DE69400024D1 - 2-Cyano-2-hydroxypropenamidederivate, Verfahren zu ihrer Herstellung ihre Verwendung als Arzneimittel und diese enthaltende pharmazeutische Zusammensetzungen. - Google Patents

2-Cyano-2-hydroxypropenamidederivate, Verfahren zu ihrer Herstellung ihre Verwendung als Arzneimittel und diese enthaltende pharmazeutische Zusammensetzungen.

Info

Publication number: DE69400024D1
Authority: DE; Germany
Prior art keywords: hydroxypropenamide; medicaments; cyano; derivatives; processes
Prior art date: 1993-01-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69400024T

Other languages

English (en)

Other versions

DE69400024T2 (de

Inventor

Elizabeth Anne Kuo

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Aventis Pharma SA

Original Assignee

Roussel Uclaf SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-01-05

Filing date

1994-01-04

Publication date

1995-11-16

1994-01-04 Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA

1995-11-16 Application granted granted Critical

1995-11-16 Publication of DE69400024D1 publication Critical patent/DE69400024D1/de

1996-04-04 Publication of DE69400024T2 publication Critical patent/DE69400024T2/de

2014-01-05 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

DE69400024T 1993-01-05 1994-01-04 2-Cyano-2-hydroxypropenamidederivate, Verfahren zu ihrer Herstellung ihre Verwendung als Arzneimittel und diese enthaltende pharmazeutische Zusammensetzungen. Expired - Lifetime DE69400024T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB939300083A GB9300083D0 (en)	1993-01-05	1993-01-05	Chemical compounds

Publications (2)

Publication Number	Publication Date
DE69400024D1 true DE69400024D1 (de)	1995-11-16
DE69400024T2 DE69400024T2 (de)	1996-04-04

Family

ID=10728304

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69400024T Expired - Lifetime DE69400024T2 (de)	1993-01-05	1994-01-04	2-Cyano-2-hydroxypropenamidederivate, Verfahren zu ihrer Herstellung ihre Verwendung als Arzneimittel und diese enthaltende pharmazeutische Zusammensetzungen.

Country Status (33)

Country	Link
US (1)	US5346912A (de)
EP (1)	EP0606175B1 (de)
JP (1)	JP3334988B2 (de)
KR (1)	KR100295717B1 (de)
CN (1)	CN1042935C (de)
AT (1)	ATE128968T1 (de)
AU (1)	AU663017B2 (de)
BR (1)	BR9400017A (de)
CA (1)	CA2112866C (de)
CZ (1)	CZ283948B6 (de)
DE (1)	DE69400024T2 (de)
DK (1)	DK0606175T3 (de)
EE (1)	EE03001B1 (de)
ES (1)	ES2078130T3 (de)
FI (1)	FI106553B (de)
GB (1)	GB9300083D0 (de)
GR (1)	GR3017723T3 (de)
HR (1)	HRP940006B1 (de)
HU (1)	HU216835B (de)
IL (1)	IL107788A (de)
LT (1)	LT3766B (de)
LV (1)	LV10712B (de)
MX (1)	MX9400274A (de)
NO (1)	NO300839B1 (de)
NZ (1)	NZ250520A (de)
PL (1)	PL175135B1 (de)
RU (1)	RU2126387C1 (de)
SI (1)	SI9300686A (de)
SK (1)	SK280508B6 (de)
TW (1)	TW259785B (de)
UA (1)	UA40573C2 (de)
YU (1)	YU49047B (de)
ZA (1)	ZA939118B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000006153A1 (en) *	1998-07-28	2000-02-10	Smithkline Beecham Corporation	Propenamides as ccr5 modulators
US20110104186A1 (en)	2004-06-24	2011-05-05	Nicholas Valiante	Small molecule immunopotentiators and assays for their detection
AR068063A1 (es)	2007-08-27	2009-11-04	Basf Plant Science Gmbh	Co mpuestos de pirazol para controlar plagas de invertebrados
JP5536073B2 (ja)	2008-09-24	2014-07-02	ビーエーエスエフソシエタス・ヨーロピア	無脊椎動物系害虫を防除するためのピラゾール化合物
CN102471321A (zh)	2009-07-06	2012-05-23	巴斯夫欧洲公司	用于防治无脊椎动物害虫的哒嗪化合物
WO2011003793A1 (en)	2009-07-06	2011-01-13	Basf Se	Pyridazine compounds for controlling invertebrate pests
US9125414B2 (en)	2009-07-24	2015-09-08	Basf Se	Pyridine derivatives compounds for controlling invertebrate pests
AU2014352920A1 (en)	2013-11-22	2016-06-23	Genzyme Corporation	Novel methods for treating neurodegenerative diseases
CN105693574B (zh) *	2014-11-25	2017-12-19	中国科学院大连化学物理研究所	2‑烷硫基烯酰胺衍生物及其合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL186239B (nl)	1975-06-05		Hoechst Ag	Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze.
DE2555789A1 (de) *	1975-12-11	1977-07-07	Hoechst Ag	Neue cyanessigsaeureanilid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
US4435407A (en) *	1982-01-07	1984-03-06	Ciba-Geigy Corporation	Certain substituted β-oxo-α-carbamoylpyrrolepropionitriles
DE3534440A1 (de)	1985-09-27	1987-04-02	Hoechst Ag	Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes
US4888357A (en)	1988-01-26	1989-12-19	Bristol-Myers Company	Antiarthritic β-cycloalkyl-β-oxopropionitriles
IL92508A0 (en) *	1988-12-08	1990-08-31	Ciba Geigy Ag	Novel alpha-cyano-beta-oxopropionamides
DK0527736T3 (da) *	1990-05-18	1997-10-20	Hoechst Ag	Isoxazol-4-carboxylsyreamider og hydroxyalkyliden-cyanoacetamider, lægemidler indeholdende disse forbindelser og anvendelsen af disse lægemidler.
IL99811A (en) *	1990-10-30	1996-03-31	Roussel Uclaf	3-Cycloalkyl-propanamides, tautomeric forms of these, their salts, method of preparation, use as drugs and preparations containing them
IL102790A (en) *	1991-09-17	1996-01-31	Roussel Uclaf	History of 3-cycloalkyl-prop-2-anamide

1993
- 1993-01-05 GB GB939300083A patent/GB9300083D0/en active Pending
- 1993-11-29 IL IL10778893A patent/IL107788A/en not_active IP Right Cessation
- 1993-12-03 AU AU52130/93A patent/AU663017B2/en not_active Expired
- 1993-12-06 ZA ZA939118A patent/ZA939118B/xx unknown
- 1993-12-20 NZ NZ250520A patent/NZ250520A/en not_active IP Right Cessation
- 1993-12-20 LT LTIP1634A patent/LT3766B/lt not_active IP Right Cessation
- 1993-12-20 US US08/170,372 patent/US5346912A/en not_active Expired - Lifetime
- 1993-12-24 SI SI9300686A patent/SI9300686A/sl unknown
- 1993-12-28 JP JP34951193A patent/JP3334988B2/ja not_active Expired - Lifetime
- 1993-12-29 SK SK1495-93A patent/SK280508B6/sk not_active IP Right Cessation
- 1993-12-29 YU YU82593A patent/YU49047B/sh unknown
- 1993-12-30 CZ CZ932921A patent/CZ283948B6/cs not_active IP Right Cessation
1994
- 1994-01-03 PL PL94301774A patent/PL175135B1/pl unknown
- 1994-01-04 ES ES94400009T patent/ES2078130T3/es not_active Expired - Lifetime
- 1994-01-04 LV LVP-94-02A patent/LV10712B/en unknown
- 1994-01-04 RU RU94000064A patent/RU2126387C1/ru active
- 1994-01-04 KR KR1019940000057A patent/KR100295717B1/ko not_active IP Right Cessation
- 1994-01-04 BR BR9400017A patent/BR9400017A/pt not_active Application Discontinuation
- 1994-01-04 AT AT94400009T patent/ATE128968T1/de active
- 1994-01-04 HR HR9300083.4A patent/HRP940006B1/xx not_active IP Right Cessation
- 1994-01-04 NO NO940020A patent/NO300839B1/no not_active IP Right Cessation
- 1994-01-04 DK DK94400009.0T patent/DK0606175T3/da active
- 1994-01-04 DE DE69400024T patent/DE69400024T2/de not_active Expired - Lifetime
- 1994-01-04 CN CN94100187A patent/CN1042935C/zh not_active Expired - Lifetime
- 1994-01-04 FI FI940031A patent/FI106553B/fi not_active IP Right Cessation
- 1994-01-04 EP EP94400009A patent/EP0606175B1/de not_active Expired - Lifetime
- 1994-01-04 UA UA94005036A patent/UA40573C2/uk unknown
- 1994-01-05 MX MX9400274A patent/MX9400274A/es unknown
- 1994-01-05 CA CA002112866A patent/CA2112866C/fr not_active Expired - Lifetime
- 1994-01-05 HU HU9400033A patent/HU216835B/hu unknown
- 1994-01-31 TW TW083100783A patent/TW259785B/zh not_active IP Right Cessation
- 1994-11-14 EE EE9400360A patent/EE03001B1/xx unknown
1995
- 1995-10-12 GR GR950401071T patent/GR3017723T3/el unknown

Also Published As

Publication number	Publication date
IL107788A0 (en)	1994-02-27
IL107788A (en)	1998-08-16
RU2126387C1 (ru)	1999-02-20
PL301774A1 (en)	1994-07-11
NO940020D0 (no)	1994-01-04
RU94000064A (ru)	1996-07-10
SK149593A3 (en)	1994-12-07
EE03001B1 (et)	1997-06-16
CN1097005A (zh)	1995-01-04
KR940018363A (ko)	1994-08-16
ZA939118B (en)	1995-01-18
NO940020L (de)	1994-07-06
AU5213093A (en)	1994-07-14
GB9300083D0 (en)	1993-03-03
DE69400024T2 (de)	1996-04-04
SK280508B6 (sk)	2000-03-13
FI940031A0 (fi)	1994-01-04
ATE128968T1 (de)	1995-10-15
TW259785B (en)	1995-10-11
LTIP1634A (en)	1995-02-27
YU49047B (sh)	2003-07-07
LT3766B (en)	1996-03-25
GR3017723T3 (en)	1996-01-31
NZ250520A (en)	1996-08-27
KR100295717B1 (ko)	2001-11-05
AU663017B2 (en)	1995-09-21
DK0606175T3 (da)	1996-02-19
BR9400017A (pt)	1994-08-02
FI106553B (fi)	2001-02-28
JP3334988B2 (ja)	2002-10-15
LV10712A (lv)	1995-06-20
CA2112866A1 (fr)	1994-07-06
FI940031A (fi)	1994-07-06
ES2078130T3 (es)	1995-12-01
YU82593A (sh)	1996-07-24
CA2112866C (fr)	2007-03-13
HUT71471A (en)	1995-11-28
JPH06211793A (ja)	1994-08-02
MX9400274A (es)	1994-08-31
US5346912A (en)	1994-09-13
NO300839B1 (no)	1997-08-04
EP0606175A1 (de)	1994-07-13
UA40573C2 (uk)	2001-08-15
CN1042935C (zh)	1999-04-14
HU9400033D0 (en)	1994-05-30
CZ292193A3 (en)	1994-07-13
LV10712B (en)	1995-12-20
CZ283948B6 (cs)	1998-07-15
HRP940006A2 (en)	1996-10-31
EP0606175B1 (de)	1995-10-11
HU216835B (hu)	1999-09-28
HRP940006B1 (en)	1999-12-31
SI9300686A (en)	1994-09-30
PL175135B1 (pl)	1998-11-30

