DE122005000012I1 - N-(Pyrrolo(2-3-d)pyrimidin-3-ylacyl)-Glutamins{urederivate. - Google Patents

N-(Pyrrolo(2-3-d)pyrimidin-3-ylacyl)-Glutamins{urederivate.

Info

Publication number: DE122005000012I1
Authority: DE; Germany
Prior art keywords: ylacyl; glutamins; pyrrolo; pyrimidin; acid derivatives
Prior art date: 1989-12-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

DE200512000012

Other languages

English (en)

Other versions

DE122005000012I2 (de

Inventor

Edward C Taylor

Dietmar G Kuhnt

Chuan Shih

Gerald B Grindey

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Princeton University

Original Assignee

Princeton University

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-11

Filing date

1990-12-10

Publication date

2005-06-23

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27503964&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE122005000012(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-05-24 Priority claimed from US07/528,805 external-priority patent/US4996206A/en

1990-12-10 Application filed by Princeton University filed Critical Princeton University

2005-06-23 Publication of DE122005000012I1 publication Critical patent/DE122005000012I1/de

2006-02-09 Publication of DE122005000012I2 publication Critical patent/DE122005000012I2/de

Status Active legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

DE200512000012 1989-12-11 1990-12-10 N-(Pyrrolo(2-3-d)pyrimidin-3-ylacyl-Glutamins{urederivate Active DE122005000012I2 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US44874289A	1989-12-11	1989-12-11
US47965590A	1990-02-08	1990-02-08
US07/528,805 US4996206A (en)	1989-12-11	1990-05-24	N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives
US07/528,155 US5028608A (en)	1989-12-11	1990-05-24	N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives

Publications (2)

Publication Number	Publication Date
DE122005000012I1 true DE122005000012I1 (de)	2005-06-23
DE122005000012I2 DE122005000012I2 (de)	2006-02-09

Family

ID=27503964

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE200512000012 Active DE122005000012I2 (de)	1989-12-11	1990-12-10	N-(Pyrrolo(2-3-d)pyrimidin-3-ylacyl-Glutamins{urederivate
DE69025723T Expired - Lifetime DE69025723T2 (de)	1989-12-11	1990-12-10	N-(Pyrrolo(2-3-d)pyrimidin-3-ylacyl)-Glutaminsäurederivate

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE69025723T Expired - Lifetime DE69025723T2 (de)	1989-12-11	1990-12-10	N-(Pyrrolo(2-3-d)pyrimidin-3-ylacyl)-Glutaminsäurederivate

Country Status (22)

