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DE69400343D1 - Neues Verfahren zur Herstellung von 6alpha, 9alphadifluoro-Sterioden und Zwischenprodukte davon - Google Patents

Neues Verfahren zur Herstellung von 6alpha, 9alphadifluoro-Sterioden und Zwischenprodukte davon

Info

Publication number
DE69400343D1
DE69400343D1 DE69400343T DE69400343T DE69400343D1 DE 69400343 D1 DE69400343 D1 DE 69400343D1 DE 69400343 T DE69400343 T DE 69400343T DE 69400343 T DE69400343 T DE 69400343T DE 69400343 D1 DE69400343 D1 DE 69400343D1
Authority
DE
Germany
Prior art keywords
6alpha
steriods
intermediates
production
new process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69400343T
Other languages
English (en)
Other versions
DE69400343T2 (de
Inventor
Jean-Yves Godard
Philippe Mackiewicz
Denis Prat
Christian Richard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Application granted granted Critical
Publication of DE69400343D1 publication Critical patent/DE69400343D1/de
Publication of DE69400343T2 publication Critical patent/DE69400343T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69400343T 1993-02-05 1994-02-03 Neues Verfahren zur Herstellung von 6alpha, 9alphadifluoro-Sterioden und Zwischenprodukte davon Expired - Lifetime DE69400343T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9301275A FR2701262B1 (fr) 1993-02-05 1993-02-05 Nouveau procédé de préparation de stéroïdes 6 alpa, 9 alpha-difluorés et nouveaus intermédiaires.

Publications (2)

Publication Number Publication Date
DE69400343D1 true DE69400343D1 (de) 1996-09-05
DE69400343T2 DE69400343T2 (de) 1997-01-16

Family

ID=9443760

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69400343T Expired - Lifetime DE69400343T2 (de) 1993-02-05 1994-02-03 Neues Verfahren zur Herstellung von 6alpha, 9alphadifluoro-Sterioden und Zwischenprodukte davon

Country Status (18)

Country Link
US (2) US5478957A (de)
EP (1) EP0610138B1 (de)
JP (1) JP3346873B2 (de)
KR (1) KR100312269B1 (de)
CN (1) CN1070499C (de)
AT (1) ATE140925T1 (de)
AU (1) AU671695B2 (de)
CA (1) CA2115015C (de)
DE (1) DE69400343T2 (de)
DK (1) DK0610138T3 (de)
ES (1) ES2091100T3 (de)
FR (1) FR2701262B1 (de)
GR (1) GR3020750T3 (de)
HU (1) HU214717B (de)
MX (1) MX9400910A (de)
RU (1) RU2127739C1 (de)
TW (1) TW243452B (de)
ZA (1) ZA94778B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641765A (en) * 1992-11-18 1997-06-24 Smithkline Beecham Corporation 17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase
KR100245651B1 (ko) * 1996-09-21 2000-02-15 윤종용 반도체 웨이퍼 보트의 이송장치
AU780751B2 (en) 1999-10-13 2005-04-14 Pharmacia & Upjohn Company Process to prepare androst-4-en-17-carboxylic acid cross-reference to related applications
IT1319663B1 (it) * 2000-11-17 2003-10-23 Farmabios Srl Processo per la preparazione di fluoro-steroidi.
PT102628B (pt) 2001-06-12 2010-09-09 Hovione Farmaciencia S A Novo processo de preparação de flumetasona e do seu análogo 17-carboxilo androsteno
ES2184628B1 (es) * 2001-07-26 2005-02-01 Ragactives, S.L. Procedimiento estereoselectivo para la produccion de 6alfa-fluorpregnanos intermedios.
CA2473471A1 (en) 2001-11-29 2003-06-12 Taro Pharmaceuticals U.S.A., Inc. Method for the preparation of 6-alpha-fluoro corticosteroids
ITMI20020676A1 (it) * 2002-03-29 2003-09-29 Farmabios S R L Ora Farmabios Processo di preparazione di 6(alfa)-fluro steroidi
US20060252926A1 (en) * 2002-12-09 2006-11-09 Macdonald Peter Process for the preparation of pregnanes
FR2854402B1 (fr) * 2003-04-29 2008-07-04 Aventis Pharma Sa Nouveau procede et intermediaires de preparation de composes 19-nor-steroides
EP1526139A1 (de) * 2003-10-24 2005-04-27 S.N.I.F.F. Italia S.P.A. Verfahren zur Herstellung von hochreinen Androstan-17-beta-carbonsäuren und Androstan-17-beta-fluoromethyl-thiocarbonsäureestern
CN100429221C (zh) * 2005-10-31 2008-10-29 浙江仙琚制药股份有限公司 皮质激素的合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947409A (en) * 1958-06-19 1976-03-30 Merck & Co., Inc. 16-Alkyl-1,4,9(11)-pregnatrienes and 9,11-epoxides thereof
US3014938A (en) * 1959-09-07 1961-12-26 Syntex Sa Preparation of 16, 21-diacetate derivative of cyclopentanophenanthrene compounds
US3546215A (en) * 1967-10-18 1970-12-08 Syntex Corp 6-gem-difluoro steroids
US3636010A (en) * 1968-12-23 1972-01-18 Ciba Geigy Corp Esters of steroid-17-carboxylic acids
US3828080A (en) * 1972-01-20 1974-08-06 Glaxo Lab Ltd Androstane-17beta-carboxylic acids and processes for the preparation thereof
NL187577C (nl) * 1978-04-05 1991-11-18 Sibla Srl 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
US4198336A (en) * 1978-04-05 1980-04-15 Syntex (U.S.A.) Inc. Chemical process for preparing androsta-4-ene 17α-carboxylic acids
US4198404A (en) * 1978-04-05 1980-04-15 Syntex (U.S.A.) Inc. 6 Alpha, 6 beta-difluoro-etianic acid derivatives
US4188322A (en) * 1978-04-28 1980-02-12 Blasinachim S.P.A. Process for the preparation of 6-halo-pregnanes
DE3227312A1 (de) * 1982-07-19 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung
US4607028A (en) * 1983-08-18 1986-08-19 Ciba-Geigy Corporation Novel carboxylic acid esters
WO1991003459A1 (en) * 1989-08-30 1991-03-21 Whitby Research, Inc. Substituted 2-aminotetralins useful as dopaminergics
JPH05507912A (ja) * 1990-06-11 1993-11-11 アルコン・ラボラトリーズ，インコーポレイテッド 血管形成を阻害するステロイド

Also Published As

Publication number Publication date
KR100312269B1 (ko) 2002-05-13
ATE140925T1 (de) 1996-08-15
TW243452B (de) 1995-03-21
US5478957A (en) 1995-12-26
DE69400343T2 (de) 1997-01-16
HU214717B (hu) 1998-05-28
GR3020750T3 (en) 1996-11-30
ZA94778B (en) 1995-02-06
HUT67405A (en) 1995-04-28
JPH06279485A (ja) 1994-10-04
ES2091100T3 (es) 1996-10-16
JP3346873B2 (ja) 2002-11-18
RU2127739C1 (ru) 1999-03-20
HU9400323D0 (en) 1994-05-30
MX9400910A (es) 1994-08-31
AU671695B2 (en) 1996-09-05
AU5489294A (en) 1994-08-11
CN1099758A (zh) 1995-03-08
KR940019721A (ko) 1994-09-14
CA2115015C (fr) 2004-01-27
DK0610138T3 (da) 1996-10-07
US5556965A (en) 1996-09-17
CA2115015A1 (fr) 1994-08-06
CN1070499C (zh) 2001-09-05
EP0610138A1 (de) 1994-08-10
FR2701262B1 (fr) 1995-03-24
EP0610138B1 (de) 1996-07-31
FR2701262A1 (fr) 1994-08-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: HOECHST MARION ROUSSEL, PUTEAUX, FR

8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS PHARMA S.A., ANTONY, FR

8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC