DE602007006531D1 - Pyrazin-2-carboxamid-derivate als cb2-rezeptormodulatoren - Google Patents
Pyrazin-2-carboxamid-derivate als cb2-rezeptormodulatorenInfo
- Publication number
- DE602007006531D1 DE602007006531D1 DE602007006531T DE602007006531T DE602007006531D1 DE 602007006531 D1 DE602007006531 D1 DE 602007006531D1 DE 602007006531 T DE602007006531 T DE 602007006531T DE 602007006531 T DE602007006531 T DE 602007006531T DE 602007006531 D1 DE602007006531 D1 DE 602007006531D1
- Authority
- DE
- Germany
- Prior art keywords
- pyrazin
- receptor modulators
- carboxamide derivatives
- carboxamide
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06121749 | 2006-10-04 | ||
PCT/EP2007/060090 WO2008040649A2 (en) | 2006-10-04 | 2007-09-24 | Pyrazine-2-carboxamide derivatives as cb2 receptor modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602007006531D1 true DE602007006531D1 (de) | 2010-06-24 |
Family
ID=39166552
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602007006531T Active DE602007006531D1 (de) | 2006-10-04 | 2007-09-24 | Pyrazin-2-carboxamid-derivate als cb2-rezeptormodulatoren |
Country Status (18)
Country | Link |
---|---|
US (1) | US7691863B2 (de) |
EP (1) | EP2076499B1 (de) |
JP (1) | JP5064506B2 (de) |
KR (1) | KR101114704B1 (de) |
CN (1) | CN101522644B (de) |
AR (1) | AR063101A1 (de) |
AT (1) | ATE467622T1 (de) |
AU (1) | AU2007304363B2 (de) |
BR (1) | BRPI0717822A2 (de) |
CA (1) | CA2664621A1 (de) |
CL (1) | CL2007002834A1 (de) |
DE (1) | DE602007006531D1 (de) |
ES (1) | ES2344128T3 (de) |
IL (1) | IL197763A0 (de) |
MX (1) | MX2009003316A (de) |
PE (1) | PE20080855A1 (de) |
TW (1) | TW200825065A (de) |
WO (1) | WO2008040649A2 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7629346B2 (en) * | 2006-06-19 | 2009-12-08 | Hoffmann-La Roche Inc. | Pyrazinecarboxamide derivatives as CB1 antagonists |
US7781593B2 (en) | 2006-09-14 | 2010-08-24 | Hoffmann-La Roche Inc. | 5-phenyl-nicotinamide derivatives |
WO2008040651A1 (en) * | 2006-10-04 | 2008-04-10 | F. Hoffmann-La Roche Ag | 3-pyridinecarboxamide and 2-pyrazinecarboxamide derivatives as hdl-cholesterol raising agents |
US8088920B2 (en) | 2008-03-31 | 2012-01-03 | Hoffmann-La Roche Inc. | 3-trifluoromethyl-pyrazine-2-carboxylic acid amide derivatives as HDL-cholesterol raising agents |
US7897621B2 (en) | 2008-03-31 | 2011-03-01 | Hoffmann-La Roche Inc. | 2-trifluoromethylnicotinamide derivatives as HDL-cholesterol raising agents |
US8354441B2 (en) | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
WO2012031817A1 (en) * | 2010-09-09 | 2012-03-15 | F. Hoffmann-La Roche Ag | Determination of abca1 protein levels in cells |
US8410107B2 (en) | 2010-10-15 | 2013-04-02 | Hoffmann-La Roche Inc. | N-pyridin-3-yl or N-pyrazin-2-yl carboxamides |
US8669254B2 (en) | 2010-12-15 | 2014-03-11 | Hoffman-La Roche Inc. | Pyridine, pyridazine, pyrimidine or pyrazine carboxamides as HDL-cholesterol raising agents |
US9321727B2 (en) * | 2011-06-10 | 2016-04-26 | Hoffmann-La Roche Inc. | Pyridine derivatives as agonists of the CB2 receptor |
US9403808B2 (en) * | 2011-10-28 | 2016-08-02 | Hoffmann-La Roche Inc. | Pyrazine derivatives |
SG11201504475QA (en) * | 2012-12-07 | 2015-07-30 | Hoffmann La Roche | Pyridine-2-amides useful as cb2 agonists |
PE20151025A1 (es) * | 2012-12-07 | 2015-07-15 | Hoffmann La Roche | Nuevos derivados de piridina |
PE20151060A1 (es) * | 2012-12-07 | 2015-07-25 | Hoffmann La Roche | Nuevos derivados de pirazina como agonistas del receptor cb2 |
SI2928868T1 (sl) * | 2012-12-07 | 2017-11-30 | F. Hoffmann-La Roche Ag | Piridin-2-amidi, uporabni kot agonisti CB2 |
EP3126349B1 (de) * | 2014-04-04 | 2019-06-26 | F. Hoffmann-La Roche AG | 5,6-disubstituierte pyridin-2-carboxamide als cannabinoid-rezeptor-agonisten |
PL3464272T3 (pl) | 2016-06-07 | 2022-03-28 | Jacobio Pharmaceuticals Co., Ltd. | Nowe pochodne heterocykliczne użyteczne jako inhibitory SHP2 |
NZ758458A (en) | 2017-03-23 | 2022-07-29 | Jacobio Pharmaceuticals Co Ltd | Novel heterocyclic derivatives useful as shp2 inhibitors |
