DK0484094T3 - Azasteroide forbindelser til behandling af prostatahypertrofi, deres fremstilling og anvendelse - Google Patents

Azasteroide forbindelser til behandling af prostatahypertrofi, deres fremstilling og anvendelse

Info

Publication number: DK0484094T3
Authority: DK; Denmark
Prior art keywords: alkyl group; substituted alkyl; carbon; preparation; treatment
Prior art date: 1990-10-29

Application number

DK91309967.7T

Other languages

English (en)

Inventor

Koichi Kojima

Hitoshi Kurata

Hiroyoshi Horikoshi

Takakazu Hamada

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-10-29

Filing date

1991-10-29

Publication date

1996-10-28

1991-10-29 Application filed by Sankyo Co filed Critical Sankyo Co

1996-10-28 Application granted granted Critical

1996-10-28 Publication of DK0484094T3 publication Critical patent/DK0484094T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK91309967.7T 1990-10-29 1991-10-29 Azasteroide forbindelser til behandling af prostatahypertrofi, deres fremstilling og anvendelse DK0484094T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP29140190		1990-10-29

Publications (1)

Publication Number	Publication Date
DK0484094T3 true DK0484094T3 (da)	1996-10-28

Family

ID=17768420

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91309967.7T DK0484094T3 (da)	1990-10-29	1991-10-29	Azasteroide forbindelser til behandling af prostatahypertrofi, deres fremstilling og anvendelse

Country Status (20)

Country	Link
US (1)	US5302621A (da)
EP (1)	EP0484094B1 (da)
JP (1)	JPH0819151B2 (da)
KR (1)	KR0134570B1 (da)
CN (2)	CN1053672C (da)
AT (1)	ATE139783T1 (da)
AU (1)	AU640279B2 (da)
CA (1)	CA2054368C (da)
CZ (1)	CZ279312B6 (da)
DE (1)	DE69120500T2 (da)
DK (1)	DK0484094T3 (da)
ES (1)	ES2091299T3 (da)
GR (1)	GR3020483T3 (da)
HK (2)	HK1005456A1 (da)
HU (2)	HU218667B (da)
IE (1)	IE76452B1 (da)
IL (1)	IL99889A (da)
PT (1)	PT99371B (da)
RU (1)	RU2070204C1 (da)
ZA (1)	ZA918570B (da)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5304562A (en) *	1991-10-09	1994-04-19	Ciba-Geigy Corporation	17β-substituted Aza-androstane derivatives
CA2084799C (en) *	1991-12-17	2003-01-28	Glenn J. Gormley	Method of prevention of prostatic carcinoma with 17 beta-n-monosubstituted-carbamoyl-4-aza-5 alpha-androst-1 -en-3-ones
CA2126203A1 (en) *	1991-12-20	1993-07-08	Stephen V. Frye	Inhibitors of 5-alpha-testosterone reductase
ATE154937T1 (de) *	1992-04-20	1997-07-15	Sankyo Co	Steroide zur behandlung von prostatisch- hypertrophe, ihre herstellung und verwendung
US5698720A (en) *	1992-04-20	1997-12-16	Sankyo Company, Limited	Steroid derivatives
JPH07508033A (ja) *	1992-05-20	1995-09-07	メルク　エンド　カンパニー　インコーポレーテッド	５α−レダクターゼ阻害剤としての３−オキソ−４−アザステロイドの新規１７−エステル，アミド及びケトン誘導体
US5710275A (en) *	1992-05-20	1998-01-20	Merck & Co., Inc.	7β-substituted-4-aza-5α-androstan-3-ones as 5α-reductase inhibitors
GB9216329D0 (en) *	1992-07-31	1992-09-16	Erba Carlo Spa	17beta-substituted 4-aza-5alpha-androstan-3-one derivatives
GB9216284D0 (en) *	1992-07-31	1992-09-16	Erba Carlo Spa	Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives
US5302589A (en) *	1992-08-07	1994-04-12	Glaxo, Inc.	Heterocyclic inhibitors of 5-α-testosterone reductase
HU212459B (en) *	1992-10-02	1996-06-28	Richter Gedeon Vegyeszet	Process for producing new 17-beta-substituted 4-aza-androstane-derivatives and pharmaceutical compositions containing them
WO1994007861A1 (en) *	1992-10-06	1994-04-14	Merck & Co., Inc.	17β-CARBOXANILIDES OF 4-AZA-5α-ANDROSTAN-3-ONES AS 5α-REDUCTASE INHIBITORS
WO1994022900A1 (en) *	1993-04-02	1994-10-13	Ciba-Geigy Ag	AZA-ANDROSTANE-17β-CARBOXAMIDES
TW408127B (en) *	1993-09-17	2000-10-11	Glaxo Inc	Androstenones
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
ATE178795T1 (de) *	1993-11-04	1999-04-15	Merck & Co Inc	7-substituierte-4-aza-steroid-derivate als 5- alpha-reductase-hemmer
US5817818A (en) *	1994-09-16	1998-10-06	Glaxo Wellcome Inc.	Androstenones
US5578724A (en) *	1994-09-20	1996-11-26	Eli Lilly And Company	Process for preparation of benzo[f]quinolinones
US5541322A (en) *	1994-10-14	1996-07-30	Glaxo Wellcome Inc.	Synthesis of 6-azaandrostenones
US5543417A (en) *	1994-10-21	1996-08-06	Merck & Co., Inc.	Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
IT1271325B (it) *	1994-12-23	1997-05-27	Poli Ind Chimica Spa	Composti diastereomericamente puri derivati da 3-oxo e 3-tioxo-4-azaandrostani e loro uso come antiandrogeni
US5656613A (en) *	1995-01-04	1997-08-12	Merck & Co., Inc.	Treatment of hyperandrogenic conditions
CN1072679C (zh) *	1995-07-30	2001-10-10	重庆医科大学	一种氮杂甾体化合物、制备及其用途
JPH11512434A (ja) *	1995-09-15	1999-10-26	メルクエンドカンパニーインコーポレーテッド	アンドロゲン過剰状態治療用の４−アザステロイド
US6001844A (en) *	1995-09-15	1999-12-14	Merck & Co., Inc.	4-Azasteroids for treatment of hyperandrogenic conditions
ATE208631T1 (de) *	1996-02-05	2001-11-15	Sankyo Co	5-alpha reductase inhibierende zusammenstellung zur oralen verabreichung, verfahren zur herstellung und deren verwendung
US6093722A (en) *	1997-02-26	2000-07-25	Sankyo Company, Limited	Method for treating prostate cancer
CN1131239C (zh) *	1997-02-26	2003-12-17	三共株式会社	治疗或预防前列腺癌的组合物
DE69822636T2 (de) *	1997-07-29	2005-01-05	Sankyo Co., Ltd.	Azasteroidverbindung zur behandlung von alopezie, hirsutismus und seborrhoe
US6187925B1 (en) *	1997-12-23	2001-02-13	Merck & Co., Inc.	Intermediates and process for the synthesis of azasteroids
US5998427A (en) *	1998-05-14	1999-12-07	Glaxo Wellcome Inc.	Androstenones
US6645974B2 (en)	2001-07-31	2003-11-11	Merck & Co., Inc.	Androgen receptor modulators and methods for use thereof
CN1784236A (zh) *	2003-05-07	2006-06-07	麦克公司	雄激素受体调节剂及其使用方法
AU2004256075B2 (en) *	2003-06-30	2008-12-04	Merck Sharp & Dohme Corp.	17-acetamido-4-azasteroid derivatives as androgen receptor modulators
WO2005005606A2 (en) *	2003-06-30	2005-01-20	Merck & Co., Inc.	17-acetamido-4-azasteroid derivatives as androgen receptor modulators
JP2007522087A (ja) *	2003-06-30	2007-08-09	メルク　エンド　カムパニー　インコーポレーテッド	アンドロゲン受容体モジュレータとしての１７−アセトアミド−４−アザステロイド誘導体
US20080125403A1 (en) *	2004-04-02	2008-05-29	Merck & Co., Inc.	Method of Treating Men with Metabolic and Anthropometric Disorders
US20090123571A1 (en) *	2005-03-25	2009-05-14	Alan Meehan	Method of treating men with testosterone supplement and 5alpha-reductase inhibitor

