DE3883082D1 - Phenol-thioether als inhibitoren von 5-lipoxygenase. - Google Patents
Phenol-thioether als inhibitoren von 5-lipoxygenase.Info
- Publication number
- DE3883082D1 DE3883082D1 DE8888108863T DE3883082T DE3883082D1 DE 3883082 D1 DE3883082 D1 DE 3883082D1 DE 8888108863 T DE8888108863 T DE 8888108863T DE 3883082 T DE3883082 T DE 3883082T DE 3883082 D1 DE3883082 D1 DE 3883082D1
- Authority
- DE
- Germany
- Prior art keywords
- lipoxygenase
- inhibitors
- phenol thioether
- thioether
- phenol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/02—Thiocyanates
- C07C331/10—Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/058,429 US4835190A (en) | 1987-06-05 | 1987-06-05 | Phenolic thioethers as inhbitors of 5-lipoxygenase |
US07/194,769 US4847305A (en) | 1987-06-05 | 1988-05-23 | Phenolic thioethers as inhibitors of 5-lipoxygenase |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3883082D1 true DE3883082D1 (de) | 1993-09-16 |
DE3883082T2 DE3883082T2 (de) | 1993-12-16 |
Family
ID=26737603
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE88108863T Expired - Fee Related DE3883082T2 (de) | 1987-06-05 | 1988-06-03 | Phenol-thioether als Inhibitoren von 5-Lipoxygenase. |
Country Status (6)
Country | Link |
---|---|
US (1) | US4847305A (de) |
EP (1) | EP0293895B1 (de) |
JP (1) | JPS6456613A (de) |
CA (1) | CA1322531C (de) |
DE (1) | DE3883082T2 (de) |
ES (1) | ES2058179T3 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2754039B2 (ja) * | 1988-06-24 | 1998-05-20 | 塩野義製薬株式会社 | ジ―tert―ブチルヒドロキシフェニルチオ誘導体 |
EP0482071B1 (de) * | 1989-07-14 | 1998-01-07 | Biodor U.S. Holding Corporation | Antivirale mittel |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3886285A (en) * | 1970-12-07 | 1975-05-27 | Reckitt & Colmann Prod Ltd | Pharmaceutical compositions containing substituted phenyl sulphoxides and sulphones and method of using same |
US4128530A (en) * | 1974-01-25 | 1978-12-05 | The Goodyear Tire & Rubber Company | Mercapto phenolic and alkylthio phenolic antioxidants |
US3967420A (en) * | 1974-04-30 | 1976-07-06 | Papsco, Inc. | Portable wall system and method of installing same |
EP0218782B1 (de) * | 1985-05-20 | 1990-05-16 | G.D. Searle & Co. | Lipoxygenase inhibierende Zusammensetzung sowie Hydroxyphenylthioalkylcarbonylverbindungen |
US4755524A (en) * | 1986-01-31 | 1988-07-05 | G. D. Searle & Co. | Novel phenolic thioethers as inhibitors of 5-lipoxygenase |
-
1988
- 1988-05-23 US US07/194,769 patent/US4847305A/en not_active Expired - Lifetime
- 1988-06-02 CA CA000568444A patent/CA1322531C/en not_active Expired - Fee Related
- 1988-06-03 ES ES88108863T patent/ES2058179T3/es not_active Expired - Lifetime
- 1988-06-03 DE DE88108863T patent/DE3883082T2/de not_active Expired - Fee Related
- 1988-06-03 EP EP88108863A patent/EP0293895B1/de not_active Expired - Lifetime
- 1988-06-03 JP JP63137201A patent/JPS6456613A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0293895A1 (de) | 1988-12-07 |
ES2058179T3 (es) | 1994-11-01 |
CA1322531C (en) | 1993-09-28 |
EP0293895B1 (de) | 1993-08-11 |
JPS6456613A (en) | 1989-03-03 |
DE3883082T2 (de) | 1993-12-16 |
US4847305A (en) | 1989-07-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |