DE69621831D1 - Piperazinderivative als tachykinin antagonisten - Google Patents
Piperazinderivative als tachykinin antagonistenInfo
- Publication number
- DE69621831D1 DE69621831D1 DE69621831T DE69621831T DE69621831D1 DE 69621831 D1 DE69621831 D1 DE 69621831D1 DE 69621831 T DE69621831 T DE 69621831T DE 69621831 T DE69621831 T DE 69621831T DE 69621831 D1 DE69621831 D1 DE 69621831D1
- Authority
- DE
- Germany
- Prior art keywords
- piperazine derivatives
- tachykinin antagonists
- pct
- date jun
- sec
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9525841.4A GB9525841D0 (en) | 1995-12-18 | 1995-12-18 | Piperazine derivatives |
| AUPN9891A AUPN989196A0 (en) | 1996-05-16 | 1996-05-16 | Piperazine derivatives |
| AUPO2683A AUPO268396A0 (en) | 1996-09-30 | 1996-09-30 | Piperazine derivatives |
| PCT/JP1996/003641 WO1997022597A1 (en) | 1995-12-18 | 1996-12-12 | Piperazine derivatives as tachykinin antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69621831D1 true DE69621831D1 (de) | 2002-07-18 |
| DE69621831T2 DE69621831T2 (de) | 2003-01-02 |
Family
ID=27157927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69621831T Expired - Fee Related DE69621831T2 (de) | 1995-12-18 | 1996-12-12 | Piperazinderivative als tachykinin antagonisten |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6087357A (de) |
| EP (1) | EP0873320B1 (de) |
| JP (1) | JP2000502100A (de) |
| KR (1) | KR20000064415A (de) |
| CN (1) | CN1209125A (de) |
| AT (1) | ATE219064T1 (de) |
| AU (1) | AU714931B2 (de) |
| CA (1) | CA2240835A1 (de) |
| DE (1) | DE69621831T2 (de) |
| ES (1) | ES2175161T3 (de) |
| HU (1) | HUP9901037A3 (de) |
| IL (1) | IL124674A0 (de) |
| WO (1) | WO1997022597A1 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2263173T3 (es) * | 1996-10-30 | 2006-12-01 | Schering Corporation | Derivados piperazino como antagonistas de neurokinina. |
| US5968929A (en) * | 1996-10-30 | 1999-10-19 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
| US5783579A (en) * | 1996-12-20 | 1998-07-21 | Schering Corporation | Spiro-substituted azacyclic-substituted piperazino derivatives as neurokinin antagonists |
| AUPO735997A0 (en) * | 1997-06-17 | 1997-07-10 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine derivatives |
| AU743723B2 (en) * | 1997-06-17 | 2002-01-31 | Astellas Pharma Inc. | Aroyl-piperazine derivatives, their preparation and their use as tachykinin antagonists |
| CZ20012130A3 (cs) * | 1998-12-14 | 2001-10-17 | Fujisawa Pharmaceutical Co., Ltd. | Piperazinový derivát, způsob jeho výroby a pouľití |
| US6331541B1 (en) | 1998-12-18 | 2001-12-18 | Soo S. Ko | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| US6525069B1 (en) | 1998-12-18 | 2003-02-25 | Bristol-Myers Squibb Pharma Co. | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| EP1158980B1 (de) | 1998-12-18 | 2005-08-24 | Bristol-Myers Squibb Pharma Company | N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren |
| CA2348923A1 (en) | 1998-12-18 | 2000-06-22 | Dean A. Wacker | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| CA2347912A1 (en) | 1998-12-18 | 2000-06-22 | Soo S. Ko | Heterocyclic piperidines as modulators of chemokine receptor activity |
| CA2347769A1 (en) | 1998-12-18 | 2000-06-22 | Dean A. Wacker | 2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity |
| JP2002532427A (ja) | 1998-12-18 | 2002-10-02 | デュポン ファーマシューティカルズ カンパニー | ケモカイン受容体活性のモジュレーターとしてのｎ−ウレイドアルキルピペリジン |
| US6897234B2 (en) | 1999-12-17 | 2005-05-24 | Bristol-Myers Squibb Pharma Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| TW591025B (en) | 2000-06-13 | 2004-06-11 | Fujisawa Pharmaceutical Co | Production of the piperazine derivative |
| AR034257A1 (es) | 2000-06-30 | 2004-02-18 | Du Pont Pharm Co | Compuesto ureido, composicion farmaceutica que lo comprende y metodo para modular la actividad del receptor de quimiocinas |
| DE10036818A1 (de) | 2000-07-28 | 2002-02-07 | Solvay Pharm Gmbh | Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten |
| UA75425C2 (en) | 2001-07-09 | 2006-04-17 | Piperazine oxime derivatives with antagonistic activity to nk-1 receptor, use thereof, a pharmaceutical composition based thereon, a method for producing and a method for producing intermediary compounds | |
| US7718802B2 (en) | 2001-08-10 | 2010-05-18 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| US7354923B2 (en) * | 2001-08-10 | 2008-04-08 | Palatin Technologies, Inc. | Piperazine melanocortin-specific compounds |
| US7456184B2 (en) * | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| US7655658B2 (en) * | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
| US7732451B2 (en) * | 2001-08-10 | 2010-06-08 | Palatin Technologies, Inc. | Naphthalene-containing melanocortin receptor-specific small molecule |
| WO2003013571A1 (en) * | 2001-08-10 | 2003-02-20 | Palatin Technologies, Inc. | Peptidomimetics of biologically active metallopeptides |
| UA77515C2 (en) | 2002-04-04 | 2006-12-15 | Diazabicyclo alkane derivatives possessing neuroldnin-nk1 receptor antagonistic activity | |
| US7727991B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific single acyl piperazine compounds |
| US7968548B2 (en) | 2003-05-01 | 2011-06-28 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine compounds with diamine groups |
| US7727990B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine and keto-piperazine compounds |
| US7709484B1 (en) | 2004-04-19 | 2010-05-04 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| CN102558075A (zh) | 2004-12-03 | 2012-07-11 | 先灵公司 | 作为cb1拮抗剂的取代哌嗪 |
| EP1909797A4 (de) * | 2005-08-02 | 2013-02-27 | Neurogen Corp | Dipiperazinyl-ketone und damit verwandte analoge |
| MX2008009354A (es) | 2006-01-18 | 2008-09-30 | Schering Corp | Moduladores de receptores cannabinoides. |
| US7834017B2 (en) | 2006-08-11 | 2010-11-16 | Palatin Technologies, Inc. | Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents |
| EP2117538A1 (de) | 2007-01-24 | 2009-11-18 | Glaxo Group Limited | Pharmazeutische zusammensetzungen mit 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-) |
| EP2170846A2 (de) | 2007-06-28 | 2010-04-07 | Intervet International BV | Substituierte piperazine als cb1-antagonisten |
| WO2011112263A1 (en) | 2010-03-11 | 2011-09-15 | New York University | AMIDO COMPOUNDS AS RORγt MODULATORS AND USES THEREOF |
| WO2013068371A1 (en) | 2011-11-08 | 2013-05-16 | Intervet International B.V. | Soft chewable dosage form compositions of cannabinoid receptor type 1 (cb-1) antagonists |
