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DK0383645T3 - Process for producing very high purity anti-haemophilia factor (FVIIIc) - Google Patents

Process for producing very high purity anti-haemophilia factor (FVIIIc)

Info

Publication number
DK0383645T3
DK0383645T3 DK90400203.7T DK90400203T DK0383645T3 DK 0383645 T3 DK0383645 T3 DK 0383645T3 DK 90400203 T DK90400203 T DK 90400203T DK 0383645 T3 DK0383645 T3 DK 0383645T3
Authority
DK
Denmark
Prior art keywords
factor
fviiic
antihaemophilic
producing
high purity
Prior art date
Application number
DK90400203.7T
Other languages
Danish (da)
Inventor
Bernard Jules Dazey
Mohamed Hamsany
Gerard Paul Vezon
Original Assignee
Ass Daquitaine Pour Le Dev De
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9378912&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0383645(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ass Daquitaine Pour Le Dev De filed Critical Ass Daquitaine Pour Le Dev De
Application granted granted Critical
Publication of DK0383645T3 publication Critical patent/DK0383645T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to a process for preparing very pure antihaemophilic factor (FVIIIc). This process for preparing very pure antihaemophilic factor (FVIIIc) predominantly devoid of von Willebrand factor, comprising a step of purification by ion exchange chromatography using a chromatography column comprising a gel, comprising a step of adsorption of the antihaemophilic factor on the gel of the aforementioned column and a step of desorption of the purified antihaemophilic factor which is collected, is characterised. An antihaemophilic factor devoid of the majority of the von Willebrand factor and having an activity as high as 250 IU/mg of proteins is thereby obtained.
DK90400203.7T 1989-02-17 1990-01-24 Process for producing very high purity anti-haemophilia factor (FVIIIc) DK0383645T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8902136A FR2644064B1 (en) 1989-02-17 1989-02-17 PROCESS FOR THE MANUFACTURE OF THE FVIIIC ANTIHEMOPHILIC FACTOR HAVING VERY HIGH PURITY AND THE FVIIIC ANTIHEMOPHILIC FACTOR THUS OBTAINED, AS WELL AS THE PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

Publications (1)

Publication Number Publication Date
DK0383645T3 true DK0383645T3 (en) 1993-08-02

Family

ID=9378912

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90400203.7T DK0383645T3 (en) 1989-02-17 1990-01-24 Process for producing very high purity anti-haemophilia factor (FVIIIc)

Country Status (7)

Country Link
EP (1) EP0383645B1 (en)
JP (1) JP2521551B2 (en)
AT (1) ATE88188T1 (en)
DE (1) DE69001309T2 (en)
DK (1) DK0383645T3 (en)
ES (1) ES2055875T3 (en)
FR (1) FR2644064B1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2665449B1 (en) * 1990-08-02 1995-04-14 Aquitaine Developp Transf Sang METHOD FOR MANUFACTURING A VON WILLEBRAND FACTOR HAVING VERY HIGH PURITY, MAINLY LACKING AN ANTIHEMOPHILIC FACTOR (FVIIIC), AND VON WILLEBRAND FACTOR THUS OBTAINED, AS WELL AS A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME.
US5760183A (en) * 1989-02-17 1998-06-02 Association D'aquitaine Pour De Developpment De La Transfusion Sanguine Et Des Recherches Hematologiques Process for the manufacture of very high-purity antithaemophilic factor (FVIIIC), and von Willebrand factor, and pharmaceutical compositions containing same
IT1248723B (en) * 1990-06-12 1995-01-26 Scalvo S P A PROCESS FOR THE PURIFICATION OF FACTOR VIII AND FACTOR VIII OBTAINED WITH SUCH PROCESS
DE4111393A1 (en) * 1991-04-09 1992-10-15 Behringwerke Ag STABILIZED FACTOR VIII PREPARATIONS
FR2686883B1 (en) * 1992-02-04 1994-05-13 Aquitaine Develop Transf Sanguin PROCESS FOR THE MANUFACTURE OF VERY HIGH PURITY FIBRINOGEN, VERY HIGH PURITY FIBRINOGENE, OBTAINED AS WELL AS A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME.
FR2772381B1 (en) * 1997-12-15 2001-06-08 Lab Francais Du Fractionnement PROCESS FOR THE PREPARATION BY FILTRATION OF A VIRALLY SECURE FACTOR VIII SOLUTION

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4495175A (en) * 1982-08-05 1985-01-22 University Of Rochester Preparation of highly purified human antihemophilic factor
US4508709A (en) * 1983-12-05 1985-04-02 Armour Pharmaceutical Company Process for purifying factor VIII:C
US4743680A (en) * 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
NL8701915A (en) * 1987-08-14 1989-03-01 Waander Riethorst ADSORBENS MATERIAL AND USE THEREOF FOR INSULATING CLOTHING FACTORS.
FR2632309B1 (en) * 1988-06-07 1990-08-24 Lille Transfusion Sanguine PROCESS FOR THE CHROMATOGRAPHIC PURIFICATION OF PROTEINS, PARTICULARLY FACTOR VIII, AND THE PRODUCTS OBTAINED
DE3904354A1 (en) * 1989-02-14 1990-08-16 Behringwerke Ag PASTEURIZED, PURIFIED OF WILLEBRAND FACTOR CONCENTRATE AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
FR2644064A1 (en) 1990-09-14
JP2521551B2 (en) 1996-08-07
DE69001309T2 (en) 1993-08-05
EP0383645B1 (en) 1993-04-14
DE69001309D1 (en) 1993-05-19
FR2644064B1 (en) 1994-05-27
JPH02282400A (en) 1990-11-19
ES2055875T3 (en) 1994-09-01
ATE88188T1 (en) 1993-04-15
EP0383645A1 (en) 1990-08-22

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