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DE69523951D1 - STABILIZATION OF PROSTAGLAND COMPOSITIONS - Google Patents

STABILIZATION OF PROSTAGLAND COMPOSITIONS

Info

Publication number
DE69523951D1
DE69523951D1 DE69523951T DE69523951T DE69523951D1 DE 69523951 D1 DE69523951 D1 DE 69523951D1 DE 69523951 T DE69523951 T DE 69523951T DE 69523951 T DE69523951 T DE 69523951T DE 69523951 D1 DE69523951 D1 DE 69523951D1
Authority
DE
Germany
Prior art keywords
compositions
prostagland
stabilization
prostaglandin
chemical stability
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69523951T
Other languages
German (de)
Other versions
DE69523951T2 (en
Inventor
Wayne Schneider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Alcon Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23427079&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69523951(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alcon Laboratories Inc filed Critical Alcon Laboratories Inc
Application granted granted Critical
Publication of DE69523951D1 publication Critical patent/DE69523951D1/en
Publication of DE69523951T2 publication Critical patent/DE69523951T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The use of polyethoxylated castor oils in prostaglandin compositions greatly enhances the prostaglandin's chemical stability.
DE69523951T 1994-12-22 1995-12-19 STABILIZATION OF PROSTAGLAND COMPOSITIONS Expired - Lifetime DE69523951T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/362,677 US5631287A (en) 1994-12-22 1994-12-22 Storage-stable prostaglandin compositions
PCT/US1995/017086 WO1997029752A1 (en) 1994-12-22 1995-12-19 Storage-stable prostaglandin compositions

Publications (2)

Publication Number Publication Date
DE69523951D1 true DE69523951D1 (en) 2001-12-20
DE69523951T2 DE69523951T2 (en) 2002-04-04

Family

ID=23427079

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69523951T Expired - Lifetime DE69523951T2 (en) 1994-12-22 1995-12-19 STABILIZATION OF PROSTAGLAND COMPOSITIONS

Country Status (12)

Country Link
US (2) US5631287A (en)
EP (1) EP0812198B1 (en)
JP (3) JP3631255B2 (en)
AT (1) ATE208621T1 (en)
AU (1) AU700574B2 (en)
CA (1) CA2181172C (en)
DE (1) DE69523951T2 (en)
DK (1) DK0812198T3 (en)
ES (1) ES2162951T3 (en)
MX (1) MX9603560A (en)
PT (1) PT812198E (en)
WO (1) WO1997029752A1 (en)

Families Citing this family (50)

