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DE69226624D1 - COMPOSITION CONTAINING A TRAMADOL COMPOUND AND ACETAMINOPHENE, AND THEIR USE - Google Patents

COMPOSITION CONTAINING A TRAMADOL COMPOUND AND ACETAMINOPHENE, AND THEIR USE

Info

Publication number
DE69226624D1
DE69226624D1 DE69226624T DE69226624T DE69226624D1 DE 69226624 D1 DE69226624 D1 DE 69226624D1 DE 69226624 T DE69226624 T DE 69226624T DE 69226624 T DE69226624 T DE 69226624T DE 69226624 D1 DE69226624 D1 DE 69226624D1
Authority
DE
Germany
Prior art keywords
compositions
tramadol
acetaminophene
composition containing
tramadol compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69226624T
Other languages
German (de)
Other versions
DE69226624T3 (en
DE69226624T2 (en
Inventor
Robert Raffa
Jeffrey L Vaught
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
McNeilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36791806&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69226624(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by McNeilab Inc filed Critical McNeilab Inc
Publication of DE69226624D1 publication Critical patent/DE69226624D1/en
Application granted granted Critical
Publication of DE69226624T2 publication Critical patent/DE69226624T2/en
Publication of DE69226624T3 publication Critical patent/DE69226624T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fats And Perfumes (AREA)

Abstract

This invention relates to a composition comprising a tramadol material and acetaminophen, and its use. As used herein tramadol refers to various forms of tramadol. The compositions are pharmacologically useful in treating pain and tussive conditions. The compositions are also subject to less opioid side-effects such as abuse liability, tolerance, constipation and respiratory depression. Furthermore, where the components of the compositions are within certain ratios the pharmacological effects of the compositions are superadditive (synergistic).
DE69226624T 1991-09-06 1992-09-03 COMPOSITION CONTAINING A TRAMADOL COMPOUND AND ACETAMINOPHES, AND ITS USE Expired - Lifetime DE69226624T3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75592491A 1991-09-06 1991-09-06
US755924 1991-09-06
PCT/US1992/007542 WO1993004675A1 (en) 1991-09-06 1992-09-03 Composition comprising a tramadol material and acetaminophen and its use
CN92112594A CN1071571C (en) 1991-09-06 1992-10-24 Composition comprising a tramadol material and acetaminophen and its use

Publications (3)

Publication Number Publication Date
DE69226624D1 true DE69226624D1 (en) 1998-09-17
DE69226624T2 DE69226624T2 (en) 1999-03-04
DE69226624T3 DE69226624T3 (en) 2009-11-05

Family

ID=36791806

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69226624T Expired - Lifetime DE69226624T3 (en) 1991-09-06 1992-09-03 COMPOSITION CONTAINING A TRAMADOL COMPOUND AND ACETAMINOPHES, AND ITS USE
DE200412000032 Active DE122004000032I2 (en) 1991-09-06 1992-09-03 Composition containing a tramadol compound and acetaminophen, and their use

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE200412000032 Active DE122004000032I2 (en) 1991-09-06 1992-09-03 Composition containing a tramadol compound and acetaminophen, and their use

Country Status (17)

Country Link
US (2) US5336691A (en)
EP (1) EP0566709B3 (en)
JP (1) JP3381190B2 (en)
KR (1) KR100243956B1 (en)
CN (1) CN1071571C (en)
AT (1) ATE169498T1 (en)
AU (1) AU651247B2 (en)
CA (1) CA2095523C (en)
DE (2) DE69226624T3 (en)
DK (1) DK0566709T5 (en)
ES (1) ES2120451T7 (en)
HU (1) HU219332B (en)
LU (1) LU91079I2 (en)
NL (1) NL300152I2 (en)
RU (1) RU2121346C1 (en)
SG (1) SG80535A1 (en)
WO (1) WO1993004675A1 (en)

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DK0566709T5 (en) 2009-05-18
DE122004000032I2 (en) 2006-02-09
ES2120451T7 (en) 2009-11-05
DE122004000032I1 (en) 2005-11-24
KR100243956B1 (en) 2000-03-02
HUT64838A (en) 1994-03-28
HU219332B (en) 2001-03-28
DE69226624T3 (en) 2009-11-05
ATE169498T1 (en) 1998-08-15
JP3381190B2 (en) 2003-02-24
JPH06502869A (en) 1994-03-31
CA2095523C (en) 2004-06-22
ES2120451T3 (en) 1998-11-01
NL300152I1 (en) 2004-08-02
AU651247B2 (en) 1994-07-14
SG80535A1 (en) 2001-05-22
HU9301313D0 (en) 1993-09-28
USRE39221E1 (en) 2006-08-01
EP0566709B3 (en) 2009-04-08
DK0566709T3 (en) 1999-05-10
EP0566709A1 (en) 1993-10-27
RU2121346C1 (en) 1998-11-10
EP0566709B1 (en) 1998-08-12
US5336691A (en) 1994-08-09
DE69226624T2 (en) 1999-03-04
CN1071571C (en) 2001-09-26
WO1993004675A1 (en) 1993-03-18
AU2579992A (en) 1993-04-05
NL300152I2 (en) 2006-05-01
LU91079I2 (en) 2004-07-26
CA2095523A1 (en) 1993-03-07
CN1086133A (en) 1994-05-04
EP0566709A4 (en) 1994-04-06

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