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DE60031790D1 - Rar-gamma selektive retinoid-agonisten zur behandlung von emphysemen - Google Patents

Rar-gamma selektive retinoid-agonisten zur behandlung von emphysemen

Info

Publication number
DE60031790D1
DE60031790D1 DE60031790T DE60031790T DE60031790D1 DE 60031790 D1 DE60031790 D1 DE 60031790D1 DE 60031790 T DE60031790 T DE 60031790T DE 60031790 T DE60031790 T DE 60031790T DE 60031790 D1 DE60031790 D1 DE 60031790D1
Authority
DE
Germany
Prior art keywords
emphysemes
rar
treatment
retinoid agonists
selective retinoid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60031790T
Other languages
English (en)
Other versions
DE60031790T2 (de
Inventor
Nanette Belloni
Michael Klaus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE60031790D1 publication Critical patent/DE60031790D1/de
Application granted granted Critical
Publication of DE60031790T2 publication Critical patent/DE60031790T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60031790T 1999-10-19 2000-10-13 Rar-gamma selektive retinoid-agonisten zur behandlung von emphysemen Expired - Lifetime DE60031790T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16041599P 1999-10-19 1999-10-19
US160415P 1999-10-19
PCT/EP2000/010076 WO2001030326A1 (en) 1999-10-19 2000-10-13 Treatment of emphysema using rar selective retinoid agonists

Publications (2)

Publication Number Publication Date
DE60031790D1 true DE60031790D1 (de) 2006-12-21
DE60031790T2 DE60031790T2 (de) 2007-09-20

Family

ID=22576814

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60031790T Expired - Lifetime DE60031790T2 (de) 1999-10-19 2000-10-13 Rar-gamma selektive retinoid-agonisten zur behandlung von emphysemen

Country Status (34)

Country Link
US (1) US6300350B1 (de)
EP (1) EP1225878B1 (de)
JP (2) JP4074458B2 (de)
KR (1) KR100485581B1 (de)
CN (1) CN1201730C (de)
AR (1) AR029648A1 (de)
AT (1) ATE344661T1 (de)
AU (1) AU777325B2 (de)
BR (1) BR0015225A (de)
CA (1) CA2387844C (de)
CY (1) CY1105941T1 (de)
CZ (1) CZ20021657A3 (de)
DE (1) DE60031790T2 (de)
DK (1) DK1225878T3 (de)
ES (1) ES2274810T3 (de)
HK (1) HK1051002A1 (de)
HR (1) HRP20020329A2 (de)
HU (1) HUP0203295A3 (de)
IL (1) IL149151A0 (de)
JO (1) JO2178B1 (de)
MA (1) MA26835A1 (de)
MX (1) MXPA02003843A (de)
MY (1) MY129001A (de)
NO (1) NO328738B1 (de)
NZ (1) NZ518118A (de)
PE (1) PE20010678A1 (de)
PL (1) PL357499A1 (de)
PT (1) PT1225878E (de)
RS (1) RS50165B (de)
RU (1) RU2257383C2 (de)
TR (1) TR200201071T2 (de)
TW (1) TWI288639B (de)
WO (1) WO2001030326A1 (de)
ZA (1) ZA200202576B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4228000A (en) * 1999-04-14 2000-11-14 Allergan Sales, Inc. Methods and compositions for the treatment and prevention of lung disease
PL370361A1 (en) * 2001-09-18 2005-05-16 F.Hoffmann-La Roche Ag Alkyl urea retinoid agonists i
DE60231888D1 (de) 2001-09-18 2009-05-20 Hoffmann La Roche Substituierte harnstoff retinoid agonisten ii
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20070042184A1 (en) 2003-08-22 2007-02-22 Danisco A/S Microcapsules
GB2388581A (en) 2003-08-22 2003-11-19 Danisco Coated aqueous beads
WO2008057930A2 (en) * 2006-11-02 2008-05-15 Aestus Therapeutics, Inc. Methods of treating neuropathic pain with retinoic acid receptor agonists
HUE051664T2 (hu) 2010-09-01 2021-03-29 Univ Jefferson Összetétel és módszer az izomjavításra és a regenerációra
KR102164567B1 (ko) 2011-06-24 2020-10-12 쥐알아이 바이오,아이엔씨. 염증 질환의 예방 및 치료
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
WO2013019626A1 (en) * 2011-07-29 2013-02-07 Tempero Pharmaceuticals, Inc. Compounds and methods
RU2018138195A (ru) 2012-12-17 2018-12-18 Пэрион Сайенсиз, Инк. Соединения 3,5-диамино-6-хлор-n-(n-(4- фенилбутил)карбамимидоил)пиразин-2-карбоксамида
DK2931713T3 (en) 2012-12-17 2017-01-30 Parion Sciences Inc CHLORPYRAZINE CARBOXAMIDE DERIVATIVES USED FOR THE TREATMENT OF DISEASES BENEFITED BY INDEPENDENT MOSPHEREWIN
US9963439B2 (en) 2013-08-20 2018-05-08 University Of Washington Through Its Center For Commercialization Specific inhibitors of cytochrome P450 26 retinoic acid hydroxylase
US10500232B2 (en) 2013-08-26 2019-12-10 The J. David Gladstone Ins., a testamentary trust established under the Will of J. David Gladstone Small molecule cellular reprogramming to generate neuronal cells
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU618590B2 (en) * 1988-04-11 1992-01-02 Allergan, Inc. Tetralin esters of phenols or benzoic acids having retinoid like activity
CA2129773C (en) * 1993-09-02 2007-05-01 Michael Klaus Aromatic carboxylic acid derivatives
US5498795A (en) * 1994-12-29 1996-03-12 Allergan, Inc. Acetylenes disubstituted with hydroxyaryl and aryl or heteroaryl groups having retinoid-like biological activity
US5807900A (en) * 1995-03-31 1998-09-15 Hoffmann-La Roche, Inc. Method for identifying compounds having increased activity for the repair of skin photodamage
US5624957A (en) * 1995-06-06 1997-04-29 Bristol-Myers Squibb Company Rary-specific retinobenzoic acid derivatives
FR2739557B1 (fr) * 1995-10-09 1997-11-14 Cird Galderma Utilisation d'un ligand agoniste specifique rar-gamma
US5726191A (en) 1995-11-16 1998-03-10 Hoffmann-La Roche Inc. Aromatic carboxylic acid esters
FR2747041B1 (fr) 1996-04-05 1998-05-22 Cird Galderma Utilisation de derives benzonaphtaleniques pour la fabrication de medicaments destines au traitement des neuropathies
KR20040031107A (ko) * 1997-11-12 2004-04-09 에프. 호프만-라 로슈 아게 레티노이드 길항제를 이용한 제2형 ｔ-보조세포 중재면역질환의 치료
US6083973A (en) * 1998-03-09 2000-07-04 Syntex (U.S.A.) Inc. Methods for inhibiting mucin secretion using RAR α selective antagonists
WO2000061232A2 (en) * 1999-04-14 2000-10-19 Allergan Sales, Inc. Methods and compositions for the treatment and prevention of lung disease involving a specific rar-beta antagonist
AU4222400A (en) 1999-04-14 2000-11-14 Allergan Sales, Inc. Methods and compositions for the treatment and prevention of lung disease
AU4228000A (en) * 1999-04-14 2000-11-14 Allergan Sales, Inc. Methods and compositions for the treatment and prevention of lung disease
MXPA02000828A (es) * 1999-08-02 2002-07-30 Hoffmann La Roche Nuevos antagonistas retinoiides selectivos.
US6479670B1 (en) * 1999-08-25 2002-11-12 Hoffmann-La Roche Inc. Selective retinoid acid receptor agonists

