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DE3750664D1 - Throminbindende Substanz und Verfahren zu ihrer Herstellung. - Google Patents

Throminbindende Substanz und Verfahren zu ihrer Herstellung.

Info

Publication number
DE3750664D1
DE3750664D1 DE3750664T DE3750664T DE3750664D1 DE 3750664 D1 DE3750664 D1 DE 3750664D1 DE 3750664 T DE3750664 T DE 3750664T DE 3750664 T DE3750664 T DE 3750664T DE 3750664 D1 DE3750664 D1 DE 3750664D1
Authority
DE
Germany
Prior art keywords
thrombin
condition
isoelectric point
molecular weight
sds page
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3750664T
Other languages
English (en)
Other versions
DE3750664T2 (de
Inventor
Nobuo Aoki
Shigeru Kimura
Masami Shiratsuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Original Assignee
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP61172626A external-priority patent/JPS6330423A/ja
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Publication of DE3750664D1 publication Critical patent/DE3750664D1/de
Application granted granted Critical
Publication of DE3750664T2 publication Critical patent/DE3750664T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/834—Urine; urinary system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE3750664T 1986-07-15 1987-07-10 Throminbindende Substanz und Verfahren zu ihrer Herstellung. Expired - Fee Related DE3750664T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP16608486 1986-07-15
JP61172626A JPS6330423A (ja) 1986-07-22 1986-07-22 トロンビン結合性物質およびその製法

Publications (2)

Publication Number Publication Date
DE3750664D1 true DE3750664D1 (de) 1994-11-24
DE3750664T2 DE3750664T2 (de) 1995-06-22

Family

ID=26490590

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3750664T Expired - Fee Related DE3750664T2 (de) 1986-07-15 1987-07-10 Throminbindende Substanz und Verfahren zu ihrer Herstellung.

Country Status (6)

Country Link
US (1) US5047503A (de)
EP (1) EP0253331B1 (de)
KR (1) KR890002388A (de)
AT (1) ATE113062T1 (de)
DE (1) DE3750664T2 (de)
ES (1) ES2065318T3 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0285511B1 (de) * 1987-04-01 1992-11-25 Mitsubishi Gas Chemical Company, Inc. Immunoassay für Thrombomodulin
JPS6445398A (en) * 1987-08-13 1989-02-17 Kowa Co Antithrombin-binding substance monoclonal antibody, hybridoma producing said antibody and method for purifying and measuring thrombin-binding substance utilizing said monoclonal antibody
JPH0720997B2 (ja) * 1988-08-29 1995-03-08 興和株式会社 新規なトロンビン結合性物質及びその製法
US5202421A (en) * 1988-12-27 1993-04-13 Mochida Pharmaceutical Co., Ltd. Anticoagulant substance obtained from urine and process for the preparation thereof
US6063763A (en) * 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
WO1992000325A1 (en) * 1990-06-27 1992-01-09 Mochida Pharmaceutical Co., Ltd. Anticoagulant polypeptides
US5492834A (en) * 1993-07-09 1996-02-20 Beckman Instruments, Inc. Method of sample preparation for urine protein analysis with capillary electrophoresis
DE60325334D1 (de) * 2002-02-05 2009-01-29 Genentech Inc Proteinaufreinigung

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2720704C2 (de) * 1977-05-07 1986-09-25 Behringwerke Ag, 3550 Marburg Neues Glycoprotein, Verfahren zu seiner Herstellung und seine Verwendung
CH643297A5 (de) * 1978-06-30 1984-05-30 Alpha Patent Ltd Verfahren zur reindarstellung von urokinase.
US4230697A (en) * 1978-07-03 1980-10-28 Morinaga Milk Industry Co. Ltd. Virus-inactivated HGI-glycoprotein capable of stimulating proliferation and differentiation of human granulocyte, process for preparing same and leukopenia curative containing same
DE2842467A1 (de) * 1978-09-29 1980-04-10 Behringwerke Ag Neues ubiquitaeres gewebsprotein pp tief 8
GB2038337B (en) * 1978-12-21 1983-01-19 Green Cross Corp Process which comprises separation of urokinases having different molecular weights
DE3013724A1 (de) * 1980-04-10 1981-10-15 Behringwerke Ag, 3550 Marburg Neues protein pp (pfeil abwaerts)9(pfeil abwaerts), verfahren zu seiner anreicherung und gewinnung sowieseine verwendung
DE3315000A1 (de) * 1983-04-26 1984-10-31 Behringwerke Ag, 3550 Marburg Gewebeprotein pp(pfeil abwaerts)4(pfeil abwaerts), verfahren zu seiner gewinnung sowie seine verwendung
DE3410694A1 (de) * 1984-03-23 1985-10-03 Behringwerke Ag, 3550 Marburg Gewebeprotein pp(pfeil abwaerts)2(pfeil abwaerts)(pfeil abwaerts)1(pfeil abwaerts), verfahren zu seiner gewinnung sowie seine verwendung
JPS60199819A (ja) * 1984-03-23 1985-10-09 Kowa Co トロンビン結合性物質およびその製法
US4708948A (en) * 1984-04-20 1987-11-24 The United States Of America As Represented By The Department Of Health And Human Services Substantially purified tumor growth inhibitory factor
EP0181465B2 (de) * 1984-09-21 1994-11-23 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Blutgerinnungshemmende Proteine, Verfahren zur Herstellung sowie deren Verwendung
US4677195A (en) * 1985-01-11 1987-06-30 Genetics Institute, Inc. Method for the purification of erythropoietin and erythropoietin compositions
CA1265446A (en) * 1985-09-30 1990-02-06 Masahiro Maki Anticoagulating substance, process for preparing same and anticoagulant comprising same as an effective component
JPH0689014B2 (ja) * 1986-01-21 1994-11-09 興和株式会社 トロンビン結合性物質およびその製法

Also Published As

Publication number Publication date
ES2065318T3 (es) 1995-02-16
US5047503A (en) 1991-09-10
EP0253331B1 (de) 1994-10-19
EP0253331A3 (en) 1989-10-11
KR890002388A (ko) 1989-04-10
ATE113062T1 (de) 1994-11-15
EP0253331A2 (de) 1988-01-20
DE3750664T2 (de) 1995-06-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee