[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

DE60232158D1 - Lipopeptid-stereoisomere, verfahren zu ihrer herstellung und nützliche zwischenprodukte - Google Patents

Lipopeptid-stereoisomere, verfahren zu ihrer herstellung und nützliche zwischenprodukte

Info

Publication number
DE60232158D1
DE60232158D1 DE60232158T DE60232158T DE60232158D1 DE 60232158 D1 DE60232158 D1 DE 60232158D1 DE 60232158 T DE60232158 T DE 60232158T DE 60232158 T DE60232158 T DE 60232158T DE 60232158 D1 DE60232158 D1 DE 60232158D1
Authority
DE
Germany
Prior art keywords
lipopeptide
stereoisomers
production
compounds
intermediate products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60232158T
Other languages
English (en)
Inventor
Michael Morytko
Yanzhi Zhang
Michael Jung
John Finn
Mario Bouchard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cubist Pharmaceuticals LLC
Original Assignee
Cubist Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cubist Pharmaceuticals LLC filed Critical Cubist Pharmaceuticals LLC
Application granted granted Critical
Publication of DE60232158D1 publication Critical patent/DE60232158D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60232158T 2001-08-06 2002-08-06 Lipopeptid-stereoisomere, verfahren zu ihrer herstellung und nützliche zwischenprodukte Expired - Fee Related DE60232158D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31031301P 2001-08-06 2001-08-06
PCT/US2002/025106 WO2003017924A2 (en) 2001-08-06 2002-08-06 Lipopeptide stereoisomers, methods for preparing same, and useful intermediates

Publications (1)

Publication Number Publication Date
DE60232158D1 true DE60232158D1 (de) 2009-06-10

Family

ID=23201948

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60232158T Expired - Fee Related DE60232158D1 (de) 2001-08-06 2002-08-06 Lipopeptid-stereoisomere, verfahren zu ihrer herstellung und nützliche zwischenprodukte

Country Status (15)

Country Link
US (5) US7262268B2 (de)
EP (2) EP1423137B1 (de)
JP (1) JP2005531486A (de)
KR (1) KR20040022233A (de)
CN (1) CN100352836C (de)
AT (1) ATE430160T1 (de)
AU (1) AU2002353775A1 (de)
BR (1) BR0211761A (de)
CA (2) CA2456323A1 (de)
DE (1) DE60232158D1 (de)
IL (1) IL160171A0 (de)
NZ (1) NZ531493A (de)
RU (1) RU2348647C2 (de)
WO (2) WO2003017924A2 (de)
ZA (1) ZA200400928B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003017924A2 (en) * 2001-08-06 2003-03-06 Cubist Pharmaceuticals, Inc. Lipopeptide stereoisomers, methods for preparing same, and useful intermediates
US6767718B2 (en) * 2002-05-10 2004-07-27 Biosource Pharm, Inc. Lipodepsipeptide antibiotics and methods of preparation
AU2004246909B2 (en) * 2003-06-19 2010-08-19 Yeda Research & Development Co. Ltd. Antimicrobial and anticancer lipopeptides
US20060004185A1 (en) 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
AU2005330517A1 (en) * 2004-11-12 2006-10-19 Cubist Pharmaceuticals, Inc. Antiinfective lipopeptides
US8968781B2 (en) * 2005-04-29 2015-03-03 Cubist Pharmaceuticals, Inc. Therapeutic compositions
AU2009239430B2 (en) * 2008-04-21 2015-01-22 Signum Biosciences, Inc. Compounds, compositions and methods for making the same
DK2379580T3 (da) 2008-12-22 2014-01-20 Cubist Pharm Inc Hidtil ukendte antibakterielle midler til behandling af gram-positive infektioner
AR074874A1 (es) 2008-12-23 2011-02-16 Biosource Pharm Inc Composiciones antibioticas para el tratamiento de infecciones gram negativas. metodo. uso. compuesto.
CN101899094B (zh) * 2009-06-01 2012-11-21 安徽丰原发酵技术工程研究有限公司 一种高纯达托霉素的制备方法
KR101013755B1 (ko) * 2010-02-02 2011-02-14 주식회사 삼광산전 정출력용 엘이디모듈 전원공급 컨버터
US8415307B1 (en) 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
CN102351775B (zh) * 2011-09-14 2013-10-09 佛山普正医药科技有限公司 一种左旋5-羟基色氨酸的制备方法
WO2013059610A1 (en) 2011-10-20 2013-04-25 Trius Therapeutics, Inc. Therapeutic combination of daptomycin and protein synthesis inhibitor antibiotic, and methods of use
TW202138383A (zh) * 2012-12-03 2021-10-16 美商諾維生物製藥有限公司 新穎縮肽及其用途
JP6634197B2 (ja) * 2013-05-08 2020-01-22 株式会社ゲノム創薬研究所 固相レジンを用いた環状ペプチド化合物の製造方法
WO2015172047A1 (en) * 2014-05-08 2015-11-12 Merck Sharp & Dohme Corp. Cyclic peptide compounds and related methods, salts and compositions
KR101671325B1 (ko) * 2015-01-09 2016-11-02 한국생명공학연구원 신규한 고리형 뎁시펩타이드계 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 항균용 약학적 조성물
US11667674B2 (en) * 2016-04-08 2023-06-06 Versitech Limited Antibacterial cyclic lipopeptides
US10072045B1 (en) 2017-06-26 2018-09-11 Ramapo Pharmaceuticals, Inc. Antibacterial lipopeptides and methods for their preparation and use
US11643438B2 (en) 2018-07-20 2023-05-09 The Board Of Regents Of The University Of Oklahoma Antimicrobial peptides and methods of use

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE32333E (en) * 1978-10-16 1987-01-20 Eli Lilly And Company A-21978 Antibiotics and process for their production
USRE32455E (en) * 1978-10-16 1987-07-07 Eli Lilly And Company A-21978 antibiotics and process for their production
US4537717A (en) * 1982-05-21 1985-08-27 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
USRE32311E (en) * 1982-05-21 1986-12-16 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
USRE32310E (en) * 1982-05-21 1986-12-16 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
US4482487A (en) * 1982-05-21 1984-11-13 Eli Lilly And Company A-21978C cyclic peptides
US4524135A (en) 1982-05-21 1985-06-18 Eli Lilly And Company A-21978C cyclic peptides
US4399067A (en) * 1982-05-21 1983-08-16 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
US4885243A (en) * 1984-10-09 1989-12-05 Eli Lilly And Company Process for producing A-21978C derivatives
US4800157A (en) * 1985-09-09 1989-01-24 Eli Lilly And Company Process for producing the A-21978C antibiotics
US4874843A (en) * 1987-12-03 1989-10-17 Eli Lilly And Company Chromatographic purification process
CA1315229C (en) * 1987-06-10 1993-03-30 Patrick J. Baker Chromatographic purification process
US5028590A (en) * 1988-04-11 1991-07-02 Eli Lilly And Company Derivatives of A54145 cyclic peptides
US5039789A (en) * 1988-04-11 1991-08-13 Eli Lilly And Company A54145 cyclic peptides
US4994270A (en) * 1988-04-11 1991-02-19 Eli Lilly And Company A54145 antibiotics and process for their production
US4977083A (en) * 1988-04-11 1990-12-11 Eli Lilly And Company Processes for preparing A54145 compounds
ATE140728T1 (de) * 1990-06-07 1996-08-15 Lilly Co Eli Lipopeptid deacylase
WO1993018141A1 (en) * 1992-03-02 1993-09-16 Biogen, Inc. Thrombin receptor antagonists
DE4411025A1 (de) * 1994-03-30 1995-10-05 Hoechst Ag Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
US6010861A (en) * 1994-08-03 2000-01-04 Dgi Biotechnologies, Llc Target specific screens and their use for discovering small organic molecular pharmacophores
ES2327981T3 (es) 1996-03-08 2009-11-05 Astellas Pharma Inc. Procedimiento para la desacilacion de lipopeptidos ciclicos.
US5958728A (en) * 1996-11-18 1999-09-28 Novo Nordiskbiotech, Inc. Methods for producing polypeptides in mutants of bacillus cells
US20010041346A1 (en) 1999-07-14 2001-11-15 Michael E. Mendelsohn Method for assaying compounds affecting smooth muscle contractile state
CA2393907A1 (en) * 1999-12-15 2001-06-21 Cubist Pharmaceuticals Inc. Novel lipopeptides as antibacterial agents
AU784942B2 (en) 1999-12-15 2006-08-03 Cubist Pharmaceuticals, Inc. Daptomycin analogs and their use as antibacterial agents
CA2394350A1 (en) * 1999-12-15 2001-06-21 Cubist Pharmaceuticals, Inc. Lipopeptides as antibacterial agents
US6696412B1 (en) 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
US6750199B2 (en) * 2000-07-17 2004-06-15 Micrologix Biotech Inc. Antimicrobial sulfonamide derivatives of lipopeptide antibiotics
WO2003017924A2 (en) * 2001-08-06 2003-03-06 Cubist Pharmaceuticals, Inc. Lipopeptide stereoisomers, methods for preparing same, and useful intermediates

Also Published As

Publication number Publication date
CN1551887A (zh) 2004-12-01
US7335726B2 (en) 2008-02-26
WO2003017924A3 (en) 2004-03-04
IL160171A0 (en) 2004-07-25
EP1423414A1 (de) 2004-06-02
EP1423137B1 (de) 2009-04-29
CN100352836C (zh) 2007-12-05
NZ531493A (en) 2006-03-31
WO2003014147A1 (en) 2003-02-20
US20060223983A1 (en) 2006-10-05
WO2003017924A2 (en) 2003-03-06
CA2456761A1 (en) 2003-02-20
EP1423137A2 (de) 2004-06-02
EP1423137A4 (de) 2005-11-30
JP2005531486A (ja) 2005-10-20
ATE430160T1 (de) 2009-05-15
EP1423414A4 (de) 2005-11-30
ZA200400928B (en) 2005-05-04
US7262268B2 (en) 2007-08-28
KR20040022233A (ko) 2004-03-11
RU2004106630A (ru) 2005-06-27
US20060194714A1 (en) 2006-08-31
BR0211761A (pt) 2007-01-09
RU2348647C2 (ru) 2009-03-10
CA2456323A1 (en) 2003-03-06
US20030083240A1 (en) 2003-05-01
US20080119395A1 (en) 2008-05-22
US20030096948A1 (en) 2003-05-22
AU2002353775A1 (en) 2003-03-10

Similar Documents

Publication Publication Date Title
DE60232158D1 (de) Lipopeptid-stereoisomere, verfahren zu ihrer herstellung und nützliche zwischenprodukte
WO2001044271A3 (en) Daptomycin analogs and their use as antibacterial agents
WO2001044272A3 (en) Daptomycin analogs as antibacterial agents
TW200505837A (en) Novel compounds
TW200519075A (en) Novel compounds
MXPA02006030A (es) Lipopeptidos como agentes antibacterianos.
SG131109A1 (en) Muteins of tear lipocalin
TNSN04199A1 (en) Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use
ATE529409T1 (de) Verfahren zur herstellung von kristallinen aripiprazolformen
DE60202958D1 (de) Stabiles polymorph von flibanserin, industrielles verfahren zu dessen herstellung und dessen verwendung zur herstellung von medikamenten
GB0216001D0 (en) Process and composition
RS19504A (en) Novel compounds and compositions as cathepsin inhibitors
DE60128112D1 (de) Aminoalkoxybenzoyl-benzofurane oder benzothiophene, verfahren zu ihrer herstellung und die enthaltenden zusammensetzungen
EA200300579A1 (ru) Соединение лактама
ATE461934T1 (de) Verfahren zur herstellung von 17-hydroxy-6 beta, 7 beta, 15 beta,16 beta-bismethylen-17alpha-pregn-4-en-3-on-21-car onsäure -lacton und schlüsselzwischenprodukte für dieses verfahren
EA200701688A1 (ru) Замещённые пирролы, содержащие их композиции, способ получения и применение
DE60309847D1 (de) Zwischenprodukte und verfahren zur herstellung von heptapeptid-oxytocinanaloga
WO2001081298A3 (en) Cyclic carboxylic acids as integrin antagonists
ATE299851T1 (de) Verfahren zur herstellung von zwischenprodukten
ATE496038T1 (de) Verfahren zur herstellung von quetiapin
WO2006110185A3 (en) Antiinfective lipopeptides
DE602004031727D1 (de) Neues verfahren und zwischenprodukte zur herstellung von 19-nor-steroiden
DE60102084D1 (de) Propanolaminotetraline, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende pharmazeutische zusammensetzungen
ATE260921T1 (de) Verfahren zur herstellung von imidazo (1,2-c) (2, 3)benzodiazepinen und zwischenprodukte bei deren herstellung
DE50002865D1 (de) Verfahren zur herstellung von benzofuranonoximen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee