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DE602005017122D1 - Derivate von heteroarylalkylcarbamaten, verfahren zu deren herstellung und deren verwendung als faah-enzyminhibitoren - Google Patents

Derivate von heteroarylalkylcarbamaten, verfahren zu deren herstellung und deren verwendung als faah-enzyminhibitoren

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Publication number
DE602005017122D1
DE602005017122D1 DE602005017122T DE602005017122T DE602005017122D1 DE 602005017122 D1 DE602005017122 D1 DE 602005017122D1 DE 602005017122 T DE602005017122 T DE 602005017122T DE 602005017122 T DE602005017122 T DE 602005017122T DE 602005017122 D1 DE602005017122 D1 DE 602005017122D1
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DE
Germany
Prior art keywords
derivatives
production
enzyme inhibitors
heteroaryl alkyl
alkyl carbamates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
DE602005017122T
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English (en)
Inventor
Ahmed Abouabdellah
Regine Bartsch-Li
Christian Hoornaert
Antoine Ravet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
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Sanofi Aventis France
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Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Publication of DE602005017122D1 publication Critical patent/DE602005017122D1/de
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
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    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
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    • C—CHEMISTRY; METALLURGY
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
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    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
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    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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DE602005017122T 2004-02-26 2005-02-25 Derivate von heteroarylalkylcarbamaten, verfahren zu deren herstellung und deren verwendung als faah-enzyminhibitoren Active DE602005017122D1 (de)

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FR0401949A FR2866886B1 (fr) 2004-02-26 2004-02-26 Derives d'aryl-et d'heteroaryl-akylcarbamates, leur preparation et leur application en therapeutique
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FR2866885B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives de piperidinylalkylcarbamates, leur prepation et leur application en therapeutique
CA2684703A1 (en) 2007-04-26 2008-11-13 Takeda Pharmaceutical Company Limited Bicyclic compound and pharmaceutical use thereof
WO2009070497A1 (en) * 2007-11-28 2009-06-04 Smithkline Beecham Corporation SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE
KR101799429B1 (ko) * 2010-05-03 2017-11-21 에스케이바이오팜 주식회사 신경 세포 사멸 또는 신경 퇴화를 억제하기 위한 약학적 조성물

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FR2866886B1 (fr) 2007-08-31
AR047973A1 (es) 2006-03-15
US20070021426A1 (en) 2007-01-25
CN1926097B (zh) 2011-06-08
TW200533637A (en) 2005-10-16
IL177329A0 (en) 2006-12-10
US20110237595A1 (en) 2011-09-29
BRPI0508193A (pt) 2007-08-14
SI1720829T1 (sl) 2010-02-26
US7645757B2 (en) 2010-01-12
ATE445592T1 (de) 2009-10-15
NZ550008A (en) 2010-06-25
IL177329A (en) 2012-01-31
ES2334449T3 (es) 2010-03-10
FR2866886A1 (fr) 2005-09-02
NO20064329L (no) 2006-09-25
PL1720829T3 (pl) 2010-03-31
CA2554609A1 (fr) 2005-09-29
EP2251324A1 (de) 2010-11-17
KR20070011297A (ko) 2007-01-24
WO2005090292A1 (fr) 2005-09-29
JP4824668B2 (ja) 2011-11-30
EP1720829A1 (de) 2006-11-15
AU2005223423A1 (en) 2005-09-29
RU2006134026A (ru) 2008-04-10
PT1720829E (pt) 2010-01-13
HK1101759A1 (en) 2007-10-26
HRP20100017T1 (hr) 2010-02-28
AU2005223423B2 (en) 2011-04-14
RU2364586C2 (ru) 2009-08-20
DK1720829T3 (da) 2010-03-01
CY1109716T1 (el) 2014-08-13
RS51246B (sr) 2010-12-31
JP2007524705A (ja) 2007-08-30
ZA200606724B (en) 2007-12-27
CN1926097A (zh) 2007-03-07
US20100069405A1 (en) 2010-03-18
MA28367A1 (fr) 2006-12-01
EP1720829B1 (de) 2009-10-14

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