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DE3614292C1 - Holder for unframed biological mitral valve implant - Google Patents

Holder for unframed biological mitral valve implant

Info

Publication number
DE3614292C1
DE3614292C1 DE3614292A DE3614292A DE3614292C1 DE 3614292 C1 DE3614292 C1 DE 3614292C1 DE 3614292 A DE3614292 A DE 3614292A DE 3614292 A DE3614292 A DE 3614292A DE 3614292 C1 DE3614292 C1 DE 3614292C1
Authority
DE
Germany
Prior art keywords
mitral valve
holder according
retaining ring
holder
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE3614292A
Other languages
German (de)
Inventor
Alexander Prof Dr Bernhard
Hans-Hinrich Dr Sievers
Mehrdad Dr Mahmoodi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BERNHARD ALEXANDER PROF DR 2300 KIEL DE
Original Assignee
BERNHARD ALEXANDER PROF DR 2300 KIEL DE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BERNHARD ALEXANDER PROF DR 2300 KIEL DE filed Critical BERNHARD ALEXANDER PROF DR 2300 KIEL DE
Priority to DE3614292A priority Critical patent/DE3614292C1/en
Application granted granted Critical
Publication of DE3614292C1 publication Critical patent/DE3614292C1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2454—Means for preventing inversion of the valve leaflets, e.g. chordae tendineae prostheses
    • A61F2/2457—Chordae tendineae prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
    • A61B50/20—Holders specially adapted for surgical or diagnostic appliances or instruments

Landscapes

  • Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

Holder for unframed biological mitral valve apparatus for the preparation, preservation, storage, fitment and/or sewing-in thereof, which comprises a holding ring designed in the form of the mitral valve ring and two plate elements each fastened on the holding ring by a respective connecting element made of a flexible material, the distance of the plate elements from the holding ring corresponding to the distance between the mitral valve ring and the papillary muscles of the mitral valve apparatus to be implanted.

Description

Die Erfindung betrifft einen Halter für ein ungerahmtes biologisches Mitralklappenimplantat.The invention relates to a holder for an unframed biological mitral valve implant.

Der Ersatz der menschlichen Mitralklappe durch biologi­ sche, vom Schwein gewonnene Mitralklappenimplantate ist seit längerem bekannt. Die dabei verwendeten Mitral­ klappenimplantate sind in einem mit dem Klappenimplantat zu implantierenden Rahmen versehen. Die Verwendung derartiger gerahmter biologischer Implantate haben jedoch den Nachteil, Raum zu benötigen und so zu einer Stenose zu führen. Weiter wird die normale Bewegung behindert, was zu Thrombosen, Verkalkung oder Degenera­ tionserscheinungen führen kann. Nachteilig ist bei derartigen gerahmten biologischen Klappenimplantaten weiter, daß andere als bei dem normalen Herz der ven­ trikulare Muskel das funktionale Öffnen und Schließen der Klappe nicht unterstützt.The replacement of the human mitral valve by biologi pork-derived mitral valve implants known for a long time. The mitral used valve implants are in one with the valve implant  frame to be implanted. The usage of such framed biological implants however, the disadvantage of requiring space and becoming one Lead stenosis. The normal movement continues hampers, leading to thrombosis, calcification or degenera tion symptoms. The disadvantage is such framed biological valve implants further that other than the normal heart of the ven tricular muscle the functional opening and closing the flap is not supported.

Es ist daher wünschenswert, komplette biologische, ungerahmte, vorzugsweise vom Schwein gewonnene Mitral­ klappenimplantate mit Sehnenfäden und Papillarmuskel­ kopf zu implantieren. Erste entsprechende Versuche waren bereits erfolgreich.It is therefore desirable to have complete biological, unframed mitral, preferably made from pork valve implants with tendon threads and papillary muscles implant head. First corresponding attempts were already successful.

Die Präparation, Konservierung, Aufbewahrung, Einpas­ sung und Einnähung dieser Mitralklappenimplantate in die linke Herzkammer ohne besondere Vorrichtungen hat sich als schwierig erwiesen.The preparation, preservation, storage, fitting solution and suturing of these mitral valve implants in the left ventricle has no special devices turned out to be difficult.

Der Erfindung liegt die Aufgabe zugrunde, einen Halter für ein ungerahmtes biologisches Mitralklappenimplantat zu deren Präparation, Konservierung, Aufbewahrung, Einpassung und/oder Einnähung zu schaffen.The invention has for its object a holder for an unframed biological mitral valve implant for their preparation, preservation, storage, To create fit and / or sewing.

Erfindungsgemäß wird diese Aufgabe gelöst durch einen in Form eines menschlichen Mitralklappenringes ausge­ bildeten Haltering und zwei mittels jeweils einem aus einem biegsamen Material bestehenden Verbindungselemen­ ten an dem Haltering befestigte Plattenelemente, wobei der Abstand der Plattenelemente von dem Haltering dem Abstand zwischen dem Mitralklappenring und den Papillar­ muskeln des zu implantierenden Mitralklappenimplantats entspricht.According to the invention, this object is achieved by a in the form of a human mitral valve ring formed retaining ring and two using one each a flexible material existing connecting elements plate elements attached to the retaining ring, wherein the distance of the plate elements from the retaining ring  Distance between the mitral valve ring and the papillary muscles of the mitral valve implant to be implanted corresponds.

Vorzugsweise ist vorgesehen, daß der Haltering mit einer zur Aufnahme eines Klemmrings dienenden Innennut versehen ist, wobei der Haltering aus einem Kunststoff besteht.It is preferably provided that the retaining ring with an inner groove for receiving a clamping ring is provided, the retaining ring made of a plastic consists.

Die Verbindungselemente bestehen vorzugsweise aus Me­ talldraht.The connecting elements preferably consist of Me tall wire.

Als Material für die Plattenelemente kommt Kunststoff in Betracht. Dabei sind vorzugsweise seitliche, eine Markierung des Vernähungsortes der Papillarmuskeln ermöglichende Ausnehmungen vorgesehen, durch die bei­ spielsweise ein Markierungsstich gesetzt werden kann. Bei einer besonders bevorzugten Ausgestaltung bestehen die Plattenelemente jedoch aus einem Teflonfilz, wobei der Teflonfilz mit den bei der Präparation auf diesen aufgenähten Papillarmuskeln in der Herzkammer vernäht wird und in dieser verbleibt. Bei dieser Ausgestaltung müssen die Verbindungselemente naturgemäß von den Plat­ tenelementen lösbar, vorzugsweise herausziehbar ausge­ bildet sein.Plastic is used as the material for the plate elements into consideration. Here are preferably lateral, one Marking the location of the papillary muscles enabling recesses provided by the for example, a marker stitch can be set. In a particularly preferred embodiment the plate elements, however, from a Teflon felt, whereby the Teflon felt with those at the preparation on it sewn on papillary muscles in the heart chamber and remains in it. With this configuration the connecting elements must of course from the plat tenelemente detachable, preferably pulled out be educated.

Weiter können besondere, sich von dem Haltering nach oben erstreckende Ösen vorgesehen sein, die zum Einfüh­ ren des Halters in die Herzkammer unter Verwendung eines besonderen Instruments dienen.Next can be special, depending on the retaining ring above-extending eyelets can be provided for insertion using the holder into the ventricle of a special instrument.

Vorgeschlagen wird weiter ein Behälter zur Aufnahme des Halters, der aus einer zylindrischen Außenwandung und einer quer zu dieser verlaufenden Trennwand besteht, wobei die Trennwand mit einer der Form des Halterings entsprechenden Ausnehmung versehen ist.A container is also proposed to hold the Holder, which consists of a cylindrical outer wall and  there is a transverse partition to this, the partition having one of the shape of the retaining ring corresponding recess is provided.

Weitere Merkmale und Vorteile der Erfindung ergeben sich aus der Zeichnung, in der ein Ausführungsbeispiel des erfindungsgemäßen Halters anhand einer Zeichnung erläutert wird. Dabei zeigtFurther features and advantages of the invention result itself from the drawing in which an embodiment of the holder according to the invention with reference to a drawing is explained. It shows

Fig. 1 eine perspektivische Darstellung des Halters, und Fig. 1 is a perspective view of the holder, and

Fig. 2 eine entsprechende Darstellung mit in den Halter eingesetztem Mitralapparat. Fig. 2 shows a corresponding representation with the mitral apparatus inserted into the holder.

Der Halter besteht aus einem Haltering 10, dessen Form dem des humanen Mitralklappenrings entspricht. An dem Haltering 10 sind mittels jeweils einem aus einem Me­ talldraht gefertigten Verbindungselement zwei Platten­ elemente 14 befestigt. Der Abstand der Plattenelemente 14 von dem Haltering 10 entspricht dabei dem Abstand zwischen dem Mitralklappenring und den Papillarmuskeln des zu implantierenden Mitralklappenapparates und kann durch eine entsprechende Biegung der Verbindungselemen­ te nach innen verkürzt werden.The holder consists of a retaining ring 10 , the shape of which corresponds to that of the human mitral valve ring. A connecting member made from a talldraht Me are means of two plates members 14 attached to the retaining ring 10th The distance between the plate elements 14 from the retaining ring 10 corresponds to the distance between the mitral valve ring and the papillary muscles of the mitral valve device to be implanted and can be shortened inward by a corresponding bending of the connecting elements.

Der Haltering 10 ist auf seiner Innenseite mit einer zur Aufnahme eines Klemmrings 16 dienenden Innennut 18 versehen, zwischen dem und der Innenwandung des Halterings 10 das Implantat eingeklemmt wird, wie dies aus Fig. 2 deutlich wird.The holding ring 10 is provided on its inside with an inner groove 18 for receiving a clamping ring 16 , between which and the inner wall of the holding ring 10 the implant is clamped, as is clear from FIG. 2.

Die Plattenelemente 14 sind mit seitlichen Ausnehmungen versehen, durch die eine Markierung des Vernähungsortes bei dem Anpassen des Implantats - beispielsweise durch einen Markierungsstich - möglich wird.The plate elements 14 are provided with lateral recesses, by means of which the location of the suturing can be marked when the implant is adapted, for example by means of a marking stitch.

Die Plattenelemente 14 können aus einem gewebefreund­ lichen Teflonfilz hergestellt sein, wobei die Papillar­ muskeln des Implantats auf diesen aufgenäht sind. Der Teflonfilz wird sodann an dem Papillarmuskelkopf ver­ näht und verbleibt in dem Herzen. Bei dieser Ausfüh­ rungsform müssen die Verbindungselemente 12 natürlich von den Plattenelementen 14 lösbar sind, beispielsweise aus den Plattenelementen 14 herausgezogen werden kön­ nen.The plate elements 14 can be made of a tissue-friendly Teflon felt, the papillary muscles of the implant being sewn onto it. The Teflon felt is then sewn to the papillary muscle head and remains in the heart. In this exporting approximately form the connecting elements 12 must of course be removable from the plate members 14, for example, be pulled out of the plate elements 14 nen Kgs.

In der Zeichnung sind weiter zwei Halteösen 20 wieder­ gegeben, die nach oben weisend an den Haltering 10 angesetzt sind und das Einführen des Halters in die Herzkammer erleichtern.In the drawing, two retaining lugs 20 are again shown, which are attached to the retaining ring 10 pointing upward and facilitate the insertion of the retainer into the heart chamber.

Der vorgeschlagene Halter erleichtert die Handhabung ungerahmter biologischer Mitralklappenapparate, sie können in diesen präpariert, konserviert, aufbewahrt und eingepaßt werden sowie bei der Vernähung des Im­ plantats in das Herz verwendet werden.The proposed holder makes handling easier Unframed biological mitral valve apparatus, you can be prepared, preserved, stored in these and be fitted as well as when sewing the Im plantats to be used in the heart.

Die vorgeschlagenen Halter können weiter vor dem Einnä­ hen des Implantats zum Maßnehmen verwendet werden. Zu diesem Zweck verfügt der Operateur über einen Satz verschieden großer Halter, die zu Vergleichszwecken nacheinander in die Herzkammer eingesetzt werden.The proposed holder can continue before Einnä hen the implant can be used to measure. To the surgeon has a set for this purpose different sized holders for comparison purposes are inserted one after the other into the ventricle.

Claims (9)

1. Halter für ein ungerahmtes biologisches Mitral­ klappenimplantat, gekennzeichnet durch einen in Form eines menschlichen Mitralklappenringes ausgebildeten Haltering (10) und zwei mittels jeweils einem aus einem biegsamen Material bestehenden Verbindungselementen (12) an dem Haltering (10) befestigte Plattenelemente (14), wobei der Abstand der Plattenelemente (14) von dem Haltering (10) dem Abstand zwischen dem Mitral­ klappenring und den Papillarmuskeln des zu implantie­ renden Mitralklappenimplantats entspricht.1. Holder for an unframed biological mitral valve implant, characterized by a formed in the shape of a human mitral valve annulus retaining ring (10) and two by means of each one consisting of a flexible material connection elements (12) attached to the retaining ring (10) plate members (14), wherein the distance of the plate elements ( 14 ) from the retaining ring ( 10 ) corresponds to the distance between the mitral valve ring and the papillary muscles of the mitral valve implant to be implanted. 2. Halter nach Anspruch 1, dadurch gekennzeichnet, daß der Haltering (10) mit einer zur Aufnahme eines Klemmrings (16) dienenden Innennut (18) versehen ist. 2. Holder according to claim 1, characterized in that the retaining ring ( 10 ) is provided with an inner groove ( 18 ) for receiving a clamping ring ( 16 ). 3. Halter nach Anspruch 1 oder 2, dadurch gekenn­ zeichnet, daß der Haltering (10) aus einem Kunststoff besteht.3. Holder according to claim 1 or 2, characterized in that the retaining ring ( 10 ) consists of a plastic. 4. Halter nach einem der vorangehenden Ansprüche, dadurch gekennzeichnet, daß die Verbindungselemente (12) aus Metalldraht bestehen.4. Holder according to one of the preceding claims, characterized in that the connecting elements ( 12 ) consist of metal wire. 5. Halter nach einem der vorangehenden Ansprüche, dadurch gekennzeichnet, daß die Plattenelemente (14) mit seitlichen, eine Markierung des Einnäherungsortes der Papillarmuskeln ermöglichenden Ausnehmungen versehen sind.5. Holder according to one of the preceding claims, characterized in that the plate elements ( 14 ) are provided with lateral, a marking of the sewing location of the papillary muscles enabling recesses. 6. Halter nach einem der vorangehenden Ansprüche, dadurch gekennzeichnet, daß die Plattenelemente (14) aus einem Teflonfilz bestehen.6. Holder according to one of the preceding claims, characterized in that the plate elements ( 14 ) consist of a Teflon felt. 7. Halter nach einem der vorangehenden Ansprüche, dadurch gekennzeichnet, daß die Verbindungselemente (12) von den Plattenelementen (14) lösbar sind.7. Holder according to one of the preceding claims, characterized in that the connecting elements ( 12 ) from the plate elements ( 14 ) are detachable. 8. Halter nach Anspruch 6, dadurch gekennzeichnet, daß die Verbindungselemente (12) aus den Plattenelemen­ ten (14) herausziehbar ausgebildet sind.8. Holder according to claim 6, characterized in that the connecting elements ( 12 ) from the Plattenelemen th ( 14 ) are designed to be pulled out. 9. Halter nach einem der vorangehenden Ansprüche, gekennzeichnet durch zwei auf den Haltering (10) aufge­ setzte, nach oben weisende Halteösen (20).9. Holder according to one of the preceding claims, characterized by two on the retaining ring ( 10 ) set up, upwardly pointing eyelets ( 20 ).
DE3614292A 1986-04-26 1986-04-26 Holder for unframed biological mitral valve implant Expired DE3614292C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE3614292A DE3614292C1 (en) 1986-04-26 1986-04-26 Holder for unframed biological mitral valve implant

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3614292A DE3614292C1 (en) 1986-04-26 1986-04-26 Holder for unframed biological mitral valve implant

Publications (1)

Publication Number Publication Date
DE3614292C1 true DE3614292C1 (en) 1987-11-19

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DE3614292A Expired DE3614292C1 (en) 1986-04-26 1986-04-26 Holder for unframed biological mitral valve implant

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Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0532678A4 (en) * 1990-06-07 1993-07-28 Robert William Mayo Frater Mitral heart valve replacements
DE4234127A1 (en) * 1992-10-09 1994-05-26 Vetter Herbert Dr Heart valve prosthesis - comprises distributor mitral valve which can be fixed to heart wall with aid of plastic patches
WO1997020524A1 (en) * 1995-12-01 1997-06-12 Medtronic, Inc. Physiologic mitral valve bioprosthesis
US5733331A (en) * 1992-07-28 1998-03-31 Newcor Industrial S.A. Total mitral heterologous bioprosthesis to be used in mitral or tricuspid heat replacement
US6165119A (en) * 1997-01-02 2000-12-26 Myocor, Inc. Heart wall tension reduction apparatus and method
US6261222B1 (en) 1997-01-02 2001-07-17 Myocor, Inc. Heart wall tension reduction apparatus and method
US6283993B1 (en) 1989-07-31 2001-09-04 Edwards Lifesciences Corporation Annuloplasty ring delivery system
US6332893B1 (en) * 1997-12-17 2001-12-25 Myocor, Inc. Valve to myocardium tension members device and method
US6402680B2 (en) 1998-07-29 2002-06-11 Myocor, Inc. Stress reduction apparatus and method
US6402679B1 (en) * 1998-09-21 2002-06-11 Myocor, Inc. External stress reduction device and method
US6406420B1 (en) 1997-01-02 2002-06-18 Myocor, Inc. Methods and devices for improving cardiac function in hearts
US6537198B1 (en) 2000-03-21 2003-03-25 Myocor, Inc. Splint assembly for improving cardiac function in hearts, and method for implanting the splint assembly
US6622730B2 (en) 2001-03-30 2003-09-23 Myocor, Inc. Device for marking and aligning positions on the heart
US6723038B1 (en) 2000-10-06 2004-04-20 Myocor, Inc. Methods and devices for improving mitral valve function
US6746471B2 (en) 1998-07-29 2004-06-08 Myocor, Inc. Transventricular implant tools and devices
US6764510B2 (en) 2002-01-09 2004-07-20 Myocor, Inc. Devices and methods for heart valve treatment
US7213601B2 (en) 1993-02-22 2007-05-08 Heartport, Inc Minimally-invasive devices and methods for treatment of congestive heart failure
US7316712B2 (en) 1999-12-30 2008-01-08 St. Jude Medical, Inc. Tissue heart valve with annulus support structure
US7666224B2 (en) 2002-11-12 2010-02-23 Edwards Lifesciences Llc Devices and methods for heart valve treatment
US7883539B2 (en) 1997-01-02 2011-02-08 Edwards Lifesciences Llc Heart wall tension reduction apparatus and method
US8092367B2 (en) 2001-09-07 2012-01-10 Mardil, Inc. Method for external stabilization of the base of the heart
US8142495B2 (en) 2006-05-15 2012-03-27 Edwards Lifesciences Ag System and a method for altering the geometry of the heart
WO2012004679A3 (en) * 2010-07-09 2012-08-23 Highlife Sas Transcatheter atrio-ventricular valve prosthesis
US9107749B2 (en) 2010-02-03 2015-08-18 Edwards Lifesciences Corporation Methods for treating a heart
CN108135695A (en) * 2015-10-08 2018-06-08 新加坡国立大学 A kind of mitral of native configurations
CN109475408A (en) * 2016-07-06 2019-03-15 卫理公会医院 Prosthetic mitral valve comprising annular ventricle coupling mechanism

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Cited By (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6802860B2 (en) 1989-07-31 2004-10-12 Edwards Lifesciences Corporation Annuloplasty ring delivery system
US6558416B2 (en) 1989-07-31 2003-05-06 Edwards Lifesciences Corporation Annuloplasty ring delivery method
US6283993B1 (en) 1989-07-31 2001-09-04 Edwards Lifesciences Corporation Annuloplasty ring delivery system
EP0532678A4 (en) * 1990-06-07 1993-07-28 Robert William Mayo Frater Mitral heart valve replacements
US5733331A (en) * 1992-07-28 1998-03-31 Newcor Industrial S.A. Total mitral heterologous bioprosthesis to be used in mitral or tricuspid heat replacement
DE4234127A1 (en) * 1992-10-09 1994-05-26 Vetter Herbert Dr Heart valve prosthesis - comprises distributor mitral valve which can be fixed to heart wall with aid of plastic patches
US7213601B2 (en) 1993-02-22 2007-05-08 Heartport, Inc Minimally-invasive devices and methods for treatment of congestive heart failure
WO1997020524A1 (en) * 1995-12-01 1997-06-12 Medtronic, Inc. Physiologic mitral valve bioprosthesis
US5824067A (en) * 1995-12-01 1998-10-20 Medtronic, Inc. Physiologic mitral valve bioprosthesis
US6406420B1 (en) 1997-01-02 2002-06-18 Myocor, Inc. Methods and devices for improving cardiac function in hearts
US6589160B2 (en) 1997-01-02 2003-07-08 Myocor Inc Heart wall tension reduction apparatus
US7695425B2 (en) 1997-01-02 2010-04-13 Edwards Lifesciences Llc Heart wall tension reduction apparatus and method
US8460173B2 (en) 1997-01-02 2013-06-11 Edwards Lifesciences, Llc Heart wall tension reduction apparatus and method
US6332864B1 (en) 1997-01-02 2001-12-25 Myocor, Inc. Heart wall tension reduction apparatus
US6261222B1 (en) 1997-01-02 2001-07-17 Myocor, Inc. Heart wall tension reduction apparatus and method
US6514194B2 (en) 1997-01-02 2003-02-04 Myocor, Inc. Heart wall tension reduction apparatus and method
US8267852B2 (en) 1997-01-02 2012-09-18 Edwards Lifesciences, Llc Heart wall tension reduction apparatus and method
US6165120A (en) * 1997-01-02 2000-12-26 Myocor, Inc. Heart wall tension reduction apparatus and method
US6332863B1 (en) 1997-01-02 2001-12-25 Myocor, Inc. Heart wall tension reduction kit
US6165119A (en) * 1997-01-02 2000-12-26 Myocor, Inc. Heart wall tension reduction apparatus and method
US6629921B1 (en) 1997-01-02 2003-10-07 Myocor, Inc. Heart wall tension reduction apparatus and method
US6793618B2 (en) 1997-01-02 2004-09-21 Myocor, Inc. Heart wall tension reduction apparatus
US7883539B2 (en) 1997-01-02 2011-02-08 Edwards Lifesciences Llc Heart wall tension reduction apparatus and method
US6755777B2 (en) 1997-01-02 2004-06-29 Myocor, Inc. Heart wall tension reduction apparatus and method
EP1637091A3 (en) * 1997-12-17 2010-09-22 Edwards Lifesciences AG Valve to myocardium tension members device and method
US8187323B2 (en) 1997-12-17 2012-05-29 Edwards Lifesciences, Llc Valve to myocardium tension members device and method
US8226711B2 (en) 1997-12-17 2012-07-24 Edwards Lifesciences, Llc Valve to myocardium tension members device and method
US6332893B1 (en) * 1997-12-17 2001-12-25 Myocor, Inc. Valve to myocardium tension members device and method
US8439817B2 (en) 1998-07-29 2013-05-14 Edwards Lifesciences, Llc Chordae capturing methods for stress reduction
US7722523B2 (en) 1998-07-29 2010-05-25 Edwards Lifesciences Llc Transventricular implant tools and devices
US6402680B2 (en) 1998-07-29 2002-06-11 Myocor, Inc. Stress reduction apparatus and method
US6746471B2 (en) 1998-07-29 2004-06-08 Myocor, Inc. Transventricular implant tools and devices
US7981020B2 (en) 1998-07-29 2011-07-19 Edwards Lifesciences Llc Transventricular implant tools and devices
US8579798B2 (en) 1998-09-21 2013-11-12 Edwards Lifesciences, Llc External cardiac stress reduction method
US6808488B2 (en) 1998-09-21 2004-10-26 Myocor, Inc. External stress reduction device and method
US6402679B1 (en) * 1998-09-21 2002-06-11 Myocor, Inc. External stress reduction device and method
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US6537198B1 (en) 2000-03-21 2003-03-25 Myocor, Inc. Splint assembly for improving cardiac function in hearts, and method for implanting the splint assembly
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