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DE3468104D1 - New aryloxypropanolamine derivatives, process for the preparation thereof, pharmaceutical compositions and therapeutic use - Google Patents

New aryloxypropanolamine derivatives, process for the preparation thereof, pharmaceutical compositions and therapeutic use

Info

Publication number
DE3468104D1
DE3468104D1 DE8484100085T DE3468104T DE3468104D1 DE 3468104 D1 DE3468104 D1 DE 3468104D1 DE 8484100085 T DE8484100085 T DE 8484100085T DE 3468104 T DE3468104 T DE 3468104T DE 3468104 D1 DE3468104 D1 DE 3468104D1
Authority
DE
Germany
Prior art keywords
hydrogen
preparation
pharmaceutical compositions
lower alkyl
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484100085T
Other languages
German (de)
Inventor
Cesare Casagrande
Massimo Nicola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierrel SpA
Original Assignee
Pierrel SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel SpA filed Critical Pierrel SpA
Application granted granted Critical
Publication of DE3468104D1 publication Critical patent/DE3468104D1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compounds having general formula I <IMAGE> I wherein R1 is hydrogen, lower alkyl, lower alkoxy, alkyl enoxy, halogen, cyano, carboxyamido or ureido group optionally separated from the phenyl ring by a methylene or ethylene bridge; R2 is hydrogen, halogen, lower alkyl or alkoxy; R3 is hydrogen, halogen, lower alkyl, lower alkoxy or R2 and R3, taken together, are a methylendioxy group; R4 is hydrogen or lower alkyl, endowed with remarkable cardioselective beta -adrenolytic properties, are described. The process for their preparation and pharmaceutical compositions containing them are also described.
DE8484100085T 1983-01-21 1984-01-06 New aryloxypropanolamine derivatives, process for the preparation thereof, pharmaceutical compositions and therapeutic use Expired DE3468104D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT19219/83A IT1193608B (en) 1983-01-21 1983-01-21 ARYOXYPROPANOLAMINE DERIVATIVES, PROCEDURE FOR THEIR PREPARATION PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR THERAPEUTIC USE

Publications (1)

Publication Number Publication Date
DE3468104D1 true DE3468104D1 (en) 1988-01-28

Family

ID=11155887

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484100085T Expired DE3468104D1 (en) 1983-01-21 1984-01-06 New aryloxypropanolamine derivatives, process for the preparation thereof, pharmaceutical compositions and therapeutic use

Country Status (6)

Country Link
US (1) US4579861A (en)
EP (1) EP0116825B1 (en)
JP (1) JPS59139362A (en)
AT (1) ATE31410T1 (en)
DE (1) DE3468104D1 (en)
IT (1) IT1193608B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL135487A (en) 2000-04-05 2005-07-25 Cupron Corp Antimicrobial and antiviral polymeric materials and a process for preparing the same
US7296690B2 (en) 2002-04-18 2007-11-20 The Cupron Corporation Method and device for inactivating viruses
US7364756B2 (en) 2003-08-28 2008-04-29 The Cuprin Corporation Anti-virus hydrophilic polymeric material
US7480393B2 (en) 2003-11-19 2009-01-20 Digimarc Corporation Optimized digital watermarking functions for streaming data
CA2587036C (en) 2004-11-09 2014-07-08 The Cupron Corporation Methods and materials for skin care
US9751830B2 (en) 2010-03-15 2017-09-05 The Trustees Of The University Of Pennsylvania Inhibitors of the tumor necrosis factor receptor complex
IT202100000782A1 (en) 2021-01-18 2022-07-18 Procos Spa PROCESS FOR THE SYNTHESIS OF IMEPITOIN

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787103A (en) * 1971-08-04 1973-02-02 Pfizer NEW PROPANOLAMINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING
DE2644833A1 (en) * 1976-10-05 1978-04-20 Boehringer Sohn Ingelheim NEW 1-ARYLOXY-2-HYDROXY-3-ALKYLENE AMINOPROPANES AND METHOD FOR THE PRODUCTION THEREOF
DK193181A (en) * 1980-06-05 1981-12-06 Hoffmann La Roche PROCEDURE FOR THE PREPARATION OF IMIDAZOLD DERIVATIVES
US4319032A (en) * 1980-06-06 1982-03-09 Alcolac Inc. Derivatives of aminoalkyl alkylene ureas

Also Published As

Publication number Publication date
EP0116825A1 (en) 1984-08-29
JPS59139362A (en) 1984-08-10
EP0116825B1 (en) 1987-12-16
IT8319219A0 (en) 1983-01-21
IT1193608B (en) 1988-07-21
US4579861A (en) 1986-04-01
ATE31410T1 (en) 1988-01-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee