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DE69334033D1 - Technetium-99M markierte Peptide zur Bilderzeugung von Thrombus - Google Patents

Technetium-99M markierte Peptide zur Bilderzeugung von Thrombus

Info

Publication number
DE69334033D1
DE69334033D1 DE69334033T DE69334033T DE69334033D1 DE 69334033 D1 DE69334033 D1 DE 69334033D1 DE 69334033 T DE69334033 T DE 69334033T DE 69334033 T DE69334033 T DE 69334033T DE 69334033 D1 DE69334033 D1 DE 69334033D1
Authority
DE
Germany
Prior art keywords
reagents
technetium
thrombus
methods
labeled peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69334033T
Other languages
English (en)
Inventor
Richard T Dean
John Lister-James
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Diatide Inc
Original Assignee
Diatide Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diatide Inc filed Critical Diatide Inc
Application granted granted Critical
Publication of DE69334033D1 publication Critical patent/DE69334033D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69334033T 1992-05-21 1993-05-21 Technetium-99M markierte Peptide zur Bilderzeugung von Thrombus Expired - Lifetime DE69334033D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US88675292A 1992-05-21 1992-05-21

Publications (1)

Publication Number Publication Date
DE69334033D1 true DE69334033D1 (de) 2006-07-27

Family

ID=25389692

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69334033T Expired - Lifetime DE69334033D1 (de) 1992-05-21 1993-05-21 Technetium-99M markierte Peptide zur Bilderzeugung von Thrombus
DE69329382T Expired - Fee Related DE69329382T2 (de) 1992-05-21 1993-05-21 Technetium-99m markierte peptide zur bilderzeugung von thrombus

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69329382T Expired - Fee Related DE69329382T2 (de) 1992-05-21 1993-05-21 Technetium-99m markierte peptide zur bilderzeugung von thrombus

Country Status (10)

Country Link
US (1) US5925331A (de)
EP (2) EP1004322B1 (de)
JP (2) JP2941057B2 (de)
AT (2) ATE196094T1 (de)
AU (1) AU677208B2 (de)
CA (1) CA2136330C (de)
DE (2) DE69334033D1 (de)
DK (1) DK0641222T3 (de)
ES (1) ES2150945T3 (de)
WO (1) WO1993023085A1 (de)