| JP6759110B2 (ja) * | 2014-05-28 | 2020-09-23 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | 新規な化合物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3935214A (en) * | 1968-07-26 | 1976-01-27 | Donau-Pharmazie Gesellschaft M.B.H. | 2-or 3 keto-3-or-2-phenyl-1,4-disubstituted piperazines |
| US5164388A (en) * | 1988-10-19 | 1992-11-17 | Abbott Laboratories | Heterocyclic peptide renin inhibitors |
| US5238938A (en) * | 1989-02-10 | 1993-08-24 | Otsuka Pharmaceutical Co., Ltd. | Indole derivatives |
| FR2676055B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| GB9222486D0 (en) * | 1992-10-26 | 1992-12-09 | Merck Sharp & Dohme | Therapeutic agents |
| US5344830A (en) * | 1992-12-10 | 1994-09-06 | Merck & Co., Inc. | N,N-diacylpiperazine tachykinin antagonists |
| US5883098A (en) * | 1993-11-29 | 1999-03-16 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine derivatives |
| IL111730A (en) * | 1993-11-29 | 1998-12-06 | Fujisawa Pharmaceutical Co | Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them |
| ES2164235T3 (es) * | 1995-03-15 | 2002-02-16 | Aventis Pharma Inc | Derivados de piperazinona sustituidos por un heterociclo que actuan como antagonistas del receptor de taquiquinina. |
| NZ306022A (en) * | 1995-04-13 | 1998-09-24 | Hoechst Marion Roussel Inc | Phenyl, naphthyl or indolyl substituted piperazine derivatives and medicaments |
| NZ307625A (en) * | 1995-05-25 | 1999-02-25 | Fujisawa Pharmaceutical Co | 1-benzoyl-2-(indolyl-3-alkyl)-piperazine derivatives as neurokinin receptor antagonists |
-
1996
- 1996-12-12 AT AT96941859T patent/ATE219064T1/de not_active IP Right Cessation
- 1996-12-12 KR KR1019980704511A patent/KR20000064415A/ko not_active Application Discontinuation
- 1996-12-12 IL IL12467496A patent/IL124674A0/xx unknown
- 1996-12-12 DE DE69621831T patent/DE69621831T2/de not_active Expired - Fee Related
- 1996-12-12 EP EP96941859A patent/EP0873320B1/de not_active Expired - Lifetime
- 1996-12-12 CA CA002240835A patent/CA2240835A1/en not_active Abandoned
- 1996-12-12 HU HU9901037A patent/HUP9901037A3/hu unknown
- 1996-12-12 US US09/091,269 patent/US6087357A/en not_active Expired - Fee Related
- 1996-12-12 ES ES96941859T patent/ES2175161T3/es not_active Expired - Lifetime
- 1996-12-12 JP JP09522654A patent/JP2000502100A/ja not_active Ceased
- 1996-12-12 AU AU11106/97A patent/AU714931B2/en not_active Ceased
- 1996-12-12 WO PCT/JP1996/003641 patent/WO1997022597A1/en active IP Right Grant
- 1996-12-12 CN CN96199963A patent/CN1209125A/zh active Pending
-
2001
- 2001-07-09 US US09/899,942 patent/US20020010182A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9901037A3 (en) | 2001-11-28 |
| WO1997022597A1 (en) | 1997-06-26 |
| EP0873320A1 (de) | 1998-10-28 |
| CA2240835A1 (en) | 1997-06-26 |
| EP0873320B1 (de) | 2002-06-12 |
| US6087357A (en) | 2000-07-11 |
| ES2175161T3 (es) | 2002-11-16 |
| AU1110697A (en) | 1997-07-14 |
| CN1209125A (zh) | 1999-02-24 |
| IL124674A0 (en) | 1998-12-06 |
| KR20000064415A (ko) | 2000-11-06 |
| US20020010182A1 (en) | 2002-01-24 |
| DE69621831T2 (de) | 2003-01-02 |
| AU714931B2 (en) | 2000-01-13 |
| JP2000502100A (ja) | 2000-02-22 |
| HUP9901037A2 (hu) | 1999-07-28 |
| ATE219064T1 (de) | 2002-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: ASTELLAS PHARMA INC., TOKIO/TOKYO, JP |
|
| 8339 | Ceased/non-payment of the annual fee |