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DE3884563D1 - Aminomethyl-oxo-oxazolidinyl-ethenylbenzen-derivate, nuetzlich als antibakterielles mittel. - Google Patents

Aminomethyl-oxo-oxazolidinyl-ethenylbenzen-derivate, nuetzlich als antibakterielles mittel.

Info

Publication number
DE3884563D1
DE3884563D1 DE88117304T DE3884563T DE3884563D1 DE 3884563 D1 DE3884563 D1 DE 3884563D1 DE 88117304 T DE88117304 T DE 88117304T DE 3884563 T DE3884563 T DE 3884563T DE 3884563 D1 DE3884563 D1 DE 3884563D1
Authority
DE
Germany
Prior art keywords
derivatives
aminomethyl
ethenylbenzen
oxazolidinyl
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88117304T
Other languages
English (en)
Other versions
DE3884563T2 (de
Inventor
David Ross Brittelli
Walter Adelman Gregory
Peter Franklin Corless
Chung-Ho Park
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Publication of DE3884563D1 publication Critical patent/DE3884563D1/de
Application granted granted Critical
Publication of DE3884563T2 publication Critical patent/DE3884563T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE88117304T 1987-10-21 1988-10-18 Aminomethyl-oxo-oxazolidinyl-ethenylbenzen-Derivate, nützlich als antibakterielles Mittel. Expired - Fee Related DE3884563T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11083787A 1987-10-21 1987-10-21

Publications (2)

Publication Number Publication Date
DE3884563D1 true DE3884563D1 (de) 1993-11-04
DE3884563T2 DE3884563T2 (de) 1994-02-17

Family

ID=22335197

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88117304T Expired - Fee Related DE3884563T2 (de) 1987-10-21 1988-10-18 Aminomethyl-oxo-oxazolidinyl-ethenylbenzen-Derivate, nützlich als antibakterielles Mittel.

Country Status (18)

Country Link
EP (1) EP0316594B1 (de)
JP (1) JPH01135777A (de)
KR (1) KR890006603A (de)
AT (1) ATE95176T1 (de)
AU (1) AU617697B2 (de)
CA (1) CA1317594C (de)
DE (1) DE3884563T2 (de)
DK (1) DK584188A (de)
ES (1) ES2059467T3 (de)
FI (1) FI884849A (de)
HU (1) HU201915B (de)
IL (1) IL88107A (de)
MY (1) MY103433A (de)
NO (1) NO884676L (de)
NZ (1) NZ226631A (de)
PT (1) PT88811B (de)
RU (1) RU1801109C (de)
ZA (1) ZA887853B (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032605A (en) * 1987-10-09 1991-07-16 Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents
US5036093A (en) * 1987-10-09 1991-07-30 Du Pont Merck Pharmaceutical Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5225565A (en) * 1988-09-15 1993-07-06 The Upjohn Company Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones
US5231188A (en) * 1989-11-17 1993-07-27 The Upjohn Company Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents
AU667198B2 (en) * 1991-11-01 1996-03-14 Pharmacia & Upjohn Company Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
CZ288788B6 (cs) * 1992-12-08 2001-09-12 Pharmacia & Upjohn Company Antibakteriální fenyloxazolidinony substituované troponem
TW299332B (de) * 1992-12-08 1997-03-01 Upjohn Co
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
ATE182142T1 (de) * 1993-11-22 1999-07-15 Upjohn Co Substituierte hydroxyacetyl piperazine phenyl oxazolidinonsäureester
CA2200433C (en) * 1994-10-26 2006-02-07 Douglas K. Hutchinson Phenyloxazolidinone antimicrobials
MX9703543A (es) * 1994-11-15 1997-08-30 Upjohn Co Antibacterianos de oxazina biciclica y oxazolidinona tiazina.
JPH10513446A (ja) * 1995-02-03 1998-12-22 ファルマシア・アンド・アップジョン・カンパニー ヘテロ芳香族環置換フェニルオキサゾリジノン抗微生物剤
MX9708627A (es) * 1995-05-11 1998-02-28 Upjohn Co Oxazolidinonas de diazinilo y carbazinilo espirociclicas y biciclicas.
MX9703040A (es) * 1995-09-12 1997-07-31 Upjohn Co Antimicrobianos de feniloxazolidinona.
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
EP0918746B1 (de) 1996-08-12 2003-04-09 Celgene Corporation Immunotherapeutische mittel und ihre anwendung in der reduzierung der cytokininwerte
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
EP1030852B1 (de) * 1997-11-12 2003-09-17 PHARMACIA & UPJOHN COMPANY Oxazolidinone derivate und pharmazeutische zusammensetzungen
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
AU764184B2 (en) * 1998-01-23 2003-08-14 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
CN1367780A (zh) * 1999-07-28 2002-09-04 法玛西雅厄普约翰美国公司 噁唑烷酮类化合物、其制备方法及其应用
DE19962924A1 (de) 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
WO2002018354A1 (en) * 2000-08-31 2002-03-07 Abbott Laboratories Oxazolidinones and their use as antibacterial agents
WO2002020515A1 (en) * 2000-09-08 2002-03-14 Abbott Laboratories Oxazolidinone antibacterial agents
DE10129725A1 (de) 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
US7125568B2 (en) 2001-08-23 2006-10-24 Sung Michael T Lipophilic drug compositions
DE10300111A1 (de) 2003-01-07 2004-07-15 Bayer Healthcare Ag Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
US7470723B2 (en) 2003-03-05 2008-12-30 Celgene Corporation Diphenylethylene compounds and uses thereof
US7312241B2 (en) 2003-03-05 2007-12-25 Celgene Corporation Diphenylethylene compounds and uses thereof
DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
JP2008512378A (ja) 2004-09-03 2008-04-24 セルジーン・コーポレーション 置換複素環式化合物及びその使用
EP1685841A1 (de) 2005-01-31 2006-08-02 Bayer Health Care Aktiengesellschaft Prophylaxe und Behandlung von thrombolischen Erkrankungen
DE102005045518A1 (de) 2005-09-23 2007-03-29 Bayer Healthcare Ag 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung
BRPI0616801B8 (pt) 2005-10-04 2021-05-25 Bayer Healthcare Ag "forma polimórfica de 5-cloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morfolinil)-fenil]-1,3-oxazolidin-5-il}-metil)-2-tiofenocarboxamida, seus processos de preparação e seus usos, medicamento, e processo para prevenção de coagulação de sangue in vitro
DE102005047561A1 (de) 2005-10-04 2007-04-05 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
CA2712613C (en) 2008-03-26 2017-02-28 Global Alliance For Tb Drug Development Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones
EP3498273A1 (de) * 2017-12-14 2019-06-19 Universität Wien Pharmazeutische zusammensetzung zur modulierung der response des gaba-a rezeptors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1222708A (en) * 1968-10-22 1971-02-17 Delalande Sa Novel 5-(n-substituted aminomethyl)-2-oxazolidinones and their process of preparation
FR2500450A1 (fr) * 1981-02-25 1982-08-27 Delalande Sa Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
US4705799A (en) * 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
ES533097A0 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents

Also Published As

Publication number Publication date
RU1801109C (ru) 1993-03-07
HU201915B (en) 1991-01-28
DK584188D0 (da) 1988-10-20
JPH01135777A (ja) 1989-05-29
DK584188A (da) 1989-04-22
AU2404388A (en) 1989-04-27
NO884676D0 (no) 1988-10-20
ZA887853B (en) 1990-06-27
MY103433A (en) 1993-06-30
ES2059467T3 (es) 1994-11-16
FI884849A0 (fi) 1988-10-20
CA1317594C (en) 1993-05-11
EP0316594B1 (de) 1993-09-29
FI884849A (fi) 1989-04-22
HUT52075A (en) 1990-06-28
PT88811B (pt) 1993-04-30
NZ226631A (en) 1991-01-29
DE3884563T2 (de) 1994-02-17
NO884676L (no) 1989-04-24
EP0316594A1 (de) 1989-05-24
ATE95176T1 (de) 1993-10-15
AU617697B2 (en) 1991-12-05
KR890006603A (ko) 1989-06-14
IL88107A0 (en) 1989-06-30
IL88107A (en) 1993-02-21

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DE3884563D1 (de) Aminomethyl-oxo-oxazolidinyl-ethenylbenzen-derivate, nuetzlich als antibakterielles mittel.
ATE73783T1 (de) Aminomethyl-oxo-oxazolidinyl-aroylbenzenderivate, nuetzlich als antibakterielles mittel.
DE3584427D1 (de) Aminomethyl-, n-phenyl-substituierte oxooxazolidin derivate nuetzlich als antibakterielle mittel.
IE892438L (en) Aminomethyloxooxazolidinyl Arylbenzene derivatives useful¹as Antibacterial agents
IT8721794A0 (it) N-(alobenzoil)-n'-2-alo-4 (1,1,2-trifluoro-2-2(trifluorometossi) etossi) fenil uree ad attivita' insetticida
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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DU PONT PHARMACEUTICALS CO., WILMINGTON, DEL., US

8327 Change in the person/name/address of the patent owner

Owner name: BRISTOL-MYERS SQUIBB PHARMA CO., PRINCETON, N.J.,

8339 Ceased/non-payment of the annual fee