DE1950606A1 - Sealed flexible container for liquids - Google Patents

Description

PATENT ADVOCATE DR. HANS-GUNTHER EGGERT, DIPLOMA CHEMIST

5 COLOGNE-UN DE N THAL PETER-KINTGEN-STRASSE 2 1950606

Cologne, 6 _C 10.1969 Eg / Ax

UNION CARBIDE CORPORATION ,

270 Park Avenue, New York, N.Y. 10017 (V.St.A.).

Sealed flexible container for liquids

The invention relates to airtight containers for liquids, in particular a flexible plastic container for the removal, storage and delivery of viable fluids such as blood u

Flexible plastic containers for removal and storage of blood and similar fluids are recently being used as replacements for the glass and metal containers that previously used for such purposes have come into use. The advantages of plastic containers compared to the glass and metal containers are obvious: They do not break, are lighter and can be lighter be handled and transported. Also take 3the less pantry space, these flexible ones However, plastic containers 3 have several problems: The flexible container or bag that holds the Contains blood, and the lines attached to the bag for the collection and delivery of the blood must be complete be kept tight. The container and lines must also be kept sterile.

The subject of the invention is a new, improved one Containers made from flexible plastic films for liquids like blood and the like. This container consists of an air

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tightly closed pouch in which the liquid is stored ^; ^ "Collected and stored, and lines that capture the ~ * ^u liquid and release and are attached to the bag and sealed so that the total container is sealed sterile and dead, and the lines can still be opened as needed"

The invention also comprises a new and simple method drive to manufacture the containers from flexible plastic "

The subject of the invention is accordingly e * in sealed, flexible container made of thermoplastic foils, .der. -marked is through a liquid storage chamber or cell that extends between a first and a second, contiguous end chamber extending through and from the first and second end chambers a first and a second, q.uer, extending across the container Heat-sealed seam is separated, a liquid supply line of thermoplastic material, which is arranged in the first end chamber and a first Having end that extends into the storage chamber through the first heat seal seam and through the heat seal seam is permanently welded to the inner walls of the container, a liquid removal line thermoplastic material disposed in the second end chamber and having a first end that tapers extends into the storage chamber through and remaining through the second heat seal seam is welded to the inner walls of the container, the inner walls of the supply line and the removal line are "releasably" welded to one another at their first ends by the first or the side heat-sealed seam and the container is closed at its ends by sealing seams.

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The invention also relates to a method for producing a sealed, flexible plastic container, which is characterized in that a conduit made of thermoplastic material at one end and a second conduit made of thermoplastic material at the "other end" is introduced into a hose made of flexible thermoplastic film, heat and simultaneously bridging the outer walls of the hose along a first transverse line extending across one end portion and across one end of the first conduit until the inner walls of the hose are permanently welded to one another and to one end of the first conduit are and the end of this conduit is flattened and a releasable Yergehweißung the inner walls delta -first line has been formed, heat and pressure along the same time on the outer walls of the tube a second §uerlinie _# extending across the other Endfeil of Schlaughs and across a End of the second line he. ^

for. Action brings t »
, / bJ-S 94-e "Inner walls of the visual tube remaining with ^

welded to each other and to one end of the second line and the end of this line is flattened and a releasable weld of the inner walls has been formed in the second conduit, thereby welding a f "er-S sealed storage chamber, and the inner walls of the hose are welded at both ends and thereby forming a welded end chamber on each side of the storage chamber which encloses a conduit.

The transverse heat-sealed seams, which form the storage chamber, expediently by the action of heat on both outer walls of the container and through the walls of the container onto the walls of the container walls touching line. The term "internal detachable weld" or as used herein

"Internal releasable seal" means one through heat

the pipe was welded to the surfaces of the inner walls /. The part of the line closed by heat sealing is flattened by the heat sealing seam. This weld can be achieved by applying pressure at an angle opened from 90 ° to the flattened welded part by, for example, squeezing the flattened part of the lead between your thumb and forefinger

The invention is described in detail below in conjunction with the drawings.

1 shows a plan view of an embodiment of the container according to the invention, consisting of a flexible plastic film, with a liquid storage chamber which extends between an associated euisüen and a second end chamber, the first end chamber having a device for supplying the liquid and the second end chamber a Includes device for withdrawing the liquid.

2 shows a plan view on an enlarged scale the second end chamber of Figure 1, which encloses the device for removing the liquid.

FIG. 3 is a top plan view of the second end chamber of FIG Figo "!, which is open and partially torn off.

4 shows a cross-section on an enlarged scale through the liquid storage chamber and the second end chamber taken along line 4-4 of Figure 2 and illustrated the position of the heating rods during the heat seal, through which the container walls and a liquid extraction line are welded together.

5 shows a cross-section on an enlarged scale length of the line 5-5 of Fig, 2 similar to the cross section

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of Fig.4 during the heat sealing through which the walls the storage chamber of the container are welded together

Fig. 6 is a plan view of another embodiment of the flexible plastic container according to the invention.

Fig.1 shows a flexible plastic container according to a Embodiment of the invention. This container consists of a flat-lying tube 10 from a biaxial oriented polyolefin film with an upper wall 11 and a lower wall 12, which extend through several transverse Seals are divided into three closed liquid-tight sterile chambers or cells, viz in a liquid storage cell 14 »which between two end chambers 16 and 18 extends. The first end chamber 16 contains two liquid supply lines 20 and 21 made of an elastic thermoplastic material such as polyethylene · The liquid supply lines 20 and 21 are completely enclosed in the end chamber 16. The second end chamber 18 contains a liquid extraction line 22, which is also made of elastic thermoplastic material such as polyethylene. The liquid extraction line 22 is in the end chamber 18 completely enclosed. The lines 20, 21 and 22 protrude into the liquid storage chamber 14 · Die Storage chamber 14 is formed by two tight heat-sealed seams 24 and 26 running across the walls of the Tubes 10 are laid. The sealing seam 26 at the Flüesigkeltiauatrittsende the storage kaxfivir proceeds preferentially eohrttg to the longitudinal axis of the sole 10, ao that • in »ion rejuvenating floor for the liquid chamber is formed when the container is held vertically » • o that the drainage of the liquid, e.g. blood, from the Torrata container is facilitated.

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The end chamber 16 is duroh two spaced apart arranged tight heat-seal seams formed, namely the heat-sealed seam 24, which separates it from the liquid chamber 24, and a closure seam 28. The end chamber 18 is also arranged by two spaced apart tight heat-sealed seams are formed, namely the heat-sealed seam 26, which is seen from the liquid chamber separates, and a final seam 30, In the one shown in Fig.1 Embodiment, the leads 20 and 21 are sealed in two separate pockets, which are in the Chamber 16 formed by a heat seal 29 for separate and individual use and regulation of each To enable liquid filling line · This separation of lines 20 and 21 is optional »Furthermore, the Number of filling lines may be different It is possible one, three or more lines depending on the type of The liquid and the liquid additives to be kept in the container must be provided "

The manufacture of the container according to the invention is described below in particular in connection with FIGS and 5. A flat-lying tube 10 made of flexible thermoplastic plastic films of certain Length and flat width, is made in a known manner. The two lines 20 and 21 are between the walls 11 and 12 at one end part of the hose like this inserted that they are completely from the side walls are covered and the Seitenwand® protrude over the lines «Di® line 22 is in the other end part of the tubing 10 inserted in the same way · The preferred heat sealing with heating rod or white ruler Let in Fig. 4 and 5 illustrate «Two working together Bars 32 and 34 are called parallel with close spacing in sswsi parallel perpendiculars. Levels are arranged M Rarely jammed with the stupid ones on walls 11 and 12 of the fXasMitianden hose

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brought into contact. Fig. 4 shows the line 22 between walls 11 and 12 with one end of the conduit flattened between heating rods 32 and 34 * On each heating rod 32, 34 an impulse band 33, 35 is attached. By the effect from both sides, exerted by the rods Pressure is applied to the inner wall surfaces of the conduit 22 against each other · Then current is applied to the pulse bands 33 and 35 laid * Since the straps are staggered, each strap has its own The weld seam, i.e. the heat coming from the band 33, welds the upper wall 11 and the line adjacent to it 22 together, and the heat from the belt 35 welds the lower wall 12 and the adjacent one Wall of the line 22 together. Since the line 22 dur ^ Flattening the heating rods causes the heat from both belts to flow through the walls of the Tubing penetrates the wall of the pipe, forming a weld 27 of the inner walls of the pipe · This weld is strong enough to prevent an exit through the hydraulic pressure from the liquid in the reservoir

to resist _Λ , ^ _Λ " ,,". _{However, ΛΛ} wanrungskamme377 gives way and opens when a higher clamping pressure is applied from the outside across the sealed part of the hose in order to loosen the weld seam. The optimal conditions in terms of time, pressure and heat can easily be determined through experiments for the selected materials for the foil and line.

