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DE69402441D1 - Neue 17,20-Epoxyd Derivate von Pregnan, ihre Verwendung zur Herstellung von Cortison-Derivaten und Zwischenprodukte dafür - Google Patents

Neue 17,20-Epoxyd Derivate von Pregnan, ihre Verwendung zur Herstellung von Cortison-Derivaten und Zwischenprodukte dafür

Info

Publication number
DE69402441D1
DE69402441D1 DE69402441T DE69402441T DE69402441D1 DE 69402441 D1 DE69402441 D1 DE 69402441D1 DE 69402441 T DE69402441 T DE 69402441T DE 69402441 T DE69402441 T DE 69402441T DE 69402441 D1 DE69402441 D1 DE 69402441D1
Authority
DE
Germany
Prior art keywords
derivatives
pregnan
manufacture
new
cortisone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69402441T
Other languages
English (en)
Other versions
DE69402441T2 (de
Inventor
Jean Buendia
Remi Chauvin
Michel Vivat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Application granted granted Critical
Publication of DE69402441D1 publication Critical patent/DE69402441D1/de
Publication of DE69402441T2 publication Critical patent/DE69402441T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Epoxy Resins (AREA)
DE69402441T 1993-01-14 1994-01-13 Neue 17,20-Epoxyd Derivate von Pregnan, ihre Verwendung zur Herstellung von Cortison-Derivaten und Zwischenprodukte dafür Expired - Lifetime DE69402441T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9300290A FR2700339B1 (fr) 1993-01-14 1993-01-14 Nouveaux dérivés 17,20-époxydes du pregnane, leur préparation, leur application à la préparation de dérivés cortisoniques et intermédiaires.

Publications (2)

Publication Number Publication Date
DE69402441D1 true DE69402441D1 (de) 1997-05-15
DE69402441T2 DE69402441T2 (de) 1997-10-30

Family

ID=9443017

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69402441T Expired - Lifetime DE69402441T2 (de) 1993-01-14 1994-01-13 Neue 17,20-Epoxyd Derivate von Pregnan, ihre Verwendung zur Herstellung von Cortison-Derivaten und Zwischenprodukte dafür

Country Status (18)

Country Link
US (2) US5504203A (de)
EP (1) EP0607088B1 (de)
JP (1) JP3356525B2 (de)
KR (1) KR100312268B1 (de)
CN (2) CN1057304C (de)
AT (1) ATE151435T1 (de)
AU (1) AU667413B2 (de)
CA (1) CA2113404C (de)
DE (1) DE69402441T2 (de)
DK (1) DK0607088T3 (de)
ES (1) ES2100023T3 (de)
FR (1) FR2700339B1 (de)
GR (1) GR3023106T3 (de)
HU (1) HU217632B (de)
PL (1) PL181805B1 (de)
RU (1) RU2125060C1 (de)
UA (1) UA40574C2 (de)
YU (1) YU49025B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2724174B1 (fr) * 1994-09-06 1997-01-17 Roussel Uclaf Procede de preparation d'un derive steroide 17beta-carboxy et nouveaux intermediaires
ES2347027T3 (es) 1998-05-22 2010-10-22 The Board Of Trustees Of The Leland Stanford Junior University Moleculas bifuncionales y terapias basadas en las mismas.
EP2147679B1 (de) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Zusammensetzungen für den Blut-Hirn-Schrankentransport
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
EP1945240B1 (de) 2005-09-16 2016-12-28 Raptor Pharmaceutical Inc Zusammensetzungen mit rezeptor-assoziierten protein (rap) varianten, die für cr-haltige proteine spezifisch sind und ihre verwendungen
AU2010216512B2 (en) 2009-02-20 2016-06-30 2-Bbb Medicines B.V. Glutathione-based drug delivery system
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US9554418B1 (en) 2013-02-28 2017-01-24 F5 Networks, Inc. Device for topology hiding of a visited network
CN107663171A (zh) * 2017-10-10 2018-02-06 常州市阳光药业有限公司 高纯度托伐普坦的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2123217A (en) * 1937-07-15 1938-07-12 Merck & Co Inc Process for the production of hormones
US2541439A (en) * 1949-02-18 1951-02-13 Merck & Co Inc Osmate esters of 20-cyanopregnanes and process
US2648688A (en) * 1950-12-23 1953-08-11 Merck & Co Inc Process for peparing 21-alkyl ethers of cortisone
US2813860A (en) * 1954-12-31 1957-11-19 Upjohn Co Steroids
US2744108A (en) * 1955-01-13 1956-05-01 Searle & Co 3-ethylene mercaptoles of 11-oxygenated derivatives of 17, 21-dihydroxy-4-pregnene-3, 20-diones
US2912446A (en) * 1955-01-14 1959-11-10 Merck & Co Inc delta1, 4-3, 20-diketo-11-oxygenated-17alpha-hydroxy-pregnadienes and 9-fluoro derivatives thereof
US2844600A (en) * 1955-10-10 1958-07-22 Upjohn Co 22-cyanohydrins of bis-nor cholen-al compounds
US3285940A (en) * 1959-06-04 1966-11-15 Merck & Co Inc 16-methyl-delta-1, 4, 16-pregnatriene-3, 20-dione compounds
US3118882A (en) * 1961-02-16 1964-01-21 American Home Prod Preparation of 17alpha-fluoroprogesterone and intermediates therein
US3074979A (en) * 1961-05-08 1963-01-22 Merck & Co Inc 3-mono-oxime derivatives of c-4 unsaturated steroids
US3419582A (en) * 1965-08-23 1968-12-31 Warner Lambert Pharmaceutical Pentacyclic steroids and process
US3378574A (en) * 1966-03-30 1968-04-16 Merck & Co Inc Process of hydrolyzing 16beta-alkyl-16alpha, 17alpha-oxido-11, 20 bis-oxygenated-1, 4-pregnadiene-3, 20-diones
DE2330581A1 (de) * 1973-06-15 1975-01-16 Warner Lambert Co Steroidyloestratriene, ihre verwendung und verfahren zur herstellung derselben
DE2336438C2 (de) * 1973-07-14 1983-07-07 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 17 β- Oxalylsteroiden
HU171166B (hu) * 1975-07-15 1977-11-28 Richter Gedeon Vegyeszet Sposob poluchenija novykh ehpoksi-androstanov
FR2423486A1 (fr) * 1978-04-19 1979-11-16 Roussel Uclaf Nouveau reactif d'epoxydation
US4600538A (en) * 1984-08-02 1986-07-15 The Upjohn Company Corticosteroids from 17-keto steroids via 20-cyano-Δ17 (20)-pregnanes
FR2676740B1 (fr) * 1991-05-23 1993-11-05 Roussel Uclaf Nouveaux derives sterouides du pregna-4,9(11),17(20)-trie-3-one, leur preparation, leur application a la preparation de composes sterouides de type pregna-4,9(11),16-triene-3,20-dione et nouveaux intermediaires.
FR2691968B1 (fr) * 1992-06-04 1994-07-29 Roussel Uclaf Nouveau procede de preparation d'un derive sterouide 11-ceto.

Also Published As

Publication number Publication date
DK0607088T3 (da) 1997-10-06
UA40574C2 (uk) 2001-08-15
ES2100023T3 (es) 1997-06-01
YU49025B (sh) 2003-07-07
HU9400094D0 (en) 1994-05-30
GR3023106T3 (en) 1997-07-30
AU667413B2 (en) 1996-03-21
CN1095847C (zh) 2002-12-11
CA2113404A1 (fr) 1994-07-15
CN1096790A (zh) 1994-12-28
EP0607088A1 (de) 1994-07-20
US5504203A (en) 1996-04-02
ATE151435T1 (de) 1997-04-15
CN1182092A (zh) 1998-05-20
YU82293A (sh) 1996-07-24
FR2700339B1 (fr) 1995-03-03
PL181805B1 (pl) 2001-09-28
KR940018395A (ko) 1994-08-16
CN1057304C (zh) 2000-10-11
EP0607088B1 (de) 1997-04-09
PL301862A1 (en) 1994-07-25
RU2125060C1 (ru) 1999-01-20
JPH06279486A (ja) 1994-10-04
DE69402441T2 (de) 1997-10-30
AU5316194A (en) 1994-07-21
CA2113404C (fr) 2004-10-19
US5892028A (en) 1999-04-06
HU217632B (hu) 2000-03-28
FR2700339A1 (fr) 1994-07-13
KR100312268B1 (ko) 2002-06-20
JP3356525B2 (ja) 2002-12-16
HUT67551A (en) 1995-04-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: HOECHST MARION ROUSSEL, PUTEAUX, FR

8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS PHARMA S.A., ANTONY, FR

8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC