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DE3883082D1 - Phenol-thioether als inhibitoren von 5-lipoxygenase. - Google Patents

Phenol-thioether als inhibitoren von 5-lipoxygenase.

Info

Publication number
DE3883082D1
DE3883082D1 DE8888108863T DE3883082T DE3883082D1 DE 3883082 D1 DE3883082 D1 DE 3883082D1 DE 8888108863 T DE8888108863 T DE 8888108863T DE 3883082 T DE3883082 T DE 3883082T DE 3883082 D1 DE3883082 D1 DE 3883082D1
Authority
DE
Germany
Prior art keywords
lipoxygenase
inhibitors
phenol thioether
thioether
phenol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888108863T
Other languages
English (en)
Other versions
DE3883082T2 (de
Inventor
Richard August Mueller
Richard Allen Partis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/058,429 external-priority patent/US4835190A/en
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of DE3883082D1 publication Critical patent/DE3883082D1/de
Application granted granted Critical
Publication of DE3883082T2 publication Critical patent/DE3883082T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/095Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10Sulfides; Sulfoxides; Sulfones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/16Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/02Thiocyanates
    • C07C331/10Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE88108863T 1987-06-05 1988-06-03 Phenol-thioether als Inhibitoren von 5-Lipoxygenase. Expired - Fee Related DE3883082T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/058,429 US4835190A (en) 1987-06-05 1987-06-05 Phenolic thioethers as inhbitors of 5-lipoxygenase
US07/194,769 US4847305A (en) 1987-06-05 1988-05-23 Phenolic thioethers as inhibitors of 5-lipoxygenase

Publications (2)

Publication Number Publication Date
DE3883082D1 true DE3883082D1 (de) 1993-09-16
DE3883082T2 DE3883082T2 (de) 1993-12-16

Family

ID=26737603

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88108863T Expired - Fee Related DE3883082T2 (de) 1987-06-05 1988-06-03 Phenol-thioether als Inhibitoren von 5-Lipoxygenase.

Country Status (6)

Country Link
US (1) US4847305A (de)
EP (1) EP0293895B1 (de)
JP (1) JPS6456613A (de)
CA (1) CA1322531C (de)
DE (1) DE3883082T2 (de)
ES (1) ES2058179T3 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2754039B2 (ja) * 1988-06-24 1998-05-20 塩野義製薬株式会社 ジ―tert―ブチルヒドロキシフェニルチオ誘導体
EP0482071B1 (de) * 1989-07-14 1998-01-07 Biodor U.S. Holding Corporation Antivirale mittel

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3886285A (en) * 1970-12-07 1975-05-27 Reckitt & Colmann Prod Ltd Pharmaceutical compositions containing substituted phenyl sulphoxides and sulphones and method of using same
US4128530A (en) * 1974-01-25 1978-12-05 The Goodyear Tire & Rubber Company Mercapto phenolic and alkylthio phenolic antioxidants
US3967420A (en) * 1974-04-30 1976-07-06 Papsco, Inc. Portable wall system and method of installing same
EP0218782B1 (de) * 1985-05-20 1990-05-16 G.D. Searle & Co. Lipoxygenase inhibierende Zusammensetzung sowie Hydroxyphenylthioalkylcarbonylverbindungen
US4755524A (en) * 1986-01-31 1988-07-05 G. D. Searle & Co. Novel phenolic thioethers as inhibitors of 5-lipoxygenase

Also Published As

Publication number Publication date
EP0293895A1 (de) 1988-12-07
ES2058179T3 (es) 1994-11-01
CA1322531C (en) 1993-09-28
EP0293895B1 (de) 1993-08-11
JPS6456613A (en) 1989-03-03
DE3883082T2 (de) 1993-12-16
US4847305A (en) 1989-07-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee