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DE69131404D1 - Enzymatische Synthese löslicher Phosphatide aus Phospholipiden - Google Patents

Enzymatische Synthese löslicher Phosphatide aus Phospholipiden

Info

Publication number
DE69131404D1
DE69131404D1 DE69131404T DE69131404T DE69131404D1 DE 69131404 D1 DE69131404 D1 DE 69131404D1 DE 69131404 T DE69131404 T DE 69131404T DE 69131404 T DE69131404 T DE 69131404T DE 69131404 D1 DE69131404 D1 DE 69131404D1
Authority
DE
Germany
Prior art keywords
salt
phospholipids
divalent
monovalent
divalent cationic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69131404T
Other languages
English (en)
Other versions
DE69131404T2 (de
Inventor
Paul A Tremblay
Frank Marziani
John A F Tino
Frank G Pilkiewicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Publication of DE69131404D1 publication Critical patent/DE69131404D1/de
Application granted granted Critical
Publication of DE69131404T2 publication Critical patent/DE69131404T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6481—Phosphoglycerides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
DE69131404T 1990-04-17 1991-04-16 Enzymatische Synthese löslicher Phosphatide aus Phospholipiden Expired - Lifetime DE69131404T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51328590A 1990-04-17 1990-04-17

Publications (2)

Publication Number Publication Date
DE69131404D1 true DE69131404D1 (de) 1999-08-05
DE69131404T2 DE69131404T2 (de) 1999-11-25

Family

ID=24042616

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69131404T Expired - Lifetime DE69131404T2 (de) 1990-04-17 1991-04-16 Enzymatische Synthese löslicher Phosphatide aus Phospholipiden
DE69123145T Expired - Lifetime DE69123145T2 (de) 1990-04-17 1991-04-16 Enzymatische synthese löslicher phosphatide aus phospholipiden

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69123145T Expired - Lifetime DE69123145T2 (de) 1990-04-17 1991-04-16 Enzymatische synthese löslicher phosphatide aus phospholipiden

Country Status (15)

Country Link
EP (2) EP0727491B1 (de)
JP (1) JP3169132B2 (de)
AT (2) ATE145244T1 (de)
AU (1) AU646458B2 (de)
CA (1) CA2080907C (de)
DE (2) DE69131404T2 (de)
DK (2) DK0727491T3 (de)
ES (2) ES2094811T3 (de)
GR (2) GR3022375T3 (de)
HU (1) HU212928B (de)
IE (1) IE911264A1 (de)
NZ (1) NZ237845A (de)
PT (1) PT97391B (de)
WO (1) WO1991016444A1 (de)
ZA (1) ZA912877B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
DE10142014B4 (de) * 2001-08-28 2004-11-11 Degussa Bioactives Deutschland Gmbh & Co. Kg Verfahren zur Herstellung von Phosphatidylserin
US7368102B2 (en) 2001-12-19 2008-05-06 Nektar Therapeutics Pulmonary delivery of aminoglycosides
US6878532B1 (en) 2003-04-28 2005-04-12 Sioux Biochemical, Inc. Method of producing phosphatidylserine

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1900959A1 (de) * 1969-01-09 1970-08-27 Unilever Nv Verfahren zur Herstellung von Pflanzenphosphatiden mit universeller Emulgierkraft
US4235792A (en) * 1977-04-14 1980-11-25 The Governing Council Of The University Of Toronto Immunological materials
SU831129A1 (ru) * 1979-07-24 1981-05-23 Дальневосточный Государственный Уни-Верситет Способ получени фосфатидилглицерина
US4485045A (en) * 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4587055A (en) * 1982-05-26 1986-05-06 Research Corporation Polymerized vesicles and compounds for their preparation
US4783402A (en) * 1983-04-11 1988-11-08 Meito Sangyo Kabushiki Kaisha Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique
JPS62205788A (ja) * 1986-03-05 1987-09-10 Shoichi Shimizu ホスフアチジルグリセロ−ル又はその誘導体の製造法
WO1989001524A1 (en) * 1987-08-14 1989-02-23 Liposome Technology, Inc. Method of preparing phosphatidylglycerol
US4997761A (en) * 1987-10-06 1991-03-05 Houston Biotechnology Incorporated Phosphatidyl treatment of viral disease
US5183750A (en) * 1989-05-26 1993-02-02 Kao Corporation Processes for the production of phosphatidic acid

Also Published As

Publication number Publication date
AU7699591A (en) 1991-11-11
ES2132780T3 (es) 1999-08-16
GR3031059T3 (en) 1999-12-31
ATE181747T1 (de) 1999-07-15
EP0727491A1 (de) 1996-08-21
JPH05509222A (ja) 1993-12-22
JP3169132B2 (ja) 2001-05-21
DK0727491T3 (da) 1999-11-22
HUT63198A (en) 1993-07-28
DE69123145D1 (en) 1996-12-19
ATE145244T1 (de) 1996-11-15
ZA912877B (en) 1992-12-30
HU212928B (en) 1996-12-30
PT97391A (pt) 1991-12-31
IE911264A1 (en) 1991-10-23
PT97391B (pt) 1999-04-30
AU646458B2 (en) 1994-02-24
EP0528834A1 (de) 1993-03-03
DE69123145T2 (de) 1997-06-12
DK0528834T3 (da) 1997-04-07
EP0727491B1 (de) 1999-06-30
EP0528834A4 (en) 1993-06-02
WO1991016444A1 (en) 1991-10-31
GR3022375T3 (en) 1997-04-30
ES2094811T3 (es) 1997-02-01
CA2080907A1 (en) 1991-10-18
NZ237845A (en) 1993-06-25
DE69131404T2 (de) 1999-11-25
EP0528834B1 (de) 1996-11-13
CA2080907C (en) 2001-08-14
HU9203258D0 (en) 1993-01-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ELAN PHARMACEUTICALS,INC.(N.D.GES.D.STAATES DE, US