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US6011062A (en) * 1994-12-22 2000-01-04 Alcon Laboratories, Inc. Storage-stable prostaglandin compositions
AR002194A1 (en) † 1997-03-17 1998-01-07 Sanchez Reynaldo Alemany COMPUTERIZED INSTRUMENT FOR THE ANALYSIS OF MOVEMENT.
US6037368A (en) * 1997-05-09 2000-03-14 Mount Sinai School Of Medicine 8-iso- prostaglandins for glaucoma therapy
AU743607B2 (en) * 1998-07-14 2002-01-31 Alcon Laboratories, Inc. Prostaglandin product
US6235781B1 (en) 1998-07-14 2001-05-22 Alcon Laboratories, Inc. Prostaglandin product
AR020661A1 (en) 1998-09-30 2002-05-22 Alcon Lab Inc A PHARMACEUTICAL COMPOSITION TOPICA OFTALMICA, OTICA OR NASAL AND THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
US7678836B2 (en) * 1999-11-04 2010-03-16 Fxs Ventures, Llc Method for rendering a contact lens wettable
US7166730B2 (en) * 2000-01-27 2007-01-23 Fine Tech Laboratories, Ltd Process for the preparation of prostaglandin derivatives
CA2422031C (en) * 2000-09-13 2011-11-15 Santen Pharmaceutical Co., Ltd. Ophthalmic solutions comprising difluoroprostaglandin f2 alpha
CN1259051C (en) 2001-04-19 2006-06-14 帝化制药株式会社 Medicines anjd medicinal kits
DE60326226D1 (en) * 2002-03-21 2009-04-02 Cayman Chemical Co PROSTAGLANDIN F2 ALPHA ANALOGUE IN COMBINATION WITH AN ANTIMICROBIAL AGENT FOR THE TREATMENT OF GLAUCOMA
US20040079671A1 (en) * 2002-08-29 2004-04-29 Paramita Bandyopadhyay Medicinal product packaging
CA2707068A1 (en) * 2002-09-09 2004-03-18 Santen Pharmaceutical Co., Ltd. Clear ophthalmic solution comprising latanoprost as active ingredient
CN100484528C (en) * 2003-11-07 2009-05-06 千寿制药株式会社 Pharmaceutical composition containing prostaglandin
GB0329620D0 (en) * 2003-12-22 2004-01-28 Pharmagene Lab Ltd EP2 receptor agonists
SI1759702T1 (en) * 2004-05-26 2009-06-30 Bayardo Arturo Jimenez Method of preparing a latanoprost ophthalmic solution and solution thus produced
EP1655021B1 (en) * 2004-11-09 2008-10-29 Novagali Pharma SA Oil-in-water type emulsion with low concentration of cationic agent and positive zeta potential
GB0501192D0 (en) * 2005-01-20 2005-03-02 Resolution Chemicals Ltd Stable prostaglandin-containing compositions
US8030349B2 (en) * 2005-08-02 2011-10-04 Santen Pharmaceutical Co., Ltd. Method for prevention of degradation of thermally unstable medicament
WO2007105691A1 (en) * 2006-03-13 2007-09-20 R-Tech Ueno, Ltd. Aqueous composition
WO2007111806A2 (en) 2006-03-23 2007-10-04 Massachusetts Eye And Ear Infirmary Cyclopentane heptanoic acid compounds for reducing body fat
WO2008052031A2 (en) * 2006-10-24 2008-05-02 Alcon Research, Ltd. 2-pyrrolidone derivatives for preservation of ophthalmic, otic and nasal compositions
WO2008096804A1 (en) 2007-02-07 2008-08-14 Teika Pharmaceutical Co., Ltd. Eye drop preparation comprising latanoprost
EP1985298A1 (en) * 2007-04-24 2008-10-29 Azad Pharma AG Ophtalmic oil-in-water emulsions containing prostaglandins
JP5646331B2 (en) 2007-10-16 2014-12-24 サン、ファーマ、アドバンスト、リサーチ、カンパニー、リミテッドＳｕｎ Ｐｈａｒｍａ Ａｄｖａｎｃｅｄｒｅｓｅａｒｃｈ Ｃｏｍｐａｎｙ Ｌｉｍｉｔｅｄ New ophthalmic composition
EP2077105A1 (en) 2008-01-02 2009-07-08 Novagali Pharma SA Ophthalmic Micellar Compositions with Enhanced Stability
EP2077104A1 (en) 2008-01-02 2009-07-08 Novagali Pharma SA Micellar compositions with ophtalmic applications
TWI544927B (en) * 2008-03-17 2016-08-11 愛爾康研究有限公司 Pharmaceutical compositions having low concentration of surfactants for promoting bioavailability of therapeutic agents
DK2254549T4 (en) 2008-03-17 2019-07-22 Alcon Res Ltd AURAL PHARMACEUTICAL COMPOSITIONS, CONTAINING BORATE-POLYOL COMPLEXES
JP2009256281A (en) * 2008-04-21 2009-11-05 Teika Seiyaku Kk Isopropyl unoprostone containing ophthalmic preparation formulation
EP2127638A1 (en) 2008-05-30 2009-12-02 Santen Pharmaceutical Co., Ltd Method and composition for treating ocular hypertension and glaucoma
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
EP2228058A1 (en) 2009-03-04 2010-09-15 Novagali Pharma S.A. Anionic oil-in-water emulsion containing prostaglandins and uses thereof
TWI489997B (en) 2009-06-19 2015-07-01 Alcon Res Ltd Aqueous pharmaceutical compositions containing borate-polyol complexes
US20120232140A1 (en) * 2009-11-11 2012-09-13 Micro Labs Limited Pharmaceutical combination of prostaglandin compound and nsaid for the treatment of glaucoma and ocular hypertension
EP2389939A1 (en) * 2010-05-28 2011-11-30 Novagali Pharma S.A. Use of prostaglandins F2alpha and analogues for the healing of corneal and conjunctival lesions
FR2961694B1 (en) 2010-06-29 2013-01-25 Thea Lab POLYMERIC DELIVERY SYSTEM FOR NON-VISCOUS SOLUTION BASED ON PROSTAGLANDIN WITHOUT PRESERVATIVE
EP2452669A1 (en) 2010-10-29 2012-05-16 Omnivision GmbH Ophthalmic composition
JP2014500275A (en) 2010-12-06 2014-01-09 フォリカ，インコーポレイテッド Methods for treating baldness and for promoting hair growth
CA2824317C (en) 2011-01-19 2014-12-16 Terakine Therapeutics, Inc. Uses of certain f-series prostaglandin analogs for treating diabetes and dyslipidemia
US8426471B1 (en) 2011-12-19 2013-04-23 Topokine Therapeutics, Inc. Methods and compositions for reducing body fat and adipocytes
ITRM20120036A1 (en) * 2012-02-02 2013-08-03 Robert Davis Steigerwalt Jr TRANSDERMAL APPLICATION OF PROSTAGLANDINE E1 FOR THE TREATMENT OF OCULAR ISCHEMIA.
CA2869676C (en) 2012-11-21 2015-06-23 Topokine Therapeutics, Inc. Uses and compositions comprising a thiazolidinedione and oleic acid for locally increasing subcutaneous fat
NO2753788T3 (en) 2013-05-10 2018-06-16
WO2014186504A1 (en) 2013-05-15 2014-11-20 Topokine Therapeutics, Inc. Methods and compositions for topical delivery of prostaglandins to subcutaneous fat
MY179951A (en) 2014-01-10 2020-11-19 Santen Pharmaceutical Co Ltd Pharmaceutical composition containing pyridylaminoacetic acid compound
CA2934612C (en) * 2014-01-10 2021-09-07 Santen Pharmaceutical Co., Ltd. Pyridylaminoacetic acid compound and polyoxyethylene castor oil-containing pharmaceutical composition
US10188661B2 (en) 2014-06-27 2019-01-29 Topokine Therapeutics, Inc. Topical dosage regimen
JP2018534018A (en) 2015-09-27 2018-11-22 フォリカ, インコーポレーテッドFollica, Inc. Needle insertion device and drug applicator
MX2021005967A (en) 2018-11-21 2021-10-13 Tremeau Pharmaceuticals Inc Purified forms of rofecoxib, methods of manufacture and use.

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DE2526938C2 (en) * 1975-02-14 1982-04-22 F. Hoffmann-La Roche & Co. AG, 4002 Basel Vitamin preparations
JPS6046094B2 (en) * 1977-06-01 1985-10-14 科研製薬株式会社 Stabilized prostaglandin E powder formulation
JPS59216820A (en) * 1983-05-20 1984-12-06 Taisho Pharmaceut Co Ltd Fat emulsion of prostaglandin
DE3347128A1 (en) * 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 9-HALOGEN- (DELTA) (ARROW HIGH) 2 (ARROW HIGH) -PROSTAGLAND IN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
DE3510978A1 (en) * 1985-03-22 1986-09-25 Schering AG, Berlin und Bergkamen, 1000 Berlin NEW 9-HALOGEN PROSTAGLANDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
US5110493A (en) * 1987-09-11 1992-05-05 Syntex (U.S.A.) Inc. Ophthalmic NSAID formulations containing a quaternary ammonium preservative and a nonionic surfactant
JP2597629B2 (en) * 1988-02-26 1997-04-09 株式会社 上野製薬応用研究所 Stabilization of 13,14-dihydro-15-ketoprostaglandins
US4960799A (en) * 1988-09-13 1990-10-02 Ciba-Geigy Corporation Stabilized aqueous solutions of pharmaceutically acceptable salts of ortho-(2,6-dichlorophenyl)-aminophenylacetic acid for opthalmic use
JPH0669966B2 (en) * 1989-07-05 1994-09-07 株式会社ミドリ十字 Angiography aid
JPH03101622A (en) * 1989-09-11 1991-04-26 Green Cross Corp:The Preventive and therapeutic agent of hepatitis
JP2785981B2 (en) * 1989-11-20 1998-08-13 株式会社資生堂 Emulsion composition
CA2031469A1 (en) * 1989-12-28 1991-06-29 Larry A. Wheeler Use of inclusion complexes of prostaglandins with cyclodextrins in the treatment of ocular hypertension
JP3256997B2 (en) * 1990-08-30 2002-02-18 千寿製薬株式会社 Stable aqueous formulation
ATE153855T1 (en) * 1992-10-13 1997-06-15 Alcon Lab Inc COMPOSITIONS FOR THE TREATMENT OF GLAUCOMA CONTAINING PROSTAGLANDINS AND CLONIDINE DERIVATIVES
US5744155A (en) * 1993-08-13 1998-04-28 Friedman; Doron Bioadhesive emulsion preparations for enhanced drug delivery
TW406020B (en) * 1993-09-29 2000-09-21 Bristol Myers Squibb Co Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent
AU687906B2 (en) * 1993-12-15 1998-03-05 Alcon Laboratories, Inc. Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension

Also Published As

Publication number Publication date
DE69523951T2 (en) 2002-04-04
WO1997029752A1 (en) 1997-08-21
AU4649596A (en) 1997-09-02
CA2181172A1 (en) 1996-06-23
EP0812198B1 (en) 2001-11-14
MX9603560A (en) 1998-01-31
CA2181172C (en) 2003-04-29
JP2010043131A (en) 2010-02-25
JP3631255B2 (en) 2005-03-23
US5631287A (en) 1997-05-20
PT812198E (en) 2002-02-28
AU700574B2 (en) 1999-01-07
US5849792A (en) 1998-12-15
JP2005015498A (en) 2005-01-20
ATE208621T1 (en) 2001-11-15
ES2162951T3 (en) 2002-01-16
EP0812198A1 (en) 1997-12-17
DK0812198T3 (en) 2002-03-18
JPH11500122A (en) 1999-01-06

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Legal Events

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8364 No opposition during term of opposition