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DE69522342D1 - Piperazine-2,5-dione-derivate als multidrugresistenz moldulatoren - Google Patents

Piperazine-2,5-dione-derivate als multidrugresistenz moldulatoren

Info

Publication number
DE69522342D1
DE69522342D1 DE69522342T DE69522342T DE69522342D1 DE 69522342 D1 DE69522342 D1 DE 69522342D1 DE 69522342 T DE69522342 T DE 69522342T DE 69522342 T DE69522342 T DE 69522342T DE 69522342 D1 DE69522342 D1 DE 69522342D1
Authority
DE
Germany
Prior art keywords
pct
moldulators
piperazine
formula
multidrug resistant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69522342T
Other languages
English (en)
Other versions
DE69522342T2 (de
Inventor
Anthony Ashworth
Sukhjit Hunjan
Andrew Pretswell
Hamish Ryder
James Brocchini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xenova Ltd
Original Assignee
Xenova Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenova Ltd filed Critical Xenova Ltd
Application granted granted Critical
Publication of DE69522342D1 publication Critical patent/DE69522342D1/de
Publication of DE69522342T2 publication Critical patent/DE69522342T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Electron Tubes For Measurement (AREA)
DE69522342T 1994-12-23 1995-12-22 Piperazine-2,5-dione-derivate als multidrugresistenz moldulatoren Expired - Fee Related DE69522342T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9426090.8A GB9426090D0 (en) 1994-12-23 1994-12-23 Pharmaceutical compounds
PCT/GB1995/003029 WO1996020180A1 (en) 1994-12-23 1995-12-22 Piperazine-2,5-dione derivatives as modulators of multidrug resistance

Publications (2)

Publication Number Publication Date
DE69522342D1 true DE69522342D1 (de) 2001-09-27
DE69522342T2 DE69522342T2 (de) 2002-01-03

Family

ID=10766502

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69522342T Expired - Fee Related DE69522342T2 (de) 1994-12-23 1995-12-22 Piperazine-2,5-dione-derivate als multidrugresistenz moldulatoren

Country Status (27)

Country Link
US (1) US5935955A (de)
EP (1) EP0799210B1 (de)
JP (1) JPH10511385A (de)
KR (1) KR100412167B1 (de)
CN (1) CN1108294C (de)
AT (1) ATE204569T1 (de)
AU (1) AU700891B2 (de)
BG (1) BG63305B1 (de)
BR (1) BR9510429A (de)
CA (1) CA2207548A1 (de)
CZ (1) CZ288935B6 (de)
DE (1) DE69522342T2 (de)
DK (1) DK0799210T3 (de)
ES (1) ES2160726T3 (de)
FI (1) FI972661A7 (de)
GB (2) GB9426090D0 (de)
HU (1) HUT77740A (de)
IL (1) IL116526A (de)
MY (1) MY131762A (de)
NO (1) NO308532B1 (de)
NZ (1) NZ297849A (de)
PL (1) PL186851B1 (de)
PT (1) PT799210E (de)
SK (1) SK283385B6 (de)
UA (1) UA61879C2 (de)
WO (1) WO1996020180A1 (de)
ZA (1) ZA9510908B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9708805D0 (en) 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
DE69929704T2 (de) 1998-10-08 2006-07-20 Smithkline Beecham Plc, Brentford Tetrahydrobenzazepin-derivate verwendbar als dopamin-d3-rezeptor-modulatoren (antipsychotische mittel)
US6828412B1 (en) * 1999-09-03 2004-12-07 School Of Pharmacy, University Of London Degradable polymers
EP1210093A4 (de) * 1999-09-03 2005-01-12 Polytherics Ltd Abbaubare polymere
EP2266607A3 (de) 1999-10-01 2011-04-20 Immunogen, Inc. Immunokonjugate für Krebsbehandlung
CA2453050A1 (en) 2000-09-06 2002-03-14 A.P. Pharma, Inc. Degradable polyacetal polymers
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
JP2005508990A (ja) * 2001-11-07 2005-04-07 ファルマシア・コーポレーション 真核細胞におけるポリアミドの取込みおよび核蓄積を促進する方法
US8710062B2 (en) * 2011-03-11 2014-04-29 Taipei Medical University Piperazinedione compounds
CN103396372B (zh) * 2013-08-09 2015-05-20 中国科学院南海海洋研究所 一类2,5-二酮哌嗪衍生物及其制备方法和在制备抗海洋污损生物防除剂中的应用
EP3903786A4 (de) * 2018-12-27 2022-09-28 Holosmedic Neuartige verbindung und pharmazeutische zusammensetzung damit zur erhöhung der antikrebsaktivität

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2718830B2 (ja) * 1992-07-10 1998-02-25 ラボラトワール、グラクソ、ソシエテ、アノニム アニリド誘導体
GB9217331D0 (en) * 1992-08-14 1992-09-30 Xenova Ltd Pharmaceutical compounds
WO1994004572A1 (en) * 1992-08-14 1994-03-03 Torii & Co., Ltd. Allergenic peptide
GB9402807D0 (en) * 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
GB9410387D0 (en) * 1994-05-24 1994-07-13 Xenova Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
NO972938L (no) 1997-06-23
ATE204569T1 (de) 2001-09-15
GB9712179D0 (en) 1997-08-13
HUT77740A (hu) 1998-07-28
EP0799210A1 (de) 1997-10-08
FI972661A0 (fi) 1997-06-19
DK0799210T3 (da) 2001-10-01
EP0799210B1 (de) 2001-08-22
PL320915A1 (en) 1997-11-10
AU700891B2 (en) 1999-01-14
IL116526A0 (en) 1996-03-31
CZ288935B6 (cs) 2001-09-12
CZ190297A3 (cs) 1998-01-14
DE69522342T2 (de) 2002-01-03
BG101601A (bg) 1998-02-27
CA2207548A1 (en) 1996-07-04
CN1176637A (zh) 1998-03-18
AU4310296A (en) 1996-07-19
US5935955A (en) 1999-08-10
PL186851B1 (pl) 2004-03-31
UA61879C2 (en) 2003-12-15
SK83597A3 (en) 1998-04-08
NZ297849A (en) 1999-04-29
CN1108294C (zh) 2003-05-14
FI972661L (fi) 1997-08-22
BR9510429A (pt) 1998-07-07
BG63305B1 (bg) 2001-09-28
JPH10511385A (ja) 1998-11-04
GB2311780B (en) 1999-03-03
SK283385B6 (sk) 2003-06-03
PT799210E (pt) 2002-01-30
WO1996020180A1 (en) 1996-07-04
HK1001974A1 (en) 1998-07-24
IL116526A (en) 1999-11-30
GB2311780A (en) 1997-10-08
NO972938D0 (no) 1997-06-23
MY131762A (en) 2007-08-30
GB9426090D0 (en) 1995-02-22
KR100412167B1 (ko) 2004-05-27
ZA9510908B (en) 1996-06-24
ES2160726T3 (es) 2001-11-16
FI972661A7 (fi) 1997-08-22
NO308532B1 (no) 2000-09-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee