01
FI990418A (fi)	1999-02-26
PL170516B1 (en)	1996-12-31
NO934691L (no)	1993-12-17
ES2092113T3 (es)	1996-11-16
HU9303668D0 (en)	1994-04-28
AU657967B2 (en)	1995-03-30
JPH06506473A (ja)	1994-07-21
DE69213451D1 (de)	1996-10-10
US20030199540A1 (en)	2003-10-23
CN1067655A (zh)	1993-01-06
NO934691D0 (no)	1993-12-17
FI935701A (fi)	1993-12-17
WO1993000331A1 (en)	1993-01-07
PT100606B (pt)	1999-10-29
HUT70499A (en)	1995-10-30
FI935701A0 (fi)	1993-12-17
ZA924528B (en)	1993-12-20
DE69213451T2 (de)	1997-01-09
CZ390892A3 (en)	1994-04-13
IE921986A1 (en)	1992-12-30
JPH07110850B2 (ja)	1995-11-29
FI990418A0 (fi)	1999-02-26
RU2114848C1 (ru)	1998-07-10
FI108794B (fi)	2002-03-28
NZ243230A (en)	1997-06-24
CN1056373C (zh)	2000-09-13
BR1100086A (pt)	2000-07-25
YU48997B (sh)	2003-04-30
KR940701383A (ko)	1994-05-28
SK390892A3 (en)	1995-09-13
HUT67434A (en)	1995-04-28
EP0589924B1 (en)	1996-09-04
PT100606A (pt)	1993-08-31
CA2109613C (en)	1996-11-19
HU221634B1 (hu)	2002-12-28
FI990419A (fi)	1999-02-26
BR9206161A (pt)	1995-10-31
HU224443B1 (hu)	2005-09-28

Publication	Publication Date	Title
DK0589924T3 (da)	1996-09-30	Fluoralkoxybenzylaminoderivater af nitrogenholdige heterocyclusser
FI941212A (fi)	1994-03-15	Fuusioituneet trisykliset, typpeä sisältävät heterosykliset yhdisteet
MX9206499A (es)	1993-05-01	Derivados de etilendiamina aciclica
GR3026231T3 (en)	1998-05-29	3-aminopiperidine derivatives and related nitrogen containing heterocycles.
ATE149497T1 (de)	1997-03-15	Azanorbornanderivate
ES2087813A1 (es)	1996-07-16	Heterociclos no-aromaticos que contienen nitrogeno bencilamino substituidos.