[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

DE69127791D1 - Diazabicyclononyl-Derivate als 5-HT3 Rezeptor Antagonisten - Google Patents

Diazabicyclononyl-Derivate als 5-HT3 Rezeptor Antagonisten

Info

Publication number
DE69127791D1
DE69127791D1 DE69127791T DE69127791T DE69127791D1 DE 69127791 D1 DE69127791 D1 DE 69127791D1 DE 69127791 T DE69127791 T DE 69127791T DE 69127791 T DE69127791 T DE 69127791T DE 69127791 D1 DE69127791 D1 DE 69127791D1
Authority
DE
Germany
Prior art keywords
diazabicyclononyl
derivatives
receptor antagonists
antagonists
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69127791T
Other languages
English (en)
Other versions
DE69127791T2 (de
Inventor
Haruhiko Kikuchi
Hiroaki Satoh
Nobuhiro Yahata
Koichiro Hagihara
Toru Hayakawa
Setsuko Mino
Makoto Yanai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nisshin Pharma Inc
Original Assignee
Nisshin Seifun Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nisshin Seifun Group Inc filed Critical Nisshin Seifun Group Inc
Application granted granted Critical
Publication of DE69127791D1 publication Critical patent/DE69127791D1/de
Publication of DE69127791T2 publication Critical patent/DE69127791T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69127791T 1990-07-31 1991-07-24 Diazabicyclononyl-Derivate als 5-HT3 Rezeptor Antagonisten Expired - Lifetime DE69127791T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP20145390 1990-07-31
JP29200090 1990-10-31
JP41854990 1990-12-28
JP8447391 1991-03-26

Publications (2)

Publication Number Publication Date
DE69127791D1 true DE69127791D1 (de) 1997-11-06
DE69127791T2 DE69127791T2 (de) 1998-02-05

Family

ID=27466980

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69127791T Expired - Lifetime DE69127791T2 (de) 1990-07-31 1991-07-24 Diazabicyclononyl-Derivate als 5-HT3 Rezeptor Antagonisten

Country Status (8)

Country Link
US (1) US5187166A (de)
EP (1) EP0469449B1 (de)
KR (1) KR0171407B1 (de)
BR (1) BR9103195A (de)
CA (1) CA2047848C (de)
DE (1) DE69127791T2 (de)
ES (1) ES2108700T3 (de)
TW (1) TW203051B (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9121170D0 (en) * 1991-10-05 1991-11-20 Smithkline Beecham Plc Pharmaceuticals
US5344831A (en) * 1992-01-31 1994-09-06 Nisshin Flour Milling Co., Ltd. Diazabicyclo derivatives
TW251287B (de) * 1993-04-30 1995-07-11 Nissei Co Ltd
JP3235913B2 (ja) * 1993-07-30 2001-12-04 エーザイ株式会社 アミノ安息香酸誘導体
CA2160420A1 (en) * 1994-10-20 1996-04-21 Haruhiko Kikuchi 5-ht4 receptor agonists
US7214686B2 (en) * 1997-06-30 2007-05-08 Targacept, Inc. Pharmaceutical compositions and methods for effecting dopamine release
DE69917907T2 (de) * 1998-07-17 2005-06-30 Agouron Pharmaceuticals, Inc., La Jolla Verbindungen und zusammensetzungen um neurales wachstum und streckung zu stimulieren
WO2000006575A2 (en) * 1998-07-28 2000-02-10 Smithkline Beecham Plc Azabicyclic compounds
GB9819032D0 (en) * 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds IV
JP3585796B2 (ja) 1999-12-17 2004-11-04 新光電気工業株式会社 多層配線基板の製造方法、及び半導体装置
IT1317841B1 (it) * 2000-02-18 2003-07-15 Univ Degli Studi Milano Derivati del 3,9-diazabiciclo(3.3.1)nonano ad attivita' analgesica.
CN100564381C (zh) * 2002-07-05 2009-12-02 塔加西普特公司 N-芳基二氮杂螺环化合物及其制备方法和制备药物的用途
WO2004009775A2 (en) 2002-07-19 2004-01-29 Targacept, Inc. Methods and compositions relating to chimeric nicotinic receptor subunits
US7098331B2 (en) * 2003-03-05 2006-08-29 Targacept, Inc. Arylvinylazacycloalkane compounds and methods of preparation and use thereof
ES2356356T3 (es) * 2003-10-15 2011-04-07 Targacept, Inc. Compuestos azabicíclicos para aliviar el dolor y tratar los trastornos del sistema nervioso central.
EP1736156A4 (de) * 2004-04-15 2010-06-16 Eisai R&D Man Co Ltd Stabilisierte 4-amino-5-chloro-n-¼(1r,3r,5s)-8-methyl-8- azabicyclo¼3.2.1 oct-3-yl -2-¼1-methylbut-2-ynyloxy -benzamid enthaltende zusammensetzung
CN101948462A (zh) * 2004-09-20 2011-01-19 塔加西普特公司 具有烟碱性胆碱能受体活性的氮杂螺烯和氮杂螺烷化合物
US7459469B2 (en) 2004-11-10 2008-12-02 Targacept, Inc. Hydroxybenzoate salts of metanicotine compounds
UA88792C2 (ru) * 2004-11-10 2009-11-25 Таргасепт, Інк. Гидроксибензоатные соли метаникотиновых соединений
WO2007024814A1 (en) * 2005-08-22 2007-03-01 Targacept, Inc. HETEROARYL-SUBSTiTUTED DIAZATRICYCLOALKANES, METHODS FOR ITS PREPARATION AND USE THEREOF
TWI389889B (zh) * 2006-05-09 2013-03-21 Targacept Inc （２ｓ）-（４ｅ）-ｎ-甲基-５-〔３-（５-異丙氧基吡啶）基〕-４-戊烯-２-胺之新穎多晶型
US8017785B2 (en) * 2006-05-09 2011-09-13 Astrazeneca Ab Salt forms of (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin)y1]-4-penten 2-amine
AR062860A1 (es) * 2006-09-15 2008-12-10 Astrazeneca Ab Combinaciones terapeuticas 482
EP2112923A1 (de) * 2007-01-22 2009-11-04 Targacept Inc. Intranasale, orale und sublinguale verabreichung von metanikotin-analogen
CA2695214A1 (en) * 2007-07-31 2009-02-05 Targacept, Inc. Transdermal administration of (2s)-(4e)-n-methyl-5-(3-(5-is0pr0p0xypyridin)yl)-4-penten-2-amine
CN104193741B (zh) * 2007-10-01 2016-08-24 阿尔法梅根有限责任公司 作为α7-烟碱乙酰胆碱受体配体的奎宁环-4-基甲基1H-吲哚-3-甲酸酯衍生物
EP2509982A1 (de) 2009-12-07 2012-10-17 Targacept, Inc. 3,6-diazabicyclo[3.1.1]heptane als neuronale nikotinische acetylcholinreceptorliganden
AR079493A1 (es) 2009-12-21 2012-02-01 Nippon Soda Co Compuesto de amina ciclica y acaricida
AR081721A1 (es) * 2010-02-25 2012-10-17 Nippon Soda Co Compuesto de amina ciclica y acaricida
BR112012029326A2 (pt) 2010-05-20 2017-08-08 Astrazeneca Ab processo para a preparação de animais olefínicas substituídas por arila
US8242276B2 (en) * 2010-06-30 2012-08-14 Hoffmann-La Roche Inc. Methods for the preparation of N-(S)-1-azabicyclo[2.2.2]oct-3-yl-1H-indazole-3-carboxamide hydrochloride salt
CN103159765B (zh) * 2011-12-15 2015-06-24 北京嘉林药业股份有限公司 一种适于产业化的吲地司琼纯化方法
JOP20130213B1 (ar) * 2012-07-17 2021-08-17 Takeda Pharmaceuticals Co معارضات لمستقبلht3-5
EP3166940A4 (de) 2014-07-11 2018-04-25 Alpharmagen, LLC Chinuclidinverbindungen zur modulierung der aktivität des alpha7-nikotinischen acetylcholinrezeptors
US10329306B2 (en) 2014-09-29 2019-06-25 Takeda Pharmaceutical Company Limited Crystalline form of 1-(1-methyl-1H-pyrazol-4-yl)-N-((IR,5S,7S)-9-methyl-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-1H-indole-3-carboxamide

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2970144A (en) * 1957-12-11 1961-01-31 Smith Kline French Lab Esters of 9-alkyl-3-oxa and 3-thia-9-azabicyclo [3. 3. 1]-nonan-7-ol
US4352802A (en) * 1980-06-10 1982-10-05 Beecham Group Limited Bicyclo[3.3.1]nonyl-benzamide
AU1508183A (en) * 1982-06-04 1983-12-08 Beecham Group Plc Benzamide and anilide derivatives of 8-azabicyclo-(3.2.1)- -octane
FR2531083B1 (fr) * 1982-06-29 1986-11-28 Sandoz Sa Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
JPS5936675A (ja) * 1982-07-13 1984-02-28 サンド・アクチエンゲゼルシヤフト 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド
EP0102195A3 (de) * 1982-08-03 1984-04-11 Beecham Group Plc Substituierte Azabicycloalkyl-Derivate mit dopaminantagonistischer Wirkung
FR2557110B1 (fr) * 1983-12-23 1989-11-24 Sandoz Sa Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments
LU85743A1 (fr) * 1984-01-25 1986-08-04 Glaxo Group Ltd Composes heterocycliques
GB8607163D0 (en) * 1986-03-22 1986-04-30 Beecham Group Plc Chemical compound
HU895334D0 (en) * 1986-07-30 1990-01-28 Sandoz Ag Process for the preparation of nasal pharmaceutical compositions
DE3827253A1 (de) * 1987-08-20 1989-03-02 Sandoz Ag Ester und amide von cyclischen carbonsaeuren und cyclischen alkoholen und aminen sowie verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen
GB8829079D0 (en) * 1988-12-13 1989-01-25 Beecham Group Plc Novel compounds

Also Published As

Publication number Publication date
EP0469449A1 (de) 1992-02-05
US5187166A (en) 1993-02-16
EP0469449B1 (de) 1997-10-01
CA2047848A1 (en) 1992-02-01
TW203051B (de) 1993-04-01
BR9103195A (pt) 1992-05-05
KR0171407B1 (ko) 1999-02-01
ES2108700T3 (es) 1998-01-01
CA2047848C (en) 2001-06-05
KR920002596A (ko) 1992-02-28
DE69127791T2 (de) 1998-02-05

Similar Documents

Publication Publication Date Title
DE69127791D1 (de) Diazabicyclononyl-Derivate als 5-HT3 Rezeptor Antagonisten
DE69431604D1 (de) Benzofuranderivate als tachykininantagonisten
DE69207351D1 (de) Fibrinogen-Rezeptor-Antagoniste
DE69325167D1 (de) Kondensierte indol-derivate als 5-ht4-rezeptor-antagonisten
DE69531458D1 (de) Chinolinderivate als tachykinin nk3 rezeptor antagonisten
MX9101311A (es) Antagonistas receptores de fibrinogeno
DE69232003D1 (de) Benzanilidderivate als 5-HT1D-Antagonisten
ATE197300T1 (de) Indolderivate als 5-ht rezeptorantagoniste
DE69605430D1 (de) Chinolin-2-on derivate als serotonin antagonisten
DE69418045D1 (de) Amidderivate als 5ht1d rezeptor antagonisten
DE59712958D1 (de) Substituierte Purinderivate als Vitronectinrezeptor-Antagonisten
MX9100717A (es) Antagonistas de la bradiquinina
FI961628A (fi) Indolijohdannaisia NMDA-antagonisteina
KR960700722A (ko) 피브리노겐 수용체 길항제(Fibrinogen receptor antagonists)
DE69121334D1 (de) DC-89-Derivate als Antitumor-Wirkstoffe
ATE116980T1 (de) Verbesserungen an leukotrien-antagonieten.
FI951798A (fi) Bentsofuraanijohdannaiset 5-HT1-kaltaisina reseptoriantagonisteina
DE69703242D1 (de) Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten
DE69406425D1 (de) Trizyklische heterozyklische verbindungen als 5-ht4 rezeptorantagonisten
NO179550C (no) Tachykinin reseptorantagonister
DE69328701D1 (de) Diazabicycloderivate als 5-HT3-Antagonisten
DE69717449D1 (de) Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten
DE69617010D1 (de) Isazole derivate als fibrinogen-rezeptor-antagonisten
ATE206421T1 (de) Heterocyclisch substituierte piperazonderivate als tachykinin rezeptor antagonisten
ITMI922854A1 (it) Uso degli antagonisti dei recettori 5-ht3

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NISSHIN PHARMA INC., TOKIO/TOKYO, JP