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DE4433191A1 - Self-adhesive plaster for delivering active substance to the environment of a wearer - Google Patents

Self-adhesive plaster for delivering active substance to the environment of a wearer

Info

Publication number
DE4433191A1
DE4433191A1 DE19944433191 DE4433191A DE4433191A1 DE 4433191 A1 DE4433191 A1 DE 4433191A1 DE 19944433191 DE19944433191 DE 19944433191 DE 4433191 A DE4433191 A DE 4433191A DE 4433191 A1 DE4433191 A1 DE 4433191A1
Authority
DE
Germany
Prior art keywords
active ingredient
skin
layer
patch according
environment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19944433191
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Priority to DE19944433191 priority Critical patent/DE4433191A1/en
Priority to PCT/EP1995/003568 priority patent/WO1996008237A2/en
Publication of DE4433191A1 publication Critical patent/DE4433191A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Pest Control & Pesticides (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Birds (AREA)
  • Plant Pathology (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

A pressure-sensitive adhesive plaster for releasing active substance into the environment of a support by evaporation consists of several layers and is characterised by a series of layers arranged as follows: (a) an active substance-impervious carrier layer that faces the skin and arranged thereon (b) an adhesive layer that faces the skin; and opposite the skin (c) one or several active substance reservoirs, and arranged thereon (d) an active substance-impervious protecting layer that is removed before the plaster is applied, allowing the active substance to be released into the environment; and (e) if required a covering layer that protects the adhesive layer prior to application.

Description

Die Erfindung betrifft ein selbstklebendes Pflaster zur Abgabe von Wirkstoff durch Verdampfung an die Umgebung ei­ nes Trägers.The invention relates to a self-adhesive plaster for Release of active ingredient by evaporation to the environment carrier.

Unter dem Begriff "Wirkstoff" sollen hierunter im weitesten Sinne alle Stoffe verstanden sein, die in der Dampfphase als Aerosole in der Umgebungsluft eine Wirkung gegenüber dem Träger des Pflasters oder anderen Organismen entfalten, beispielsweise therapeutisch oder psychotherapeutisch wir­ kende Stoffe, Geruchsstoffe, Bakterizide, Repellents, atmungserleichternde, schnupfenmildernde Stoffe etc. Um Düfte bzw. Wirkstoffe unmittelbar von der Haut abzuge­ ben, ist es bekannt, Lösungen und insbesondere alkoholische Lösungen auf die Haut zu applizieren. Dies ist vor allem im Bereich von Parfums usw. üblich; auch Repellents werden in dieser Form auf die Haut appliziert und verdampfen von dort in die Umgebungsluft.The term "active ingredient" is meant to be the broadest Meaning all substances are understood to be in the vapor phase an effect as aerosols in the ambient air unfold the carrier of the patch or other organisms, for example, therapeutically or psychotherapeutically substances, odorants, bactericides, repellents, breathable, snuff-reducing substances etc. To remove fragrances or active ingredients directly from the skin ben, it is known to be solutions and especially alcoholic To apply solutions to the skin. Most of all, this is common in the field of perfumes etc. also become repellents applied to the skin in this form and evaporate from there into the ambient air.

Die Abgabe unmittelbar von der Hautoberfläche an die Umge­ bung hat den Nachteil, daß die Haut fallweise Reizungen ausgesetzt sein und allergisch reagieren kann, wobei über­ dies die Konzentration der Wirkstoffe wegen möglicher schädigender Einwirkungen auf die Haut relativ gering sein muß.The release directly from the skin surface to the reverse Exercise has the disadvantage that the skin is occasionally irritated may be exposed and allergic, with over this is the concentration of the active ingredients because of possible harmful effects on the skin can be relatively low got to.

Hautschädigende Wirkstoffe scheiden für eine Applikation vollkommen aus. Andererseits kann es wünschenswert sein, bestimmte Stoffe unter Umständen von einer relativ kleinen Oberfläche aus sehr intensiv an die Umgebung abzugeben. Dies gilt beispielsweise für Duftstoffe, fallweise auch für Repellents, ebenso wie für schleimlösende, atmungserleich­ ternde Wirkstoffe sowie unter Umständen auch für Insekten­ vertilgungsmittel und ähnliche.Active substances that damage the skin are ruled out for one application completely out. On the other hand, it may be desirable certain substances may be of a relatively small size To give off surface very intensively to the environment. This applies, for example, to fragrances, and occasionally also to  Repellents, as well as for expectorant, breathable active ingredients and possibly also for insects killing agents and the like.

