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DE60237373D1 - Isolierte polypeptide auf der grundlage des neutralisierenden epitops des p17-proteins vom hiv geeignet als impfstoffe und neutralisierende anti-p17-antikörper, die besagtes epitop spezifisch erkennen - Google Patents

Isolierte polypeptide auf der grundlage des neutralisierenden epitops des p17-proteins vom hiv geeignet als impfstoffe und neutralisierende anti-p17-antikörper, die besagtes epitop spezifisch erkennen

Info

Publication number
DE60237373D1
DE60237373D1 DE60237373T DE60237373T DE60237373D1 DE 60237373 D1 DE60237373 D1 DE 60237373D1 DE 60237373 T DE60237373 T DE 60237373T DE 60237373 T DE60237373 T DE 60237373T DE 60237373 D1 DE60237373 D1 DE 60237373D1
Authority
DE
Germany
Prior art keywords
neutralizing
arg
amino acid
acid residue
residue selected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60237373T
Other languages
English (en)
Inventor
Arnaldo Caruso
Jose Sebastian Franzone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medestea Internazionale SpA
Original Assignee
Medestea Internazionale SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT2001TO000795A external-priority patent/ITTO20010795A1/it
Priority claimed from ITTO20011042 external-priority patent/ITTO20011042A1/it
Application filed by Medestea Internazionale SpA filed Critical Medestea Internazionale SpA
Application granted granted Critical
Publication of DE60237373D1 publication Critical patent/DE60237373D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6897—Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies
    • A61K47/6898—Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies using avidin- or biotin-conjugated antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nanotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE60237373T 2001-08-07 2002-08-05 Isolierte polypeptide auf der grundlage des neutralisierenden epitops des p17-proteins vom hiv geeignet als impfstoffe und neutralisierende anti-p17-antikörper, die besagtes epitop spezifisch erkennen Expired - Lifetime DE60237373D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT2001TO000795A ITTO20010795A1 (it) 2001-08-07 2001-08-07 Polipeptide isolato basato sulla sequenza della proteina p17 utile come vaccino anti-hiv.
ITTO20011042 ITTO20011042A1 (it) 2001-11-02 2001-11-02 Polipeptidi isolati basati sulla sequenza della proteina p17 di hiv utili come vaccino anti-hiv.
PCT/IB2002/003093 WO2003016337A1 (en) 2001-08-07 2002-08-05 Isolated polypeptides based on the neutralizing epitope of the p17 protein of hiv useful as vaccines, and neutralizing anti-p17 antibodies which specifically recognize said neutralizing epitope

Publications (1)

Publication Number Publication Date
DE60237373D1 true DE60237373D1 (de) 2010-09-30

Family

ID=26332884

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60237373T Expired - Lifetime DE60237373D1 (de) 2001-08-07 2002-08-05 Isolierte polypeptide auf der grundlage des neutralisierenden epitops des p17-proteins vom hiv geeignet als impfstoffe und neutralisierende anti-p17-antikörper, die besagtes epitop spezifisch erkennen

Country Status (8)

Country Link
US (1) US7541036B2 (de)
EP (1) EP1417222B1 (de)
AT (1) ATE478089T1 (de)
DE (1) DE60237373D1 (de)
DK (1) DK1417222T3 (de)
PT (1) PT1417222E (de)
RU (1) RU2337922C9 (de)
WO (1) WO2003016337A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITTO20020286A1 (it) * 2002-03-29 2003-09-29 Medestea Int Spa Uso della proteina p17 isolata per la preparazione di un medicamento atto ad inibire gli effetti immunostimolanti che la proteina prodotta d
MXPA05011997A (es) * 2005-11-08 2007-05-07 Univ Mexico Nacional Autonoma Vacuna intranasal contra la enfermedad ocasionada por escherichia coli enterotoxigenica.
US8759300B2 (en) 2007-06-14 2014-06-24 The Research Foundation For The State University Of New York Polypeptides and methods of use
ITTO20080027A1 (it) * 2008-01-15 2009-07-16 Medestea Res & Production S P A Forma troncata della proteina p17 di hiv.
IT1401359B1 (it) * 2010-03-31 2013-07-18 Medestea Res & Production S P A Anticorpo monoclonale diretto contro la proteina p17 di hiv, atto a neutralizzare il legame fra la proteina p17 e il recettore della proteina p17 (p17r)
RU2475264C2 (ru) * 2010-12-29 2013-02-20 Федеральное государственное бюджетное учреждение "Государственный научный центр "Институт иммунологии" Федерального медико-биологического агентства Вакцина против вич/спид
US10729741B2 (en) 2017-03-27 2020-08-04 Neomatrix Therapeutics Inc. Methods of treating burns with i.v. cP12 in a window from 2 to 6 hours after injury
EP3791179A4 (de) 2018-05-09 2022-01-26 Arizona Board of Regents on behalf of Arizona State University Verfahren zur elektronischen detektion und quantifizierung von antikörpern
CA3100693A1 (en) 2018-05-17 2019-11-21 Stuart Lindsay Device, system and method for direct electrical measurement of enzyme activity
AU2020214334A1 (en) * 2019-01-30 2021-08-12 Arizona Board Of Regents On Behalf Of Arizona State University Bioelectronic circuits, systems and methods for preparing and using them
RU2727673C1 (ru) * 2019-08-09 2020-07-22 Федеральное государственное унитарное предприятие «Государственный научно-исследовательский институт особо чистых биопрепаратов» Федерального медико-биологического агентства Антитела против белка р17 ВИЧ-1 субтипа А
US11913070B2 (en) 2020-02-28 2024-02-27 Arizona Board Of Regents On Behalf Of Arizona State University Methods for sequencing biopolymers

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ235538A (en) * 1989-10-12 1992-06-25 Viral Technologies Inc Peptides immunoreactive with antibodies to hiv p17; carrier-bound peptides, vaccines, immunoassay and a method for forming antibody enriched sera
US6093400A (en) * 1996-08-09 2000-07-25 Cel Sci Corporation Modified HGP-30 peptides, conjugates, compositions and methods of use

Also Published As

Publication number Publication date
EP1417222B1 (de) 2010-08-18
RU2337922C2 (ru) 2008-11-10
US7541036B2 (en) 2009-06-02
DK1417222T3 (da) 2010-12-13
ATE478089T1 (de) 2010-09-15
WO2003016337A1 (en) 2003-02-27
EP1417222A1 (de) 2004-05-12
PT1417222E (pt) 2010-10-12
RU2004106618A (ru) 2005-07-10
RU2337922C9 (ru) 2009-02-10
US20040249124A1 (en) 2004-12-09

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