[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

DE3679204D1 - Verfahren zur herstellung kleiner vesikel durch mikroemulgierung. - Google Patents

Verfahren zur herstellung kleiner vesikel durch mikroemulgierung.

Info

Publication number
DE3679204D1
DE3679204D1 DE8686300641T DE3679204T DE3679204D1 DE 3679204 D1 DE3679204 D1 DE 3679204D1 DE 8686300641 T DE8686300641 T DE 8686300641T DE 3679204 T DE3679204 T DE 3679204T DE 3679204 D1 DE3679204 D1 DE 3679204D1
Authority
DE
Germany
Prior art keywords
microemulgation
vesicles
producing small
small vesicles
lipid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686300641T
Other languages
English (en)
Inventor
Ronald Carl Gamble
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nexstar Pharmaceuticals Inc
Original Assignee
Vestar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vestar Inc filed Critical Vestar Inc
Application granted granted Critical
Publication of DE3679204D1 publication Critical patent/DE3679204D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Colloid Chemistry (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
DE8686300641T 1985-01-31 1986-01-30 Verfahren zur herstellung kleiner vesikel durch mikroemulgierung. Expired - Lifetime DE3679204D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/696,727 US4753788A (en) 1985-01-31 1985-01-31 Method for preparing small vesicles using microemulsification

Publications (1)

Publication Number Publication Date
DE3679204D1 true DE3679204D1 (de) 1991-06-20

Family

ID=24798285

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686300641T Expired - Lifetime DE3679204D1 (de) 1985-01-31 1986-01-30 Verfahren zur herstellung kleiner vesikel durch mikroemulgierung.

Country Status (7)

Country Link
US (1) US4753788A (de)
EP (1) EP0190050B1 (de)
JP (1) JPH0776170B2 (de)
AT (1) ATE63456T1 (de)
CA (1) CA1282699C (de)
DE (1) DE3679204D1 (de)
IE (1) IE57225B1 (de)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE60901B1 (en) * 1986-08-21 1994-08-24 Vestar Inc Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics
US4783220A (en) * 1986-12-18 1988-11-08 Xerox Corporation Vesicle ink compositions
FR2634375B3 (fr) * 1988-06-30 1991-07-05 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles de lipide amphiphiles sous forme de liposomes submicroniques
US5023086A (en) * 1987-03-13 1991-06-11 Micro-Pak, Inc. Encapsulated ionophore growth factors
WO1992011083A1 (en) * 1987-09-28 1992-07-09 Redding Bruce K Jr Apparatus and method for making microcapsules
US5271881A (en) * 1987-09-28 1993-12-21 Redding Bruce K Apparatus and method for making microcapsules
IL88076A (en) * 1987-10-28 1993-01-14 Nippon Shinyaku Co Ltd Fat emulsions as drug carriers
US5013497A (en) * 1988-03-03 1991-05-07 Micro-Pak, Inc. Method and apparatus for producing lipid vesicles
US4895452A (en) * 1988-03-03 1990-01-23 Micro-Pak, Inc. Method and apparatus for producing lipid vesicles
MX9203504A (es) * 1988-04-20 1992-07-01 Liposome Co Inc Complejo agente: lipido activo de alta proporcion.
WO1989011272A1 (en) * 1988-05-20 1989-11-30 The Liposome Company, Inc. High ratio active agent:lipid complex
US4935171A (en) * 1989-01-27 1990-06-19 Vestar, Inc. Method for vesicle formation
EP0469082B1 (de) * 1989-04-18 1995-04-05 Vestar, Inc. Markierung mit liposomen von ischämischen geweben
FR2649335B1 (fr) * 1989-07-05 1991-09-20 Texinfine Sa Procede et dispositif de production directe de liposomes
WO1991001367A1 (en) * 1989-07-20 1991-02-07 Bioeng, Inc. Supercritical fluid disruption of and extraction from microbial cells
US5776429A (en) * 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5123414A (en) * 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5820848A (en) * 1990-01-12 1998-10-13 The Liposome Company, Inc. Methods of preparing interdigitation-fusion liposomes and gels which encapsulate a bioactive agent
GB9000705D0 (en) * 1990-01-12 1990-03-14 Royal Postgrad Med School Improvements in or relating to radiotherapeutic agents
EP0562306B1 (de) * 1992-03-06 1995-08-30 Zdzislaw Dr. Fiutowski Pharmazeutische Zusammensetzung mit antiviraler und antibakterieller Wirkung
ES2041597B1 (es) * 1992-05-05 1994-06-01 Bazaco Joan Freixas Nuevo procedimiento para la preparacion de liposomas que encapsulan productos farmaceuticos y cosmeticos.
ATE210426T1 (de) * 1992-10-14 2001-12-15 Liposome Co Inc Interdigitation-fusionsliposomen und gels
US5958449A (en) 1992-12-02 1999-09-28 Nexstar Pharmaceuticals, Inc. Antibiotic formulation and use for bacterial infections
AU3244393A (en) * 1992-12-02 1994-06-22 Vestar, Inc. Antibiotic formulation and process
US5916596A (en) * 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US5665382A (en) * 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of pharmaceutically active agents for in vivo delivery
US5997904A (en) * 1993-02-22 1999-12-07 American Bioscience, Inc. Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof
WO1994018954A1 (en) * 1993-02-22 1994-09-01 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of biologics and compositions useful therefor
US5650156A (en) * 1993-02-22 1997-07-22 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of nutriceuticals and compositions useful therefor
US5439686A (en) * 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US6753006B1 (en) 1993-02-22 2004-06-22 American Bioscience, Inc. Paclitaxel-containing formulations
US6528067B1 (en) 1993-02-22 2003-03-04 American Bioscience, Inc. Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof
US5759571A (en) * 1993-05-11 1998-06-02 Nexstar Pharmaceuticals, Inc. Antibiotic formulation and use for drug resistant infections
WO1995001164A1 (en) * 1993-06-30 1995-01-12 Genentech, Inc. Method for preparing liposomes
WO1995003035A1 (en) * 1993-07-23 1995-02-02 Massachusetts Institute Of Technology Polymerized liposomes with enhanced stability for oral delivery
US6004534A (en) * 1993-07-23 1999-12-21 Massachusetts Institute Of Technology Targeted polymerized liposomes for improved drug delivery
CA2176005A1 (en) * 1993-11-08 1995-05-18 Trevor G. Redgrave Labelled diagnostic compositions and methods of their use
US5468499A (en) * 1993-11-15 1995-11-21 Ohio State University Liposomes containing the salt of phosphoramide mustard and related compounds
US5589189A (en) * 1994-09-14 1996-12-31 Nexstar Pharmaceuticals, Inc. Liposome dispersion
US5662929A (en) * 1994-12-23 1997-09-02 Universite De Montreal Therapeutic liposomal formulation
AU728176B2 (en) 1995-05-04 2001-01-04 Gilead Sciences, Inc. Nucleic acid ligand complexes
DE19639811A1 (de) * 1996-09-27 1998-04-02 Artur Herzog Dr Mesmer Verwendung einer Liposomenlösung zur Verstärkung der Wirksamkeit und/oder Verminderung der Toxizität von Arzneimitteln
US6060082A (en) 1997-04-18 2000-05-09 Massachusetts Institute Of Technology Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
AUPP032097A0 (en) * 1997-11-11 1997-12-04 Peptide Delivery Systems Pty Ltd Improved labelled diagnostic compositions and methods of their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US6727079B1 (en) 1998-02-25 2004-04-27 The United States Of America As Represented By The Department Of Health And Human Services cDNA encoding a gene BOG (B5T Over-expressed Gene) and its protein product
US6171652B1 (en) * 1998-05-26 2001-01-09 Brij P. Singh Method for modifying surfaces with ultra thin films
US6613352B2 (en) 1999-04-13 2003-09-02 Universite De Montreal Low-rigidity liposomal formulation
MXPA02007415A (es) * 2000-01-31 2004-09-10 Collaborative Technologies Inc Composiciones topicas libres de tensioctivo y metodos para su preparacion rapida.
ES2275675T3 (es) * 2000-03-23 2007-06-16 Elan Pharmaceuticals, Inc. Compuestos y metodos para tratar la enfermedad de alzheimer.
US6992081B2 (en) 2000-03-23 2006-01-31 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
JP2004503491A (ja) 2000-06-09 2004-02-05 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド ベンゾキナゾリンチミジル酸シンターゼ阻害剤のリポソーム製剤
ES2252257T3 (es) * 2000-06-30 2006-05-16 Elan Pharmaceuticals, Inc. Compuestos para tratar la enfermedad de alzheimer.
US20030096864A1 (en) * 2000-06-30 2003-05-22 Fang Lawrence Y. Compounds to treat alzheimer's disease
US6846813B2 (en) * 2000-06-30 2005-01-25 Pharmacia & Upjohn Company Compounds to treat alzheimer's disease
PE20020276A1 (es) 2000-06-30 2002-04-06 Elan Pharm Inc COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
WO2002079402A2 (en) * 2001-03-23 2002-10-10 The Regents Of The University Of Michigan Method of inhibiting cancerous cell proliferation using ras mutants of gdp-bound conformation
US6984395B2 (en) * 2001-04-11 2006-01-10 Qlt, Inc. Drug delivery system for hydrophobic drugs
CA2452039A1 (en) * 2001-06-27 2003-01-09 Elan Pharmaceuticals, Inc. Beta-hydroxyamine derivatives useful in treatment of alzheimer's disease
EA200200925A1 (ru) * 2002-07-18 2003-04-24 Ооо "Био-3" Способ получения вододисперсионных препаратов жирорастворимых витаминов и антиоксидантов
CN100367932C (zh) * 2002-11-26 2008-02-13 吉里德科学公司 借助梯度的脂质体中药物装填的方法
US9944713B2 (en) 2004-11-24 2018-04-17 Medicinal Bioconvergence Research Center Antibody specific to the AIMP2-DX2
US7459529B2 (en) 2004-11-24 2008-12-02 Seoul National University Industry Foundation AIMP2-DX2 and its uses
US20080045575A1 (en) * 2004-12-29 2008-02-21 Van Dyke Thomas E Delivery of H2 Antagonists
EP2010117A4 (de) * 2006-04-12 2010-12-01 Massachusetts Inst Technology Zusammensetzungen und verfahren zur adhäsionshemmung
EP3115060A1 (de) 2008-04-18 2017-01-11 VaxInnate Corporation Flagellin deletionsmutanten und deren verwendung
US9226984B2 (en) * 2010-12-14 2016-01-05 Technical University of Denmark and Rigshospitalet Entrapment of radionuclides in nanoparticle compositions
KR20140027232A (ko) 2011-04-07 2014-03-06 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 장시간 작용하는 펩티드 유사체
GB201204384D0 (en) 2012-03-13 2012-04-25 Univ Dundee Anti-flammatory agents
US10188728B2 (en) 2012-12-12 2019-01-29 Temple University—Of the Commonwealth System of Higher Education Compositions and methods for treatment of cancer
KR101638156B1 (ko) 2013-10-29 2016-07-08 가톨릭대학교 산학협력단 C형 간염 바이러스 감염 질환의 예방 또는 치료용 약학 조성물
CA2970795A1 (en) 2014-12-18 2016-06-23 Alnylam Pharmaceuticals, Inc. Reversir compounds
SG11201909478UA (en) 2017-04-24 2019-11-28 Cocrystal Pharma Inc Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication
EP3829719A1 (de) 2018-07-27 2021-06-09 Cocrystal Pharma, Inc. Pyrrolo[2,3-b]pyridinderivate als inhibitoren der influenzavirusreplikation
CN113286793B (zh) 2018-09-10 2024-04-05 共结晶制药公司 吡咯并吡嗪和吡啶并三嗪类流感病毒复制抑制剂
FI3866778T3 (fi) 2018-10-17 2023-03-21 Cocrystal Pharma Inc Influenssa viruksen replikaation estäjien yhdistelmät
EP3887355A1 (de) 2018-11-26 2021-10-06 Cocrystal Pharma, Inc. Inhibitoren der influenzavirenreplikation
US20230151034A1 (en) 2020-03-17 2023-05-18 Cocrystal Pharma, Inc. Peptidomimetic n5-methyl-n2-(nonanoyl-l-leucyl)-l-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds as inhibitors of norovirus and coronavirus replication
US20230159453A1 (en) 2020-04-10 2023-05-25 Cocrystal Pharma, Inc. Inhibitors of norovirus and coronavirus replication
AU2022322889A1 (en) 2021-08-03 2024-02-22 Cocrystal Pharma, Inc. Inhibitors for coronaviruses
WO2024168010A2 (en) 2023-02-09 2024-08-15 Alnylam Pharmaceuticals, Inc. Reversir molecules and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5186117A (en) * 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
US4263428A (en) * 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
US4310506A (en) * 1979-02-22 1982-01-12 California Institute Of Technology Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species
CA1173360A (en) * 1979-06-22 1984-08-28 Jurg Schrank Pharmaceutical preparations
US4310505A (en) * 1979-11-08 1982-01-12 California Institute Of Technology Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances
US4485054A (en) * 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
FR2534487B1 (fr) * 1982-10-15 1988-06-10 Dior Christian Parfums Procede d'homogeneisation de dispersions de phases lamellaires lipidiques hydratees, et suspensions obtenues par ce procede
US4544545A (en) * 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting

Also Published As

Publication number Publication date
IE860273L (en) 1986-07-31
EP0190050B1 (de) 1991-05-15
JPS61218515A (ja) 1986-09-29
US4753788A (en) 1988-06-28
EP0190050A2 (de) 1986-08-06
JPH0776170B2 (ja) 1995-08-16
CA1282699C (en) 1991-04-09
ATE63456T1 (de) 1991-06-15
IE57225B1 (en) 1992-06-03
EP0190050A3 (en) 1987-09-30

Similar Documents

Publication Publication Date Title
DE3679204D1 (de) Verfahren zur herstellung kleiner vesikel durch mikroemulgierung.
GB2246632B (en) Method and apparatus for the examination and treatment of internal organs
EP0524968A4 (en) Heterovesicular liposomes
ATE149556T1 (de) Verfahren zur herstellung von reinigungs- und pflegemitteln
ATE74513T1 (de) Stabilisierte arzneistoffe, verfahren zu ihrer herstellung sowie stabile arzneizubereitungen.
DE58902737D1 (de) Verfahren zur herstellung pharmazeutischer mischungen.
DK0478686T3 (da) Flour- og phosphorholdige amphiphile molekyler med overfladeaktive egenskaber
ATE330002T1 (de) Verfahren zur herstellung von membranvesikeln
DE3674995D1 (de) Verfahren zur herstellung eines emulsionssprengstoffs vom typ wasser-in-oel und eine oxydationskomposition fuer die verwendung in dem verfahren.
ATE133867T1 (de) Verfahren zur herstellung eines durch einbau einer lipophilen wirksubstanz modifizierten lipoproteins
DE3883206D1 (de) Arzneistoff enthaltende fettemulsion des typs "kurz vor gebrauch hergestellt" sowie verfahren zur herstellung einer arzneihaltigen fettemulsion.
DE68904999D1 (de) Verfahren zur herstellung dispergierbarer kolloidaler systeme aus amphiphilen lipiden in form von liposomen in submikrongroesse.
US3553148A (en) Method of making a calcium gel and the product of this method
ATE59035T1 (de) Basisch substituierte benzofurancarbonsaeureamide, verfahren zu ihrer herstellung und sie enthaltende therapeutische mittel.
DE68903570D1 (de) Verfahren zur herstellung von hydroxyalkylierungsmitteln, die erhaltenen mittel und deren verwendung.
ATE148694T1 (de) Verfahren zur herstellung von 3(5)- methylpyrazolen
Redman Nasopalatine duct cyst with pigmented lining suggestive of olfactory epithelium
DE69113643D1 (de) Verfahren zur Herstellung eines Adduktes eines ungesättigten Alkohols und eines jodierten Fluoralkans.
DE3864820D1 (de) Verfahren zur herstellung von 9-(hydroxy-alkyl) hypoxanthinen.
JPS644236A (en) Water-in-oil emulsion
Walker PRACTICAL PROCEDURES.
Walker PRACTICAL PROCEDURES.
ATE117694T1 (de) Ketophosphamidglycoside, verfahren zu ihrer herstellung sowie ihre verwendung als pharmazeutische wirkstoffe.
GR65676B (en) Method for the production of new 1,4-cycloaleano-oxazepine
SU742492A1 (ru) Раствор дл электрохимического полировани нержавеющих сталей

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NEXSTAR PHARMACEUTICALS INC. (N.D.GES.D. STAATES D