Der Erfindung liegt, ausgehend vom vorgenannten Stand der Technik, die Aufgabe zugrunde, ein selbstklebendes Pflaster zur Abgabe von Wirkstoff durch Verdampfung an die Umgebung eines Trägers anzugeben, das die Nachteile und technischen Grenzen des Standes der Technik vermeidet und ohne Erregung von Hautirritationen bei einer relativ kleinen Haft- bzw. Abgabefläche eine ausreichend intensive Abgabe von Wirk­ stoff an die unmittelbare Umgebungsatmosphäre des Trägers ermöglicht.The invention is based on the aforementioned state of the Technology based on the task of a self-adhesive plaster to release active ingredient by evaporation to the environment to specify a carrier that has the disadvantages and technical Avoids the limits of the prior art and without excitation of skin irritation with a relatively small adhesive or Delivery area a sufficiently intensive delivery of active ingredient material to the immediate ambient atmosphere of the wearer enables.

Die Aufgabe wird erfindungsgemäß durch einen Aufbau des Pflasters entsprechend dem Anspruch 1 gelöst. Damit wird praktisch ein "umgekehrtes dermales System" auf die Haut appliziert, wie es einerseits als Membranpflaster, anderer­ seits als Matrixpflaster Stand der Technik ist. Dabei ver­ hindert die für Wirkstoff undurchlässige Trägerschicht, der auf der hautzugewandten Seite eine Selbstklebeschicht und auf der hautabgewandten Seite ein oder mehrere Wirkstoff­ reservoire zugeordnet sind, eine Hautirritation. Anderer­ seits ermöglicht das oder die Wirkstoffreservoire eine sehr hohe Beladung mit Wirkstoff für eine sehr intensive Abgabe. Infolge Trennung von Klebstoffschicht und Wirkstoffreservoir gelingt es, eine relativ große Wirk­ stoffmenge einzutragen. Dabei ist auch die Ge­ staltungsfreiheit relativ unbegrenzt.The object is achieved by a structure of the Patch solved according to claim 1. So that will practically an "inverted dermal system" on the skin Applied as it is on the one hand as a membrane plaster, others the state of the art as a matrix plaster. Ver prevents the carrier layer, which is impermeable to the active ingredient on the skin-facing side a self-adhesive layer and one or more active ingredients on the side facing away from the skin reservoirs are associated with skin irritation. Other On the one hand, the active ingredient reservoir or reservoirs makes a very high load of active ingredient for a very intensive release. Due to separation of adhesive layer and Drug reservoir manages to have a relatively large effect Enter the amount of substance. It also includes the Ge freedom of design relatively unlimited.

Weiterhin können erfindungsgemäße Pflaster, ähnlich den be­ kannten Membranpflastern, zur gesteuerten Wirkstoffabgabe gestaltet sein und auch eine größere Dicke aufweisen und infolgedessen größere Mengen an Wirkstoff aufnehmen. Furthermore, plasters according to the invention, similar to the be Known membrane plasters, for controlled drug delivery be designed and also have a greater thickness and consequently absorb larger amounts of active ingredient.  

Die Applikation des Pflasters ist problemlos möglich, wobei ein Wirkstoffpflaster auf die Haut aufgebracht und die Schutzschicht entfernt wird, wonach das Pflaster über län­ gere Zeit Wirkstoffe an die Umgebung abgibt.The application of the patch is possible without any problems an active ingredient patch applied to the skin and the Protective layer is removed, after which the patch over long releases active substances to the environment.

Dabei wird eine Hautreizung oder Hautschädigung vermieden und der Effekt von Repellents, Parfums usw. bleibt voll erhalten. Im Zusammenhang mit Parfums und ähnlichen Duft­ stoffen können die Eigenschaften des Pflasters im Rahmen einer plakativen Kosmetik, analog zu früheren Schönheits­ pflästerchen, ausgestaltet werden.Skin irritation or skin damage is avoided and the effect of repellents, perfumes, etc. remains full receive. In connection with perfumes and similar scents The properties of the patch can be used in the frame striking cosmetics, analogous to earlier beauty patches.

Beispielexample

Das Pflaster nach der Erfindung umfaßt im Schichtaufbau eine Trägerfolie (1) mit wenigstens einer Klebschicht (2) auf der hautzugewandten Seite sowie mit wenigstens einer oder mehreren Reservoirschichten (3 bzw. 4) auf der haut­ abgewandten Seite, in welchen sich eine wirkstoffhaltige Zubereitung befindet, die zunächst bis zur Applikation mit einer Schutzschicht (5) abgedeckt ist. Sowohl die Trägerfo­ lie (1) als auch die Schutzschicht (5) bestehen aus einem für Wirkstoff undurchlässigen Material. Zwischen einem Reservoir (3 oder 4) und der Schutzschicht (5) kann eine die Wirkstofffreisetzung steuernde Membran (6) angeordnet sein. Die Klebschicht (2) ist zunächst mit einer Schutzfo­ lie als Abdeckschicht (7) abgedeckt.The plaster according to the invention comprises, in the layer structure, a carrier film ( 1 ) with at least one adhesive layer ( 2 ) on the side facing the skin and with at least one or more reservoir layers ( 3 or 4 ) on the side facing away from the skin, in which there is an active ingredient-containing preparation which is initially covered with a protective layer ( 5 ) until application. Both the Trägerfo lie ( 1 ) and the protective layer ( 5 ) consist of a material impermeable to the active ingredient. A membrane ( 6 ) which controls the release of active substance can be arranged between a reservoir ( 3 or 4 ) and the protective layer ( 5 ). The adhesive layer ( 2 ) is initially covered with a protective film as a covering layer ( 7 ).

Bei der Anwendung wird zunächst die Abdeckschicht (7) von der der Haut zuzuwendenden Kleberschicht (2) entfernt und das Pflaster auf dem Substrat, z. B. der Haut, aufgebracht. Anschließend wird die Schutzfolie (5) vom Pflaster abgezo­ gen, so daß die Reservoirschicht (3) bzw. (4) Wirkstoff an die Umgebung des Substrats abgeben kann. Fallweise wird dabei die Abgabe durch eine der Reservoirschicht (3) bzw. (4) aufliegende Steuermembran (6) zeitlich gesteuert.In use, the cover layer ( 7 ) is first removed from the adhesive layer ( 2 ) facing the skin and the plaster on the substrate, e.g. B. the skin applied. Subsequently, the protective film ( 5 ) is peeled off from the plaster, so that the reservoir layer ( 3 ) or ( 4 ) can release active ingredient to the surroundings of the substrate. In some cases, the dispensing is timed by a control membrane ( 6 ) resting on the reservoir layer ( 3 ) or ( 4 ).

Bevorzugte Wirkstoffe sind solche, die einen genügend hohen Dampfdruck haben, so daß sie die Steuermembran (6) gezielt durchdringen können.Preferred active ingredients are those which have a sufficiently high vapor pressure so that they can penetrate the control membrane ( 6 ) in a targeted manner.

Claims (8)

1. Selbstklebendes Pflaster zur Abgabe von Wirkstoff durch Verdampfung an die Umgebung eines Trägers, bestehend aus mehreren Schichten, gekennzeichnet durch eine Folge von Schichten mit
  • a) einer hautzugewandten und für Wirkstoff undurchlässigen Trägerschicht (1), und auf dieser
  • b) einer hautseitigen Kleberschicht (2), sowie auf der hautabgewandten Seite
  • c) einem oder mehreren Wirkstoffreservoirs (3) bzw. (4), und auf diesen
  • d) einer wirkstoffundurchlässigen Schutzschicht (5), wel­ che vor der Applikation des Pflasters entfernt wird und die Wirkstoffabgabe an die Umgebung freigibt, sowie
  • e) fallweise einer die Kleberschicht (2) bis zur Applika­ tion schützenden Abdeckschicht (7).
1. Self-adhesive plaster for delivering active ingredient by evaporation to the environment of a carrier, consisting of several layers, characterized by a sequence of layers with
  • a) a skin-facing and impermeable to active ingredient carrier layer ( 1 ), and on this
  • b) a skin-side adhesive layer ( 2 ) and on the side facing away from the skin
  • c) one or more drug reservoirs ( 3 ) or ( 4 ), and on this
  • d) an active ingredient-impermeable protective layer ( 5 ), which is removed prior to application of the patch and releases the release of active ingredient to the environment, and
  • e) in some cases a cover layer ( 7 ) protecting the adhesive layer ( 2 ) up to the application.
2. Pflaster nach Anspruch 1, dadurch gekennzeichnet, daß das Wirkstoffreservoir (3) bzw. (4) eine Steuermembran (6) zur Steuerung einer gezielten Wirkstofffreisetzung auf­ weist.2. Patch according to claim 1, characterized in that the drug reservoir ( 3 ) or ( 4 ) has a control membrane ( 6 ) for controlling a targeted drug release. 3. Pflaster nach Anspruch 1, dadurch gekennzeichnet, daß die Haftkleberschicht einen die Durchblutung der Haut anre­ genden Wirkstoff enthält.3. Patch according to claim 1, characterized in that the layer of pressure sensitive adhesive stimulates the blood supply to the skin contains active ingredient. 4. Pflaster nach Anspruch 1 oder 2, dadurch gekennzeich­ net, daß die Wirkstoffe wenigstens eine spasmolytische Kom­ ponente enthalten.4. Patch according to claim 1 or 2, characterized net that the active ingredients at least one spasmolytic com component included. 5. Pflaster nach Anspruch 1, dadurch gekennzeichnet, daß es einen broncholytischen Wirkstoff enthält. 5. Patch according to claim 1, characterized in that it contains a broncholytic agent.   6. Pflaster nach Anspruch 1, dadurch gekennzeichnet, daß es einen antiasthmatischen Wirkstoff enthält.6. Patch according to claim 1, characterized in that it contains an anti-asthmatic agent. 7. Pflaster nach Anspruch 1, dadurch gekennzeichnet, daß es ein Insektenrepellent als Wirkstoff enthält.7. Patch according to claim 1, characterized in that it contains an insect repellent as an active ingredient. 8. Pflaster nach Anspruch 1, dadurch gekennzeichnet, daß es einen kosmetischen Wirkstoff, bevorzugt einen Duftstoff enthält.8. Patch according to claim 1, characterized in that it is a cosmetic active ingredient, preferably a fragrance contains.
DE19944433191 1994-09-17 1994-09-17 Self-adhesive plaster for delivering active substance to the environment of a wearer Withdrawn DE4433191A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE19944433191 DE4433191A1 (en) 1994-09-17 1994-09-17 Self-adhesive plaster for delivering active substance to the environment of a wearer
PCT/EP1995/003568 WO1996008237A2 (en) 1994-09-17 1995-09-11 Pressure-sensitive adhesive plaster for releasing active substance into the environment of a support

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19944433191 DE4433191A1 (en) 1994-09-17 1994-09-17 Self-adhesive plaster for delivering active substance to the environment of a wearer

Publications (1)

Publication Number Publication Date
DE4433191A1 true DE4433191A1 (en) 1996-03-21

Family

ID=6528493

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19944433191 Withdrawn DE4433191A1 (en) 1994-09-17 1994-09-17 Self-adhesive plaster for delivering active substance to the environment of a wearer

Country Status (2)

Country Link
DE (1) DE4433191A1 (en)
WO (1) WO1996008237A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045891A1 (en) * 1998-03-10 1999-09-16 Unilever Plc Fragranced cosmetic product
FR2792192A1 (en) * 1999-04-19 2000-10-20 Lcw Les Colorants Wackherr Skin make-up set, comprises detachable protective film, pressure-adhesive layer, layer linked to adhesive layer, and/or exterior protective layer
WO2001039752A2 (en) * 1999-11-27 2001-06-07 Hexal Ag Transdermal therapeutic system containing highly volatile active ingredients
DE10114382A1 (en) * 2001-03-23 2002-09-26 Beiersdorf Ag Moisture-absorbing material used for plasters, medical fixings, wound coverings and bandages comprises adhesive matrix of silicon, gel former and optionally silicone resin
WO2003047557A3 (en) * 2001-12-07 2003-09-18 Norbert Hoenzelaer Device and patch for controlling the release of vanillin

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4007275A1 (en) * 1990-03-08 1991-09-12 Gerold Tebbe Impregnated fabrics
DE4204222C1 (en) * 1992-02-13 1993-04-15 Chemische Fabrik Geefa Gmbh & Co Kg, 2358 Kaltenkirchen, De Pad for alleviating cold symptoms and respiratory infections - comprises bonded fabric support and bonded fabric layer with membrane function which releases vapour of essential oils
DE4230589C1 (en) * 1992-09-12 1994-02-03 Lohmann Therapie Syst Lts Dosing process for volatile or thermolabile substances in liquid form for the production of i.a. flat pharmaceutical forms, in particular for the production of transdermal or dermal therapeutic systems
DE4318141A1 (en) * 1993-06-01 1994-12-08 Gerold Tebbe Cloth containing an active substance
DE4332094A1 (en) * 1993-09-22 1995-03-23 Lohmann Therapie Syst Lts Active ingredient plasters that can be produced without solvents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3216609A1 (en) * 1982-05-04 1983-11-10 Dietic Dr. Widmann Pharma + Diät GmbH, 6930 Eberbach Plaster inhalant
HU187414B (en) * 1984-10-12 1986-01-28 Leopold,Gaspar,Hu Process for producing cough-preparation of physiologically relieving and sedative effect, fixable on skin
AU6630086A (en) * 1985-11-14 1987-06-02 David I. Rosen Transdermal application of nicotine
HU203285B (en) * 1988-02-01 1991-07-29 Egyt Gyogyszervegyeszeti Gyar Method for producing transdermal preparation containing vegetable extract
JP2834476B2 (en) * 1989-06-16 1998-12-09 エーザイ株式会社 Nasal inhalation patch
US5455043A (en) * 1990-06-13 1995-10-03 Fischel-Ghodsian; Fariba Device for controlled release of vaporous medications through nasal route
EP0593807A1 (en) * 1992-10-22 1994-04-27 LTS Lohmann Therapie-Systeme GmbH & Co. KG Patch for transdermal administration of volatile pharmaceutically active ingredients of chemically basic nature and a process for preparation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4007275A1 (en) * 1990-03-08 1991-09-12 Gerold Tebbe Impregnated fabrics
DE4204222C1 (en) * 1992-02-13 1993-04-15 Chemische Fabrik Geefa Gmbh & Co Kg, 2358 Kaltenkirchen, De Pad for alleviating cold symptoms and respiratory infections - comprises bonded fabric support and bonded fabric layer with membrane function which releases vapour of essential oils
DE4230589C1 (en) * 1992-09-12 1994-02-03 Lohmann Therapie Syst Lts Dosing process for volatile or thermolabile substances in liquid form for the production of i.a. flat pharmaceutical forms, in particular for the production of transdermal or dermal therapeutic systems
DE4318141A1 (en) * 1993-06-01 1994-12-08 Gerold Tebbe Cloth containing an active substance
DE4332094A1 (en) * 1993-09-22 1995-03-23 Lohmann Therapie Syst Lts Active ingredient plasters that can be produced without solvents

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045891A1 (en) * 1998-03-10 1999-09-16 Unilever Plc Fragranced cosmetic product
US6106857A (en) * 1998-03-10 2000-08-22 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Fragranced cosmetic product for removal of keratotic plugs from skin pores
FR2792192A1 (en) * 1999-04-19 2000-10-20 Lcw Les Colorants Wackherr Skin make-up set, comprises detachable protective film, pressure-adhesive layer, layer linked to adhesive layer, and/or exterior protective layer
WO2001039752A2 (en) * 1999-11-27 2001-06-07 Hexal Ag Transdermal therapeutic system containing highly volatile active ingredients
WO2001039752A3 (en) * 1999-11-27 2001-12-06 Hexal Ag Transdermal therapeutic system containing highly volatile active ingredients
DE10114382A1 (en) * 2001-03-23 2002-09-26 Beiersdorf Ag Moisture-absorbing material used for plasters, medical fixings, wound coverings and bandages comprises adhesive matrix of silicon, gel former and optionally silicone resin
WO2003047557A3 (en) * 2001-12-07 2003-09-18 Norbert Hoenzelaer Device and patch for controlling the release of vanillin

Also Published As

Publication number Publication date
WO1996008237A3 (en) 1996-04-18
WO1996008237A2 (en) 1996-03-21

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