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DE3480704D1 - 1,4-dihydropyridine derivate, verfahren zu deren herstellung und verwendung in der pharmazie. - Google Patents

1,4-dihydropyridine derivate, verfahren zu deren herstellung und verwendung in der pharmazie.

Info

Publication number
DE3480704D1
DE3480704D1 DE8484303653T DE3480704T DE3480704D1 DE 3480704 D1 DE3480704 D1 DE 3480704D1 DE 8484303653 T DE8484303653 T DE 8484303653T DE 3480704 T DE3480704 T DE 3480704T DE 3480704 D1 DE3480704 D1 DE 3480704D1
Authority
DE
Germany
Prior art keywords
pharmaceutics
production
dihydropyridine derivatives
dihydropyridine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8484303653T
Other languages
English (en)
Inventor
Hisao Yamaguchi
Yoshiaki Odamiya
Hideo Kanno
Kiyotaka Sunakawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP9699583A external-priority patent/JPS59222474A/ja
Priority claimed from JP10085783A external-priority patent/JPS59227859A/ja
Priority claimed from JP20917883A external-priority patent/JPS60104065A/ja
Application filed by Teijin Ltd filed Critical Teijin Ltd
Application granted granted Critical
Publication of DE3480704D1 publication Critical patent/DE3480704D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/55—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8484303653T 1983-06-02 1984-05-31 1,4-dihydropyridine derivate, verfahren zu deren herstellung und verwendung in der pharmazie. Expired - Lifetime DE3480704D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP9699583A JPS59222474A (ja) 1983-06-02 1983-06-02 １，４―ジヒドロピリジン―３，５―ジカルボン酸ジエステル誘導体の製造法
JP10085783A JPS59227859A (ja) 1983-06-08 1983-06-08 １，４―ジヒドロピリジン―３，５―ジカルボン酸ジエステル誘導体の製造法
JP20917883A JPS60104065A (ja) 1983-11-09 1983-11-09 １，４―ジヒドロピリジン―３．５―ジカルボン酸ジエステル誘導体の製造法

Publications (1)

Publication Number Publication Date
DE3480704D1 true DE3480704D1 (de) 1990-01-18

Family

ID=27308271

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484303653T Expired - Lifetime DE3480704D1 (de) 1983-06-02 1984-05-31 1,4-dihydropyridine derivate, verfahren zu deren herstellung und verwendung in der pharmazie.

Country Status (9)

Country Link
US (1) US4578395A (de)
EP (1) EP0128010B1 (de)
KR (1) KR890004144B1 (de)
AU (1) AU561213B2 (de)
CA (1) CA1271196A (de)
DE (1) DE3480704D1 (de)
DK (1) DK162886C (de)
HU (1) HU192406B (de)
MY (1) MY101142A (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60120861A (ja) * 1983-12-02 1985-06-28 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体
JPS60156671A (ja) * 1984-01-25 1985-08-16 Yamanouchi Pharmaceut Co Ltd ジヒドロピリジン誘導体およびその製造法
GB8403866D0 (en) * 1984-02-14 1984-03-21 Recordati Chem Pharm Diphenylalkylaminoalkyl esters
US4994476A (en) * 1984-10-31 1991-02-19 Bristol-Myers Company Dihydropyridin-3,5-dicarboxylates incorporating aryloxypropanolamine moieties
JPS61137860A (ja) * 1984-12-10 1986-06-25 Teijin Ltd １，４−ジヒドロピリジン酸誘導体の製造法
IE59632B1 (en) * 1985-08-21 1994-03-09 Glaxo Spa Heterocyclic derivatives
US4814455A (en) * 1986-04-16 1989-03-21 Bristol-Myers Company Dihydro-3,5-dicarboxylates
DE3617976A1 (de) * 1986-05-28 1988-01-14 Alter Sa 1,4-dihydropyridin, verfahren zu dessen herstellung und dessen verwendung in antithrombotischen medikamenten
WO1988002750A1 (en) * 1986-10-15 1988-04-21 Byk Gulden Lomberg Chemische Fabrik Gmbh 1,4-dihydropyridine
JPH0688973B2 (ja) * 1987-03-12 1994-11-09 京都薬品工業株式会社 １，４−ジヒドロピリジン誘導体
DE3724909A1 (de) * 1987-07-28 1989-02-09 Bayer Ag Neue substituierte nitro-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung
EP0336132A1 (de) * 1988-03-11 1989-10-11 Byk Gulden Lomberg Chemische Fabrik GmbH Neue 1-Phenylpropylverbindungen
US5310917A (en) * 1991-09-13 1994-05-10 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropydrines
US6187744B1 (en) 1992-03-11 2001-02-13 Michael W. Rooney Methods and compositions for regulating the intravascular flow and oxygenating activity of hemoglobin in a human or animal subject

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2218644C3 (de) * 1972-04-18 1982-08-19 Bayer Ag, 5090 Leverkusen Basische Ester von 1,4-Dihydropyridinen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US3985758A (en) * 1973-02-20 1976-10-12 Yamanouchi Pharmaceutical Co., Ltd. 1,4-Dihydropyridine derivatives
JPS5611702B2 (de) * 1974-01-21 1981-03-16
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
SE429652B (sv) * 1978-06-30 1983-09-19 Haessle Ab 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester
US4307103A (en) * 1978-09-08 1981-12-22 Fujisawa Pharmaceutical Co., Ltd. Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same
DE2949464A1 (de) * 1978-12-18 1980-06-26 Sandoz Ag Benzoxadiazole und benzothiadiazole, ihre herstellung und verwendung
JPS5762257A (en) * 1980-10-03 1982-04-15 Yoshitomi Pharmaceut Ind Ltd 1,4-dihydropyridine-3,5-dicarboxylic acid ester or its salt
JPS5919938B2 (ja) * 1981-04-08 1984-05-09 山之内製薬株式会社 新規な１．４−ジヒドロピリジン−３．５−ジカルボン酸アミノアルキルエステル誘導体の製法
DE3207982A1 (de) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
GB8403866D0 (en) * 1984-02-14 1984-03-21 Recordati Chem Pharm Diphenylalkylaminoalkyl esters

Also Published As

Publication number Publication date
HU192406B (en) 1987-06-29
EP0128010A3 (en) 1987-07-01
US4578395A (en) 1986-03-25
MY101142A (en) 1991-07-31
CA1271196A (en) 1990-07-03
AU2848284A (en) 1984-12-06
HUT34448A (en) 1985-03-28
EP0128010A2 (de) 1984-12-12
DK162886B (da) 1991-12-23
DK272784D0 (da) 1984-06-01
DK272784A (da) 1984-12-03
EP0128010B1 (de) 1989-12-13
KR850000398A (ko) 1985-02-27
DK162886C (da) 1992-05-18
AU561213B2 (en) 1987-04-30
KR890004144B1 (ko) 1989-10-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee