DE69914951D1 - Substituierte tricyclische Verbindungen und deren Verwendung zur Behandlung von sPLA2-bedingten Erkrankungen - Google Patents

Substituierte tricyclische Verbindungen und deren Verwendung zur Behandlung von sPLA2-bedingten Erkrankungen

Info

Publication number: DE69914951D1
Authority: DE; Germany
Prior art keywords: spla2; treatment; related diseases; tricyclic compounds; substituted tricyclic
Prior art date: 1998-04-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69914951T

Other languages

English (en)

Other versions

DE69914951T2 (de

Inventor

Nicholas James Bach

Jolie Anne Bastian

Douglas Wade Beight

Michael Dean Kinnick

Michael John Martinelli

Edward David Mihelich

Morlin, Jr

Daniel Jon Sall

Jason Scott Sawyer

Edward C R Smith

Tulio Suarez

Quiping Wang

Thomas Michael Wilson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eli Lilly and Co

Original Assignee

Eli Lilly and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-17

Filing date

1999-04-16

Publication date

2004-03-25

1999-04-16 Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co

2004-03-25 Publication of DE69914951D1 publication Critical patent/DE69914951D1/de

2004-12-23 Application granted granted Critical

2004-12-23 Publication of DE69914951T2 publication Critical patent/DE69914951T2/de

2019-04-17 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pyridine Compounds (AREA)

DE69914951T 1998-04-17 1999-04-16 Substituierte tricyclische Verbindungen und deren Verwendung zur Behandlung von sPLA2-bedingten Erkrankungen Expired - Fee Related DE69914951T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US6216598A	1998-04-17	1998-04-17
US62165		1998-04-17

Publications (2)

Publication Number	Publication Date
DE69914951D1 true DE69914951D1 (de)	2004-03-25
DE69914951T2 DE69914951T2 (de)	2004-12-23

Family

ID=22040624

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE69914951T Expired - Fee Related DE69914951T2 (de)	1998-04-17	1999-04-16	Substituierte tricyclische Verbindungen und deren Verwendung zur Behandlung von sPLA2-bedingten Erkrankungen
DE69912670T Expired - Fee Related DE69912670T2 (de)	1998-04-17	1999-04-16	Substituierte tricyclische Verbindungen und deren Verwendung zur Behandlung von sPLA2-bedingten Erkrankungen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE69912670T Expired - Fee Related DE69912670T2 (de)	1998-04-17	1999-04-16	Substituierte tricyclische Verbindungen und deren Verwendung zur Behandlung von sPLA2-bedingten Erkrankungen

Country Status (27)

Country	Link
EP (2)	EP0950661B1 (de)
JP (1)	JP4435325B2 (de)
KR (1)	KR19990083234A (de)
CN (1)	CN1235968A (de)
AR (1)	AR018185A1 (de)
AT (2)	ATE259818T1 (de)
AU (1)	AU757454B2 (de)
BR (1)	BR9901275A (de)
CA (1)	CA2269256A1 (de)
CO (1)	CO5080728A1 (de)
CZ (1)	CZ137199A3 (de)
DE (2)	DE69914951T2 (de)
EA (1)	EA003129B1 (de)
ES (2)	ES2210979T3 (de)
HU (1)	HUP9901219A1 (de)
ID (1)	ID23219A (de)
IL (1)	IL129484A0 (de)
NO (1)	NO991823L (de)
NZ (1)	NZ335252A (de)
PE (1)	PE20000472A1 (de)
PL (1)	PL332564A1 (de)
SG (1)	SG106035A1 (de)
SV (1)	SV1999000052A (de)
TR (1)	TR199900842A2 (de)
TW (1)	TW555760B (de)
YU (1)	YU19099A (de)
ZA (1)	ZA992773B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2301586A1 (en) *	1997-08-28	1999-03-04	William Louis Macias	Method for treatment of non-rheumatoid arthritis
AU2001244635A1 (en) *	2000-03-30	2001-10-15	Yamanouchi Pharmaceutical Co..Ltd.	Hydrazide derivatives
AU2001272915A1 (en) *	2000-07-14	2002-01-30	Eli Lilly And Company	Method for treating sepsis
EP1349836B1 (de) *	2000-12-18	2006-06-14	Eli Lilly And Company	Tetracyclische derivate als spla2 inhibitoren
DE60218155D1 (de)	2001-03-28	2007-03-29	Lilly Co Eli	Substituierte carbazole als inhibitoren von spla2
US7160909B2 (en)	2001-08-09	2007-01-09	Eli Lilly And Company	Cyclopenta[b]indole derivatives as sPLA2 inhibitors
ATE312817T1 (de)	2001-08-09	2005-12-15	Lilly Co Eli	Cyclohept'bö indolderivate als spla2-inhibitoren
US6992100B2 (en)	2001-12-06	2006-01-31	Eli Lilly And Company	sPLA2 inhibitors
JP2008518917A (ja)	2004-11-01	2008-06-05	ワイス	Ｃｎｓ薬剤としての置換インドリジンおよび誘導体
BRPI0907122B8 (pt)	2008-01-11	2021-05-25	Albany Molecular Res Inc	compostos de piridoindóis (1-azinona) substituídos, composição farmacêutica compreendendo os referidos compostos, e usos dos mesmos
WO2011003021A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
US8993765B2 (en)	2010-12-21	2015-03-31	Albany Molecular Research, Inc.	Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
PL2697223T3 (pl) *	2011-04-14	2017-01-31	Actelion Pharmaceuticals Ltd.	Pochodne kwasu 7-(heteroaryloamino)-6,7,8,9-tetrahydropirydo[1,2-a]indolooctowego i ich zastosowanie jako modulatorów receptora prostaglandyny D2
SI2825541T1 (sl)	2012-03-16	2016-10-28	Vitae Pharmaceuticals, Inc.	Modulatorji jetrnega receptorja X
BR112014022780A8 (pt)	2012-03-16	2021-06-15	Vitae Pharmaceuticals Inc	composto modulador de receptor de fígado x, composição farmacêutica que o compreende e seu uso

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3979391A (en) *	1972-11-22	1976-09-07	Sterling Drug Inc.	1,2,3,4-Tetrahydrocarbazoles
PT95692A (pt) *	1989-10-27	1991-09-13	American Home Prod	Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
IL109311A0 (en) *	1993-04-16	1994-07-31	Lilly Co Eli	1H-indole-3-acetamide sPla2 inhibitors
IL109309A (en) *	1993-04-16	2000-06-29	Lilly Co Eli	1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
BR9508298A (pt) *	1994-07-21	1998-11-03	Shionogi & Co	Inibidores de indolizina de spla2
WO1997021664A1 (en) *	1995-12-13	1997-06-19	Eli Lilly And Company	NAPHTHYL ACETAMIDES AS sPLA2 INHIBITORS
EA003992B1 (ru) *	1996-10-30	2003-12-25	Эли Лилли Энд Компани	Замещенные трициклические соединения
AU9664198A (en) *	1997-09-26	1999-04-23	Eli Lilly And Company	Method for the treatment of cystic fibrosis
EP1043991A4 (de) *	1997-11-14	2005-02-02	Lilly Co Eli	Behandlung der alzheimer-erkrankung

