DK0402068T3 - Polypeptider og polypeptidanaloger med inhiberende virkning mod human elastase - Google Patents

Polypeptider og polypeptidanaloger med inhiberende virkning mod human elastase

Info

Publication number: DK0402068T3
Authority: DK; Denmark
Prior art keywords: pro; cys; polypeptides; lys; gly
Prior art date: 1989-06-09

Application number

DK90306037.4T

Other languages

English (en)

Inventor

Enno Prof Christophers

Jens-Michael Dr Schroder

David Dr Pioli

Oliver Dr Wiedow

Michael Derek Dr Edge

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-09

Filing date

1990-06-04

Publication date

1996-04-22

1989-06-09 Priority claimed from GB898913349A external-priority patent/GB8913349D0/en

1989-06-09 Priority claimed from GB898913346A external-priority patent/GB8913346D0/en

1989-09-25 Priority claimed from GB898921613A external-priority patent/GB8921613D0/en

1989-11-02 Priority claimed from GB898924717A external-priority patent/GB8924717D0/en

1990-06-04 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

1996-04-22 Application granted granted Critical

1996-04-22 Publication of DK0402068T3 publication Critical patent/DK0402068T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Mycology (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK90306037.4T 1989-06-09 1990-06-04 Polypeptider og polypeptidanaloger med inhiberende virkning mod human elastase DK0402068T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB898913349A GB8913349D0 (en)	1989-06-09	1989-06-09	Polypeptides
GB898913346A GB8913346D0 (en)	1989-06-09	1989-06-09	Polypeptide analogues
GB898921613A GB8921613D0 (en)	1989-09-25	1989-09-25	Polypeptides-1st update
GB898924717A GB8924717D0 (en)	1989-11-02	1989-11-02	Polypeptides

Publications (1)

Publication Number	Publication Date
DK0402068T3 true DK0402068T3 (da)	1996-04-22

Family

ID=27450350

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90306037.4T DK0402068T3 (da)	1989-06-09	1990-06-04	Polypeptider og polypeptidanaloger med inhiberende virkning mod human elastase

Country Status (16)

Country	Link
US (4)	US5464822A (da)
EP (1)	EP0402068B1 (da)
JP (1)	JP2989853B2 (da)
AT (1)	ATE131493T1 (da)
AU (1)	AU636148B2 (da)
CA (1)	CA2018592C (da)
DE (1)	DE69024104T2 (da)
DK (1)	DK0402068T3 (da)
ES (1)	ES2080800T3 (da)
FI (1)	FI106471B (da)
GR (1)	GR3018401T3 (da)
IE (1)	IE70520B1 (da)
IL (1)	IL94602A (da)
NO (1)	NO177716C (da)
NZ (1)	NZ233974A (da)
PT (1)	PT94326B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NO177716C (no) *	1989-06-09	1995-11-08	Zeneca Ltd	Fremgangsmåte for fremstilling av terapeutisk aktive polypeptider, DNA-sekvens, ekspresjonsvektor og antistoff
DK0458537T3 (da) *	1990-05-24	1999-10-18	Zeneca Ltd	Anvendelse af en terapeutisk forbindelse til behandling af bronkitis
IE911697A1 (en) *	1990-05-24	1991-12-04	Zeneca Ltd	Therapeutic agent
US5162348A (en) *	1990-05-24	1992-11-10	Imperial Chemical Industries Plc	Treatment of cystic fibrosis
US5734014A (en) *	1992-08-11	1998-03-31	Tsumura & Co.	Elafin derivative
US5835061A (en)	1995-06-06	1998-11-10	Wayport, Inc.	Method and apparatus for geographic-based communications service
US8606851B2 (en)	1995-06-06	2013-12-10	Wayport, Inc.	Method and apparatus for geographic-based communications service
EP0834556A1 (en) *	1996-09-25	1998-04-08	Academisch Ziekenhuis Leiden	Methods for culturing cells
US7034132B2 (en)	2001-06-04	2006-04-25	Anderson David W	Therapeutic polypeptides, nucleic acids encoding same, and methods of use
AU2001241913A1 (en) *	2000-03-01	2001-09-12	The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Methods for wound treatment
US7247704B2 (en)	2000-12-18	2007-07-24	Arriva Pharmaceuticals, Inc.	Multifunctional protease inhibitors and their use in treatment of disease
US7041787B2 (en) *	2000-12-29	2006-05-09	Kimberly-Clark Worldwide, Inc.	Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases
US6600057B2 (en)	2000-12-29	2003-07-29	Kimberly-Clark Worldwide, Inc.	Matrix metalloproteinase inhibitors
US20030119073A1 (en) *	2001-12-21	2003-06-26	Stephen Quirk	Sensors and methods of detection for proteinase enzymes
US20030170617A1 (en)	2002-01-28	2003-09-11	Pasloske Brittan L.	Crude biological derivatives competent for nucleic acid detection
JP4651946B2 (ja) *	2002-04-25	2011-03-16	ザスクリプスリサーチインスティテュート	肺病態の治療および予防
FR2849375B1 (fr) *	2002-12-30	2006-10-20	Jean Noel Thorel	Compositions cosmetiques, par exemple pour traiter le vieillissement cutane photo-induit
CA2524626A1 (en) *	2003-05-07	2004-11-18	Vib Vzw	The use of a polypeptide domain of slpi to modulate the tumorigenic and metastatic potential of cancer cells
US20090163409A1 (en) *	2005-05-16	2009-06-25	Ball T Blake	Trappin-2 (elafin) inhibits HIV
US7964350B1 (en)	2007-05-18	2011-06-21	Applied Biosystems, Llc	Sample preparation for in situ nucleic acid analysis
EP2367954B1 (en) *	2008-12-19	2015-02-18	Life Technologies Corporation	Proteinase k inhibitors, methods and compositions therefor
GB201003559D0 (en) *	2010-03-03	2010-04-21	Proteo Biotech Ag	Novel use of elafin
WO2023122590A1 (en) *	2021-12-20	2023-06-29	Tiakis Biotech Ag	Use of elafin in the treatment of covid-19

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4746729A (en) *	1986-07-30	1988-05-24	Kuettner Klaus E	Cartilage-derived leukocyte elastase-inhibitor
US5811128A (en) *	1986-10-24	1998-09-22	Southern Research Institute	Method for oral or rectal delivery of microencapsulated vaccines and compositions therefor
AU5192790A (en) *	1989-02-23	1990-09-26	Center For Blood Research, The	Human elastase inhibitor
NO177716C (no) *	1989-06-09	1995-11-08	Zeneca Ltd	Fremgangsmåte for fremstilling av terapeutisk aktive polypeptider, DNA-sekvens, ekspresjonsvektor og antistoff

1990
- 1990-06-01 NO NO902444A patent/NO177716C/no not_active IP Right Cessation
- 1990-06-03 IL IL9460290A patent/IL94602A/en active IP Right Grant
- 1990-06-04 AT AT90306037T patent/ATE131493T1/de not_active IP Right Cessation
- 1990-06-04 EP EP90306037A patent/EP0402068B1/en not_active Expired - Lifetime
- 1990-06-04 ES ES90306037T patent/ES2080800T3/es not_active Expired - Lifetime
- 1990-06-04 DK DK90306037.4T patent/DK0402068T3/da active
- 1990-06-04 DE DE69024104T patent/DE69024104T2/de not_active Expired - Lifetime
- 1990-06-05 AU AU56808/90A patent/AU636148B2/en not_active Expired
- 1990-06-05 IE IE200690A patent/IE70520B1/en not_active IP Right Cessation
- 1990-06-07 NZ NZ233974A patent/NZ233974A/xx unknown
- 1990-06-08 CA CA002018592A patent/CA2018592C/en not_active Expired - Lifetime
- 1990-06-08 PT PT94326A patent/PT94326B/pt not_active IP Right Cessation
- 1990-06-08 JP JP2148816A patent/JP2989853B2/ja not_active Expired - Lifetime
- 1990-06-08 FI FI902880A patent/FI106471B/fi active IP Right Grant
1992
- 1992-08-10 US US07/926,371 patent/US5464822A/en not_active Expired - Lifetime
1995
- 1995-04-24 US US08/427,170 patent/US6245739B1/en not_active Expired - Fee Related
- 1995-12-14 GR GR940404015T patent/GR3018401T3/el unknown
2001
- 2001-04-13 US US09/833,799 patent/US6893843B2/en not_active Expired - Fee Related
2005
- 2005-03-21 US US11/084,860 patent/US20060068480A1/en not_active Abandoned

Also Published As

Publication number	Publication date
FI902880A0 (fi)	1990-06-08
NO902444D0 (no)	1990-06-01
PT94326A (pt)	1991-02-08
ES2080800T3 (es)	1996-02-16
US6893843B2 (en)	2005-05-17
US20060068480A1 (en)	2006-03-30
US6245739B1 (en)	2001-06-12
DE69024104T2 (de)	1996-06-13
FI106471B (fi)	2001-02-15
IL94602A (en)	1996-06-18
NZ233974A (en)	1993-05-26
EP0402068A1 (en)	1990-12-12
IE902006L (en)	1990-12-09
EP0402068B1 (en)	1995-12-13
US20020187535A1 (en)	2002-12-12
GR3018401T3 (en)	1996-03-31
ATE131493T1 (de)	1995-12-15
CA2018592A1 (en)	1990-12-09
IL94602A0 (en)	1991-04-15
AU5680890A (en)	1990-12-13
NO177716C (no)	1995-11-08
JP2989853B2 (ja)	1999-12-13
DE69024104D1 (de)	1996-01-25
NO177716B (no)	1995-07-31
PT94326B (pt)	1997-01-31
US5464822A (en)	1995-11-07
CA2018592C (en)	2002-08-27
JPH03148299A (ja)	1991-06-25
NO902444L (no)	1990-12-10
IE70520B1 (en)	1996-12-11
AU636148B2 (en)	1993-04-22

Publication	Publication Date	Title
DK0402068T3 (da)	1996-04-22	Polypeptider og polypeptidanaloger med inhiberende virkning mod human elastase
NO852673L (no)	1986-01-06	Tumor-nekrosefaktor.
DK0592566T3 (da)	1999-12-13	IL-6-muteiner med reduceret cysteinantal
DE3770661D1 (de)	1991-07-18	1,2,3,4-tetrahydro-6-substituierte-4-aryl(oder heterozyklo)3-((substituierte amino)carbonyl)-2-thioxo(oder oxo)-5-pyrimidinkarbonsaeuren und -ester.
ATE218616T1 (de)	2002-06-15	Humanes zirkulierendes cytokin cc-1
DE68917837D1 (de)	1994-10-06	Peptid-Verbindungen.
FI893681A0 (fi)	1989-08-03	N-2,3-butadienyltri- och tetra-aminoalkanderivat.
DK610287A (da)	1988-05-22	Peptider, deres fremstilling og anvendelse
FI895456A0 (fi)	1989-11-16	Rekombinant interleukin 2-hybridproteiner.
ATE313333T1 (de)	2006-01-15	Verwendung eines leukämie-hemmenden faktor antagonisten
DE68908958D1 (de)	1993-10-14	Peptide.
CA2118498A1 (en)	1993-11-11	A novel anti-neoplastic cytokine
ES2066897T3 (es)	1995-03-16	5,11-dihidro-6h-pirido(2,3-b)(1,4)benzodiazepin-6-onas y -tionas y su uso en la prevencion o el tratamiento del sida.
DE60138885D1 (de)	2009-07-16	Polypeptide mit aktivität der stimulierung von neutrophilen
DK527287A (da)	1987-12-08	Polypeptid med interleukin-2-aktiviteter
IT8821123A0 (it)	1988-06-28	Clonaggio del gene che codifica l'enzima isoamilasi e suo impiego per la produzione di detto enzima o suoi analoghi.
IT8821282A0 (it)	1988-07-08	Clonaggio del gene che codifica l'enzima isoamilasi e suo impiego per la produzione di detto enzima o suoi analoghi.
IT8622597V0 (it)	1986-07-21	Struttura di schema particolare per giochi enigmistici del tipo parole crociate.
NO893283L (no)	1991-02-18	Engangssproeyte med innebygget kanyle.