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DE69634122D1 - Heterocyclische amidverbindungen und deren medizinische verwendung - Google Patents

Heterocyclische amidverbindungen und deren medizinische verwendung

Info

Publication number
DE69634122D1
DE69634122D1 DE69634122T DE69634122T DE69634122D1 DE 69634122 D1 DE69634122 D1 DE 69634122D1 DE 69634122 T DE69634122 T DE 69634122T DE 69634122 T DE69634122 T DE 69634122T DE 69634122 D1 DE69634122 D1 DE 69634122D1
Authority
DE
Germany
Prior art keywords
medicine
amide compounds
heterocyclic amide
heterocyclic
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69634122T
Other languages
English (en)
Inventor
Fumihiko-The Green Cr Akahoshi
Takuya-The Green Cro Yoshimura
Masahiro-The Green Cross C Eda
Atsuyuki-The Green Cr Ashimori
Hajime-The Green Cros Fukuyama
Masahide-The Green Cr Nakajima
Teruaki-The Green Cross Imada
Hideki Okunishi
Mizuo Miyazaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Pharma Corp
Original Assignee
Mitsubishi Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp
Application granted granted Critical
Publication of DE69634122D1 publication Critical patent/DE69634122D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/96—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69634122T 1995-04-27 1996-04-26 Heterocyclische amidverbindungen und deren medizinische verwendung Expired - Lifetime DE69634122D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10431495 1995-04-27
PCT/JP1996/001171 WO1996033974A1 (fr) 1995-04-27 1996-04-26 Composes heterocycliques amides et leur utilisation medicinale

Publications (1)

Publication Number Publication Date
DE69634122D1 true DE69634122D1 (de) 2005-02-03

Family

ID=14377479

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69634122T Expired - Lifetime DE69634122D1 (de) 1995-04-27 1996-04-26 Heterocyclische amidverbindungen und deren medizinische verwendung

Country Status (7)

Country Link
US (1) US5948785A (de)
EP (1) EP0826671B1 (de)
KR (1) KR100400639B1 (de)
CN (2) CN1131210C (de)
CA (1) CA2219364A1 (de)
DE (1) DE69634122D1 (de)
WO (1) WO1996033974A1 (de)

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US6194435B1 (en) 1996-10-11 2001-02-27 Cor Therapeutics, Inc. Lactams as selective factor Xa inhibitors
US6063794A (en) 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
US6080738A (en) * 1996-10-25 2000-06-27 Yoshitomi Pharmaceuticals Industries, Ltd. Heterocyclic amide compounds and medicinal uses thereof
JP2001508796A (ja) * 1997-01-22 2001-07-03 メルク エンド カンパニー インコーポレーテッド トロンビン阻害薬
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US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6333321B1 (en) 1997-08-11 2001-12-25 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6218382B1 (en) 1997-08-11 2001-04-17 Cor Therapeutics, Inc Selective factor Xa inhibitors
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US6528514B1 (en) 1998-03-11 2003-03-04 Welfide Corporation IgE antibody production inhibitors and autoimmune diseases inhibitors
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US20050267148A1 (en) * 1998-07-15 2005-12-01 Teijin Limited Benzimidazole derivative
KR20010074838A (ko) * 1998-08-20 2001-08-09 요시다 쇼지 안 순환 장해의 예방 또는 치료제
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US6458952B1 (en) 1999-05-19 2002-10-01 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6750342B1 (en) 1999-05-19 2004-06-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US7015230B1 (en) 1999-05-19 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6867217B1 (en) 1999-05-19 2005-03-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
EP1178970A1 (de) * 1999-05-19 2002-02-13 Pharmacia Corporation Substituierte polyzyklisch aryl und heteroaryl pyrimidinonen brauchbar als gerinnungshemmende mittel
US6653316B1 (en) 1999-05-19 2003-11-25 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
JP4556371B2 (ja) * 1999-09-30 2010-10-06 三菱化学株式会社 アシルスルホンアミド誘導体
AU7954900A (en) * 1999-10-25 2001-05-08 Senju Pharmaceutical Co., Ltd. Tension-relieving agents for ciliary muscle
CN1335778A (zh) * 1999-11-01 2002-02-13 三得利株式会社 含有糜蛋白酶抑制物质的血管脂质沉积抑制剂
KR20010109356A (ko) 2000-02-22 2001-12-08 도리이 신이치로 키마제 억제제를 유효성분으로 함유하는 피부염의 예방또는 치료제
CN1245978C (zh) 2000-02-22 2006-03-22 第一阿斯比奥制药株式会社 含有胃促胰酶抑制剂作为活性成分的预防和治疗各种与嗜酸性粒细胞增多有关的疾病的药物
WO2001062292A1 (fr) 2000-02-22 2001-08-30 Suntory Limited Medicaments preventifs ou therapeutiques pour traiter la fibrose et contenant des inhibiteurs de chymase comme ingredients actifs
US6852761B2 (en) 2000-03-13 2005-02-08 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
US6875791B2 (en) 2000-04-05 2005-04-05 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade
JP2004505013A (ja) 2000-04-05 2004-02-19 ファルマシア・コーポレーション 凝固カスケードを選択的に阻害するのに有用な多環式アリール及びヘテロアリール置換４−ピリドン類
WO2001079155A2 (en) 2000-04-17 2001-10-25 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade
WO2001087851A1 (en) * 2000-05-18 2001-11-22 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
KR100850728B1 (ko) 2000-06-12 2008-08-06 에자이 알앤드디 매니지먼트 가부시키가이샤 1,2-디하이드로피리딘 화합물, 그의 제조 방법 및 그의 용도
EP1301490A2 (de) * 2000-07-18 2003-04-16 Neurogen Corporation 5-substituierte 2-aryl-4-pyrimidinone
US7119094B1 (en) 2000-11-20 2006-10-10 Warner-Lambert Company Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade
US7015223B1 (en) 2000-11-20 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
EP1351686A2 (de) 2000-11-20 2003-10-15 Pharmacia Corporation Substituierte polycyclische aryl- und heteroarylpyridine für die selektive hemmung der koagulationskaskade
US20040063936A1 (en) * 2000-12-26 2004-04-01 Tsuneyuki Sugiura Pyrimidine derivatives and process for preparing the same
WO2003007964A1 (fr) * 2001-07-18 2003-01-30 Nippon Kayaku Kabushiki Kaisha Remede ou agent preventif de cardiopathie ou d'anevrysme contenant un compose d'inhibition de la chymase
CA2462305A1 (en) 2001-10-03 2003-04-10 Michael S. South 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade
EP1432687A2 (de) 2001-10-03 2004-06-30 Pharmacia Corporation Substitutierte fünfgliedrige polyzyclischen vebindungen für die selektive hemmung der koagulationskaskade
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
EP1553090A4 (de) * 2002-06-14 2006-07-05 Ajinomoto Kk Verfahren zur herstellung einer pyrimidinverbindung
CZ20041239A3 (cs) * 2002-07-30 2006-04-12 Société de Conseil de Recherches et d´Applications Scientifique, S.A.S Pouzití inhibitoru chymázy pro výrobu léciva pro prevenci a/nebo lécbu selhání arteriovenózního stepu
US20050176966A1 (en) * 2003-04-11 2005-08-11 Ajinomoto Co., Inc. Process for the preparation of pyrimidine derivative, intermediate therefor and process for the preparation thereof
PE20050159A1 (es) * 2003-05-27 2005-04-19 Vertex Pharma Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa
US20070032466A1 (en) * 2003-08-22 2007-02-08 Teijin Pharma Limited Drug containing chymase inhibitor as the active ingredient
US7358368B2 (en) 2003-11-04 2008-04-15 Ajinomoto Co., Inc. Azlactone compound and method for preparation thereof
EP1695967A1 (de) * 2003-11-04 2006-08-30 Ajinomoto Co., Inc. Verfahren zur herstellung von pyrimidinderivaten und zwischenprodukten
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
EP1833794B1 (de) 2004-11-24 2012-02-01 Vertex Pharmceuticals Incorporated 3-[2-(3-azylamino-2-oxo-2h-pyridin-1-yl)acetylamino]-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren
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JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
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HU224731B1 (en) * 1994-03-31 2006-01-30 Vertex Pharma Pyrimidinyl derivatives as interleukin inhibitors and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CN1188472A (zh) 1998-07-22
CN1131210C (zh) 2003-12-17
CN1188401C (zh) 2005-02-09
WO1996033974A1 (fr) 1996-10-31
EP0826671A4 (de) 1998-09-02
EP0826671A1 (de) 1998-03-04
US5948785A (en) 1999-09-07
KR100400639B1 (ko) 2003-12-31
CA2219364A1 (en) 1996-10-31
KR19990007998A (ko) 1999-01-25
EP0826671B1 (de) 2004-12-29
CN1304931A (zh) 2001-07-25

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