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DK0481522T3 - Nye mercaptoacetylamid-derivater anvendelige som inhibitorer af enkephalinase og ACE - Google Patents

Nye mercaptoacetylamid-derivater anvendelige som inhibitorer af enkephalinase og ACE

Info

Publication number
DK0481522T3
DK0481522T3 DK91117849.9T DK91117849T DK0481522T3 DK 0481522 T3 DK0481522 T3 DK 0481522T3 DK 91117849 T DK91117849 T DK 91117849T DK 0481522 T3 DK0481522 T3 DK 0481522T3
Authority
DK
Denmark
Prior art keywords
enkephalinase
ace
inhibitors
new
derivatives useful
Prior art date
Application number
DK91117849.9T
Other languages
English (en)
Inventor
Gary A Flynn
Douglas W Beight
Philippe Bey
Alan M Warshawsky
Shujaath Mehdi
Eugene L Giroux
Timothy P Burkholder
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of DK0481522T3 publication Critical patent/DK0481522T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Biophysics (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
DK91117849.9T 1990-10-18 1991-10-18 Nye mercaptoacetylamid-derivater anvendelige som inhibitorer af enkephalinase og ACE DK0481522T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60005290A 1990-10-18 1990-10-18
US73549691A 1991-07-25 1991-07-25

Publications (1)

Publication Number Publication Date
DK0481522T3 true DK0481522T3 (da) 1998-03-09

Family

ID=27083513

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91117849.9T DK0481522T3 (da) 1990-10-18 1991-10-18 Nye mercaptoacetylamid-derivater anvendelige som inhibitorer af enkephalinase og ACE

Country Status (18)

Country Link
EP (1) EP0481522B1 (da)
JP (1) JP3181335B2 (da)
KR (1) KR100372491B1 (da)
CN (2) CN1036590C (da)
AT (1) ATE161536T1 (da)
AU (1) AU642535B2 (da)
CA (1) CA2053340C (da)
DE (1) DE69128516T2 (da)
DK (1) DK0481522T3 (da)
ES (1) ES2114870T3 (da)
FI (2) FI95255C (da)
GR (1) GR3026222T3 (da)
HU (1) HU210008B (da)
IE (1) IE913648A1 (da)
IL (1) IL99769A (da)
NO (1) NO180718C (da)
NZ (1) NZ240230A (da)
PT (1) PT99267B (da)

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US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
DE69317764T2 (de) * 1992-02-14 1998-07-30 Merrell Pharmaceuticals Inc., Cincinnati, Ohio Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
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US5644055A (en) * 1993-06-30 1997-07-01 Ciba-Geigy Corporation Antihypertensive tricyclic azepine derivatives useful as inhibitors of enkephalinase and ACE
ES2076096B1 (es) * 1993-07-14 1996-03-16 Squibb & Sons Inc Compuestos inhibidores de la enzima convertidora de angiotensinas y dela endopeptidasa neutra, y metodos para prepararlos.
US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
ATE209205T1 (de) * 1994-02-14 2001-12-15 Merrell Pharma Inc Indan-2-mercaptoacetylamid disulfidderivate als enkephalinase inhibitoren
HUT74385A (en) * 1994-02-14 1996-12-30 Merrell Pharma Inc Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo[c]azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace
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Also Published As

Publication number Publication date
FI95255B (fi) 1995-09-29
FI914905A (fi) 1992-04-19
NO914092L (no) 1992-04-21
PT99267B (pt) 1999-04-30
DE69128516T2 (de) 1998-07-23
AU642535B2 (en) 1993-10-21
JPH04282382A (ja) 1992-10-07
ES2114870T3 (es) 1998-06-16
IL99769A0 (en) 1992-08-18
NZ240230A (en) 1993-01-27
FI914905A0 (fi) 1991-10-17
IL99769A (en) 1998-12-27
JP3181335B2 (ja) 2001-07-03
GR3026222T3 (en) 1998-05-29
EP0481522A1 (en) 1992-04-22
HU913282D0 (en) 1992-01-28
CN1166490A (zh) 1997-12-03
NO914092D0 (no) 1991-10-17
NO180718C (no) 1997-06-04
PT99267A (pt) 1992-08-31
CN1061971A (zh) 1992-06-17
AU8581991A (en) 1992-04-30
KR920008040A (ko) 1992-05-27
FI943363A0 (fi) 1994-07-14
EP0481522B1 (en) 1997-12-29
CN1058013C (zh) 2000-11-01
DE69128516D1 (de) 1998-02-05
NO180718B (no) 1997-02-24
HU210008B (en) 1995-01-30
CA2053340A1 (en) 1992-04-19
FI95255C (fi) 1996-01-10
CA2053340C (en) 2002-04-02
FI943363A (fi) 1994-07-14
FI96691B (fi) 1996-04-30
HUT63419A (en) 1993-08-30
CN1036590C (zh) 1997-12-03
IE913648A1 (en) 1992-04-22
KR100372491B1 (ko) 2003-05-27
ATE161536T1 (de) 1998-01-15
FI96691C (fi) 1996-08-12

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