The weld seam 24 on the liquid inlet side of the Storage chamber and the internal welds 27 in the liquid supply lines 20 and 21 are shown in FIG laid the same way

The method of heat sealing described above is used preferred, but the heat-sealed seams can also be laid in another way. For example, the hose lying flat and lines horizontal

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arranged and clamped in the usual way between two heating rods or welding rulers, which are arranged parallel to each other in a common vertical plane To weld hoses to each other and to the lines. However, when the heat is applied from both sides at the same time, the conditions of time, temperature and pressure must be precisely controlled. The heating rods have to give enough heat to the walls of the flat-lying hoses permanently to one another and to weld the pipes, but the interior walls of the flattened lines may not consistently miteiander be welded, egg _ne way to solve this problem is that you the elektr * see impulses one after the other to a heating rod and then to the other heating rod and interposed cooling. It has been found that the best way to solve the problem is to arrange the heating rods in two parallel, closely spaced vertical planes and supplying the electrical energy simultaneously to the belts on both heating rods in the catfish described above. This method has the further advantage of forming a double heat seal, one from each side of the lay-flat hose, or a heat seal that is approximately twice as wide as if the heating rods were in the same vertical plane. Such a weld ensures an absolutely tight liquid chamber.

The final welds 28 and 30 Kftrden then across laid the flat tube 10 to close the end chambers 16 and 18 and the sterilized tubes

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20, 21 and 22 to be completely encased and sealed and in this way to keep them in a sterile state. These finishing seams can be made in any convenient manner, i.e. by heat sealing or by using a "If necessary, the sealing seam 29, which separates the liquid supply lines, which are enclosed in the end chamber 16, are laid at the same time. The sealed end chamber 18 has the Another advantage that in the event of a leak in the weld seam 27 in the extraction line, the chamber 18 has a represents an additional receptacle for the liquid stored in the chamber 14.

If necessary, a second weld 27 of the inner wall in the extraction line 22 can be carried out before this line is inserted into the hose 10. This second weld serves as a safety seal that prevents liquid from escaping from the chamber if a leak occurs in the detachable weld seam 27, and can be opened in any conventional manner. Instead of a second weld, an elongated plug can also be inserted into the extraction line. Preferably, the spout and extraction lines should not contain any liquid that is stored in the chamber 14, although these lines and the entire container are in a sterile state. The reason for this is that these liquids, e.g. blood, may contain preservatives and the homogeneity of the obtained blood mixture is more difficult to maintain if some blood were to stand and be trapped in the lines. The sole seams 27 in the lines, which coincide with the heat- sealed seams 24 and 26, which form the liquid chamber , exclude this possibility . For the same reason, a plug of a second heat- sealed seam in the extraction line would be preferable.

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An incision 36 is provided at one end of the end seals 28 and 30 for the purpose of tearing the seals and to facilitate the removal of the end chambers 16 and 18, as shown in Pig. 3 The incision 36 is preferably at an acute angle to the sealing seams 28, 30, arranged to lead the tear under the sealing seams and allow the end chambers to be removed without compromising the sterility of the line

When the container is ready for use, the chamber 16, which encloses the supply lines, is torn open the sealing seam 28 opened The inner welds 27 in the supply lines 20 and 21 are opened, by exerting pressure on these tubes, and the liquid chamber 14 becomes with the one to be stored therein Liquid filled. When the liquid chamber is filled, the lines 20 and 21 are closed, by flattening them and placing a permanent heat seal across their compressed Walls is laid in the usual way. To empty the container, the sealing seam 30 of the chamber 18 is torn out and the chamber removed as shown in Figure 3. the Sampling line 20 is connected to another device for conveying the liquid, and the inner one Closure 27 is opened to empty the container.

In Fig. 6 another embodiment of the container according to the invention is shown. This container is similar to the container shown in Fig. 1 with the exception of the supply and removal lines 38, 39 and 40, which are longer and in their respective chambers. 16 and 18 are rolled up. An additional heat seal seam 42 is placed next to the heat seal seam 26 to form a sealed area on the edge of the container for a deep incision 4-4. This incision in the sealed area allows a clean tear across the c * <* n form the container along the HeiBaiegelnaht 26 su and you chamber

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to separate from the storage chamber 14 and thereby the line 40 for the removal of the stored liquid to fully expose.

A wide variety of thermoplastic materials are suitable for the manufacture of the container and the lines according to the invention. The flexible film of the container walls and the material from which the lines are made must of course be able to be welded to one another by the action of heat, but they do not necessarily have to be consist of the same material. Examples of suitable materials are the homo- and copolymers of olefins such as ethylene and propylene or vinyl chloride homopolymers or copolymers. A biaxially oriented polyolefin film, as described in the German patent, · .........

Patent application P 19 oil 751.7) of the Anaelderin is described for the production of containers that are used for the storage of liquids at extremely low temperatures, ie about -196 ° C, due to the good properties of such a film at these depths Temperatures preferred. The possibility of using the container according to the invention for the storage of liquids not only at the commonly used temperatures of about 4 to 10 ⁰ O, but also for freezing the liquid in the container and for storing the frozen liquid at extreme low temperatures is a great advantage over known containers. For example, when freezing the stored liquid in the storage chamber, the ratio of surface to volume of the liquid can be changed by flattening the storage chamber so that a maximum cooling speed is achieved. or de s Mixture of stored liquids can, if necessary, be lightened by kneading the flexible walls of the storage chamber «

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Claims (1)

Claims Sealed, flexible container made of thermoplastic films, characterized by a liquid storage chamber or cell (l4), which is between a first (l6) and a second, contiguous End chamber (l8) extends and from the first and second end chamber (l6, 18) through a first and second, extending heat-sealed seam (24, 26) extending across the container is separated, a liquid supply line (2o, 21) made of thermoplastic material, which is arranged in the first end chamber (ΐβ) and a first Has end (27) which protrudes into the liquid chamber (l4) through the first heat-sealed seam (24) and through the Heat-sealed seam is permanently welded to the inner walls of the container, a liquid extraction line (22) made of thermoplastic material, which is arranged in the second end chamber (l8) and has a first end (27) which extends into the liquid chamber (14) through the second heat seal seam (26) and through this The heat-sealed seam is permanently welded to the inner walls of the container, the inner walls of the supply line (2o, 21) and the removal line (22) at their first ends through the first and the second heat-sealed seam, respectively (24, 26) are welded together and the container is closed at its ends by sealed seams (.28, ^ o) is. 2. Container according to claim 1, characterized by several thermoplastic liquid supply lines (2o, 21) in the first end chamber (l6). 009840/1841 5. Container according to claim 2, characterized in that each thermoplastic liquid supply line (2o, 21) separately enclosed in the first end chamber (16) is. 4. Container according to claim 1 to 5 * characterized in that that the first transversely placed heat seal seam (24) and the second transversely placed heat seal seam (26) each consist of two closely spaced parallel heat-sealed seams exist. 5. Container according to claim 1 to 4, characterized in that the second transversely placed heat seal seam (26) extends obliquely over the container. 6. Container according to claim 1 to 5 *, characterized in that that the walls (11, 12) of the container consist of biaxially oriented polyolefin film and an incision (36, 44) provided at one end of each sealing seam (30, 28) closing the ends of the container and at an acute angle is arranged to these sealing seams. 7. A method for producing a sealed flexible plastic container, characterized in that one introduces a line made of thermoplastic material at one end and a second line made of thermoplastic material at the other end in a hose made of flexible thermoplastic film, heat and pressure simultaneously on the outer walls of the Hoses along a first transverse line that extends across one end portion and across one end of the first conduit for action 009840/1841 brings up the inner walls of the hose becoming permanent together and are welded to one end of the first line and the end of this line is flattened and turned has formed a releasable weld of the inner walls of the first conduit, heat and pressure at the same time the outer walls of the hose along a second transverse line extending across the other end portion of the hose unä extends across one end of the second conduit, acts until the inner walls of the Schlauehs are permanently welded to one another and to one end of the second conduit and the end of this conduit is flattened is and a releasable weld of the inner walls has formed in the second line, whereby one a sealed, sealed storage chamber is provided, and the inner walls of the hose are sealed at both ends and thereby forming a welded end chamber on each side of the storage chamber which forms a conduit includes. 8. The method according to claim J _t, characterized in that the heat sealing of the walls of the hose to one another and to the lines is carried out by applying heat to one outer wall along a first line across the container and at the same time applying heat to the opposite outer wall along another line parallel to the first line is brought into action at a close distance from it. 9. The method according to claim 7 or 8, characterized in that that one of the transverse heat-sealed seams delimiting the storage chamber is perpendicular along a line 009840/1841 to the longitudinal axis of the container, and the other transverse Heat-sealed seam is placed along a line running obliquely to the longitudinal axis of the container. A method according to Claims J to 9, characterized in that two lines of thermoplastic material are inserted into the hose at one end portion of the hose and one end of each line is welded by heat sealing onto the walls of the hose and closed by releasably welding the inner walls of the line . 11. The method according to claim lo, characterized in that the two lines are separately included in the end part of ^{the hose 1} >, by the inner walls of the hose are welded to one another by heat sealing between the two lines. 12. The method according to claim ¹ J to 11, characterized in that a polyolefin film is used as the thermoplastic film of the tube, which is biaxially oriented prior to the formation of the tube. 009840/1841 ty Blank page