DE69820481D1 - Verfahren zur herstellung von cholecalciferol-derivaten und zwischenverbindungen - Google Patents

Verfahren zur herstellung von cholecalciferol-derivaten und zwischenverbindungen

Info

Publication number: DE69820481D1
Authority: DE; Germany
Prior art keywords: formula; hydroxyl protecting; intermediate compounds; cholecalciferol derivatives; producing
Prior art date: 1998-01-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69820481T

Other languages

English (en)

Other versions

DE69820481T2 (de

Inventor

Andrzej Kutner

Micha Dollar M D Chodynski

Wies Dollar M D Aw Szelejewski

Ma Dollar M D Gorz Odrzywolska

Hanna Fitak

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Instytut Farmaceutiyczny

Original Assignee

Instytut Farmaceutiyczny

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-01-14

Filing date

1998-12-29

Publication date

2004-01-22

1998-12-29 Application filed by Instytut Farmaceutiyczny filed Critical Instytut Farmaceutiyczny

2004-01-22 Publication of DE69820481D1 publication Critical patent/DE69820481D1/de

2004-10-14 Application granted granted Critical

2004-10-14 Publication of DE69820481T2 publication Critical patent/DE69820481T2/de

2018-12-30 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 title abstract 3
150000003704 vitamin D3 derivatives Chemical class 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 2
BJYLYJCXYAMOFT-RRXOBRNQSA-N (1r,3s,5z)-5-[(2e)-2-[(1r,3as,7ar)-1-[(2r)-5-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCC(O)C(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C BJYLYJCXYAMOFT-RRXOBRNQSA-N 0.000 abstract 1
REYZXWIIUPKFTI-UHFFFAOYSA-N 2-propan-2-yloxirane Chemical compound CC(C)C1CO1 REYZXWIIUPKFTI-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
239000000010 aprotic solvent Substances 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
150000007530 organic bases Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)

DE69820481T 1998-01-14 1998-12-29 Verfahren zur herstellung von cholecalciferol-derivaten und zwischenverbindungen Expired - Lifetime DE69820481T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
PL98324274A PL188697B1 (pl)	1998-01-14	1998-01-14	Sposób otrzymywania pochodnych cholekalcyferolu oraz nowe związki pośrednie
PL32427498		1998-01-14
PCT/PL1998/000051 WO1999036400A1 (en)	1998-01-14	1998-12-29	Method of preparation of cholecalciferol derivatives and new intermediate compounds

Publications (2)

Publication Number	Publication Date
DE69820481D1 true DE69820481D1 (de)	2004-01-22
DE69820481T2 DE69820481T2 (de)	2004-10-14

Family

ID=20071356

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69820481T Expired - Lifetime DE69820481T2 (de)	1998-01-14	1998-12-29	Verfahren zur herstellung von cholecalciferol-derivaten und zwischenverbindungen

Country Status (6)

Country	Link
EP (1)	EP1047671B1 (de)
AT (1)	ATE256108T1 (de)
DE (1)	DE69820481T2 (de)
ES (1)	ES2214756T3 (de)
PL (1)	PL188697B1 (de)
WO (1)	WO1999036400A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL208188B1 (pl) *	2007-07-12	2011-03-31	Inst Farmaceutyczny	Sposób otrzymywania kalcypotriolu
AU2003262179A1 (en)	2002-04-11	2003-10-27	Instytut Farmaceutyczny	Preparation of 24 alkyl analogs of cholecalciferol and non-racemic compounds
PL216135B1 (pl)	2009-08-07	2014-03-31	Inst Farmaceutyczny	Nowe syntony i ich zastosowanie do otrzymywania pochodnych 19-nor witamin D
CN103122009B (zh) *	2013-01-09	2015-11-25	江苏吉贝尔药业股份有限公司	两种用于合成他卡西醇支链的重要中间体化合物
CN103012463B (zh) *	2013-01-17	2016-02-10	南京理工大学	(s)-3-甲基-2-(叔丁基二甲基硅氧基)-1-溴丁烷的合成方法
CN105439927A (zh) *	2014-09-29	2016-03-30	南京理工大学	一种对映选择性合成他卡西醇的制备方法
CN104496871B (zh) *	2014-12-22	2016-03-09	上海皓元生物医药科技有限公司	一种他卡西醇的制备方法
CN108017567A (zh) *	2017-12-30	2018-05-11	南京海融制药有限公司	一种他卡西醇的异构体杂质py2及其制备方法和用途
CN108663441B (zh) *	2017-12-30	2021-03-30	南京海融制药有限公司	一种他卡西醇软膏剂有关物质检查方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL77668A (en) *	1986-01-21	1989-03-31	Teva Pharma	Production of cholecalciferol derivatives and novel intermediates used therefor
ATE124416T1 (de) *	1988-07-05	1995-07-15	Kuraray Co	Steroid-verbindungen.

1998
- 1998-01-14 PL PL98324274A patent/PL188697B1/pl unknown
- 1998-12-29 AT AT98960122T patent/ATE256108T1/de not_active IP Right Cessation
- 1998-12-29 DE DE69820481T patent/DE69820481T2/de not_active Expired - Lifetime
- 1998-12-29 EP EP98960122A patent/EP1047671B1/de not_active Expired - Lifetime
- 1998-12-29 WO PCT/PL1998/000051 patent/WO1999036400A1/en active IP Right Grant
- 1998-12-29 ES ES98960122T patent/ES2214756T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
PL188697B1 (pl)	2005-03-31
WO1999036400A1 (en)	1999-07-22
ES2214756T3 (es)	2004-09-16
DE69820481T2 (de)	2004-10-14
EP1047671B1 (de)	2003-12-10
EP1047671A1 (de)	2000-11-02
PL324274A1 (en)	1999-07-19
ATE256108T1 (de)	2003-12-15

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Legal Events

Date	Code	Title	Description
2005-01-05	8364	No opposition during term of opposition
2009-05-14	8328	Change in the person/name/address of the agent	Representative=s name: KOENIG, B., DIPL.-PHYS. DR.RER.NAT., PAT.-ANW., 80