CN109384734B (zh) * | 2017-08-14 | 2023-04-11 | 上海科胜药物研发有限公司 | 一种塞尔西帕中间体的制备方法 |
CN112119068A (zh) | 2018-06-27 | 2020-12-22 | 豪夫迈·罗氏有限公司 | 作为大麻素受体2的抑制剂的新型氮杂环丁烷-取代的吡啶和吡嗪化合物 |
CN112074513B (zh) * | 2018-06-27 | 2024-06-14 | 豪夫迈·罗氏有限公司 | 作为优先大麻素2激动剂的吡啶和吡嗪衍生物 |
KR20210028202A (ko) * | 2018-06-27 | 2021-03-11 | 에프. 호프만-라 로슈 아게 | 칸나비노이드 수용체 2의 억제제로서 신규한 피리딘 및 피라진 화합물 |
CN112638430B (zh) | 2018-06-27 | 2023-05-16 | 豪夫迈·罗氏有限公司 | 放射性标记的大麻素受体2配体 |
WO2023082145A1 (en) * | 2021-11-11 | 2023-05-19 | 4B Technologies (Suzhou) Limited | Intermediate compound of quinoxaline and preparation process thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5738778A (en) * | 1980-08-18 | 1982-03-03 | Kyowa Gas Chem Ind Co Ltd | Novel cyanopyrazine derivative |
UY27939A1 (es) * | 2002-08-21 | 2004-03-31 | Glaxo Group Ltd | Compuestos |
GB0222493D0 (en) | 2002-09-27 | 2002-11-06 | Glaxo Group Ltd | Compounds |
AU2004221812B2 (en) * | 2003-03-19 | 2010-02-18 | Exelixis Inc. | Tie-2 modulators and methods of use |
CA2527033A1 (en) * | 2003-06-18 | 2004-12-23 | Astrazeneca Ab | 2-substitued 5,6-diaryl-pyrazine derivatives as cb1 modulators |
US7326706B2 (en) * | 2003-08-15 | 2008-02-05 | Bristol-Myers Squibb Company | Pyrazine modulators of cannabinoid receptors |
GB0402357D0 (en) * | 2004-02-03 | 2004-03-10 | Glaxo Group Ltd | Novel compounds |
BRPI0609685A2 (pt) | 2005-04-06 | 2010-04-20 | Hoffmann La Roche | compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem, método para tratamento e/ou profilaxia de enfermidades que estão associados com a modulação de receptores de cb1, e utilização dos mesmos |
US7629346B2 (en) * | 2006-06-19 | 2009-12-08 | Hoffmann-La Roche Inc. | Pyrazinecarboxamide derivatives as CB1 antagonists |
US7781593B2 (en) | 2006-09-14 | 2010-08-24 | Hoffmann-La Roche Inc. | 5-phenyl-nicotinamide derivatives |
-
2007
- 2007-09-24 MX MX2009003316A patent/MX2009003316A/es active IP Right Grant
- 2007-09-24 WO PCT/EP2007/060090 patent/WO2008040649A2/en active Application Filing
- 2007-09-24 BR BRPI0717822-0A2A patent/BRPI0717822A2/pt not_active IP Right Cessation
- 2007-09-24 KR KR1020097008997A patent/KR101114704B1/ko not_active IP Right Cessation
- 2007-09-24 AT AT07820497T patent/ATE467622T1/de active
- 2007-09-24 US US11/903,581 patent/US7691863B2/en not_active Expired - Fee Related
- 2007-09-24 AU AU2007304363A patent/AU2007304363B2/en not_active Ceased
- 2007-09-24 JP JP2009530841A patent/JP5064506B2/ja not_active Expired - Fee Related
- 2007-09-24 ES ES07820497T patent/ES2344128T3/es active Active
- 2007-09-24 EP EP07820497A patent/EP2076499B1/de not_active Not-in-force
- 2007-09-24 CN CN2007800372430A patent/CN101522644B/zh not_active Expired - Fee Related
- 2007-09-24 DE DE602007006531T patent/DE602007006531D1/de active Active
- 2007-09-24 CA CA002664621A patent/CA2664621A1/en not_active Abandoned
- 2007-10-02 AR ARP070104363A patent/AR063101A1/es unknown
- 2007-10-02 TW TW096136934A patent/TW200825065A/zh unknown
- 2007-10-02 CL CL200702834A patent/CL2007002834A1/es unknown
- 2007-10-03 PE PE2007001334A patent/PE20080855A1/es not_active Application Discontinuation
-
2009
- 2009-03-23 IL IL197763A patent/IL197763A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP2076499B1 (de) | 2010-05-12 |
CL2007002834A1 (es) | 2008-05-16 |
JP2010505788A (ja) | 2010-02-25 |
AR063101A1 (es) | 2008-12-30 |
BRPI0717822A2 (pt) | 2013-11-12 |
JP5064506B2 (ja) | 2012-10-31 |
PE20080855A1 (es) | 2008-06-28 |
IL197763A0 (en) | 2009-12-24 |
ES2344128T3 (es) | 2010-08-18 |
CA2664621A1 (en) | 2008-04-10 |
AU2007304363B2 (en) | 2013-01-17 |
CN101522644B (zh) | 2013-04-24 |
US20080085905A1 (en) | 2008-04-10 |
EP2076499A2 (de) | 2009-07-08 |
MX2009003316A (es) | 2009-04-09 |
AU2007304363A1 (en) | 2008-04-10 |
WO2008040649A3 (en) | 2008-05-29 |
ATE467622T1 (de) | 2010-05-15 |
KR101114704B1 (ko) | 2012-03-14 |
TW200825065A (en) | 2008-06-16 |
CN101522644A (zh) | 2009-09-02 |
WO2008040649A2 (en) | 2008-04-10 |
KR20090084842A (ko) | 2009-08-05 |
US7691863B2 (en) | 2010-04-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |