DE2641210A1 - METHOD OF MANUFACTURING A CARRIER ASSEMBLY AND A COMPOSITION MANUFACTURED HEREIN - Google Patents

Description

GARY CHEMICALS PTY. LTD., 13 Futura Road, Noble Park, Victoria, 3174 (Australia)

Process for making a carrier composition as well as a composition made hereafter

The invention relates to a method for producing a carrier composition and to a composition produced therefrom .

Carrier compositions for use in the manufacture of Cosmetics are known. Usually one of the known carrier compositions suitable perfumes, fragrances or the like are added to thereby obtain a wide variety of desirable products. General are such known carriers etzmens etz ungen desired which to lead to relatively highly viscous and possibly gelled products. A large number of known carrier compositions are based on petroleum products, which generally have the desired thickening

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or have gelling properties. However, petroleum products generally have the disadvantage that they feel greasy and also look fat-like, with an added pungent odor. These properties are of course common to many uses of such carriers
completely unsuitable. Frequently

It is also necessary to use such petroleum-based carrier compositions with non-aqueous solvents
to combine, but with the disadvantage that numerous non-aqueous solvents can be dangerous if they are absorbed by the human body,
in that the lymphatic system or the capillary vessels can be impaired with prolonged exposure. Furthermore, non-aqueous solvents have a tendency to remove or destroy oils, fats and the microflora of the skin, it should be noted that such oils, fats and the microflora
in many cases have a beneficial effect. This can lead to undesirable dermatological effects
appear.

The invention is based on the object of creating a carrier substance and a method for producing it, which
ensure that the carrier substance can be used in certain compounds or mixtures without the use of non-aqueous solvents, although the possibility should also exist in some applications
Use non-aqueous solvents. The carrier composition should be in certain. Connections a suitable one
Form a gel or an emulsion and also have sufficient stability under storage and use conditions.

According to the invention, this object is achieved by a method of
initially mentioned type solved, which is characterized

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is that a carboxyvinyl polymer is heated. The carrier composition according to the invention is accordingly characterized that it is made by heating a carboxyvinyl polymer.

The carrier compositions according to the invention are thus made that in a novel way carboxyvinyl polymers are heated to make the composition. For this Suitable carboxyvinyl polymers or mixtures of such polymers of any type can be used for this purpose, but are suitable is preferably a high molecular weight carboxyvinyl polymer. Preferably the carboxyvinyl polymer used in accordance with the invention used is the form of a powder such as is available on the market under the trade name CARBOPOL. As an an example for a polymer powder of this type the following properties can be given: bulk density about 0.2 g / cm (J3 lbs./cubic foot), specific gravity about 1.41, moisture content up to 2%, pH in 1% water solution about 3 to 5. Another suitable carboxyvinyl polymer is under the trade name NATUROSOL by Hercules, Ine., manufactured substance.

Attempts have already been made to find a suitable carrier composition which avoids the disadvantages described at the outset by using a high molecular weight carboxyvinyl polymer such as is available from Goodrich Chemical Company under the trademark CARBOPOL. But while Carbopol resins are used in some applications are to be used satisfactorily, it is difficult to stabilize such resins, so that an emulsion or a gel which formed from such resins is likely to collapse after a relatively short period of time. It is accordingly difficult, a satisfactorily gelled or emulsifiable adorned compound or composition by means of such carrier

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to produce compositions or carriers of a known type. In particular, difficulties arise with substances or compounds which contain aspirin and which, as is well known, are difficult to stabilize. All of these difficulties are going through the composition according to the invention, which is produced by heating a carboxyvinyl polymer of the type described, avoided.

According to the invention, the carboxyvinyl polymer can be different, suitable temperatures are heated, for example to a temperature of 204 to 315 C. An even more preferred The range is from 248 to 271 C while the most preferred heating temperature is 260 C. The carboxy vinyl polymer can be heated in various ways, for example above or below a heating plate or by that the powder is passed by a hot plate about 2.54 cm (1 ") away, for example. A preferred heating time is about 2 minutes. The polymer can be stirred or swirled as desired during the heating step. The preferred carboxyvinyl polymer the previously described CARBOPOL, i.e. a high molecular weight, colloidal carboxyviny! polymer, is used.

In a particularly preferred embodiment of the invention Process for the production of the carrier composition, which in principle is suitable as a carrier substance, and by heating a carboxyvinyl polymer is prepared in the form described, wherein the carrier composition is both can be used dry as well as in emulsified form or as a gel, in particular in non-aqueous Solvent-free preparations, including creams for medical and non-medical purposes, will make the polymer heated by being heated on a moving bard.

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will give, which is about 12.2 m / min. (40 feet / minute) moved through a tunnel. Inside the tunnel there is a heating element about 90 cm (3 feet) above the belt, which extends the entire length of the tunnel.

The material that comes out of the tunnel is preferred dried and sifted to a fineness of 26 χ 10 particles / cubic foot, the material then being customary has a specific gravity of about 1.47. Immediately after sieving or classifying, the carrier composition produced in this way becomes preferably stored in tightly closed containers, otherwise it may deteriorate to be worried about under the influence of moisture and light.

The actual physical and chemical changes which occur in the carboxy vinyl polymer as a result of those described above Treatment may occur, and the reasons for these changes are not fully understood at this time.

The treatment described above results in a carrier composition with particularly desirable properties.

The carrier composition can with water or an aqueous Solution for the preparation of a base mixture are compounded, this base mixture being used in various preparations can be. However, the carrier composition can also can be used in solid form.

Some care is required when mixing the carrier composition with water or an aqueous solution to achieve satisfactory mixing. It has been shown that Lightnin mixers or Silverson mixers like them by Silverson Machines Ltd., Buckinghamshire, Great Britain, are particularly suitable.

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A relatively small machine is the model L2R manufactured by Silverson, but there are also larger ones Machines are available for production use.

If the carrier composition is mixed with water in an amount of 10% by weight, the pH of the mixture can be adjusted to about 4 sink.

This mixing with water results in a product which is generally a mixture in the form of a slime gel, the can look white and milky. Any suitable preservative can be added to the mixture thus prepared be added, such as, for example, a benzoate, in particular a parahydroxy- or parapropylmethylbenzoate. Preferably about 1% by weight of the preservative is added; colorants can usually be added in an amount of 0.005 to 0.10% by weight, based on the total mixture, can be added if so desired. That way Emulsifying and surface-active agents can be added to the prepared mixture. Suitable agents for this Purpose are polyoxyethylene derivatives of fatty acid partial esters of sorbitol anhydride, such as sorbiton monooleate. Preferably, such agents are mixed in steadily increasing amounts with a carrier composition and water by small additives can be added while stirring.

If desired, further additives can be mixed with the carrier composition - for example surface-active agents o in connection with the. Polyoxyäthylenderivaten of fatty acid partial esters of Sorbitolanhydrides, as described above _B are particularly suitable the Fettsäureaminoxyäthylate, such as the Stearylaminoxyäthylat and coconut diethanolamine (for example, available under the trade name Teric 350 substance). Preferably

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these additives are added gradually in small amounts, mixing after each individual addition until the pH value is reduced stabilized. During the addition of each small additional amount, it may be found that the mixture thickened, which means that more vigorous stirring of the mixture is required.

More water can then be added. After this has taken place, a neutralizing agent is preferably mixed intensively with the mixture, for example to a pH of about 5.5 to 7.5 to be observed. Various basic compounds are suitable as neutralization agents, but one is special effective to call the triethanolarain.

The additives described above can be used in different amounts can be used. The inventive Carrier composition can continue with different Materials are dry compounded and then compressed into tablets.

Further features and distributions of the invention emerge from the claims and from the following description, in which various exemplary embodiments are explained in detail.

example 1

The substance available under the trade name CASBOPOL was placed on a belt and then moved through a tunnel in which a heating element was placed about 90 cm (3 feet) above the belt. The Carbopol was heated to 260 C (5QO ⁰ F). After passing through the tunnel, the Carbopol was dried, sized and stored in sealed containers.

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Example II

1,000 ml of water at 40 ⁰ C was fed into a stirred vessel and stirred there by a Silverson mixer model L2R. Ten grams of Carbopol, not treated by the method of the present invention, was added to the water and mixed for four minutes. One gram of parahydroxymethyl benzoate was then added. The pH was then examined and found to be 4.5. Mixing was continued for an additional 6 minutes after which time an additive composition was added. The additive composition contained the following ingredients, in% by weight, based on the total mixture:

4% sorbitol monooleate,
2% coconut diethanolamine
1% denatured alcohol.

Mixing was continued for an additional minute. A neutralizing agent was then added in an amount of 0.5% based on the total amount admitted. Triethanolamine was used as the neutralizing agent. After further mixing for a minute the pH was re-examined, which was 10.0. The resulting mixture was frothy and tended for separating.

Example III

The procedure was as in Example II, but instead 10 g of the product produced in Example I were used from 10 g of Carbopol. All other process steps and additions were the same as in Example II, with the exception that the pH after the addition of the parahydroxymethylbenzoate was 2.75 while the end product was a viscous emulsion with a pH value of 6.5, there was no foaming and no ten-

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showed the tendency to separate. The viscosity exceeded that of the product which had been obtained according to Example II. It should be noted that an exothermic process obviously occurred in the formation of the end product, namely, when heat was given off.

Example IV

The product prepared according to Example III is already suitable In this condition it is excellent as a hand cleaner for industrial and household purposes. It also represents the product a barrier agent that is fully gelled, not separated, not greasy, stable and highly effective when used shows. For aesthetic reasons, however, this substance was preferably a dye in an amount of about 1%, based on the total mixture, added. It is of particular importance that the hand cleaning agent described above proved successful in a number of attempts relating to dermatological properties. That Cleaning agent did not contain any non-aqueous solvents. It has been shown positively that the use of the cleaning agent contributes to the reduction of skin diseases in industrial workers.

Example V

Part of the end product obtained according to Example III was compounded with peanut oil and perfume, with peanut oil in one Amount of 1% and perfume in an amount of 0.25%, based on the total mixture, were used. There was a substance which could be used experimentally as a cosmetic hand cream for women. The hand cream caused the occurrence of rash from dishwashing has been avoided.

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Example VI

A face cream was made as follows:

Product of Example III 95.75%

medicinal mineral oil 2%

Peanut oil 2%

Perfume 0.25%

Example VII

A moisturizer and cleanser for use on the face was made as follows:

Product of Example III 96.75% Peanut Oil 3%

Perfume 0.25%

Example VIII

Similar to Examples IV to VII, an aftershave lotion, a pre-shaving treatment lotion, a suntan, and a pharmaceutical composition for treatment produced by pain, sores, inflammation, bruises and the like.

Example IX

A detergent or soap tablet was made by dry compounding of the following substances:

Basic composition of

Example I 0.06%

Sodium trx polyphosphate 53.0% Decorative flakes 26.5%

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Wheat starch 12.72%

Talc 6.36%

optical brightener 0.18%

Alginic acid 0.18%

Microcell perfume 1, O%

The mixture then became soap tablets at 3 tons / cubic inch pressed.

The soap tablets were 97.8% biological within 7 days degradable. It was found that the tablets were very handy to use because they were easy for a user to use could be broken. At the same time, however, the tablets were sufficiently stable to withstand the production, packaging and distribution conditions meet.

Example X

Similar to Example IX, a cleaning tablet was used Use in washing machines, a cleaning tablet for car washing, an antiseptic deodorant tablet and a cleaning tablet manufactured for dentures.

The carrier composition of Example I also worked successfully for the production of liquid soaps, detergents, stain removers for clothing, cleaning agents for Upholstery, floor cleaning products, protein shampoos, cleaning products Degreasing agents for cars, car polishes, carpet cleaning agents and furniture polishes.

Furthermore, the Trägerzusairenensetzung of Example I was also successful in synthetic pla ± c foaming include, such as polyurethane foams, where the cell resistance and the manufacturing process could be improved. The carrier composition can also be used for manufacture in front of cardboard

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or use cardboard, including the manufacture of compressed materials or cardboard from sawdust, sand, rice husks, Steel shavings or peanut shells. Furthermore, the carrier composition of the invention was found to be useful the treatment of Metal1 waste slag.

Example XI

6 ml of water, 100 ml of ethanol and 80 ml of peanut oil were mixed in a Silverson mixer, model L2R, for 1 minute. The mixer was then set to half speed, whereupon 20 g of the product from Example I and 10 ml Crillet 4 (a surfactant cleaning agent) were added. After 15 minutes of mixing there was an additional 15 grams of the product of Example 1 and 10 ml of Crillet 4 were added, followed by mixing for a further 15 minutes - 10 g of propylparabanomethyl (a preservative) was added to 95 ml of water at 80 ° C, whereupon the mixture thus obtained was added to the above mixture described was added. To the resulting mixture, 50 g of aspirin was slowly added, with has been mixed continuously ο after the addition process has ended mixing was continued for 10 minutes. Then 15 g of the product from Example 1 and 10 ml Crillet 4 (Crilat) was added, followed by 15 minutes at full speed was further mixed. Another 5 g of the product from Example 1 and 10 ml of Crillet 4 were then added, whereupon mixed for an additional 10 minutes. A mixture of diethanolamine and triethanolamine, in a large amount of 1.5% by weight in each case, based on the total mixture, were then incorporated into the mixture thus obtained. The resulting The mixture was then allowed to cool for an hour and filled into glass containers. The product thus obtained was a stable aspirin suspension, which was suitable for local use.

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Example XII

Similar to Example XI, suspensions of insulin, histamines and piperoxine were prepared.

Within the concept of the invention are self-evident
manifold modifications and configurations of the examples described above are possible. The concept of the invention, as expressed in the claims, of course also extends to such products as can be produced according to the examples described above.

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Claims (15)

BOEI-'uVERT & FOEHMERT GX CLAIMS 1. A method for preparing a carrier composition, characterized in that a carboxyvinyl polymer is heated. 2. The method according to claim 1, characterized in that the Carboxyvinyl polymers heated to a temperature of 204-315 ° C will. 3. The method according to claim 1 or 2, characterized in that the Karboxyviny! heats up ". Carboxyvinyl polymers to a temperature of 248 to 271 C 4. Carrier composition, characterized in that it is through Heating a carboxyvinyl polymer is made. 5. Carrier composition according to claim 4, characterized in that cie by heating a carboxyvinyl polymer to a Temperature of 204 to 315 C has been established. 6. Carrier composition according to claim 4 or 5, characterized in that that it is made by heating a carboxyvinyl polymer to a temperature of 248 to 271 ° C. 709812 / 11U BOEHMERT & BOEHMERT 7. Carrier composition according to one of claims 4 to 6, characterized in that it is produced by heating a high molecular weight, colloidal carboxyvxnyl polymer to a temperature of:
is. of 260 C and subsequent drying and sieving 8. Carrier composition according to one of claims 4 to 6, characterized in that it is produced by heating a high molecular weight, colloidal carboxy vinyl polymers to a temperature of 260 C, subsequent drying and sieving, Mix with water at 40 C for four minutes, add parahydroxymethyl benzoate and continue mixing for a period of time of 6 minutes with the addition of, based on the total mixture, 4% by weight sorbitol monooleate, 2% by weight coconut diethanolamine and 1% by weight denatured alcohol, followed by Mixing for one minute and neutralizing with 0.5% by weight, based on the total mixture, of triethanoiamine as neutralizing agent, and finally mixing for one minute, the resulting viscous emulsion having a pH of 6.5. 9. Carrier composition according to claim 8, characterized by a dye content of about 1%. 10. Carrier composition according to claim 8, characterized in that by adding about 1% by weight of peanut oil and about 0.25% by weight, each based on the total mixture, of perfume. 11. Carrier composition according to claim 8, characterized by an addition of about 2 wt .-% peanut oil, about 0.25 wt .-% Perfume and about 2% by weight medicinal mineral oil. 12. Carrier composition according to claim 8, characterized by adding about 3% by weight of peanut oil and about 0.25% by weight of perfume. 709812 / 11U BOEIiMERT & B0 £ HM6RT 13. Trägerzusainmensetzung according to claim 7, characterized in that for the preparation of a soap tablet O, O6 wt .-% of the composition, 53.0 wt, -% of sodium tripolyphosphate, 26, 5 wt .-% Dekolflocken, 12.72 wt .-% Wheat starch, 6.36% by weight of talc, 0.18% by weight of an optical brightener, 0.18% by weight of alginic acid and 1.0% by weight of microcell perfume are dry mixed and the mixture is then pressed into soap tablets is. 14. Use of the carrier composition according to any one of the claims 4 to 13 in dry form as a binder. 15. Use of the carrier composition according to any one of claims 4 to 13 in gel or emulsion form. 709812 / 11U