Also Published As

Publication number Publication date
HUP0203295A3 (en) 2003-04-28
RU2257383C2 (ru) 2005-07-27
ATE344661T1 (de) 2006-11-15
HRP20020329A2 (en) 2004-04-30
IL149151A0 (en) 2002-11-10
CZ20021657A3 (cs) 2002-10-16
NO328738B1 (no) 2010-05-03
KR20020043640A (ko) 2002-06-10
CN1201730C (zh) 2005-05-18
AU777325B2 (en) 2004-10-14
HK1051002A1 (en) 2003-07-18
PL357499A1 (en) 2004-07-26
BR0015225A (pt) 2002-07-16
CY1105941T1 (el) 2011-04-06
JO2178B1 (en) 2003-04-23
AU1137401A (en) 2001-05-08
CA2387844A1 (en) 2001-05-03
NO20021823L (no) 2002-04-18
CA2387844C (en) 2009-04-14
AR029648A1 (es) 2003-07-10
JP2007302689A (ja) 2007-11-22
WO2001030326A1 (en) 2001-05-03
NO20021823D0 (no) 2002-04-18
JP2003512418A (ja) 2003-04-02
KR100485581B1 (ko) 2005-04-27
EP1225878B1 (de) 2006-11-08
JP4850791B2 (ja) 2012-01-11
NZ518118A (en) 2004-02-27
MY129001A (en) 2007-03-30
ES2274810T3 (es) 2007-06-01
DE60031790T2 (de) 2007-09-20
PT1225878E (pt) 2007-01-31
JP4074458B2 (ja) 2008-04-09
PE20010678A1 (es) 2001-07-04
RS50165B (sr) 2009-05-06
DK1225878T3 (da) 2007-03-05
CN1382042A (zh) 2002-11-27
US6300350B1 (en) 2001-10-09
TR200201071T2 (tr) 2002-08-21
TWI288639B (en) 2007-10-21
YU29002A (sh) 2005-06-10
MXPA02003843A (es) 2002-09-30
EP1225878A1 (de) 2002-07-31
ZA200202576B (en) 2003-09-23
MA26835A1 (fr) 2004-12-20
HUP0203295A2 (hu) 2003-01-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition