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DE602006003666D1 - Indol-3-ylcarbonylpiperidinbenzimidazolderivate als v1a-rezeptorantagonisten - Google Patents

Indol-3-ylcarbonylpiperidinbenzimidazolderivate als v1a-rezeptorantagonisten

Info

Publication number
DE602006003666D1
DE602006003666D1 DE602006003666T DE602006003666T DE602006003666D1 DE 602006003666 D1 DE602006003666 D1 DE 602006003666D1 DE 602006003666 T DE602006003666 T DE 602006003666T DE 602006003666 T DE602006003666 T DE 602006003666T DE 602006003666 D1 DE602006003666 D1 DE 602006003666D1
Authority
DE
Germany
Prior art keywords
ylcarbonylpiperidinbenzimidazole
indol
derivatives
receptor antagonists
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006003666T
Other languages
English (en)
Inventor
Caterina Bissantz
Christophe Grundschober
Hasane Ratni
Mark Rogers-Evans
Patrick Schnider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE602006003666D1 publication Critical patent/DE602006003666D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE602006003666T 2005-07-21 2006-07-11 Indol-3-ylcarbonylpiperidinbenzimidazolderivate als v1a-rezeptorantagonisten Active DE602006003666D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05106695 2005-07-21
EP05110506 2005-11-09
PCT/EP2006/064075 WO2007009906A1 (en) 2005-07-21 2006-07-11 Indol-3-yl-carbonyl-piperidin-benzoimidazol derivatives as v1a receptor antagonists

Publications (1)

Publication Number Publication Date
DE602006003666D1 true DE602006003666D1 (de) 2008-12-24

Family

ID=37192471

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006003666T Active DE602006003666D1 (de) 2005-07-21 2006-07-11 Indol-3-ylcarbonylpiperidinbenzimidazolderivate als v1a-rezeptorantagonisten

Country Status (21)

Country Link
US (2) US7803815B2 (de)
EP (1) EP1912976B1 (de)
JP (1) JP4839374B2 (de)
KR (1) KR100984893B1 (de)
CN (1) CN101268067A (de)
AR (1) AR056188A1 (de)
AT (1) ATE414078T1 (de)
AU (1) AU2006271804B2 (de)
BR (1) BRPI0613656A2 (de)
CA (1) CA2616063A1 (de)
DE (1) DE602006003666D1 (de)
DK (1) DK1912976T3 (de)
ES (1) ES2314941T3 (de)
IL (1) IL188722A (de)
MX (1) MX2008000886A (de)
NO (1) NO20080291L (de)
PL (1) PL1912976T3 (de)
PT (1) PT1912976E (de)
RU (1) RU2415139C2 (de)
TW (1) TWI324601B (de)
WO (1) WO2007009906A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2616937A1 (en) * 2005-07-29 2007-02-08 F. Hoffman-La Roche Ag Indol-3-yl-carbonyl-piperidin and piperazin derivatives
US20080139617A1 (en) 2006-12-08 2008-06-12 Caterina Bissantz Indoles
PE20081401A1 (es) * 2006-12-28 2008-10-24 Hoffmann La Roche Derivados de indol como antagonistas de receptores vasopresina
DK2240482T3 (da) * 2008-01-31 2013-10-21 Sanofi Sa Cykliske azaindol-3-carboxamider, deres fremstilling og deres anvendelse som lægemidler
HUP1000598A2 (en) 2010-11-05 2012-09-28 Richter Gedeon Nyrt Indole derivatives
EP2548864B1 (de) 2011-07-22 2014-02-19 Université Joseph Fourier Neue Bis-Indol-Derivate, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
CA3072766A1 (en) * 2017-09-05 2019-03-14 Blackthorn Therapeutics, Inc. 2,6-diazaspiro[3.3]hepatan-2-yl derivatives and pharmaceutical compostions thereof useful as vasopressin receptor antagonists
TW201938171A (zh) 2017-12-15 2019-10-01 匈牙利商羅特格登公司 作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物
HU231206B1 (hu) 2017-12-15 2021-10-28 Richter Gedeon Nyrt. Triazolobenzazepinek

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686624A (en) * 1992-01-30 1997-11-11 Sanofi 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
AUPP150098A0 (en) * 1998-01-27 1998-02-19 Fujisawa Pharmaceutical Co., Ltd. Benzamide derivatives
EP1330451B1 (de) * 2000-10-27 2008-01-23 Ortho-McNeil Pharmaceutical, Inc. Substituierte benzimidazol-2-one als vasopressin receptor antagonisten und neuropeptide y modulatoren
US6933316B2 (en) * 2001-12-13 2005-08-23 National Health Research Institutes Indole compounds

Also Published As

Publication number Publication date
CN101268067A (zh) 2008-09-17
US20100256140A1 (en) 2010-10-07
AR056188A1 (es) 2007-09-26
TWI324601B (en) 2010-05-11
JP4839374B2 (ja) 2011-12-21
RU2415139C2 (ru) 2011-03-27
KR20080027950A (ko) 2008-03-28
ATE414078T1 (de) 2008-11-15
PL1912976T3 (pl) 2009-04-30
WO2007009906A1 (en) 2007-01-25
CA2616063A1 (en) 2007-01-25
IL188722A0 (en) 2008-08-07
DK1912976T3 (da) 2009-01-26
MX2008000886A (es) 2008-03-18
RU2008100780A (ru) 2009-08-27
TW200740792A (en) 2007-11-01
JP2009501757A (ja) 2009-01-22
PT1912976E (pt) 2009-01-07
KR100984893B1 (ko) 2010-10-01
AU2006271804B2 (en) 2011-03-31
EP1912976B1 (de) 2008-11-12
AU2006271804A1 (en) 2007-01-25
EP1912976A1 (de) 2008-04-23
US20070021463A1 (en) 2007-01-25
ES2314941T3 (es) 2009-03-16
NO20080291L (no) 2008-03-06
IL188722A (en) 2012-12-31
US7803815B2 (en) 2010-09-28
BRPI0613656A2 (pt) 2011-01-25

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