1999
- 1999-04-15 ID IDP990342D patent/ID23219A/id unknown
- 1999-04-15 IL IL12948499A patent/IL129484A0/xx unknown
- 1999-04-16 AR ARP990101769A patent/AR018185A1/es not_active Application Discontinuation
- 1999-04-16 BR BR9901275-8A patent/BR9901275A/pt not_active IP Right Cessation
- 1999-04-16 CN CN99108097A patent/CN1235968A/zh active Pending
- 1999-04-16 NZ NZ335252A patent/NZ335252A/xx unknown
- 1999-04-16 DE DE69914951T patent/DE69914951T2/de not_active Expired - Fee Related
- 1999-04-16 HU HU9901219A patent/HUP9901219A1/hu unknown
- 1999-04-16 AU AU23818/99A patent/AU757454B2/en not_active Ceased
- 1999-04-16 AT AT01203116T patent/ATE259818T1/de not_active IP Right Cessation
- 1999-04-16 YU YU19099A patent/YU19099A/sh unknown
- 1999-04-16 CZ CZ991371A patent/CZ137199A3/cs unknown
- 1999-04-16 SV SV1999000052A patent/SV1999000052A/es not_active Application Discontinuation
- 1999-04-16 PL PL99332564A patent/PL332564A1/xx not_active Application Discontinuation
- 1999-04-16 EA EA199900304A patent/EA003129B1/ru not_active IP Right Cessation
- 1999-04-16 CO CO99022891A patent/CO5080728A1/es unknown
- 1999-04-16 TR TR1999/00842A patent/TR199900842A2/xx unknown
- 1999-04-16 NO NO991823A patent/NO991823L/no not_active Application Discontinuation
- 1999-04-16 DE DE69912670T patent/DE69912670T2/de not_active Expired - Fee Related
- 1999-04-16 CA CA002269256A patent/CA2269256A1/en not_active Abandoned
- 1999-04-16 AT AT99302969T patent/ATE254128T1/de not_active IP Right Cessation
- 1999-04-16 PE PE1999000321A patent/PE20000472A1/es not_active Application Discontinuation
- 1999-04-16 EP EP99302969A patent/EP0950661B1/de not_active Expired - Lifetime
- 1999-04-16 ES ES99302969T patent/ES2210979T3/es not_active Expired - Lifetime
- 1999-04-16 JP JP10965699A patent/JP4435325B2/ja not_active Expired - Fee Related
- 1999-04-16 ES ES01203116T patent/ES2213668T3/es not_active Expired - Lifetime
- 1999-04-16 SG SG9901844A patent/SG106035A1/en unknown
- 1999-04-16 TW TW088106131A patent/TW555760B/zh not_active IP Right Cessation
- 1999-04-16 EP EP01203116A patent/EP1156050B1/de not_active Expired - Lifetime
- 1999-04-16 ZA ZA9902773A patent/ZA992773B/xx unknown
- 1999-04-16 KR KR1019990013439A patent/KR19990083234A/ko not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP0950661A1 (de)	1999-10-20
AU757454B2 (en)	2003-02-20
CO5080728A1 (es)	2001-09-25
SV1999000052A (es)	2000-03-14
NZ335252A (en)	2000-11-24
ATE254128T1 (de)	2003-11-15
ES2213668T3 (es)	2004-09-01
CA2269256A1 (en)	1999-10-17
DE69912670D1 (de)	2003-12-18
TR199900842A2 (xx)	2000-09-21
EA199900304A3 (ru)	2000-04-24
TW555760B (en)	2003-10-01
KR19990083234A (ko)	1999-11-25
JP4435325B2 (ja)	2010-03-17
DE69912670T2 (de)	2004-08-12
ES2210979T3 (es)	2004-07-01
EP0950661B1 (de)	2003-11-12
JPH11322745A (ja)	1999-11-24
PL332564A1 (en)	1999-10-25
PE20000472A1 (es)	2000-06-02
EP1156050A2 (de)	2001-11-21
AR018185A1 (es)	2001-10-31
HUP9901219A1 (hu)	2000-08-28
EP1156050A3 (de)	2001-11-28
IL129484A0 (en)	2000-02-29
NO991823D0 (no)	1999-04-16
CN1235968A (zh)	1999-11-24
EA003129B1 (ru)	2003-02-27
ID23219A (id)	2000-03-30
AU2381899A (en)	1999-10-28
CZ137199A3 (cs)	1999-11-17
EA199900304A2 (ru)	1999-10-28
NO991823L (no)	1999-10-18
ZA992773B (en)	2002-07-16
YU19099A (sh)	2001-09-28
SG106035A1 (en)	2004-09-30
DE69914951T2 (de)	2004-12-23
HU9901219D0 (en)	1999-06-28
ATE259818T1 (de)	2004-03-15
EP1156050B1 (de)	2004-02-18
BR9901275A (pt)	2000-05-02

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Legal Events

Date	Code	Title	Description
2007-04-12	8364	No opposition during term of opposition
2010-02-18	8339	Ceased/non-payment of the annual fee