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US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5645815A (en) * 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
DK0570493T3 (da) * 1991-02-08 2000-06-26 Diatide Inc Technetium-99m-mærkede polypeptider til billeddannelse.
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US7238340B1 (en) * 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US6019958A (en) * 1991-02-08 2000-02-01 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5830856A (en) * 1991-02-08 1998-11-03 Diatide, Inc. Radiolabeled compounds for thrombus imaging
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
PT630265E (pt) * 1992-03-13 2003-07-31 Diatide Inc Peptidos marcados com tecnecio 99m para processamento de imagem de inflamacao
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
AU687080B2 (en) * 1993-04-08 1998-02-19 Cis Bio International Radiolabeled compounds for thrombus imaging
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5620675A (en) 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5750088A (en) 1993-03-30 1998-05-12 The Dupont Merck Pharmaceutical Company Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
JP3320734B2 (ja) * 1993-07-28 2002-09-03 ダイアタイド・インコーポレイテッド 放射性同位体標識したグルカン類
DE4337600A1 (de) * 1993-11-01 1995-05-04 Diagnostikforschung Inst N-Alkyl-Peptidchelatbildner, deren Metallkomplexe mit Radionukliden, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Zusammesetzungen
DE4337599A1 (de) * 1993-11-01 1995-05-04 Diagnostikforschung Inst Metallbindende cysteinfreie Peptide für Diagnose und Therapie, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
US5480970A (en) * 1993-12-22 1996-01-02 Resolution Pharmaceuticals Metal chelators
WO1995025720A1 (en) * 1994-03-18 1995-09-28 Diatech, Inc. Piperidyl-4-substituted thyrosine derivatives as scintigraphic imaging agents for the diagnosis of thrombosis
JPH09512555A (ja) * 1994-05-02 1997-12-16 ダイアテック・インコーポレイテッド テクネチウム−９９ｍ標識イメージング剤
IL113610A0 (en) * 1994-06-03 1995-08-31 Immunomedics Inc A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
CA2204254C (en) * 1994-11-17 2010-02-16 Stephen Lewis Hart Internalisation of dna, using conjugates of poly-l-lysine and an integrin receptor ligand
US5891418A (en) * 1995-06-07 1999-04-06 Rhomed Incorporated Peptide-metal ion pharmaceutical constructs and applications
US6331285B1 (en) 1996-06-05 2001-12-18 Palatin Technologies, Inc. Structurally determined cyclic metallo-constructs and applications
WO1997047329A2 (en) * 1996-06-10 1997-12-18 G.D. Searle & Co. Radiopharmaceutical compositions capable of localizing at sites of thrombus
US6028056A (en) * 1998-02-06 2000-02-22 Diatide, Inc. Pharmaceutical compositions for imaging and treating thrombi
SE523817C2 (sv) 1999-02-05 2004-05-18 Corline Systems Ab Användning av ett koagulationsförebyggande ämne i samband med transplantation av insulinproducerande celler
US6808698B1 (en) 1999-03-26 2004-10-26 Bristol-Myers Squibb Pharma Company Method for localization of blood clots
US6254852B1 (en) 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
EP1203026A4 (de) * 1999-07-29 2005-03-16 Dyax Corp Bindungsstellen für fibrin
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
US7385025B2 (en) 2000-12-19 2008-06-10 Palatin Technologies, Inc. Metallopeptide compounds
AU2002313616A1 (en) 2001-07-10 2003-01-29 Amersham Health As Peptide-based compounds for targeting intergin receptors
US20040023981A1 (en) * 2002-07-24 2004-02-05 Yu Ren Salt forms with tyrosine kinase activity
EP1437145A1 (de) * 2003-01-07 2004-07-14 Schering AG Verbesserte szintigraphische bildgebende Mittel zur Darstellung von Infektionen und Entzündungen
US7317104B2 (en) 2003-06-13 2008-01-08 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7319149B2 (en) 2003-06-13 2008-01-15 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
GB0516091D0 (en) * 2005-08-04 2005-09-14 Haemostatix Ltd Therapeutic agent
RU2504331C1 (ru) * 2013-01-21 2014-01-20 Государственное бюджетное учреждение здравоохранения города Москвы Научно-исследовательский институт скорой помощи имени Н.В. Склифосовского Департамента здравоохранения г. Москвы Способ радионуклидной оценки степени ишемии при остром тромбозе магистральных артерий нижних конечностей у больных с двусторонним атеросклеротическим поражением артерий
CN108976284B (zh) * 2017-05-31 2021-11-30 首都医科大学 含Gly-Pro-Arg-Pro的五肽修饰的华法林,其合成,活性和应用
CN108976285B (zh) * 2017-05-31 2021-11-30 首都医科大学 Gly-Pro-Arg-Pro-AA修饰的华法林,其合成,活性和应用

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US4427646A (en) * 1981-04-02 1984-01-24 Research Corporation Use of radiolabeled peptide derived from crosslinked fibrin to locate thrombi in vivo
US4792525A (en) * 1982-08-04 1988-12-20 La Jolla Cancer Research Foundation Tetrapeptide
US4578079A (en) * 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide
US4661471A (en) * 1984-04-10 1987-04-28 New England Deaconess Hospital Method of inhibiting and inducing human platelet aggregation
US4638051A (en) * 1984-04-30 1987-01-20 The Johns Hopkins University Brain imaging radiopharmaceuticals
SE447579B (sv) * 1985-04-01 1986-11-24 Biopool Ab Solubiliserbar, fibrinbaserad komposition och anvendning av kompositionen vid bestemning av fibrinolysparametrar
FR2604371B1 (fr) * 1986-09-30 1990-07-06 Toulouse Inst Nal Sciences App Procede et dispositif d'echange entre un gaz et un liquide
EP0325639A4 (en) * 1987-07-07 1990-10-24 Cytrx Biopool Ltd. Fibrin-binding compound and method
US4843647A (en) * 1987-08-31 1989-07-04 Burlington Industries, Inc. Cold weather system
US4889524A (en) * 1987-09-04 1989-12-26 Haemonetics Corporation Portable centrifuge apparatus
DE3731266A1 (de) * 1987-09-17 1989-04-06 Kernforschungsz Karlsruhe Huellmaterial fuer supraleitende draehte
WO1989002752A1 (en) * 1987-09-25 1989-04-06 Genentech, Inc. Method of diagnosing blood clots using fibrin-binding proteins
GB8723547D0 (en) * 1987-10-07 1987-11-11 Automotive Prod Plc Clutch control
WO1989010135A1 (en) * 1988-04-29 1989-11-02 New England Deaconess Hospital Corporation Hybrid peptides and methods of their use
WO1989010759A1 (en) * 1988-04-29 1989-11-16 Mallinckrodt, Inc. Diaminedithiol chelating agents for radiopharmaceuticals
WO1989012680A1 (en) * 1988-06-20 1989-12-28 Washington University USE OF MODIFIED tPA TO DETECT BLOOD CLOTS
FR2634400B1 (fr) * 1988-07-19 1991-12-06 Becker Arnaud Broyeur a marteaux pour le dechiquetage d'objets metalliques muni d'un dispositif de protection du tambour d'entrainement des marteaux
CA2000666C (en) * 1988-10-14 1996-07-09 Jeffrey Lawrence Finnan Method of making a free-flowing, spray-dried edible powder comprising an oil
FR2639232A1 (fr) * 1988-10-21 1990-05-25 Sanofi Sa Medicaments contenant une interleukine-2 glycosylee
US5196510A (en) * 1988-12-29 1993-03-23 Cytogen Corporation Molecular recognition units
US4986979A (en) * 1989-03-14 1991-01-22 Neorx Corporation Imaging tissue sites of inflammation
GB8914020D0 (en) * 1989-06-19 1989-08-09 Antisoma Ltd Synthetic peptides for use in thrombus detection
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
FR2651077B1 (fr) * 1989-08-18 1994-06-10 Letourneur Gregoire Dispositif de traitement d'echo notamment acoustique dans une ligne telephonique
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
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WO1992005154A1 (en) * 1990-09-14 1992-04-02 Mallinckrodt Medical, Inc. Novel nitrogen-sulfur ligands useful in radiographic imaging agents
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
DK0570493T3 (da) * 1991-02-08 2000-06-26 Diatide Inc Technetium-99m-mærkede polypeptider til billeddannelse.
US5371184A (en) * 1992-02-05 1994-12-06 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds

Also Published As

Publication number Publication date
AU4384593A (en) 1993-12-13
EP0641222B1 (de) 2000-09-06
CA2136330A1 (en) 1993-11-25
ATE329624T1 (de) 2006-07-15
DE69329382D1 (de) 2000-10-12
EP1004322B1 (de) 2006-06-14
US5925331A (en) 1999-07-20
DK0641222T3 (da) 2000-12-11
JP3380738B2 (ja) 2003-02-24
EP1004322A3 (de) 2003-12-03
JP2941057B2 (ja) 1999-08-25
DE69329382T2 (de) 2001-03-15
EP1004322A2 (de) 2000-05-31
EP0641222A1 (de) 1995-03-08
JPH07508289A (ja) 1995-09-14
ES2150945T3 (es) 2000-12-16
JPH10291939A (ja) 1998-11-04
AU677208B2 (en) 1997-04-17
CA2136330C (en) 2002-03-19
WO1993023085A1 (en) 1993-11-25
ATE196094T1 (de) 2000-09-15

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Legal Events

Date Code Title Description
8332 No legal effect for de