DE60119492D1 - Purinderivate - Google Patents

Purinderivate

Info

Publication number: DE60119492D1
Authority: DE; Germany
Prior art keywords: purine derivatives; purine; derivatives
Prior art date: 2000-02-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE60119492T

Other languages

English (en)

Other versions

DE60119492T2 (de

Inventor

Simon John Mantell

Sandra M Monaghan

Peter Stephenson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Ltd

Original Assignee

Pfizer Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-18

Filing date

2001-02-09

Publication date

2006-06-14

2001-02-09 Application filed by Pfizer Ltd filed Critical Pfizer Ltd

2006-06-14 Application granted granted Critical

2006-06-14 Publication of DE60119492D1 publication Critical patent/DE60119492D1/de

2006-11-09 Publication of DE60119492T2 publication Critical patent/DE60119492T2/de

2021-02-10 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Cardiology (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Crystallography & Structural Chemistry (AREA)
Otolaryngology (AREA)
Urology & Nephrology (AREA)
Gynecology & Obstetrics (AREA)
Reproductive Health (AREA)
Obesity (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)

DE60119492T 2000-02-18 2001-02-09 Purinderivate Expired - Fee Related DE60119492T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB0003960.2A GB0003960D0 (en)	2000-02-18	2000-02-18	Purine derivatives
GB0003960		2000-02-18
PCT/IB2001/000167 WO2001060835A1 (en)	2000-02-18	2001-02-09	Purine derivatives

Publications (2)

Publication Number	Publication Date
DE60119492D1 true DE60119492D1 (de)	2006-06-14
DE60119492T2 DE60119492T2 (de)	2006-11-09

Family

ID=9886026

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60119492T Expired - Fee Related DE60119492T2 (de)	2000-02-18	2001-02-09	Purinderivate

Country Status (39)

Country	Link
US (1)	US6525032B2 (de)
EP (1)	EP1255764B8 (de)
JP (1)	JP2004508284A (de)
KR (1)	KR20030036138A (de)
CN (1)	CN1400975A (de)
AP (1)	AP2002002598A0 (de)
AR (1)	AR027437A1 (de)
AT (1)	ATE325807T1 (de)
AU (1)	AU2001230440A1 (de)
BG (1)	BG106906A (de)
BR (1)	BR0108408A (de)
CA (1)	CA2400619A1 (de)
CO (1)	CO5271668A1 (de)
CR (1)	CR6722A (de)
CZ (1)	CZ20022703A3 (de)
DE (1)	DE60119492T2 (de)
EA (1)	EA004987B1 (de)
EE (1)	EE200200452A (de)
ES (1)	ES2260199T3 (de)
GB (1)	GB0003960D0 (de)
GT (1)	GT200100027A (de)
HN (1)	HN2001000027A (de)
HR (1)	HRP20020676A2 (de)
HU (1)	HUP0301055A2 (de)
IL (1)	IL150543A0 (de)
IS (1)	IS6458A (de)
MA (1)	MA26873A1 (de)
MX (1)	MXPA02008068A (de)
NO (1)	NO20023894L (de)
NZ (1)	NZ519971A (de)
OA (1)	OA12177A (de)
PA (1)	PA8511801A1 (de)
PE (1)	PE20011122A1 (de)
PL (1)	PL357220A1 (de)
SK (1)	SK11692002A3 (de)
SV (1)	SV2002000317A (de)
TN (1)	TNSN01028A1 (de)
WO (1)	WO2001060835A1 (de)
ZA (1)	ZA200206526B (de)

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US8178509B2 (en)	2006-02-10	2012-05-15	University Of Virginia Patent Foundation	Method to treat sickle cell disease
GB0607951D0 (en) *	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
GB0607950D0 (en)	2006-04-21	2006-05-31	Novartis Ag	Organic compounds
BRPI0710573A2 (pt) *	2006-04-21	2012-02-28	Novartis Ag	compostos orgánicos, usos e processos para a preparação dos referidos compostos, bem como composição farmacêutica compreendendo os mesmos
US8188063B2 (en) *	2006-06-19	2012-05-29	University Of Virginia Patent Foundation	Use of adenosine A2A modulators to treat spinal cord injury
EP1889846A1 (de)	2006-07-13	2008-02-20	Novartis AG	Purinderivate als A2a Agonisten
EP1903044A1 (de)	2006-09-14	2008-03-26	Novartis AG	Adenosinderivate als Agonisten des A2A-Rezeptors
CA2664378A1 (en)	2006-09-29	2008-04-03	Novartis Ag	Pyrazolopyrimidines as pi3k lipid kinase inhibitors
KR20090075714A (ko)	2006-10-30	2009-07-08	노파르티스 아게	소염제로서의 헤테로시클릭 화합물
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US8058259B2 (en) *	2007-12-20	2011-11-15	University Of Virginia Patent Foundation	Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
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UA104010C2 (en) *	2008-12-18	2013-12-25	Эли Лилли Энд Компани	Purine compounds
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CA2771432A1 (en)	2009-08-20	2011-02-24	Novartis Ag	Heterocyclic oxime compounds
PT2523669T (pt)	2010-01-11	2017-01-31	Inotek Pharmaceuticals Corp	Associação, conjunto ( kit ) e método de redução da pressão intraocular
US8476247B2 (en)	2010-03-26	2013-07-02	Inotek Pharmaceuticals Corporation	Method of reducing intraocular pressure in humans
UY33597A (es)	2010-09-09	2012-04-30	Irm Llc	Compuestos y composiciones como inhibidores de la trk
WO2012034095A1 (en)	2010-09-09	2012-03-15	Irm Llc	Compounds and compositions as trk inhibitors
EP2673277A1 (de)	2011-02-10	2013-12-18	Novartis AG	[1, 2, 4] triazolo [4, 3]pyridazinverbindungen als inhibitoren dec-met-tyrosinkinase
JP5808826B2 (ja)	2011-02-23	2015-11-10	インテリカイン，エルエルシー	複素環化合物およびその使用
JP5959541B2 (ja)	2011-02-25	2016-08-02	ノバルティスアーゲー	Ｔｒｋ阻害剤としてのピラゾロ［１，５−ａ］ピリジン
AU2012310168B2 (en)	2011-09-15	2015-07-16	Novartis Ag	6 - substituted 3 - (quinolin- 6 - ylthio) - [1,2,4] triazolo [4, 3 -a] pyradines as tyrosine kinase
US20130209543A1 (en)	2011-11-23	2013-08-15	Intellikine Llc	Enhanced treatment regimens using mtor inhibitors
RS56150B1 (sr)	2012-01-26	2017-11-30	Inotek Pharmaceuticals Corp	Anhidrovani polimorfi (2r,3s,4r,5r)-5-(6-(ciklopentilamino)-9h-purin-9-yl)-3,4-dihidroksitetrahidrofuran-2-yl)} metil-nitrata i postupak njegove pripreme
RU2660354C2 (ru)	2012-04-03	2018-07-05	Новартис Аг	Комбинированные продукты, содержащие ингибиторы тирозинкиназ, и их применение
EP2968389A4 (de)	2013-03-15	2016-08-24	Inotek Pharmaceuticals Corp	Ophthalmische formulierungen
CN105246482A (zh)	2013-03-15	2016-01-13	因特利凯有限责任公司	激酶抑制剂的组合及其用途
TW201605450A (zh)	2013-12-03	2016-02-16	諾華公司	Ｍｄｍ２抑制劑與ＢＲＡＦ抑制劑之組合及其用途
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GB9924361D0 (en)	1999-10-14	1999-12-15	Pfizer Ltd	Purine derivatives

2000
- 2000-02-18 GB GBGB0003960.2A patent/GB0003960D0/en not_active Ceased
2001
- 2001-02-09 EE EEP200200452A patent/EE200200452A/xx unknown
- 2001-02-09 KR KR1020027010481A patent/KR20030036138A/ko active IP Right Grant
- 2001-02-09 SK SK1169-2002A patent/SK11692002A3/sk unknown
- 2001-02-09 EA EA200200770A patent/EA004987B1/ru not_active IP Right Cessation
- 2001-02-09 AU AU2001230440A patent/AU2001230440A1/en not_active Abandoned
- 2001-02-09 PL PL01357220A patent/PL357220A1/xx not_active Application Discontinuation
- 2001-02-09 WO PCT/IB2001/000167 patent/WO2001060835A1/en active IP Right Grant
- 2001-02-09 AP APAP/P/2002/002598A patent/AP2002002598A0/en unknown
- 2001-02-09 HU HU0301055A patent/HUP0301055A2/hu unknown
- 2001-02-09 NZ NZ519971A patent/NZ519971A/en unknown
- 2001-02-09 EP EP01902583A patent/EP1255764B8/de not_active Expired - Lifetime
- 2001-02-09 BR BR0108408-9A patent/BR0108408A/pt not_active IP Right Cessation
- 2001-02-09 MX MXPA02008068A patent/MXPA02008068A/es active IP Right Grant
- 2001-02-09 OA OA1200200250A patent/OA12177A/en unknown
- 2001-02-09 DE DE60119492T patent/DE60119492T2/de not_active Expired - Fee Related
- 2001-02-09 JP JP2001560219A patent/JP2004508284A/ja active Pending
- 2001-02-09 IL IL15054301A patent/IL150543A0/xx unknown
- 2001-02-09 CA CA002400619A patent/CA2400619A1/en not_active Abandoned
- 2001-02-09 CZ CZ20022703A patent/CZ20022703A3/cs unknown
- 2001-02-09 CN CN01805069A patent/CN1400975A/zh active Pending
- 2001-02-09 AT AT01902583T patent/ATE325807T1/de not_active IP Right Cessation
- 2001-02-09 ES ES01902583T patent/ES2260199T3/es not_active Expired - Lifetime
- 2001-02-12 GT GT200100027A patent/GT200100027A/es unknown
- 2001-02-15 CO CO01012091A patent/CO5271668A1/es not_active Application Discontinuation
- 2001-02-15 AR ARP010100690A patent/AR027437A1/es not_active Application Discontinuation
- 2001-02-15 PA PA20018511801A patent/PA8511801A1/es unknown
- 2001-02-15 HN HN2001000027A patent/HN2001000027A/es unknown
- 2001-02-16 SV SV2001000317A patent/SV2002000317A/es not_active Application Discontinuation
- 2001-02-16 PE PE2001000174A patent/PE20011122A1/es not_active Application Discontinuation
- 2001-02-16 TN TNTNSN01028A patent/TNSN01028A1/fr unknown
- 2001-02-20 US US09/789,236 patent/US6525032B2/en not_active Expired - Fee Related
2002
- 2002-07-05 BG BG106906A patent/BG106906A/xx unknown
- 2002-07-05 IS IS6458A patent/IS6458A/is unknown
- 2002-08-06 CR CR6722A patent/CR6722A/es not_active Application Discontinuation
- 2002-08-12 MA MA26771A patent/MA26873A1/fr unknown
- 2002-08-15 ZA ZA200206526A patent/ZA200206526B/en unknown
- 2002-08-16 NO NO20023894A patent/NO20023894L/no not_active Application Discontinuation
- 2002-08-19 HR HRP20020676 patent/HRP20020676A2/hr not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP1255764B8 (de)	2006-06-28
EE200200452A (et)	2003-12-15
DE60119492T2 (de)	2006-11-09
CO5271668A1 (es)	2003-04-30
EP1255764B1 (de)	2006-05-10
TNSN01028A1 (fr)	2005-11-10
ATE325807T1 (de)	2006-06-15
OA12177A (en)	2006-05-09
ZA200206526B (en)	2003-10-16
NO20023894L (no)	2002-10-01
EA200200770A1 (ru)	2002-12-26
PA8511801A1 (es)	2002-02-21
SK11692002A3 (sk)	2003-11-04
PE20011122A1 (es)	2001-11-06
GB0003960D0 (en)	2000-04-12
IS6458A (is)	2002-07-05
EA004987B1 (ru)	2004-10-28
NO20023894D0 (no)	2002-08-16
AR027437A1 (es)	2003-03-26
CR6722A (es)	2003-11-25
US20010020089A1 (en)	2001-09-06
AP2002002598A0 (en)	2002-09-30
ES2260199T3 (es)	2006-11-01
BG106906A (en)	2003-04-30
US6525032B2 (en)	2003-02-25
HN2001000027A (es)	2001-09-11
AU2001230440A1 (en)	2001-08-27
CN1400975A (zh)	2003-03-05
CZ20022703A3 (cs)	2003-09-17
GT200100027A (es)	2001-12-19
WO2001060835A1 (en)	2001-08-23
HRP20020676A2 (en)	2004-12-31
PL357220A1 (en)	2004-07-26
KR20030036138A (ko)	2003-05-09
NZ519971A (en)	2004-04-30
CA2400619A1 (en)	2001-08-23
WO2001060835A8 (en)	2001-11-29
MXPA02008068A (es)	2004-04-05
SV2002000317A (es)	2002-07-16
BR0108408A (pt)	2002-11-26
IL150543A0 (en)	2003-02-12
MA26873A1 (fr)	2004-12-20
HUP0301055A2 (hu)	2003-08-28
JP2004508284A (ja)	2004-03-18
EP1255764A1 (de)	2002-11-13

Publication	Publication Date	Title
ATE325807T1 (de)	2006-06-15	Purinderivate
ATE267836T1 (de)	2004-06-15	Purinderivate
ATE431356T1 (de)	2009-05-15	2-aminocarbonyl-9h-purinderivative
DE60116260D1 (de)	2006-02-02	Antivirale azaindolderivate
ATE321065T1 (de)	2006-04-15	Purin-derivate
DE60002356D1 (de)	2003-05-28	Purin-derivate
EE200100681A (et)	2003-04-15	Puriinderivaadid
DE60130463D1 (de)	2007-10-25	Pyrimidin-derivate
ATE298332T1 (de)	2005-07-15	Decahydro-isochinolinderivate
DK1280809T3 (da)	2005-11-07	Antitumorecteinascidinderivater
AR028282A1 (es)	2003-04-30	Derivados de aminofenil pirimidona
DK1322593T3 (da)	2004-10-11	O-substituerede-6-methyl-tramadol-derivater
DK1246791T3 (da)	2005-02-14	Aminomethyl-phenyl-cyklohexanonderivater
ATE374776T1 (de)	2007-10-15	Pyrrolotriazolopyrimidinonderivate
NO20024393D0 (no)	2002-09-13	2-fenylpyran-4-on-derivater

Legal Events

Date	Code	Title	Description
2007-05-31	8364	No opposition during term of opposition
2008-12-24	8339	Ceased/non-payment of the annual fee