Publication	Publication Date	Title
DE69300261D1 (de)	1995-08-24	Cyano-2-Hydroxy-3-Enamid-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel, diese enthaltende pharmazeutische Zusammensetzungen und erhaltene Zwischenprodukte.
DE59401924D1 (de)	1997-04-10	Substituierte heterocyclische Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
ATE129503T1 (de)	1995-11-15	Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien.
ATE170510T1 (de)	1998-09-15	3-(hydroxybenzylidenyl)-indolin-2-one und diese enthaltende arzneimittel
ATE179706T1 (de)	1999-05-15	N-heteroaryl-n'-phenylharnstoffderivate, ihre herstellung und verwendung
ATE127452T1 (de)	1995-09-15	Poly-4-aminopyrrole-2-carboxamide derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
DE59209965D1 (de)	2002-10-17	Chinoxaline, Verfahren zu ihrer Herstellung und ihre Verwendung
DE69400024D1 (de)	1995-11-16	2-Cyano-2-hydroxypropenamidederivate, Verfahren zu ihrer Herstellung ihre Verwendung als Arzneimittel und diese enthaltende pharmazeutische Zusammensetzungen.
ES2111871T3 (es)	1998-03-16	Nuevos derivados de aminoacidos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
ATE260252T1 (de)	2004-03-15	Thiocolchicin-derivate mit entzündungshemmender und muskelrelaxierender wirkung
DE69424734D1 (de)	2000-07-06	Phenyl-Carboxamide-Isoxazole-Derivate und Salze, Verfahren zu ihrer Herstellung ihre Anwendung als Arzneimittel und pharmazeutische Zusammensetzungen die sie enthalten
ATE172976T1 (de)	1998-11-15	3-aminochroman-spiroderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen
ATE139777T1 (de)	1996-07-15	20-21-dinoreburnamenin-derivate, verfahren zu ihrer herstellung und zwischenverbindungen, ihre anwendung als arzneimittel und diese enthaltende zusammenstellungen
ATE189810T1 (de)	2000-03-15	Eine trifluormethylsulfonylphenyl- oder trifluormethylsulfinylphenylgruppe enthaltende 2- cyan-3-hydroxy-propenamidderivate, verfahren zu ihrer herstellung, ihre anwendung als arzneimittel und diese enthaltende pharmazeutische zusammensetzungen
DE68906049D1 (de)	1993-05-27	Benzocyclohexan- und benzocycloheptan-derivate und deren salze, verfahren und zwischenprodukte zu deren herstellung, deren verwendung als heilmittel und diese enthaltende zusammensetzungen.
ATE97130T1 (de)	1993-11-15	13-brom und 13, 14-dibrom-ergoline, ihre herstellung und verwendung in arzneimitteln.
ATE96803T1 (de)	1993-11-15	Indolo(3,2,1-de>(1,4>-oxazino(2,3,4ij>(1,5>naphthyridinderivate, verfahren zu ihrer herstellung und zwischenprodukte, ihre verwendung als arzneimittel und diese enthaltende zubereitungen.
DE69322218D1 (de)	1999-01-07	Heteroarenylpiperazine, Verfahren zu ihrer Herstellung und ihre Anwendung als Medikamente
DE69419083D1 (de)	1999-07-22	Salmycine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Legal Events

Date	Code	Title	Description
1996-11-07	8364	No opposition during term of opposition
2000-03-30	8327	Change in the person/name/address of the patent owner	Owner name: HOECHST MARION ROUSSEL, PUTEAUX, FR
2003-04-03	8327	Change in the person/name/address of the patent owner	Owner name: AVENTIS PHARMA S.A., ANTONY CEDEX, FR
2006-10-26	8328	Change in the person/name/address of the agent	Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN
2009-07-30	8328	Change in the person/name/address of the agent	Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC