[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

DK0487719T3 - Fremgangsmåde til fremstilling af 9-beta-D-arabinofuranosyl-2-fluoradenin-5'-phosphat - Google Patents

Fremgangsmåde til fremstilling af 9-beta-D-arabinofuranosyl-2-fluoradenin-5'-phosphat

Info

Publication number
DK0487719T3
DK0487719T3 DK91913406T DK91913406T DK0487719T3 DK 0487719 T3 DK0487719 T3 DK 0487719T3 DK 91913406 T DK91913406 T DK 91913406T DK 91913406 T DK91913406 T DK 91913406T DK 0487719 T3 DK0487719 T3 DK 0487719T3
Authority
DK
Denmark
Prior art keywords
fluoroadenine
arabinofuranosyl
beta
phosphate
preparation
Prior art date
Application number
DK91913406T
Other languages
English (en)
Inventor
Peter Blumbergs
Mohammed S Khan
Richard L Kalamas
Ambalal Patel
Maurice P Lamontagne
Original Assignee
Ash Stevens Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ash Stevens Inc filed Critical Ash Stevens Inc
Application granted granted Critical
Publication of DK0487719T3 publication Critical patent/DK0487719T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK91913406T 1990-06-27 1991-06-26 Fremgangsmåde til fremstilling af 9-beta-D-arabinofuranosyl-2-fluoradenin-5'-phosphat DK0487719T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54474690A 1990-06-27 1990-06-27
PCT/US1991/004566 WO1992000312A1 (en) 1990-06-27 1991-06-26 Process for the preparation of 9-beta-d-arabinofuranosyl-2-fluoroadenine 5'-phosphate

Publications (1)

Publication Number Publication Date
DK0487719T3 true DK0487719T3 (da) 1999-05-17

Family

ID=24173421

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91913406T DK0487719T3 (da) 1990-06-27 1991-06-26 Fremgangsmåde til fremstilling af 9-beta-D-arabinofuranosyl-2-fluoradenin-5'-phosphat

Country Status (9)

Country Link
EP (1) EP0487719B1 (da)
JP (1) JPH0678352B2 (da)
AT (1) ATE169631T1 (da)
AU (1) AU633755B2 (da)
CA (1) CA2064723C (da)
DE (1) DE69129971T2 (da)
DK (1) DK0487719T3 (da)
ES (1) ES2118752T3 (da)
WO (1) WO1992000312A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602246A (en) * 1992-11-25 1997-02-11 Schering Aktiengesellschaft Process for the preparation of fludarabine or fludarabine phosphate from guanosine
HU226997B1 (en) * 1997-12-11 2010-04-28 Alcafleu Man Gmbh & Co Kg Method for producing lithium, sodium, potassium, calcium and magnesium salts of fludarabin phosphate purification method for producing fludarabin phosphate and fludarabin phosphate which is at least 99,5% pure
ITMI20031994A1 (it) * 2003-10-15 2005-04-16 Adorkem Technology Spa Procedimento per la preparazione di fludarabina fosfato
CN104592337B (zh) * 2013-10-31 2018-09-07 山东新时代药业有限公司 一种9-β-D-阿拉伯呋喃糖基-2-氟代腺嘌呤-5’-磷酸酯的制备方法
EA023851B1 (ru) * 2014-02-20 2016-07-29 Республиканское Унитарное Производственное Предприятие "Белмедпрепараты" (Руп "Белмедпрепараты") Способ получения флударабин фосфата
CN105859812B (zh) * 2016-05-03 2019-07-26 河南师范大学 一种磷酸氟达拉滨的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1645896C3 (de) * 1965-03-17 1975-01-02 Ajinomoto Co., Inc., Tokio Verfahren zur Herstellung von 5'-Ribonucleotiden nd S'-Desoxyribonucleotiden
US4093714A (en) * 1974-03-15 1978-06-06 Icn Pharmaceuticals, Inc. 9β-D-Arabinofuranosylpurine nucleotides and method of use
GB1562899A (en) * 1975-06-17 1980-03-19 Wellcome Found Pharmaceutical compositions containing substituted 9-( -d-arabnofuranosyl)purine-5'-phosphate and salts thereof
US4123609A (en) * 1976-11-03 1978-10-31 Warner-Lambert Company Process for the production of 9-(β-D-arabinofuranosyl)adenine, 5'-phosphate
US4357324A (en) * 1981-02-24 1982-11-02 The United States Of America As Represented By The Department Of Health And Human Services Prodrug derivatives of 9β-D-arabinofuranosyl-2-fluoroadenine

Also Published As

Publication number Publication date
EP0487719A4 (en) 1992-10-28
CA2064723C (en) 1997-09-09
WO1992000312A1 (en) 1992-01-09
EP0487719A1 (en) 1992-06-03
DE69129971D1 (de) 1998-09-17
ES2118752T3 (es) 1998-10-01
EP0487719B1 (en) 1998-08-12
JPH0678352B2 (ja) 1994-10-05
JPH05500375A (ja) 1993-01-28
ATE169631T1 (de) 1998-08-15
CA2064723A1 (en) 1991-12-28
AU633755B2 (en) 1993-02-04
AU8283891A (en) 1992-01-23
DE69129971T2 (de) 1998-12-24

Similar Documents

Publication Publication Date Title
FI890068A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten 1,2-bis(aminometyyli)syklobutaani-platinakompleksien valmistamiseksi
IL110804A (en) Triphenyl- methylthiazolidine-2, 4-dione derivatives and processes utilizing the same
DK0592435T3 (da) Fremgangsmåde til fremstilling af pyrimidinforbindelser
IT8720748A0 (it) Impianto di rivestimento sotto vuoto per substrati ottici.
ATE147750T1 (de) Phosphotriester-typ biologisch-aktiver verbindungen
DK0403351T3 (da) Fremgangsmåde til fremstilling af ascorbinsyre
DZ2135A1 (fr) Procédé de préparation de mélamine pure.
DK281482A (da) Fremgangsmaade til fremstilling af 2-aryl-3,4-diazabicyclo(4.n.o)alken-(2)-on-5-forbindelser
DZ1569A1 (fr) Procédé de préparation de ginkgolide b a partir deginkgolide c.
DK0487719T3 (da) Fremgangsmåde til fremstilling af 9-beta-D-arabinofuranosyl-2-fluoradenin-5'-phosphat
FR2371432A1 (fr) Procede de preparation de n-imides a partir d'acides amiques
FR2658199B1 (fr) Procede de preparation de polyphosphazenes par substitution de polydichlorophosphazene.
FI813289L (fi) Fosfonohydroxiacetonitril foerfarande foer dess framstaellning och dess anvaendning som mellanprodukt vid framstaellning av laekemedel
HUT54113A (en) Process for producing butenecarboxylic acid derivatives and pharmaceutical compositions comprising such compounds
DK218388A (da) Aktivt princip isoleret fra hajvaev
ES2054755T3 (es) Un proceso para la produccion de 2,4,5-trifluoroisoftalonitrilo.
DE69007775D1 (de) 5'-alkylphosphonylnukleoside als antivirale verbindungen.
DK0431305T3 (da) Fremgangsmåde til fremstilling af molluskicide 2,4,5-tribrompyrrol-3-carbonitriler
GR1001309B (el) Μεθοδος παρασκευης παραγωγου ενωσεως της διχλωροανιλινης.
DK0661263T3 (da) Fremgangsmåde til fremstilling af 2,4,5-tribrompyrrol-3-carbonitril
OA06879A (fr) Procédé de préparation de dérivés d'hétéroprostaglandines.
ES2042436T1 (es) Procedimiento mejorado para la preparacion de 2-amino(2,3,5-tri-o-bencil-beta-d-arabinofuranosil)-adenina.
DE59603757D1 (de) Verfahren zur Herstellung von kristallinem O-Isopropylisoharnstoff-hydrochlorid
DE59104766D1 (de) Phosphatierverfahren.
DK632187A (da) Ny forbedret fremgangsmaade til fremstilling af penicillansyrederivater