Country	Link
EP (1)	EP0432677B1 (de)
JP (1)	JP3016876B2 (de)
CN (1)	CN1030608C (de)
AR (1)	AR245129A1 (de)
AT (1)	ATE135007T1 (de)
AU (1)	AU640182B2 (de)
CA (1)	CA2031890C (de)
CY (1)	CY2076B1 (de)
DE (2)	DE122005000012I2 (de)
DK (1)	DK0432677T3 (de)
ES (1)	ES2084639T4 (de)
GR (1)	GR3019784T3 (de)
HK (1)	HK1000920A1 (de)
HU (1)	HU218483B (de)
IE (1)	IE904445A1 (de)
IL (1)	IL96531A (de)
LU (1)	LU91147I2 (de)
NL (1)	NL300181I2 (de)
NZ (1)	NZ236385A (de)
PT (1)	PT96140B (de)
RU (1)	RU2057131C9 (de)
SG (1)	SG48098A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5254687A (en)	1991-12-04	1993-10-19	The Trustees Of Princeton University	Process for the preparation of pyrrolo[2,3-d]pyrimidines
US5235053A (en) *	1992-06-22	1993-08-10	Eli Lilly And Company	Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates
KR20040088519A (ko)	2002-02-22	2004-10-16	뉴 리버 파마슈티칼스, 인크.	활성 제제 전달 시스템 및 활성 제제의 보호 및 투여 방법
CN100344615C (zh) *	2004-11-25	2007-10-24	重庆医药工业研究院有限责任公司	制备N－(吡咯并[2,3－d]嘧啶－5－基)酰基谷氨酸衍生物的方法及中间体
MX2007008810A (es)	2005-01-21	2007-11-21	Astex Therapeutics Ltd	Compuestos farmaceuticos.
JP2008543975A (ja)	2006-08-14	2008-12-04	シコールインコーポレイティド	高度に純粋なペメトレキセド二酸およびその調製方法
JP2008543974A (ja)	2006-08-14	2008-12-04	シコールインコーポレイティド	ペメトレキセド二酸の結晶形およびその調製方法
JP2008543976A (ja)	2006-08-14	2008-12-04	シコールインコーポレイティド	ペメトレキセド二酸の医薬上許容される凍結乾燥塩の調製方法
ES2555154T3 (es)	2006-08-14	2015-12-29	Sicor, Inc.	Procesos para la preparación de intermedios del pemetrexed
US8883790B2 (en)	2006-10-12	2014-11-11	Astex Therapeutics Limited	Pharmaceutical combinations
WO2008044041A1 (en)	2006-10-12	2008-04-17	Astex Therapeutics Limited	Pharmaceutical combinations
CN101417998B (zh)	2007-10-24	2012-10-24	重庆医药工业研究院有限责任公司	一种培美曲塞盐的纯化方法
AU2015210337B2 (en) *	2008-06-06	2017-02-02	Boehringer Ingelheim International Gmbh	Pharmaceutical combination
PE20100084A1 (es)	2008-06-06	2010-02-05	Boehringer Ingelheim Int	Combinacion farmaceutica
CN101684121B (zh) *	2008-09-22	2013-04-03	重庆医药工业研究院有限责任公司	培美曲塞二酸的新晶型及其制备方法
WO2011064256A1 (en)	2009-11-24	2011-06-03	Azad Pharmaceutical Ingredients Ag	A new crystalline form of pemetrexed disodium
US9421207B2 (en)	2012-05-30	2016-08-23	Fresenius Kabi Oncology Limited	Pharmaceutical compositions comprising pemetrexed and tromethamine
ITRM20120398A1 (it)	2012-08-08	2014-02-09	Berlin Chemie Ag	Procedimento di sintesi pemetrexed e suo sale di lisina.
WO2014167585A1 (en)	2013-04-12	2014-10-16	Actavis Group Ptc Ehf.	Pemetrexed formulation
EP2997031A1 (de)	2013-05-17	2016-03-23	Instytut Farmaceutyczny	Verfahren zur herstellung von hochreinem amorphem pemetrexed-dinatrium und kristallinen formen von n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutaminsäure
ES2657944T3 (es)	2013-06-14	2018-03-07	Synthon B.V.	Sal estable de arginina de pemetrexed y composiciones que la comprenden
EP3021849B1 (de)	2013-07-16	2019-10-09	Dr. Reddy's Laboratories Ltd.	Neuartige kristalline formen von pemetrexed-tromethamin-salzen
NZ630292A (en)	2013-11-25	2015-02-27	Shilpa Medicare Ltd	Process for crystalline pemetrexed dipotassium salt
EA034559B1 (ru)	2014-10-16	2020-02-20	Синтон Б.В.	Жидкая фармацевтическая композиция, содержащая пеметрексед
CN104672241B (zh) *	2015-01-29	2018-04-24	王磊	吡咯并[2,3-d]嘧啶类化合物及其用途
FR3037956B1 (fr) *	2015-06-23	2017-08-04	Servier Lab	Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP7158023B2 (ja)	2016-03-15	2022-10-21	オリソンヘノミクスエセ．アー．	固形腫瘍の治療における使用のための、ｌｓｄ１阻害剤の組合せ
US10793573B2 (en) *	2017-08-31	2020-10-06	Duquesne University Of The Holy Spirit	First-in-class of SHMT2 and MTHFD2 inhibitors as antitumor agents
CN110305136A (zh) *	2018-03-20	2019-10-08	鲁南制药集团股份有限公司	一种培美曲塞二钠中间体及其制备方法
CN110305134B (zh) *	2018-03-20	2022-02-22	鲁南制药集团股份有限公司	一种培美曲塞二钠中间体及其制备方法
CN110305137A (zh) *	2018-03-20	2019-10-08	鲁南制药集团股份有限公司	一种培美曲塞二钠中间体及其制备方法
CN110305135B (zh) *	2018-03-20	2022-02-22	鲁南制药集团股份有限公司	一种培美曲塞二钠中间体及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4818819A (en) *	1986-10-20	1989-04-04	The Trustees Of Princeton University	Process for the preparation of fused pyridine compounds
NO169490C (no) *	1988-03-24	1992-07-01	Takeda Chemical Industries Ltd	Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
DK172753B1 (da) *	1988-05-25	1999-06-28	Lilly Co Eli	N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat
US4883799A (en) *	1988-06-29	1989-11-28	The Trustees Of Princeton University	N-(4-(1-hydroxy-3-(5,6,7,8-tetrahydropyrido(2,3,-d)-pyrimidin-6-yl)prop-2-yl)benzoyl)glutamic acid derivatives

1990
- 1990-12-04 IL IL9653190A patent/IL96531A/en active Protection Beyond IP Right Term
- 1990-12-05 AU AU67791/90A patent/AU640182B2/en not_active Expired
- 1990-12-07 NZ NZ236385A patent/NZ236385A/en unknown
- 1990-12-10 DE DE200512000012 patent/DE122005000012I2/de active Active
- 1990-12-10 EP EP90123671A patent/EP0432677B1/de not_active Expired - Lifetime
- 1990-12-10 IE IE444590A patent/IE904445A1/en not_active IP Right Cessation
- 1990-12-10 AT AT90123671T patent/ATE135007T1/de active
- 1990-12-10 DK DK90123671.1T patent/DK0432677T3/da active
- 1990-12-10 CA CA002031890A patent/CA2031890C/en not_active Expired - Lifetime
- 1990-12-10 AR AR90318580A patent/AR245129A1/es active
- 1990-12-10 PT PT96140A patent/PT96140B/pt not_active IP Right Cessation
- 1990-12-10 HU HU147/90A patent/HU218483B/hu unknown
- 1990-12-10 ES ES90123671T patent/ES2084639T4/es not_active Expired - Lifetime
- 1990-12-10 SG SG1996007025A patent/SG48098A1/en unknown
- 1990-12-10 DE DE69025723T patent/DE69025723T2/de not_active Expired - Lifetime
- 1990-12-11 JP JP2409992A patent/JP3016876B2/ja not_active Expired - Lifetime
- 1990-12-11 CN CN90110125A patent/CN1030608C/zh not_active Ceased
1991
- 1991-02-07 RU SU4894454/04A patent/RU2057131C9/ru active Protection Beyond IP Right Term
1996
- 1996-04-29 GR GR960401164T patent/GR3019784T3/el unknown
1997
- 1997-12-22 HK HK97102541A patent/HK1000920A1/xx not_active IP Right Cessation
1998
- 1998-09-11 CY CY9802076A patent/CY2076B1/xx unknown
2005
- 2005-03-14 LU LU91147C patent/LU91147I2/fr unknown
- 2005-03-16 NL NL300181C patent/NL300181I2/nl unknown

Also Published As

Publication number	Publication date
IL96531A (en)	1995-08-31
ES2084639T4 (es)	2013-06-11
RU2057131C9 (ru)	2006-04-10
NZ236385A (en)	1992-05-26
NL300181I2 (nl)	2005-06-01
HU218483B (hu)	2000-09-28
AR245129A1 (es)	1993-12-30
EP0432677A1 (de)	1991-06-19
CN1055182A (zh)	1991-10-09
GR3019784T3 (en)	1996-07-31
IL96531A0 (en)	1991-09-16
CA2031890C (en)	2000-07-25
NL300181I1 (nl)	2005-05-02
PT96140B (pt)	1997-06-30
DE69025723T2 (de)	1996-10-31
AU6779190A (en)	1991-06-13
HU908147D0 (en)	1991-06-28
RU2057131C1 (ru)	1996-03-27
CY2076B1 (en)	1998-09-11
CN1030608C (zh)	1996-01-03
CA2031890A1 (en)	1991-06-12
AU640182B2 (en)	1993-08-19
ES2084639T3 (es)	1996-05-16
JP3016876B2 (ja)	2000-03-06
PT96140A (pt)	1991-09-30
HUT58335A (en)	1992-02-28
EP0432677B1 (de)	1996-03-06
DE69025723D1 (de)	1996-04-11
IE904445A1 (en)	1991-06-19
HK1000920A1 (en)	1998-05-08
DK0432677T3 (da)	1996-04-09
SG48098A1 (en)	1998-04-17
ATE135007T1 (de)	1996-03-15
DE122005000012I2 (de)	2006-02-09
JPH083166A (ja)	1996-01-09
LU91147I2 (fr)	2005-05-17

Publication	Publication Date	Title
DE122005000012I1 (de)	2005-06-23	N-(Pyrrolo(2-3-d)pyrimidin-3-ylacyl)-Glutamins{urederivate.
DE68915207D1 (de)	1994-06-16	Aminosäure-Derivate.
NO901399L (no)	1990-10-01	Aminosyrederivater.
DE59008394D1 (de)	1995-03-16	Aminosäureamid-Derivate.
DK340088D0 (da)	1988-06-21	Aminosyrederivater
DE69014865D1 (de)	1995-01-19	Peroxycarbonsäure.
NO901033L (no)	1990-09-07	Aminosyrederivater.
NO903832L (no)	1991-03-05	Aminosyrederivater.
DE3872937D1 (de)	1992-08-27	Benzoylaminophenoxybuttersaeure-derivate.
DE3787657D1 (de)	1993-11-11	Aminosäure-Derivate.
NO884434L (no)	1989-04-07	Aminosyrederivater.
NO901533L (no)	1990-10-08	Aminosyrederivater.
NO900025D0 (no)	1990-01-04	Pyrrolylfenyl-substituerte hydroksamsyrederivater.
NO884361L (no)	1989-04-03	Katechol-karboksylsyrederivater.
FI882277A (fi)	1988-11-20	Nitrogen innehaollande epipodofyllotoxin-glukosid-derivat.
NO892728L (no)	1990-01-02	Aminoalkyl-aminokarbonyl-aminodiolaminosyre derivater somanti-hypertensive midler.
DE69018816D1 (de)	1995-05-24	Aminosäurederivate.
DE69019217D1 (de)	1995-06-14	Perylenquinon (UCN-1028D)-Derivate.
DE59002430D1 (de)	1993-09-30	Cyclopropanoylaminosäureamid-Derivate.
DE3864841D1 (de)	1991-10-24	Carbonsaeure-derivate.
NO901519L (no)	1990-10-05	Aminosyrederivater.
DE3854064D1 (de)	1995-08-03	Hydrochinonylphenyl-Buttersäureamid-Derivate.
DE3886125D1 (de)	1994-01-20	Harnstoff-Derivate.
ATE105549T1 (de)	1994-05-15	Aminosaeure-derivate.
ATE95518T1 (de)	1993-10-15	Aminosaeure-derivate.