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4377584A (en) *	1978-04-13	1983-03-22	Merck & Co., Inc.	4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
US4179453A (en)	1978-04-13	1979-12-18	Merck & Co., Inc.	Process for preparing 17β-carboxy-5-androsten-3-ones
AU527030B2 (en) *	1978-04-13	1983-02-10	Merck & Co., Inc.	4-aza-17-substituted-5a-androstan-3-ones
US4220775A (en) *	1979-03-15	1980-09-02	Merck & Co., Inc.	Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors
US4760071A (en)	1984-02-27	1988-07-26	Merck & Co., Inc.	17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
NZ211145A (en) *	1984-02-27	1988-10-28	Merck & Co Inc	4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions
GB8505862D0 (en) *	1985-03-07	1985-04-11	Erba Farmitalia	Steroidic 5alpha-reductase inhibitors
US5021575A (en) *	1989-11-13	1991-06-04	Merck & Co., Inc.	Method for introducing a 1,2 double bond into azasteroids

1991
- 1991-10-25 IE IE374791A patent/IE76452B1/en not_active IP Right Cessation
- 1991-10-28 CA CA002054368A patent/CA2054368C/en not_active Expired - Fee Related
- 1991-10-28 ZA ZA918570A patent/ZA918570B/xx unknown
- 1991-10-28 RU SU5010339/04A patent/RU2070204C1/ru not_active IP Right Cessation
- 1991-10-28 JP JP3281484A patent/JPH0819151B2/ja not_active Expired - Fee Related
- 1991-10-29 DK DK91309967.7T patent/DK0484094T3/da active
- 1991-10-29 DE DE69120500T patent/DE69120500T2/de not_active Expired - Fee Related
- 1991-10-29 HU HU396/91A patent/HU218667B/hu not_active IP Right Cessation
- 1991-10-29 PT PT99371A patent/PT99371B/pt not_active IP Right Cessation
- 1991-10-29 IL IL9988991A patent/IL99889A/en not_active IP Right Cessation
- 1991-10-29 EP EP91309967A patent/EP0484094B1/en not_active Expired - Lifetime
- 1991-10-29 ES ES91309967T patent/ES2091299T3/es not_active Expired - Lifetime
- 1991-10-29 AT AT91309967T patent/ATE139783T1/de not_active IP Right Cessation
- 1991-10-29 CN CN91111440A patent/CN1053672C/zh not_active Expired - Fee Related
- 1991-10-29 CZ CS913269A patent/CZ279312B6/cs not_active IP Right Cessation
- 1991-10-29 KR KR1019910019062A patent/KR0134570B1/ko not_active IP Right Cessation
- 1991-10-29 AU AU86821/91A patent/AU640279B2/en not_active Ceased
1993
- 1993-02-26 US US08/023,871 patent/US5302621A/en not_active Expired - Fee Related
1995
- 1995-06-29 HU HU95P/P00567P patent/HU211642A9/hu unknown
1996
- 1996-07-09 GR GR960401851T patent/GR3020483T3/el unknown
1997
- 1997-01-24 CN CN97102330A patent/CN1072935C/zh not_active Expired - Fee Related
1998
- 1998-05-27 HK HK98104572A patent/HK1005456A1/xx not_active IP Right Cessation
1999
- 1999-06-17 HK HK99102601A patent/HK1017274A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE139783T1 (de)	1996-07-15
DE69120500D1 (de)	1996-08-01
EP0484094A2 (en)	1992-05-06
CS326991A3 (en)	1992-05-13
PT99371A (pt)	1992-09-30
IL99889A (en)	1995-06-29
CA2054368C (en)	2001-10-02
IE913747A1 (en)	1992-05-22
RU2070204C1 (ru)	1996-12-10
PT99371B (pt)	1999-04-30
CN1209319A (zh)	1999-03-03
HU913396D0 (en)	1992-01-28
GR3020483T3 (en)	1996-10-31
ZA918570B (en)	1992-08-26
IE76452B1 (en)	1997-10-22
HK1017274A1 (en)	1999-11-19
US5302621A (en)	1994-04-12
HU218667B (hu)	2000-10-28
EP0484094B1 (en)	1996-06-26
CZ279312B6 (cs)	1995-04-12
EP0484094A3 (en)	1993-07-14
CN1072935C (zh)	2001-10-17
IL99889A0 (en)	1992-08-18
JPH0532693A (ja)	1993-02-09
CN1053672C (zh)	2000-06-21
JPH0819151B2 (ja)	1996-02-28
AU8682191A (en)	1992-04-30
KR0134570B1 (ko)	1998-04-14
HK1005456A1 (en)	1999-01-08
KR920008063A (ko)	1992-05-27
ES2091299T3 (es)	1996-11-01
DE69120500T2 (de)	1997-02-27
AU640279B2 (en)	1993-08-19
HU211642A9 (en)	1995-12-28
HUT59417A (en)	1992-05-28
CA2054368A1 (en)	1992-04-30
CN1062145A (zh)	1992-06-24

Publication	Publication Date	Title
DK0484094T3 (da)	1996-10-28	Azasteroide forbindelser til behandling af prostatahypertrofi, deres fremstilling og anvendelse
DK0567271T3 (da)	1998-02-16	Steroidderivater til behandling af prostatahypertrofi, fremgangsmåde til fremstilling heraf og anvendelser heraf
NO870771D0 (no)	1987-02-25	Fremgangsmaate ved fremstilling av nye, terapeutisk aktive 1,2,5,6-tetrahydropyridin-3-carboxaldehydoximderivater.
ES2010514B3 (es)	1989-11-16	Derivados de 6-alquil-idenandrosteno-3,17-dionas sustituidas en la posicion 4 y proceso para su preparacion.
ATE114465T1 (de)	1994-12-15	Pharmazeutische zusammensetzung zur inhibierung der knochenresorption.
EP0347815A3 (en)	1990-03-28	Cleaner for thermostatic water bath
DE59207425D1 (de)	1996-11-28	Imidazolylmethyl-Pyridine
ATE131061T1 (de)	1995-12-15	Förderung der osteogenese durch verwendung von vitamin d-derivaten.
SE8505369D0 (sv)	1985-11-13	New thienopyridine derivatives, a process of preparation thereof and therapeutic compositions containing the same
TW225989B (da)	1994-07-01
EP0802179A4 (en)	2000-04-05	DERIVATE SUBSTITUTED AMIDINONAPHTHYLESTER
DK0764443T3 (da)	2002-10-07	Midler tl behandling af med tumorer forbundet kakeksi
DK401779A (da)	1980-03-28	Fremgangsmaade til isomerisering af 3-azabicyclo-(3.1.0) hexanderivater
DK0627419T3 (da)	2000-04-25	Optisk aktive derivater af 1-phenylpyrrolidon og fremgangsmåde til fremstilling deraf
TH919A (th)	1983-04-22	การเตรียมอนุพันธ์ 1-แอลคิล-2-อะมิโน-เททราลิน