DE69220133D1 - N-Cyclohexyl Benzamide Derivate, ihre Herstellungen und therapeutischen Anwendungen - Google Patents
N-Cyclohexyl Benzamide Derivate, ihre Herstellungen und therapeutischen AnwendungenInfo
- Publication number
- DE69220133D1 DE69220133D1 DE69220133T DE69220133T DE69220133D1 DE 69220133 D1 DE69220133 D1 DE 69220133D1 DE 69220133 T DE69220133 T DE 69220133T DE 69220133 T DE69220133 T DE 69220133T DE 69220133 D1 DE69220133 D1 DE 69220133D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- preparation
- therapeutic applications
- benzamide derivatives
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- KQJYDHWNYPRIRY-UHFFFAOYSA-N n-cyclohexylbenzamide Chemical class C=1C=CC=CC=1C(=O)NC1CCCCC1 KQJYDHWNYPRIRY-UHFFFAOYSA-N 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000007659 motor function Effects 0.000 abstract 1
- 125000005936 piperidyl group Chemical group 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000021 stimulant Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9103959A FR2674849B1 (fr) | 1991-04-02 | 1991-04-02 | Nouveaux derives de n-cyclohexyl benzamides ou thiobenzamides, leurs preparations et leurs applications en therapeutique. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69220133D1 true DE69220133D1 (de) | 1997-07-10 |
| DE69220133T2 DE69220133T2 (de) | 1997-09-18 |
Family
ID=9411357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69220133T Expired - Fee Related DE69220133T2 (de) | 1991-04-02 | 1992-03-31 | N-Cyclohexyl Benzamide Derivate, ihre Herstellungen und therapeutischen Anwendungen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5273983A (de) |
| EP (1) | EP0507672B1 (de) |
| JP (1) | JP2574591B2 (de) |
| KR (1) | KR0169497B1 (de) |
| AT (1) | ATE154021T1 (de) |
| DE (1) | DE69220133T2 (de) |
| DK (1) | DK0507672T3 (de) |
| ES (1) | ES2104865T3 (de) |
| FR (1) | FR2674849B1 (de) |
| GR (1) | GR3024575T3 (de) |
| HK (1) | HK1004895A1 (de) |
| TW (1) | TW203038B (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2735693B1 (fr) * | 1995-06-23 | 1997-09-26 | Logeais Labor Jacques | Nouvelles applications therapeutiques de n-cyclohexyl benzamides |
| FR2766484B1 (fr) * | 1997-07-25 | 1999-09-17 | Logeais Labor Jacques | Nouveaux derives benzamides stimulants de la motricite gastrointestinale haute et basse |
| FR2766486B1 (fr) * | 1997-07-25 | 1999-09-17 | Logeais Labor Jacques | Cycloalkyles benzamides stimulants de la motricite gastrointestinale haute et basse |
| NZ570134A (en) | 2003-01-28 | 2010-02-26 | Ironwood Pharmaceuticals Inc | Methods and compositions for the treatment of gastrointestinal disorders |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| TW200815351A (en) * | 2006-05-02 | 2008-04-01 | Astrazeneca Ab | Novel compounds |
| WO2008151257A2 (en) | 2007-06-04 | 2008-12-11 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| EP3239170B1 (de) | 2008-06-04 | 2019-03-20 | Synergy Pharmaceuticals Inc. | Für die behandlung von gastrointestinalen erkrankungen, entzündungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase |
| CA2730603C (en) | 2008-07-16 | 2019-09-24 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP2384318B1 (de) | 2008-12-31 | 2017-11-15 | Ardelyx, Inc. | Verbindungen und verfahren zur inhibierung des nhe-vermittelten antiports bei der behandlung von mit flüssigkeitsretention und salzüberlastung assoziierten erkrankungen und erkrankungen des magen-darm-trakts |
| WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| WO2014029983A1 (en) | 2012-08-21 | 2014-02-27 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| NZ752535A (en) | 2013-04-12 | 2022-08-26 | Ardelyx Inc | Nhe3-binding compounds and methods for inhibiting phosphate transport |
| BR112019013963A2 (pt) | 2017-01-09 | 2020-04-28 | Ardelyx Inc | inibidores de antiporte mediado por nhe |
| WO2018129552A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds useful for treating gastrointestinal tract disorders |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1015921A (en) * | 1961-10-06 | 1966-01-05 | Benger Lab Ltd | Benzamides |
| AR216043A1 (es) * | 1974-03-21 | 1979-11-30 | Anphar Sa | Procedimiento para la preparacion de 1-derivados de benzoilamino-4-piperidina y sus sales fisiologicamente aceptables |
| US4098904A (en) * | 1976-11-12 | 1978-07-04 | The Upjohn Company | Analgesic n-(2-aminocycloaliphatic)benzamides |
| CA1183847A (en) * | 1981-10-01 | 1985-03-12 | Georges Van Daele | N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
| CA1223873A (en) * | 1982-04-14 | 1987-07-07 | Francis D. King | Pharmaceutically active compounds |
| ES2036181T3 (es) * | 1985-10-25 | 1993-05-16 | The Upjohn Company | Uso de cis-n-(2-aminocicloalifatica ) benzeno acetamida y benzamida para la fabricacion de anticonvulsionantes. |
| US5374637A (en) * | 1989-03-22 | 1994-12-20 | Janssen Pharmaceutica N.V. | N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives |
| GB9005014D0 (en) * | 1990-03-06 | 1990-05-02 | Janssen Pharmaceutica Nv | N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives |
-
1991
- 1991-04-02 FR FR9103959A patent/FR2674849B1/fr not_active Expired - Fee Related
-
1992
- 1992-03-24 TW TW081102213A patent/TW203038B/zh active
- 1992-03-25 US US07/857,395 patent/US5273983A/en not_active Expired - Fee Related
- 1992-03-31 DE DE69220133T patent/DE69220133T2/de not_active Expired - Fee Related
- 1992-03-31 AT AT92400897T patent/ATE154021T1/de not_active IP Right Cessation
- 1992-03-31 EP EP92400897A patent/EP0507672B1/de not_active Expired - Lifetime
- 1992-03-31 DK DK92400897.2T patent/DK0507672T3/da active
- 1992-03-31 ES ES92400897T patent/ES2104865T3/es not_active Expired - Lifetime
- 1992-04-01 KR KR1019920005467A patent/KR0169497B1/ko not_active IP Right Cessation
- 1992-04-02 JP JP4080595A patent/JP2574591B2/ja not_active Expired - Lifetime
-
1997
- 1997-08-28 GR GR970402214T patent/GR3024575T3/el unknown
-
1998
- 1998-04-08 HK HK98102924A patent/HK1004895A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US5273983A (en) | 1993-12-28 |
| KR920019746A (ko) | 1992-11-19 |
| DE69220133T2 (de) | 1997-09-18 |
| ES2104865T3 (es) | 1997-10-16 |
| JP2574591B2 (ja) | 1997-01-22 |
| FR2674849A1 (fr) | 1992-10-09 |
| GR3024575T3 (en) | 1997-12-31 |
| HK1004895A1 (en) | 1998-12-11 |
| TW203038B (de) | 1993-04-01 |
| EP0507672A1 (de) | 1992-10-07 |
| EP0507672B1 (de) | 1997-06-04 |
| KR0169497B1 (ko) | 1999-01-15 |
| ATE154021T1 (de) | 1997-06-15 |
| FR2674849B1 (fr) | 1994-12-23 |
| DK0507672T3 (da) | 1997-12-15 |
| JPH0597805A (ja) | 1993-04-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69220133D1 (de) | N-Cyclohexyl Benzamide Derivate, ihre Herstellungen und therapeutischen Anwendungen | |
| ATE353870T1 (de) | Dibenzylaminverbindung und deren medizinische verwendung | |
| DK0622361T3 (da) | Heterocykliske forbindelser som bradykininantagonister | |
| DE60140456D1 (de) | Aza heterocyclische derivate und ihre therapeutische verwendung | |
| NO903851L (no) | Fremgangsmaate for fremstilling av n-substituerte-4-pyrimidinaminer og -pyrimidindiaminer, og deres anvendelse som medikamenter. | |
| DE69226729D1 (de) | 2-(Indol-2-yl-carbonylamino)-thiazolderivate, ihre Herstellung und diese enthaltende pharmazeutische Zubereitungen | |
| ES2132284T3 (es) | Derivados de carbamato de 2-(piperidin-4-il, piridin-4-il y tetrahidropiridin-4-il)-benzofurano-7, su preparacion y su uso como inhibidores de acetilcolinesterasa. | |
| DE69120100D1 (de) | Annelierte Thiophen-Derivate, ihre Herstellung und Verwendung | |
| DE59104205D1 (de) | Substituierte Aminoalkylbiphenylderivate, antimykotische Präparate damit und Zwischenprodukte für ihre Herstellung. | |
| ATE377602T1 (de) | Morphinanderivate und ihre medizinische anwendung | |
| DK0734383T3 (da) | Cykliske amidderivater som neurokinin-A-antagonister | |
| DK132188A (da) | Anvendelse af tetrahydrobenz(c,d)indol-6-carboxamider som anxiolytika | |
| DE3673688D1 (de) | Succinimide derivate, herstellung und anwendung. | |
| DK0404359T3 (da) | Dibenzothiazepin-derivater, der er nyttige som antispasmodiske midler | |
| DE68913365D1 (de) | 4-Amino-3-carboxynaphthyridin-Derivate, ihre Herstellung und pharmazeutische Zusammensetzungen. | |
| NO852514L (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive 8-alkyltio-2-piperazino-pyrimido (5,4-d) pyrimidin-derivater. | |
| MX25858A (es) | 3-[1-tiazolidinilbutil-4-piperazinil]-1h-indazolesun procedimiento para su preparacion y su uso comomedicamentos. | |
| ATE169015T1 (de) | Aminobenzoesäure derivate | |
| BR9812939B1 (pt) | compostos derivados ciclo-hexánicos difuncionalizados, processo de preparação de compostos quìmicos, e, composição farmacêutica. | |
| ES2045514T3 (es) | Utilizacion de derivados del cromano para el tratamiento de los estados depresivos. | |
| NZ233618A (en) | Optionally heterocyclic substituted pyrrolidone derivatives and pharmaceutical compositions | |
| IL69931A (en) | N-(6-chloro-pyrazin-2-yl)-4-hydroxy-2h-1,2-benzothiazine-3-carboxamide-1,1-dioxides,their preparation and pharmaceutical compositions containing them | |
| EP1325913A3 (de) | Piperidincarbonsäuramid-Derivate | |
| TH17780A (de) | ||
| DE69002217D1 (de) | Dibenzodioxazecin- und dibenzodioxaazacycloundecin-derivate. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: CHIESI S.A., COURBEVOIE, FR |
|
| 8339 | Ceased/non-payment of the annual fee |